{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:07:45Z","timestamp":1788815265668,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373915"],"award-info":[{"award-number":["82373915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515011458"],"award-info":[{"award-number":["2025A1515011458"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118321","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:30:40Z","timestamp":1786059040000},"page":"118321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["The L-type calcium channel Cav1.2 mediates influenza A virus infection by regulating viral internalization and endoplasmic reticulum homeostasis"],"prefix":"10.1016","volume":"253","author":[{"given":"Zhixuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xucheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118321_b0005","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1462802","article-title":"Viral co-detection of influenza virus and other respiratory viruses in hospitalized Brazilian patients during the first three years of the coronavirus disease (COVID)-19 pandemic: an epidemiological profile","volume":"15","author":"Siqueira","year":"2024","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118321_b0010","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nrmicro1027","article-title":"Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus","volume":"2","author":"Reid","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2026.118321_b0015","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0140-6736(17)33293-2","article-title":"Estimates of global seasonal influenza-associated respiratory mortality: a modelling study","volume":"391","author":"Iuliano","year":"2018","journal-title":"Lancet"},{"issue":"Suppl 4","key":"10.1016\/j.bcp.2026.118321_b0020","doi-asserted-by":"crossref","first-page":"D59","DOI":"10.1016\/j.vaccine.2008.07.025","article-title":"Pathology of human influenza revisited","volume":"26","author":"Kuiken","year":"2008","journal-title":"Vaccine"},{"issue":"11","key":"10.1016\/j.bcp.2026.118321_b0025","doi-asserted-by":"crossref","DOI":"10.1111\/irv.70045","article-title":"Inpatient Burden of respiratory syncytial virus Infection and Influenza in Children Younger than 5\u2009Years in Japan, 2011-2022: a Database Study","volume":"18","author":"Arashiro","year":"2024","journal-title":"Influenza Other Respi. Viruses"},{"issue":"10334","key":"10.1016\/j.bcp.2026.118321_b0030","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0140-6736(22)00383-X","article-title":"SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses","volume":"399","author":"Swets","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.118321_b0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/IDR.S105473","article-title":"Drug resistance in influenza a virus: the epidemiology and management","volume":"10","author":"Hussain","year":"2017","journal-title":"Infect. Drug Resist."},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2026.118321_b0040","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1086\/591851","article-title":"Developing new antiviral agents for influenza treatment: what does the future hold?","volume":"48","author":"Hayden","year":"2009","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.bcp.2026.118321_b0045","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1517\/14656566.2.8.1317","article-title":"Ribavirin\u2013current status of a broad spectrum antiviral agent","volume":"2","author":"Snell","year":"2001","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118321_b0050","doi-asserted-by":"crossref","unstructured":"F. Dufrasne, Baloxavir Marboxil: An Original New Drug against Influenza. Pharmaceuticals (Basel), 15(1) (2021) 28, https:\/\/doi.org\/10.3390\/ph15010028.","DOI":"10.3390\/ph15010028"},{"key":"10.1016\/j.bcp.2026.118321_b0055","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJMoa1716197","article-title":"Baloxavir Marboxil for Uncomplicated Influenza in adults and Adolescents","volume":"379","author":"Hayden","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118321_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008937","article-title":"Favipiravir-resistant influenza a virus shows potential for transmission","volume":"17","author":"Goldhill","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2026.118321_b0065","doi-asserted-by":"crossref","first-page":"e984","DOI":"10.1002\/iid3.984","article-title":"Arbidol: the current demand, strategies, and antiviral mechanisms","volume":"11","author":"Kang","year":"2023","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.bcp.2026.118321_b0070","first-page":"1","article-title":"Channelopathies. Korean","volume":"57","author":"Kim","year":"2014","journal-title":"J. Pediatr."},{"key":"10.1016\/j.bcp.2026.118321_b0075","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1093\/jac\/dku091","article-title":"The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry","volume":"69","author":"Gehring","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.bcp.2026.118321_b0080","first-page":"995","article-title":"Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment","author":"Sakurai","year":"2015","journal-title":"Science 347"},{"key":"10.1016\/j.bcp.2026.118321_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006845","article-title":"Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection","volume":"14","author":"Hover","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2026.118321_b0090","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.bbrc.2014.03.050","article-title":"Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB","volume":"446","author":"Zheng","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118321_b0095","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1038\/s41564-024-01713-x","article-title":"Influenza virus uses mGluR2 as an endocytic receptor to enter cells","volume":"9","author":"Ni","year":"2024","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118321_b0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/cells9010094","article-title":"Host Calcium Channels and Pumps in Viral Infections","volume":"9","author":"Chen","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118321_b0105","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1038\/ncomms3763","article-title":"A Ca2+-dependent signalling circuit regulates influenza a virus internalization and infection","volume":"4","author":"Fujioka","year":"2013","journal-title":"Nat. Commun."