{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:53:33Z","timestamp":1791910413452,"version":"4.3.4"},"reference-count":151,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118297","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:24:46Z","timestamp":1785698686000},"page":"118297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species"],"prefix":"10.1016","volume":"253","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9040-1681","authenticated-orcid":false,"given":"Yasuhiro","family":"Uno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-6062","authenticated-orcid":false,"given":"Koya","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-4261","authenticated-orcid":false,"given":"Hiroshi","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00008571-200401000-00001","article-title":"Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants","volume":"14","author":"Nelson","year":"2004","journal-title":"Pharmacogenetics"},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0010","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.106.022673","article-title":"CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone","volume":"70","author":"Uno","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0015","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/00498250600968275","article-title":"CYP2C76-mediated species difference in drug metabolism: a comparison of pitavastatin metabolism between monkeys and humans","volume":"37","author":"Uno","year":"2007","journal-title":"Xenobiotica"},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pharmthera.2005.01.001","article-title":"Mammalian flavin-containing monooxygenases: structure\/function, genetic polymorphisms and role in drug metabolism","volume":"106","author":"Krueger","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2026.118297_b0025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.pharmtox.46.120604.141043","article-title":"Human flavin-containing monooxygenases","volume":"46","author":"Cashman","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/00498254.2019.1643515","article-title":"Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease","volume":"50","author":"Phillips","year":"2020","journal-title":"Xenobiotica"},{"issue":"12","key":"10.1016\/j.bcp.2026.118297_b0035","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.bcp.2013.04.012","article-title":"Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque","volume":"85","author":"Uno","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115125","article-title":"Molecular and functional characterization of flavin-containing monooxygenases in pigs, dogs, and cats","volume":"202","author":"Uno","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"7676","key":"10.1016\/j.bcp.2026.118297_b0045","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0140-6736(70)90241-2","article-title":"Trimethylaminuria: the fish-odour syndrome","volume":"2","author":"Humbert","year":"1970","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0050","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1038\/ejhg.2011.214","article-title":"Clinical utility gene card for: trimethylaminuria","volume":"20","author":"Shephard","year":"2012","journal-title":"Eur. J. Hum. Genet."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0055","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/ATVBAHA.114.303252","article-title":"Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine","volume":"34","author":"J. Hartiala, B.J. Bennett, W.H. Tang, Z. Wang, A.F. Stewart, R. Roberts, R. McPherson, A.J. Lusis, S.L. Hazen, H. Allayee, C.A. Consortium","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0060","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bcp.2014.07.004","article-title":"CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques","volume":"91","author":"Uno","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2015.03.008","article-title":"Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo","volume":"95","author":"Utoh","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118297_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmd.2025.100189","article-title":"Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol","volume":"53","author":"Uno","year":"2025","journal-title":"Drug Metab. Dispos."},{"issue":"Pt 4","key":"10.1016\/j.bcp.2026.118297_b0075","article-title":"Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole","volume":"242","author":"Uno","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117790","article-title":"Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide","volume":"247","author":"Uno","year":"2026","journal-title":"Biochem. Pharmacol."},{"issue":"Pt 1","key":"10.1016\/j.bcp.2026.118297_b0085","article-title":"Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations","volume":"242","author":"Uno","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116124","article-title":"A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models","volume":"228","author":"Uno","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0095","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0009-2797(01)00162-4","article-title":"Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man","volume":"134","author":"Lu","year":"2001","journal-title":"Sprague-Dawley Rat, Minipig, and Beagle Dog, Chem Biol Interact"},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0100","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/004982598239308","article-title":"Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver","volume":"28","author":"Nishibe","year":"1998","journal-title":"Xenobiotica"},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/genes11111295","article-title":"A Review of the Important Role of CYP2D6 in Pharmacogenomics","volume":"11","author":"Taylor","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bcp.2026.118297_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmpk.2020.11.005","article-title":"Update on next generation sequencing of pharmacokinetics-related genes: Development of the PKseq panel, a platform for amplicon sequencing of drug-metabolizing enzyme and drug transporter genes","volume":"37","author":"Fukunaga","year":"2021","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s10038-020-0815-x","article-title":"Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population","volume":"66","author":"Fukunaga","year":"2021","journal-title":"J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41439-021-00135-z","article-title":"Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)","volume":"8","author":"Runcharoen","year":"2021","journal-title":"Hum. Genome Var."