{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:07:37Z","timestamp":1788815257887,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010881","name":"Suzhou City Science and Technology Bureau","doi-asserted-by":"publisher","award":["SKYD2023002"],"award-info":[{"award-number":["SKYD2023002"]}],"id":[{"id":"10.13039\/501100010881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202001"],"award-info":[{"award-number":["82202001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010008","name":"Postdoctoral Science Foundation of Guangxi Province of China","doi-asserted-by":"publisher","award":["2024M761196"],"award-info":[{"award-number":["2024M761196"]}],"id":[{"id":"10.13039\/501100010008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118314","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:27:05Z","timestamp":1786145225000},"page":"118314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Liver cells-derived extracellular vesicles deliver a dual-functional RNA ligand for TACE treatment of hepatocellular carcinoma"],"prefix":"10.1016","volume":"253","author":[{"given":"Huayuan","family":"Xiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxuan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-0188","authenticated-orcid":false,"given":"Lingxiang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118314_b0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bcp.2026.118314_b0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bcp.2026.118314_b0015","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1097\/CM9.0000000000002641","article-title":"Precision diagnosis of hepatocellular carcinoma","volume":"136","author":"Wang","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bcp.2026.118314_b0020","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2147\/JHC.S374555","article-title":"Safety and efficacy of drug-eluting beads trans-arterial chemoembolization for hepatocellular carcinoma in Taiwan (SERENADE-T)","volume":"9","author":"Liu","year":"2022","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.bcp.2026.118314_b0025","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.rx.2010.07.010","article-title":"Comparison of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) with conventional transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma","volume":"53","author":"Ferrer Puchol","year":"2011","journal-title":"Radiologia"},{"key":"10.1016\/j.bcp.2026.118314_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122346","article-title":"Doxorubicin-liposome combined with clodronate-liposome inhibits hepatocellular carcinoma through the depletion of macrophages and tumor cells","volume":"629","author":"Zhang","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bcp.2026.118314_b0035","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"Management of hepatocellular carcinoma","volume":"69","author":"EASL Clinical Practice Guidelines","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bcp.2026.118314_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CAD.0000000000000572","article-title":"Autophagy and doxorubicin resistance in cancer","volume":"29","author":"Chen","year":"2018","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bcp.2026.118314_b0045","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1007\/s11033-021-06334-9","article-title":"Interplay of autophagy and cancer stem cells in hepatocellular carcinoma","volume":"48","author":"Wong","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bcp.2026.118314_b0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fcell.2019.00114","article-title":"Transcriptional regulation of autophagy: mechanisms and diseases","volume":"7","author":"Di Malta","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118314_b0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-018-0856-3","article-title":"Critical role of FOXO3a in carcinogenesis","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.118314_b0060","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41419-020-03233-y","article-title":"Hypoxia induces sorafenib resistance mediated by autophagy via activating FOXO3a in hepatocellular carcinoma","volume":"11","author":"Liang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118314_b0065","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41419-019-2053-8","article-title":"miR-223 overexpression inhibits doxorubicin-induced autophagy by targeting FOXO3a and reverses chemoresistance in hepatocellular carcinoma cells","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118314_b0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/ajcp\/aqx132","article-title":"Overexpression of Forkhead Box O3a and its association with aggressive phenotypes and poor prognosis in human hepatocellular carcinoma","volume":"149","author":"Ahn","year":"2018","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.bcp.2026.118314_b0075","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202300050","article-title":"(2E)-1-(2,4,6-trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one, a chalcone derivative, promotes apoptosis by suppressing RAS-ERK and AKT\/FOXO3a pathways in hepatocellular carcinoma cells","volume":"20","author":"Zhang","year":"2023","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bcp.2026.118314_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1069093","article-title":"Crebanine induces ROS-dependent apoptosis in human hepatocellular carcinoma cells via the AKT\/FoxO3a signaling pathway","volume":"14","author":"Tan","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118314_b0085","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.7150\/ijbs.47203","article-title":"miRNA-based biomarkers, therapies, and resistance in cancer","volume":"16","author":"He","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2026.118314_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.immuni.2009.05.008","article-title":"Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus","volume":"31","author":"Schlee","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2026.118314_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1153410","article-title":"Editorial: updates on RIG-I-like receptor-mediated innate immune responses","volume":"14","author":"Kishore","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118314_b0100","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/cdd.2014.96","article-title":"RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8(+) T cells","volume":"21","author":"Duewell","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2026.118314_b0105","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/nm.1887","article-title":"5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma","volume":"14","author":"Poeck","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.118314_b0110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ccr.2013.11.011","article-title":"Hepatic RIG-I predicts survival and interferon-\u03b1 therapeutic response in hepatocellular carcinoma","volume":"25","author":"Hou","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118314_b0115","doi-asserted-by":"crossref","unstructured":"E.L.A. S, I. M\u00e4ger, X.O. Breakefield, M.J. Wood, Extracellular vesicles: biology and emerging therapeutic opportunities, Nat. Rev. Drug Discov. 12 (2013) 347\u2013357. 