},{"issue":"34","key":"10.1016\/j.bcp.2026.118321_b0110","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202202857","article-title":"The Transient Receptor potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection through the Ca2+-LRMDA Axis in Myeloid Cells","volume":"9","author":"Guo","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bcp.2026.118321_b0115","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-gated calcium channels","volume":"3","author":"Catterall","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bcp.2026.118321_b0120","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage-gated Ca2+ channels","volume":"16","author":"Catterall","year":"2000","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118321_b0125","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","article-title":"Nomenclature of voltage-gated calcium channels","volume":"25","author":"Ertel","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.bcp.2026.118321_b0130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/physrev.00016.2013","article-title":"L-type Cav1.2 calcium channels: from in vitro findings to in vivo function","volume":"94","author":"Hofmann","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bcp.2026.118321_b0135","doi-asserted-by":"crossref","first-page":"L154","DOI":"10.1152\/ajplung.00313.2012","article-title":"Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2","author":"Wan","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol 305"},{"key":"10.1016\/j.bcp.2026.118321_b0140","doi-asserted-by":"crossref","first-page":"L27","DOI":"10.1152\/ajplung.00468.2021","article-title":"Cellular mechanism underlying the facilitation of contractile response induced by IL-25 in mouse tracheal smooth muscle","volume":"323","author":"Huang","year":"2022","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bcp.2026.118321_b0145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01309305","article-title":"Verapamil inhibits influenza a virus replication","volume":"81","author":"Nugent","year":"1984","journal-title":"Arch. Virol"},{"key":"10.1016\/j.bcp.2026.118321_b0150","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4149\/av_2017_412","article-title":"Calcium signaling involved in bovine herpesvirus 1 replication in MDBK cells","volume":"61","author":"Zhu","year":"2017","journal-title":"Acta Virol."},{"key":"10.1016\/j.bcp.2026.118321_b0155","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1021\/acsinfecdis.1c00023","article-title":"Inhibitors of L-Type Calcium Channels Show Therapeutic potential for Treating SARS-CoV-2 Infections by Preventing Virus Entry and Spread","volume":"7","author":"Straus","year":"2021","journal-title":"ACS Infect. Dis."},{"issue":"5573","key":"10.1016\/j.bcp.2026.118321_b0160","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.118321_b0165","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118321_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000141","article-title":"Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus","volume":"4","author":"Saeed","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bcp.2026.118321_b0175","doi-asserted-by":"crossref","DOI":"10.4161\/sgtp.28318","article-title":"Favoreel, Rho'ing in and out of cells: viral interactions with Rho GTPase signaling","volume":"5","author":"Van den Broeke","year":"2014","journal-title":"Small GTPases"},{"issue":"15","key":"10.1016\/j.bcp.2026.118321_b0180","doi-asserted-by":"crossref","first-page":"7941","DOI":"10.1128\/JVI.02848-06","volume":"81","author":"Raghu","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118321_b0185","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3480241","article-title":"Rho GTPases and their effector proteins","volume":"348","author":"Bishop","year":"2000","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2026.118321_b0190","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3390\/microorganisms8071067","article-title":"Regulation of Host Immune responses against Influenza a Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)","volume":"8","author":"Yu","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.bcp.2026.118321_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2023.109672","article-title":"Cell entry of Bovine herpesvirus-1 through clathrin- and caveolin-mediated endocytosis requires activation of PI3K-akt-NF-\u03baB and ras-p38 MAPK pathways as well as the interaction of BoHV-1 gD with cellular receptor nectin-1","volume":"279","author":"Liu","year":"2023","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.bcp.2026.118321_b0200","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1128\/JVI.00804-10","article-title":"Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism","volume":"84","author":"Marchant","year":"2010","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118321_b0205","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3390\/v16101555","article-title":"Viral Infections and their Ability to Modulate Endoplasmic Reticulum stress Response Pathways","volume":"16","author":"da Fonseca","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.bcp.2026.118321_b0210","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1074\/jbc.M111.284695","article-title":"Influenza a viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway","volume":"287","author":"Hassan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118321_b0215","article-title":"Innate sensing of influenza a virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation","volume":"92","author":"Frabutt","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118321_b0220","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.3390\/v14122738","article-title":"Nisoldipine Inhibits Influenza a Virus Infection by Interfering with Virus Internalization Process","volume":"14","author":"Huang","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.bcp.2026.118321_b0225","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12916-025-04022-0","article-title":"Cilnidipine exerts antiviral effects in vitro and in vivo by inhibiting the internalization and fusion of influenza a virus","volume":"23","author":"Li","year":"2025","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118321_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceca.2009.05.005","article-title":"Viral calciomics: interplays between Ca2+ and virus","volume":"46","author":"Zhou","year":"2009","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcp.2026.118321_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016324","article-title":"The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses","volume":"6","author":"Fujioka","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bcp.2026.118321_b0240","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.bcp.2026.118321_b0245","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1074\/jbc.M900146200","article-title":"Bcl-2 expression and p38MAPK activity in cells infected with influenza a virus: impact on virally induced apoptosis and viral replication","volume":"284","author":"Nencioni","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.bcp.2026.118321_b0250","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1091\/mbc.e07-01-0062","article-title":"Multiple receptor interactions trigger release of membrane and intracellular calcium stores critical for herpes simplex virus entry","volume":"18","author":"Cheshenko","year":"2007","journal-title":"Mol. Biol. Cell"},{"issue":"4","key":"10.1016\/j.bcp.2026.118321_b0255","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41401-022-00975-7","article-title":"TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation","volume":"44","author":"Jiang","year":"2023","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600660X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600660X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:14:08Z","timestamp":1788812048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522600660X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":51,"alternative-id":["S000629522600660X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118321","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The L-type calcium channel Cav1.2 mediates influenza A virus infection by regulating viral internalization and endoplasmic reticulum homeostasis","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118321"}}