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s42003-021-01698-x","article-title":"A novel canine reference genome resolves genomic architecture and uncovers transcript complexity","volume":"4","author":"Wang","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2026.118297_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.663175","article-title":"Sequencing of the Canine Cytochrome P450 CYP2C41 Gene and Genotyping of its Polymorphic Occurrence in 36 Dog Breeds","volume":"8","author":"Karakus","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.bcp.2026.118297_b0135","article-title":"Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes","volume":"265","author":"Uno","year":"2023","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2026.118297_b0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2009.03.003","article-title":"Expression and inducibility of CYP1A1, 1A2, 1B1 by b-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig","volume":"260","author":"Messina","year":"2009","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.rvsc.2012.07.015","article-title":"Expression and inducibility of CYP1A1, 1A2, 1B1 by b-naphthoflavone and CYP2B22, CYP3As by rifampicin in heart regions and coronary arteries of pig","volume":"94","author":"Messina","year":"2013","journal-title":"Res. Vet. Sci."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0150","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/jvp.12400","article-title":"Use of RNA-seq to determine variation in canine cytochrome P450 mRNA expression between blood, liver, lung, kidney and duodenum in healthy beagles","volume":"40","author":"Visser","year":"2017","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.bcp.2026.118297_b0155","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1124\/dmd.31.9.1161","article-title":"Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450","volume":"31","author":"Shou","year":"2003","journal-title":"Drug Metab. Dispos."},{"issue":"8","key":"10.1016\/j.bcp.2026.118297_b0160","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1292\/jvms.17-0192","article-title":"Biochemical characterization of variants of canine CYP1A1 using heterologous expression","volume":"79","author":"Yu","year":"2017","journal-title":"J. Vet. Med. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0165","first-page":"97","article-title":"Toxicological significance of dog liver cytochrome P-450: examination with the enzyme expressed in Saccharomyces cerevisiae using recombinant expression plasmid","volume":"269","author":"Fukuta","year":"1992","journal-title":"Mutat. Res."},{"issue":"9","key":"10.1016\/j.bcp.2026.118297_b0170","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1124\/dmd.108.022301","article-title":"Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes","volume":"36","author":"Mise","year":"2008","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0175","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/dmd.108.025312","article-title":"Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase","volume":"37","author":"Locuson","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/jvp.12256","article-title":"Evaluation of tizanidine as a marker of canine CYP1A2 activity","volume":"39","author":"Locuson","year":"2016","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2026.118297_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2025.1511341","article-title":"Evaluation of the relationship between cytochrome P450 (CYP) 1A2 gene copy number variation and CYP1A2 protein content and enzyme activity in canine liver","volume":"12","author":"Zamora","year":"2025","journal-title":"Front. Vet. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0190","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1124\/mol.113.087700","article-title":"Specificity determinants of CYP1B1 estradiol hydroxylation","volume":"84","author":"Nishida","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0195","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jbt.20118","article-title":"Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes","volume":"20","author":"Graham","year":"2006","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0200","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0026-895X(25)09467-2","article-title":"Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs","volume":"38","author":"Uchida","year":"1990","journal-title":"Mol. Pharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0205","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1124\/dmd.30.11.1206","article-title":"In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs","volume":"30","author":"Graham","year":"2002","journal-title":"Drug Metab. Dispos."},{"issue":"6\u20137","key":"10.1016\/j.bcp.2026.118297_b0210","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/00498254.2023.2266840","article-title":"Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation","volume":"53","author":"Uno","year":"2023","journal-title":"Xenobiotica"},{"issue":"7","key":"10.1016\/j.bcp.2026.118297_b0215","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1124\/dmd.105.003913","article-title":"Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity","volume":"33","author":"Gibson","year":"2005","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0220","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/dmd.32.2.240","article-title":"Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs","volume":"32","author":"Mise","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0225","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00008571-200411000-00008","article-title":"Identification of non-functional allelic variant of CYP1A2 in dogs","volume":"14","author":"Mise","year":"2004","journal-title":"Pharmacogenetics"},{"issue":"9","key":"10.1016\/j.bcp.2026.118297_b0230","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/00498250412331285436","article-title":"Identification