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Microbiol."},{"key":"10.1016\/j.bcp.2026.118341_b0910","doi-asserted-by":"crossref","unstructured":"A.F. Hofmann, Biliary secretion and excretion in health and disease: Current concepts, Ann. Hepatol. (n.d.). https:\/\/doi.org\/10.1016\/S1665-2681(19)31949-0.","DOI":"10.1016\/S1665-2681(19)31949-0"},{"key":"10.1016\/j.bcp.2026.118341_b0915","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1194\/jlr.M400294-JLR200","article-title":"Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative","volume":"46","author":"Adachi","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bcp.2026.118341_b0920","doi-asserted-by":"crossref","unstructured":"M. Makishima, T.T. Lu, W. Xie, G.K. Whitfield, H. Domoto, R.M. Evans, M.R. Haussler, D.J. 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