{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:01:11Z","timestamp":1789574471282,"version":"build-2803163510"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of War","doi-asserted-by":"publisher","award":["HT9425-25-1-0363"],"award-info":[{"award-number":["HT9425-25-1-0363"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118363","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:33:23Z","timestamp":1786980803000},"page":"118363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P2","title":["NQO1 at the crossroads of oxidative stress, cancer, and therapeutic innovation"],"prefix":"10.1016","volume":"253","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1360-077X","authenticated-orcid":false,"given":"Meagan M.","family":"Ybarra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5596-6265","authenticated-orcid":false,"given":"Addanki P.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-4861","authenticated-orcid":false,"given":"Rita","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bcp.2026.118363_b0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/antiox9060472","article-title":"An update on mitochondrial reactive oxygen species production","volume":"9","author":"Mailloux","year":"2020","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.bcp.2026.118363_b0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.sbi.2019.03.001","article-title":"Structure and mechanisms of ROS generation by NADPH oxidases","volume":"59","author":"Magnani","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118363_b0015","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.3390\/ijms20102407","article-title":"Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases","volume":"20","author":"Collin","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118363_b0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-319-56017-5_2","article-title":"Ultraviolet light induced generation of reactive oxygen species","volume":"996","author":"de Jager","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118363_b0025","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/tx100020p","article-title":"Xenobiotic metabolism: a view through the metabolometer","volume":"23","author":"Patterson","year":"2010","journal-title":"Chem. Res. Toxicol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118363_b0030","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","article-title":"The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: current state","volume":"15","author":"Kurutas","year":"2016","journal-title":"Nutr. J."},{"issue":"11","key":"10.1016\/j.bcp.2026.118363_b0045","article-title":"Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases","volume":"10","author":"Chaudhary","year":"2023","journal-title":"Front. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0050","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/fsn3.3217","article-title":"Natural antioxidants from some fruits, seeds, foods, natural products, and associated health benefits: an update","volume":"11","author":"Rahaman","year":"2023","journal-title":"Food Sci. Nutr."},{"issue":"13","key":"10.1016\/j.bcp.2026.118363_b0055","article-title":"Three classes of antioxidant defense systems and the development of postmenopausal osteoporosis","volume":"3","author":"Yang","year":"2022","journal-title":"Front. Physiol."},{"issue":"27","key":"10.1016\/j.bcp.2026.118363_b0060","doi-asserted-by":"crossref","first-page":"13572","DOI":"10.1016\/S0021-9258(18)68280-8","article-title":"Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16","volume":"263","author":"Jaiswal","year":"1988","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0065","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00008571-199906000-00020","article-title":"Localization of human NQO1 gene to chromosome 16q22 and NQO2-6p25 and associated polymorphisms","volume":"9","author":"Jaiswal","year":"1999","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.bcp.2026.118363_b0070","unstructured":"https:\/\/ensembl.org."},{"key":"10.1016\/j.bcp.2026.118363_b0075","unstructured":"https:\/\/www.internationalgenome.org."},{"key":"10.1016\/j.bcp.2026.118363_b0080","unstructured":"https:\/\/dnalife.academy\/nqo1-oestrogen\/."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0085","article-title":"Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy","volume":"5","author":"Aleo","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0090","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00008571-199808000-00004","article-title":"NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, chinese and Canadian Native Indian and Inuit populations","volume":"8","author":"Gaedigk","year":"1998","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.bcp.2026.118363_b0095","unstructured":"https:\/\/gtexportal.org\/home\/aboutAdultGtex (accessed on June 27, 2026."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0100","first-page":"282","article-title":"One-electron-transfer reactions in biochemical systems. V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)","volume":"216","author":"Iyanagi","year":"1970","journal-title":"BBA"},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0105","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1074\/jbc.270.3.1198","article-title":"DT-diaphorase. Redox potential, steady-state, and rapid reaction studies","volume":"270","author":"Tedeschi","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118363_b0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0009-2797(00)00199-X","article-title":"NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms","volume":"129","author":"Ross","year":"2000","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0006-2952(94)00333-5","article-title":"Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism","volume":"49","author":"Cadenas","year":"1995","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0120","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00689803","article-title":"DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C","volume":"12","author":"Ross","year":"1993","journal-title":"Cancer Metastasis Rev."