of the novel canine CYP1A2 1117 C > T SNP causing protein deletion","volume":"34","author":"Tenmizu","year":"2004","journal-title":"Xenobiotica"},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0235","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s00204-006-0100-6","article-title":"Genetic polymorphism of cytochrome P450s in beagles: possible influence of CYP1A2 deficiency on toxicological evaluations","volume":"80","author":"Kamimura","year":"2006","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0240","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.cvsm.2013.05.001","article-title":"Canine cytochrome P-450 pharmacogenetics","volume":"43","author":"Court","year":"2013","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0245","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1124\/dmd.105.008722","article-title":"The canine CYP1A2 deficiency polymorphism dramatically affects the pharmacokinetics of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-D]-pyrimidine-2-(1H)-one (YM-64227), a phosphodiesterase type 4 inhibitor","volume":"34","author":"Tenmizu","year":"2006","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0250","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1124\/dmd.111.041848","article-title":"Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs","volume":"40","author":"Whiterock","year":"2012","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0255","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1124\/dmd.122.001152","article-title":"Newly Identified tree Shrew Cytochrome P450 2A13 is expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog Cytochrome P450 2A13 and Pig Cytochrome P450 2A19","volume":"51","author":"Ushirozako","year":"2023","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.bcp.2026.118297_b0260","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1124\/dmd.110.033068","article-title":"Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells","volume":"38","author":"Zhou","year":"2010","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0265","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1124\/dmd.109.030528","article-title":"Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5","volume":"38","author":"Wiercinska","year":"2010","journal-title":"Drug Metab. Dispos."},{"issue":"12","key":"10.1016\/j.bcp.2026.118297_b0270","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1080\/00498250802474437","article-title":"Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2","volume":"38","author":"Messina","year":"2008","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0275","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/00498254.2023.2197037","article-title":"2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22","volume":"53","author":"Uno","year":"2023","journal-title":"Xenobiotica"},{"issue":"19","key":"10.1016\/j.bcp.2026.118297_b0280","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.csbj.2014.09.003","article-title":"Regulation of porcine hepatic cytochrome P450 - implication for boar taint","volume":"11","author":"Rasmussen","year":"2014","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.bcp.2026.118297_b0285","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0006-2952(99)00015-5","article-title":"Expression of CYP2A genes in human liver and extrahepatic tissues","volume":"57","author":"Koskela","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0290","first-page":"5074","article-title":"Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone","volume":"60","author":"Su","year":"2000","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0295","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1124\/dmd.119.088070","article-title":"Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes using Label-Free Standard-Free Analysis reveals Interbreed Variability","volume":"47","author":"Martinez","year":"2019","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0300","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1600-0773.1999.tb00088.x","article-title":"Cytochrome P450 sex differences in minipigs and conventional pigs","volume":"85","author":"Skaanild","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.bcp.2026.118297_b0305","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.toxlet.2019.08.008","article-title":"Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in G\u00f6ttingen minipigs","volume":"314","author":"Rasmussen","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bcp.2026.118297_b0310","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3389\/fphar.2018.00470","article-title":"The Ontogeny of Cytochrome P450 Enzyme activity and Protein Abundance in conventional Pigs in support of Preclinical Pediatric Drug Research","volume":"9","author":"Millecam","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0315","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1021\/acs.jafc.3c08663","article-title":"Key Role of Porcine Cytochrome P450 2A19 in the Bioactivation of aflatoxin B(1) in the Liver","volume":"72","author":"Wang","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0320","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2052.2004.01140.x","article-title":"Molecular cloning, expression and functional characterization of the cytochrome P450 2A6 gene in pig liver","volume":"35","author":"Lin","year":"2004","journal-title":"Anim. Genet."