10.1038\/nrd3978.","DOI":"10.1038\/nrd3978"},{"key":"10.1016\/j.bcp.2026.118314_b0120","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.7150\/thno.68667","article-title":"Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy","volume":"12","author":"Jayasinghe","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2026.118314_b0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4939-7253-1_18","article-title":"Detection and characterization of extracellular vesicles by transmission and cryo-transmission electron microscopy","volume":"1660","author":"Cizmar","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bcp.2026.118314_b0130","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ebiom.2019.02.056","article-title":"RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade","volume":"41","author":"Heidegger","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bcp.2026.118314_b0135","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1701854","article-title":"A minimal RNA ligand for potent RIG-I activation in living mice","volume":"4","author":"Linehan","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bcp.2026.118314_b0140","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1039\/D4CC06241H","article-title":"Exploring the homing effect and enhanced drug delivery potential of small extracellular vesicles","volume":"61","author":"Zhang","year":"2025","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.bcp.2026.118314_b0145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s41417-021-00312-w","article-title":"FOXO3-induced lncRNA LOC554202 contributes to hepatocellular carcinoma progression via the miR-485-5p\/BSG axis","volume":"29","author":"Yang","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.bcp.2026.118314_b0150","first-page":"3181","article-title":"High expression of FOXO3 is associated with poor prognosis in patients with hepatocellular carcinoma","volume":"19","author":"Song","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bcp.2026.118314_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13215349","article-title":"Association of FOXO3 expression with tumor pathogenesis, prognosis and clinicopathological features in hepatocellular carcinoma: a systematic review with meta-analysis","volume":"13","author":"Fondevila","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.bcp.2026.118314_b0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12943-017-0661-4","article-title":"C10ORF10\/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy","volume":"16","author":"Salcher","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.118314_b0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2016.09.033","article-title":"Osteopontin induces autophagy to promote chemo-resistance in human hepatocellular carcinoma cells","volume":"383","author":"Liu","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.118314_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101892","article-title":"Dysfunction of Akt\/FoxO3a\/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline","volume":"81","author":"Yu","year":"2024","journal-title":"Mol. Metab."},{"key":"10.1016\/j.bcp.2026.118314_b0175","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.ymthe.2018.11.012","article-title":"Nanoparticle delivery of RIG-I agonist enables effective and safe adjuvant therapy in pancreatic cancer","volume":"27","author":"Das","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bcp.2026.118314_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.03.001","article-title":"Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonists","volume":"154","author":"Bourquin","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2026.118314_b0185","doi-asserted-by":"crossref","unstructured":"D. Peng, L. Chen, Y. Sun, L. Sun, Q. Yin, S. Deng, L. Niu, F. Lou, Z. Wang, Z. Xu, C. Wang, L. Fan, H. Wang, H. Wang, Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 125 (2020) 109984. 10.1016\/j.biopha.2020.109984.","DOI":"10.1016\/j.biopha.2020.109984"},{"key":"10.1016\/j.bcp.2026.118314_b0190","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and type III interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2026.118314_b0195","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1158\/0008-5472.CAN-11-3850","article-title":"Therapeutic efficacy of bifunctional siRNA combining TGF-\u03b21 silencing with RIG-I activation in pancreatic cancer","volume":"73","author":"Ellermeier","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118314_b0200","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1007\/s00262-022-03191-8","article-title":"Treatment with a retinoic acid-inducible gene I (RIG-I) agonist as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: results from two phase 1 studies","volume":"71","author":"Moreno","year":"2022","journal-title":"Cancer Immunol., Immunother. CII"},{"key":"10.1016\/j.bcp.2026.118314_b0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26010042","article-title":"Biogenesis of extracellular vesicles (EVs) and the potential use of embryo-derived EVs in medically assisted reproduction","volume":"26","author":"Ov\u010dar","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118314_b0210","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1038\/s41598-024-65623-y","article-title":"Efficient and highly reproducible production of red blood cell-derived extracellular vesicle mimetics for the loading and delivery of RNA molecules","volume":"14","author":"Biagiotti","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118314_b0215","doi-asserted-by":"crossref","unstructured":"M.A. Kumar, S.K. Baba, H.Q. Sadida, S.A. Marzooqi, J. Jerobin, F.H. Altemani, N. Algehainy, M.A. Alanazi, A.B. Abou-Samra, R. Kumar, A.S. Al-Shabeeb Akil, M.A. Macha, R. Mir, A.A. Bhat, Extracellular vesicles as tools and targets in therapy for diseases, Signal transduction and targeted therapy 9 (2024) 27. 10.1038\/s41392-024-01735-1.","DOI":"10.1038\/s41392-024-01735-1"},{"key":"10.1016\/j.bcp.2026.118314_b0220","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abp9435","article-title":"Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases","volume":"8","author":"Wan","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bcp.2026.118314_b0225","article-title":"Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy","volume":"11","author":"Peng","year":"2022","journal-title":"J. Extracell. Vesic."},{"key":"10.1016\/j.bcp.2026.118314_b0230","doi-asserted-by":"crossref","DOI":"10.1002\/jex2.59","article-title":"Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina","volume":"1","author":"Driedonks","year":"2022","journal-title":"J Extracell Biol"},{"key":"10.1016\/j.bcp.2026.118314_b0235","article-title":"Dosing regimens of immune checkpoint inhibitors: attempts at lower dose, less frequency, shorter course","volume":"12","author":"Jiang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2026.118314_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.559161","article-title":"Combination strategies to augment immune check point inhibitors efficacy - implications for translational research","volume":"11","author":"Varayathu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2026.118314_b0245","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1007\/s13346-023-01370-3","article-title":"Extracellular vesicle-based drug delivery in cancer immunotherapy","volume":"13","author":"Najafi","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.bcp.2026.118314_b0250","first-page":"353","article-title":"Modification of extracellular vesicle surfaces: an approach for targeted drug delivery","volume":"37","author":"Mohammadi","year":"2023","journal-title":"BioDrugs Clin. Immunotherap., Biopharm. Gene Ther."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226006532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226006532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:12:38Z","timestamp":1788811958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226006532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":50,"alternative-id":["S0006295226006532"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118314","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver cells-derived extracellular vesicles deliver a dual-functional RNA ligand for TACE treatment of hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118314"}}