{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:52:57Z","timestamp":1791910377494,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473182"],"award-info":[{"award-number":["82473182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118318","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:04:05Z","timestamp":1785942245000},"page":"118318","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Intranodal injection of PD1 antibody enhances memory T cell responses to improve the efficacy of neoantigen vaccines"],"prefix":"10.1016","volume":"253","author":[{"given":"Sen","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohua","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bcp.2026.118318_b0005","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/1747493019881349","article-title":"National trends in hospital admission, case fatality, and sex differences in atrial fibrillation-related strokes","volume":"15","author":"Jewett","year":"2020","journal-title":"Int. J. Stroke"},{"issue":"4","key":"10.1016\/j.bcp.2026.118318_b0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMoa1412082","article-title":"Nivolumab in previously untreated melanoma without BRAF mutation","volume":"372","author":"Robert","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"26","key":"10.1016\/j.bcp.2026.118318_b0015","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118318_b0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4137\/JCNSD.S4888","article-title":"A review of eslicarbazepine acetate for the adjunctive treatment of partial-onset epilepsy","volume":"3","author":"Singh","year":"2011","journal-title":"J Cent Nerv Syst Dis"},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0025","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1038\/s41467-019-11526-w","article-title":"Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution","volume":"10","author":"Kircher","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cllc.2024.10.014","article-title":"Brief report: phase II clinical trial of atezolizumab in advanced nonsmall cell lung cancer patients previously treated with PD-1-directed therapy","volume":"26","author":"Fortman","year":"2025","journal-title":"Clin. Lung Cancer"},{"issue":"6","key":"10.1016\/j.bcp.2026.118318_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2022.100635","article-title":"The impact of single agent PD-1 or PD-L1 inhibition on advanced endometrial cancers: meta-analysis","volume":"7","author":"Kok","year":"2022","journal-title":"ESMO Open"},{"issue":"7662","key":"10.1016\/j.bcp.2026.118318_b0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature23003","article-title":"Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer","volume":"547","author":"Sahin","year":"2017","journal-title":"Nature"},{"issue":"7696","key":"10.1016\/j.bcp.2026.118318_b0045","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature25145","article-title":"Corrigendum: an immunogenic personal neoantigen vaccine for patients with melanoma","volume":"555","author":"Ott","year":"2018","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2026.118318_b0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41588-023-01355-5","article-title":"Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer","volume":"55","author":"Ravi","year":"2023","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.bcp.2026.118318_b0055","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2418306122","article-title":"Dual mRNA nanoparticles strategy for enhanced pancreatic cancer treatment and beta-elemene combination therapy","volume":"122","author":"Zhu","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bcp.2026.118318_b0060","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-009543","article-title":"Personalized neoantigen hydrogel vaccine combined with PD-1 and CTLA-4 double blockade elicits antitumor response in liver metastases by activating intratumoral CD8(+)CD69(+) T cells","volume":"12","author":"Tang","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"2","key":"10.1016\/j.bcp.2026.118318_b0065","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cell.2020.08.053","article-title":"A phase Ib trial of personalized neoantigen therapy plus anti-PD-1 in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer","volume":"183","author":"Ott","year":"2020","journal-title":"Cell"},{"issue":"100","key":"10.1016\/j.bcp.2026.118318_b0070","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adq8843","article-title":"Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4(+) T cell response","volume":"9","author":"Chudnovskiy","year":"2024","journal-title":"Sci. Immunol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118318_b0075","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ccell.2020.09.001","article-title":"The PD-1\/PD-L1-checkpoint restrains T cell immunity in tumor-draining lymph nodes","volume":"38","author":"Dammeijer","year":"2020","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-immunol-090222-110914","article-title":"T cell exhaustion","volume":"42","author":"Baessler","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bcp.2026.118318_b0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2022.09.015","article-title":"Lymph node-targeting nanovaccines for cancer immunotherapy","volume":"351","author":"Wang","year":"2022","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.bcp.2026.118318_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061646","article-title":"Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice","volume":"8","author":"Kourtis","year":"2013","journal-title":"PLoS One"},{"issue":"563","key":"10.1016\/j.bcp.2026.118318_b0095","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay3575","article-title":"Blockade of immune checkpoints in lymph nodes through locoregional delivery augments cancer immunotherapy","volume":"12","author":"Francis","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"12","key":"10.1016\/j.bcp.2026.118318_b0100","doi-asserted-by":"crossref","first-page":"8820","DOI":"10.1007\/s12010-024-04971-x","article-title":"In silico design of CT26 polytope and its surface display by clearcoli-derived outer membrane vesicles as a cancer vaccine candidate against colon carcinoma","volume":"196","author":"Sharif","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0105","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1471-2164-15-190","article-title":"Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma","volume":"15","author":"Castle","year":"2014","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0110","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12951-022-01397-7","article-title":"Lymph node-targeted neoantigen nanovaccines potentiate anti-tumor immune responses of post-surgical melanoma","volume":"20","author":"Chu","year":"2022","journal-title":"J Nanobiotechnology"},{"issue":"7","key":"10.1016\/j.bcp.2026.118318_b0115","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.7150\/thno.122439","article-title":"The novel B-cell epitope peptide vaccine, MAX449, exhibits significant anti-tumor efficacy and enhances the therapeutic effects of PD-1 antibodies on tumors by modulating the activity of PMN-MDSCs","volume":"16","author":"Yang","year":"2026","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.bcp.2026.118318_b0120","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1158\/0008-5472.CAN-16-1638","article-title":"Tumor-localized secretion of soluble PD1 enhances oncolytic virotherapy","volume":"77","author":"Bartee","year":"2017","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.bcp.2026.118318_b0125","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.ccell.2024.06.014","article-title":"Lymphatic-localized treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity","volume":"42","author":"You","year":"2024","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.bcp.2026.118318_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110331","article-title":"PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes","volume":"38","author":"Nagasaki","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0135","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1038\/s41467-022-33768-x","article-title":"TGF-beta-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"issue":"25","key":"10.1016\/j.bcp.2026.118318_b0140","doi-asserted-by":"crossref","first-page":"12410","DOI":"10.1073\/pnas.1905675116","article-title":"TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion","volume":"116","author":"Seo","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2026.118318_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1548234","article-title":"Deciphering T-cell exhaustion in the tumor microenvironment: paving the way for innovative solid tumor therapies","volume":"16","author":"Nair","year":"2025","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118318_b0150","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1172\/JCI133215","article-title":"Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability","volume":"130","author":"Guedan","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bcp.2026.118318_b0155","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.immuni.2024.11.026","article-title":"Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion","volume":"58","author":"Waibl Polania","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2026.118318_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102409","article-title":"Molecular mechanisms of tumour necrosis factor signalling via TNF receptor 1 and TNF receptor 2 in the tumour microenvironment","volume":"86","author":"Alim","year":"2024","journal-title":"Curr. Opin. Immunol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118318_b0165","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41577-022-00707-2","article-title":"A guide to antigen processing and presentation","volume":"22","author":"Pishesha","year":"2022","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600657X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600657X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:30:37Z","timestamp":1791909037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522600657X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":33,"alternative-id":["S000629522600657X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118318","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranodal injection of PD1 antibody enhances memory T cell responses to improve the efficacy of neoantigen vaccines","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118318","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118318"}}