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0325","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1742-7843.2005.pto_148.x","article-title":"Porcine CYP2A polymorphisms and activity","volume":"97","author":"Skaanild","year":"2005","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118297_b0330","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/00498254.2022.2141153","article-title":"Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes","volume":"52","author":"Uno","year":"2022","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0335","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11095-014-1446-8","article-title":"Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine","volume":"32","author":"Heikkinen","year":"2015","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0340","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41598-019-56660-z","article-title":"Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization","volume":"10","author":"Martinez","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0345","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0026-895X(25)09688-9","article-title":"Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity","volume":"46","author":"Hasler","year":"1994","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0350","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3109\/03602532.2013.765445","article-title":"Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics","volume":"45","author":"Martinez","year":"2013","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.bcp.2026.118297_b0355","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11419-018-0450-9","article-title":"Metabolism of triacetone triperoxide (TATP) by canine cytochrome P450 2B11","volume":"37","author":"Colizza","year":"2019","journal-title":"Forensic Toxicol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118297_b0360","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3109\/00498259609046746","article-title":"Quantitation of cytochrome P450 enzymes (CYP1A1\/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay","volume":"26","author":"Eguchi","year":"1996","journal-title":"Xenobiotica"},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0365","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1124\/dmd.122.001236","article-title":"Novel Cytochrome P450 2C94 Functionally Metabolizes Diclofenac and Omeprazole in dogs","volume":"51","author":"Uno","year":"2023","journal-title":"Drug Metab. Dispos."},{"issue":"9\u201311","key":"10.1016\/j.bcp.2026.118297_b0370","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/00498254.2022.2148139","article-title":"A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs","volume":"52","author":"Uno","year":"2022","journal-title":"Xenobiotica"},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0375","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1124\/dmd.111.040618","article-title":"Cytochrome P450 Pig liver pie: determination of individual cytochrome P450 isoform contents in microsomes from two pig livers using liquid chromatography in conjunction with mass spectrometry [corrected]","volume":"39","author":"Achour","year":"2011","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0380","doi-asserted-by":"crossref","first-page":"9233","DOI":"10.1038\/s41598-019-45212-0","article-title":"Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from a Quantitative, activity and Selectivity Perspective","volume":"9","author":"Schelstraete","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118297_b0385","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.665644","article-title":"Hepatic Cytochrome P450 Abundance and activity in the developing and Adult Gottingen Minipig: Pivotal Data for PBPK Modeling","volume":"12","author":"Buyssens","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0390","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.dmpk.2016.02.001","article-title":"Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs","volume":"31","author":"Kojima","year":"2016","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.bcp.2026.118297_b0395","doi-asserted-by":"crossref","DOI":"10.1111\/jvp.70094","article-title":"Different roles of canine cytochrome P450 2C and 3A enzymes involved in the oxidative metabolism of phenobarbital, a key anticonvulsant for dogs: comparison with human P450 enzymes","author":"Uno","year":"2026","journal-title":"J Vet Pharmacol Ther, in Press"},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0400","first-page":"278","article-title":"Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression","volume":"26","author":"Blaisdell","year":"1998","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0405","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/0049825021000048782","article-title":"mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates","volume":"33","author":"Graham","year":"2003","journal-title":"Xenobiotica"},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0410","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1124\/dmd.123.001603","article-title":"Novel tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan","volume":"52","author":"Ushirozako","year":"2024","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0415","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/abbi.1998.0801","article-title":"Expression and characterization of canine cytochrome P450 2D15","volume":"357","author":"Roussel","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0420","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1006\/abbi.1995.1307","article-title":"A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization","volume":"319","author":"Sakamoto","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"issue":"10","key":"10.1016\/j.bcp.2026.118297_b0425","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0090-9556(24)15037-4","article-title":"Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib","volume":"27","author":"Paulson","year":"1999","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0430","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/oxfordjournals.jbchem.a021905","article-title":"Expression and characterization of dog CYP2D15 using baculovirus expression system","volume":"123","author":"Tasaki","year":"1998","journal-title":"J. Biochem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0435","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1124\/dmd.32.4.376","article-title":"Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs","volume":"32","author":"Sakuma","year":"2004","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0440","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1034\/j.1600-0773.2002.t01-2-910403.x","article-title":"Is cytochrome P450 CYP2D activity present in pig liver?","volume":"91","author":"Skaanild","year":"2002","journal-title":"Pharmacol. Toxicol."},{"issue":"8","key":"10.1016\/j.bcp.2026.118297_b0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmd.2025.100110","volume":"53","author":"Gangl","year":"2025","journal-title":"Drug Metab. Dispos."},{"issue":"12","key":"10.1016\/j.bcp.2026.118297_b0450","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1124\/dmd.116.071902","article-title":"Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs)","volume":"44","author":"Perez Jimenez","year":"2016","journal-title":"Drug Metab. Dispos."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0455","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/jvp.12706","article-title":"Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes","volume":"41","author":"Perez Jimenez","year":"2018","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0460","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/jvp.12890","article-title":"Analysis of polymorphisms of canine Cytochrome P 450-CYP2D15","volume":"43","author":"van Hagen","year":"2020","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0465","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jvp.13113","article-title":"Association of cytochrome P450 2D15 (CYP2D15) nonsynonymous polymorphisms and exon 3 deleted RNA splice variant with CYP2D15 protein content and enzyme function in dog liver microsomes","volume":"46","author":"Jimenez","year":"2023","journal-title":"J. Vet. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0470","doi-asserted-by":"crossref","DOI":"10.2460\/ajvr.24.12.0377","article-title":"Dextromethorphan phenotyping of healthy pet dogs reveals breed-associated differences in cytochrome P450 2D15-mediated drug metabolism","volume":"86","author":"Jimenez","year":"2025","journal-title":"Am. J. Vet. Res."},{"issue":"10\u201311","key":"10.1016\/j.bcp.2026.118297_b0475","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/00498254.2023.2280996","article-title":"Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p-nitrophenol","volume":"53","author":"Ushirozako","year":"2023","journal-title":"Xenobiotica"},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0480","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.bbrc.2012.11.060","article-title":"Serum androgen level is determined by autosomal dominant inheritance and regulates sex-related CYP genes in pigs","volume":"430","author":"Kojima","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.bcp.2026.118297_b0485","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0090-9556(24)15173-2","article-title":"Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles","volume":"28","author":"Lankford","year":"2000","journal-title":"Drug Metab. Dispos."},{"issue":"12","key":"10.1016\/j.bcp.2026.118297_b0490","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1080\/00498250010021684","article-title":"Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man","volume":"30","author":"Bogaards","year":"2000","journal-title":"Xenobiotica"},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0495","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1742-7843.2007.00083.x","article-title":"Is bupropion a more specific substrate for porcine CYP2E than chlorzoxazone and p-nitrophenol?","volume":"101","author":"Skaanild","year":"2007","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"4\u20135","key":"10.1016\/j.bcp.2026.118297_b0500","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jsbmb.2005.07.001","article-title":"Functional polymorphism in porcine CYP2E1 gene: its association with skatole levels","volume":"99","author":"Lin","year":"2006","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"8","key":"10.1016\/j.bcp.2026.118297_b0505","article-title":"Effect of SNPs in the Promoter Region on the Expression of Cytochrome P450 2E1 (CYP2E1) in Pig Liver","volume":"14","author":"Archer","year":"2024","journal-title":"Animals (basel)"},{"issue":"11","key":"10.1016\/j.bcp.2026.118297_b0510","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1124\/dmd.122.000930","article-title":"Cytochrome P450 2J Genes are Expressed in dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes","volume":"50","author":"Uno","year":"2022","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0515","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1124\/dmd.121.000749","article-title":"A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) reveals a Functional Role of newly Identified CYP3A98 in Small Intestine","volume":"51","author":"Uno","year":"2023","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bcp.2026.118297_b0520","article-title":"Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes","volume":"267","author":"Uno","year":"2023","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116846","article-title":"Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol","volume":"235","author":"Uno","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0530","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1124\/dmd.122.000864","article-title":"Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and dogs","volume":"50","author":"Wu","year":"2022","journal-title":"Drug Metab. Dispos."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0535","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/dmd.121.000385","article-title":"Tertiary Oxidation of Deoxycholate is Predictive of CYP3A activity in dogs","volume":"49","author":"Zeng","year":"2021","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0540","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/00498254.2023.2211673","article-title":"Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs","volume":"53","author":"Uno","year":"2023","journal-title":"Xenobiotica"},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0545","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0009-2797(01)00164-8","article-title":"Induction of intestinal cytochrome P450 (CYP3A) by rifampicin in beagle dogs","volume":"134","author":"Kyokawa","year":"2001","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0550","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00498254.2024.2326973","article-title":"Assessment of cytochrome P450 induction in canine intestinal organoid models","volume":"54","author":"Nagao","year":"2024","journal-title":"Xenobiotica"},{"issue":"12","key":"10.1016\/j.bcp.2026.118297_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmd.2025.100191","article-title":"Canine duodenal organoids as a functional platform for intestinal CYP regulation and drug metabolism studies","volume":"53","author":"Nakazawa","year":"2025","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0560","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.yexcr.2017.09.011","article-title":"Induction of cytochrome P450 mRNA in porcine primary hepatocytes cultured under serum free conditions: Comparison of freshly isolated cells and cryopreserved","volume":"360","author":"Rasmussen","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bcp.2026.118297_b0565","first-page":"149","article-title":"Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR","volume":"2","author":"Gerbal-Chaloin","year":"2021","journal-title":"CAR and PXR, Curr Res Toxicol"},{"issue":"5","key":"10.1016\/j.bcp.2026.118297_b0570","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2133\/dmpk.DMPK-11-RG-146","article-title":"Effects of time culture and prototypical cytochrome P450 3A (CYP3A) inducers on CYP2B22, CYP2C, CYP3A and nuclear receptor (NR) mRNAs in long-term cryopreserved pig hepatocytes (CPHs)","volume":"27","author":"Giantin","year":"2012","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"8","key":"10.1016\/j.bcp.2026.118297_b0575","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/00498254.2010.489125","article-title":"Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22, and CYP3As in porcine liver, kidney, small intestine, and nasal tissues","volume":"40","author":"Puccinelli","year":"2010","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bcp.2026.118297_b0580","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.foodchem.2013.09.068","article-title":"Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory","volume":"146","author":"Rasmussen","year":"2014","journal-title":"Food Chem."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2026.118297_b0585","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tox.2008.08.004","article-title":"Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig","volume":"252","author":"Nannelli","year":"2008","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0590","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/138920011795713698","article-title":"Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model","volume":"12","author":"Puccinelli","year":"2011","journal-title":"Curr. Drug Metab."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118297_b0595","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tox.2007.07.015","article-title":"Inducibility of AhR-regulated CYP genes by beta-naphthoflavone in the liver, lung, kidney and heart of the pig","volume":"240","author":"Chirulli","year":"2007","journal-title":"Toxicology"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118297_b0600","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11010-009-0292-1","article-title":"Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs","volume":"337","author":"Nannelli","year":"2010","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0605","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/toxsci\/kfl009","article-title":"Cloning, tissue expression, and regulation of beagle dog CYP4A genes","volume":"92","author":"Graham","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2026.118297_b0610","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1124\/dmd.124.001780","article-title":"Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, tree Shrews, and dogs in Comparison with the Metabolic Capacity of Human P450 4A11","volume":"52","author":"Uno","year":"2024","journal-title":"Drug Metab. Dispos."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0615","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1101\/gr.083741.108","article-title":"Mapping DNA structural variation in dogs","volume":"19","author":"Chen","year":"2009","journal-title":"Genome Res."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2026.118297_b0620","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj3630297","article-title":"Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25]","volume":"363","author":"Lundell","year":"2002","journal-title":"Biochem. J"},{"issue":"8","key":"10.1016\/j.bcp.2026.118297_b0625","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1248\/bpb.b21-00333","article-title":"Androgen-Dependent differences in the Amounts of CYP mRNAs in the Pig Kidney","volume":"44","author":"Kojima","year":"2021","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0630","doi-asserted-by":"crossref","first-page":"R1525","DOI":"10.1152\/ajpregu.00751.2004","article-title":"Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPAR\u03b1 in nonproliferating species","volume":"288","author":"Cheon","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"13","key":"10.1016\/j.bcp.2026.118297_b0635","doi-asserted-by":"crossref","first-page":"9606","DOI":"10.1074\/jbc.M006584200","article-title":"Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily","volume":"276","author":"Lundell","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0640","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbalip.2003.09.002","article-title":"Gene structure of pig sterol 12a-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6a-hydroxylase (CYP4A21)","volume":"1634","author":"Lundell","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bcp.2026.118297_b0645","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116894","article-title":"Exploration of functional cytochrome P450 4F enzymes in liver, intestine, and kidney from dogs, cats, pigs, and tree shrews and comparison of their metabolic capacities with human P450 4F2 and 4F12","volume":"236","author":"Uno","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118297_b0650","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1124\/dmd.109.027714","article-title":"Expression and characterization of functional dog flavin-containing monooxygenase 3","volume":"37","author":"Lickteig","year":"2009","journal-title":"Drug Metab. Dispos."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0655","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/bi00453a014","article-title":"The flavin-containing monooxygenase expressed in pig liver: primary sequence, distribution, and evidence for a single gene","volume":"29","author":"Gasser","year":"1990","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.bcp.2026.118297_b0660","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1432-1033.1996.00683.x","article-title":"Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin-containing monooxygenase family of man, FMO1, FMO3 and FM04","volume":"235","author":"Dolphin","year":"1996","journal-title":"Eur. J. Biochem."},{"issue":"19","key":"10.1016\/j.bcp.2026.118297_b0665","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1016\/S0021-9258(18)98908-8","article-title":"Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1)","volume":"266","author":"Dolphin","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0670","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1203\/00006450-200202000-00018","article-title":"Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression","volume":"51","author":"Koukouritaki","year":"2002","journal-title":"Pediatr. Res."},{"issue":"46","key":"10.1016\/j.bcp.2026.118297_b0675","doi-asserted-by":"crossref","first-page":"30599","DOI":"10.1074\/jbc.273.46.30599","article-title":"The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein","volume":"273","author":"Dolphin","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2026.118297_b0680","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/FPC.0b013e3283097311","article-title":"The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa","volume":"18","author":"Veeramah","year":"2008","journal-title":"Pharmacogenet. Genomics"},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0685","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/dmd.30.2.119","article-title":"Cloning, sequencing, and tissue-dependent expression of flavin-containing monooxygenase (FMO) 1 and FMO3 in the dog","volume":"30","author":"Lattard","year":"2002","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0690","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1124\/mol.63.2.271","article-title":"Expression and characterization of functional dog flavin-containing monooxygenase 1","volume":"63","author":"Stevens","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118297_b0695","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bcp.2014.04.019","article-title":"Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs","volume":"90","author":"Yamazaki","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118297_b0700","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1016\/S0021-9258(18)53500-6","article-title":"Expression in Escherichia coli of the cloned flavin-containing monooxygenase from pig liver","volume":"268","author":"Lomri","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118297_b0705","doi-asserted-by":"crossref","DOI":"10.1111\/jvim.70190","article-title":"Adverse Drug-Drug Interaction between Phenobarbital and Fluconazole in two dogs","volume":"39","author":"Jaramillo","year":"2025","journal-title":"J. Vet. Intern. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118297_b0710","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1124\/dmd.118.083444","article-title":"Oral Coadministration of Fluconazole with Tramadol Markedly increases Plasma and Urine Concentrations of Tramadol and the O-Desmethyltramadol Metabolite in healthy dogs","volume":"47","author":"Perez Jimenez","year":"2019","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.bcp.2026.118297_b0715","doi-asserted-by":"crossref","DOI":"10.2460\/ajvr.24.02.0049","article-title":"Validation of a bupropion, dextromethorphan, and omeprazole cocktail for simultaneous phenotyping of cytochrome P450 2B11, 2D15, and 3A12 activities in dogs","volume":"85","author":"Martinez","year":"2024","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.bcp.2026.118297_b0720","first-page":"173","article-title":"Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans","volume":"5","author":"Sakai","year":"2014","journal-title":"J Drug Metab Toxicol"},{"issue":"10","key":"10.1016\/j.bcp.2026.118297_b0725","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3109\/00498254.2014.903532","article-title":"Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs","volume":"44","author":"Koyanagi","year":"2014","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bcp.2026.118297_b0730","doi-asserted-by":"crossref","unstructured":"C. Sakai, E. Higashi, S. Iwano, Y. Miyamoto, H. Yamazaki, M. Uchida, In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs, Xenobiotica, in press (2026).doi: 10.1080\/00498254.2026.2711041.","DOI":"10.1080\/00498254.2026.2711041"},{"key":"10.1016\/j.bcp.2026.118297_b0735","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2016.06.008","article-title":"Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes","volume":"121","author":"Uno","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0740","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bcp.2017.12.015","article-title":"Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans","volume":"153","author":"Uno","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113721","article-title":"The marmoset cytochrome P450 superfamily: Sequence\/phylogenetic analyses, genomic structure, and catalytic function","volume":"171","author":"Uehara","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118297_b0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114887","article-title":"Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans","volume":"197","author":"Uno","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118297_b0755","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s00204-020-02710-9","article-title":"Porcine cytochrome P450 3A: current status on expression and regulation","volume":"94","author":"Rasmussen","year":"2020","journal-title":"Arch. Toxicol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226006362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226006362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:25:07Z","timestamp":1791908707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226006362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":151,"alternative-id":["S0006295226006362"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118297","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118297"}}