},{"issue":"Pt 1","key":"10.1016\/j.bcp.2026.118363_b0125","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/bj20031123","volume":"377","author":"Ma","year":"2004","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2026.118363_b0130","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bcp.2018.07.039","article-title":"Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR\/Nrf2\/NQO1 pathway","volume":"155","author":"Wang","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.chemrestox.6b00256","article-title":"Formation and biological targets of quinones: cytotoxic versus cytoprotective effects","volume":"30","author":"Bolton","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bcp.2026.118363_b0140","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2017.09.030","article-title":"Structural requirements of flavonoids to induce heme oxygenase-1 expression","volume":"113","author":"Croft","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.bcp.2026.118363_b0145","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/tx900148k","article-title":"Catechol type polyphenol is a potential modifier of protein sulfhydryls: development and application of a new probe for understanding the dietary polyphenol actions","volume":"22","author":"Ishii","year":"2009","journal-title":"Chem. Res. Toxicol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118363_b0150","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.freeradbiomed.2008.07.023","article-title":"Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation","volume":"45","author":"Ishii","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.bcp.2026.118363_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21932","article-title":"(-)-Epigallocatechin-3-gallate inhibits human angiotensin-converting enzyme activity through an autoxidation-dependent mechanism","volume":"31","author":"Liu","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3164\/jcbn.18-26","article-title":"Covalent adduction of endogenous and food-derived quinones to a protein: its biological significance","volume":"62","author":"Kato","year":"2018","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"6","key":"10.1016\/j.bcp.2026.118363_b0165","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1073\/pnas.93.6.2528","article-title":"The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems","volume":"93","author":"Beyer","year":"1996","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0170","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1124\/mol.52.2.300","article-title":"The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant","volume":"52","author":"Siegel","year":"1997","journal-title":"Mol. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2026.118363_b0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jsbmb.2009.07.003","article-title":"NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells","volume":"117","author":"Singh","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0180","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1124\/mol.106.024703","article-title":"A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition","volume":"70","author":"Zafar","year":"2006","journal-title":"Mol. Pharmacol."},{"issue":"13","key":"10.1016\/j.bcp.2026.118363_b0185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fnins.2019.00271","article-title":"On the role of aminochrome in mitochondrial dysfunction and endoplasmic reticulum stress in Parkinson's disease","volume":"29","author":"Segura-Aguilar","year":"2019","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0190","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12640-018-9953-8","article-title":"DT-diaphorase prevents aminochrome-induced lysosome dysfunction in SH-SY5Y Cells","volume":"35","author":"Mel\u00e9ndez","year":"2019","journal-title":"Neurotox. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0195","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s12640-009-9148-4","article-title":"Aminochrome induces disruption of actin, alpha-, and beta-tubulin cytoskeleton networks in substantia-nigra-derived cell line","volume":"18","author":"Paris","year":"2010","journal-title":"Neurotox. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0200","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12640-017-9747-4","article-title":"DT-diaphorase protects against autophagy induced by aminochrome-dependent alpha-synuclein oligomers","volume":"32","author":"Mu\u00f1oz","year":"2017","journal-title":"Neurotox. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0205","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12640-017-9719-8","article-title":"On the role of DT-diaphorase inhibition in aminochrome-induced neurotoxicity in vivo","volume":"32","author":"Herrera-Soto","year":"2017","journal-title":"Neurotox. Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0210","first-page":"141","article-title":"Dopaminergic neuron-specific oxidative stress caused by dopamine itself","volume":"62","author":"Miyazaki","year":"2008","journal-title":"Acta Med. Okayama"},{"issue":"11","key":"10.1016\/j.bcp.2026.118363_b0215","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/nm1314","article-title":"Dopamine covalently modifies and functionally inactivates parkin","volume":"11","author":"LaVoie","year":"2005","journal-title":"Nat. Med."},{"issue":"5545","key":"10.1016\/j.bcp.2026.118363_b0220","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.1063522","article-title":"Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct","volume":"294","author":"Conway","year":"2001","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jphs.2015.11.002","article-title":"Dopamine inhibits lipopolysaccharide-induced nitric oxide production through the formation of dopamine quinone in murine microglia BV-2 cells","volume":"130","author":"Yoshioka","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.118363_b0230","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.freeradbiomed.2016.05.019","article-title":"Quinone-induced protein modifications: Kinetic preference for reaction of 1,2-benzoquinones with thiol groups in proteins","volume":"97","author":"Li","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"3\u20134","key":"10.1016\/j.bcp.2026.118363_b0235","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0891-5849(00)00310-5","article-title":"Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues","volume":"29","author":"Siegel","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.bcp.2026.118363_b0240","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1124\/mol.65.5.1238","article-title":"NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger","volume":"65","author":"Siegel","year":"2004","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0245","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s12012-007-9001-z","article-title":"The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger","volume":"7","author":"Zhu","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0250","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbrc.2004.03.156","article-title":"The chemical inducibility of mouse cardiac antioxidants and phase 2 enzymes in vivo","volume":"317","author":"Cao","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"20","key":"10.1016\/j.bcp.2026.118363_b0255","doi-asserted-by":"crossref","first-page":"13125","DOI":"10.1073\/pnas.202480499","article-title":"Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1","volume":"99","author":"Asher","year":"2002","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0260","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1101\/gad.319905","article-title":"A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73","volume":"19","author":"Asher","year":"2005","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0265","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1128\/MCB.00868-09","article-title":"NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome","volume":"30","author":"Alard","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118363_b0270","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.freeradbiomed.2016.08.005","article-title":"Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation","volume":"99","author":"Di Francesco","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.bcp.2026.118363_b0275","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/jcb.20271","article-title":"Transcriptional activities of mutant p53: when mutations are more than a loss","volume":"93","author":"Kim","year":"2004","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0280","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chembiol.2003.12.019","article-title":"Identification of a novel protein regulating microtubule stability through a chemical approach","volume":"11","author":"Wignall","year":"2004","journal-title":"Chem. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118363_b0285","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2012.04.031","article-title":"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins","volume":"149","author":"Castello","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0290","doi-asserted-by":"crossref","first-page":"873","DOI":"10.7150\/thno.77444","article-title":"NQO1 regulates cell cycle progression at the G2\/M phase","volume":"13","author":"Oh","year":"2023","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0295","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molcel.2012.05.049","article-title":"A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1","volume":"47","author":"Moscovitz","year":"2012","journal-title":"Mol. Cell"},{"issue":"21","key":"10.1016\/j.bcp.2026.118363_b0300","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1021\/jm991060m","article-title":"Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)","volume":"42","author":"Skelly","year":"1999","journal-title":"J. Med. Chem."},{"issue":"19","key":"10.1016\/j.bcp.2026.118363_b0305","doi-asserted-by":"crossref","first-page":"8846","DOI":"10.1073\/pnas.92.19.8846","article-title":"The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction","volume":"92","author":"Li","year":"1995","journal-title":"PNAS"},{"issue":"20","key":"10.1016\/j.bcp.2026.118363_b0310","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1021\/bi0600087","article-title":"The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol","volume":"45","author":"Asher","year":"2006","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0315","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/pro.5560030107","article-title":"A two-domain structure for the two subunits of NAD(P)H:quinone acceptor oxidoreductase","volume":"3","author":"Chen","year":"1994","journal-title":"Protein Sci."},{"issue":"8","key":"10.1016\/j.bcp.2026.118363_b0320","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3389\/fphys.2017.00595","article-title":"Functions of NQO1 in cellular protection and CoQ10metabolism and its potential role as a redox sensitive molecular switch","volume":"24","author":"Ross","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bcp.2026.118363_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101950","article-title":"The diverse functionality of NQO1 and its roles in redox control","volume":"41","author":"Ross","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0330","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190717","article-title":"Redox modulation of NQO1","volume":"13","author":"Siegel","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0335","doi-asserted-by":"crossref","first-page":"e4957","DOI":"10.1002\/pro.4957","article-title":"Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations","volume":"33","author":"Grieco","year":"2024","journal-title":"Protein Sci."},{"key":"10.1016\/j.bcp.2026.118363_b0340","doi-asserted-by":"crossref","DOI":"10.1111\/febs.70511","article-title":"Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry","author":"Rivero","year":"2026","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.bcp.2026.118363_b0345","doi-asserted-by":"crossref","first-page":"20331","DOI":"10.1038\/srep20331","article-title":"Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands","volume":"3","author":"Medina-Carmona","year":"2016","journal-title":"Sci. Rep."},{"issue":"18","key":"10.1016\/j.bcp.2026.118363_b0350","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1002\/1873-3468.12772","article-title":"A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R","volume":"591","author":"Mu\u00f1oz","year":"2017","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0355","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/1873-3468.13636","article-title":"A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro","volume":"594","author":"Strandback","year":"2020","journal-title":"FEBS Lett."},{"issue":"18","key":"10.1016\/j.bcp.2026.118363_b0360","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1016\/S0021-9258(18)99004-6","article-title":"The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity","volume":"266","author":"Rushmore","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2026.118363_b0365","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/bj20030754","article-title":"Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence","volume":"374","author":"Nioi","year":"2003","journal-title":"Biochem. J."},{"issue":"28","key":"10.1016\/j.bcp.2026.118363_b0370","doi-asserted-by":"crossref","first-page":"21349","DOI":"10.1074\/jbc.M110.121863","article-title":"An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance","volume":"285","author":"Kaspar","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118363_b0375","first-page":"149","article-title":"Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors","volume":"555","author":"Nioi","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bcp.2026.118363_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101530","article-title":"The aryl hydrocarbon receptor as a target of environmental stressors - Implications for pollution mediated stress and inflammatory responses","volume":"34","author":"Vogel","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.118363_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2025.104674","article-title":"Dimethylmonothioarsinic acid (DMMTAV) induces NQO1 expression through coordinated activation of NRF2 and AHR pathways","volume":"115","author":"El-Mahrouk","year":"2025","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0390","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jcmgh.2021.05.013","article-title":"Activation of AhR-NQO1 signaling pathway protects against alcohol-induced liver injury by improving redox balance","volume":"12","author":"Dong","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2026.118363_b0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116769","article-title":"Heavy metals, oxidative stress, and the role of AhR signaling","volume":"482","author":"Kou","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"38","key":"10.1016\/j.bcp.2026.118363_b0400","doi-asserted-by":"crossref","first-page":"61403","DOI":"10.18632\/oncotarget.8968","article-title":"Sulforaphane-induced apoptosis involves the type 1 IP3 receptor","volume":"7","author":"Hudecova","year":"2016","journal-title":"Oncotarget"},{"issue":"24","key":"10.1016\/j.bcp.2026.118363_b0405","doi-asserted-by":"crossref","first-page":"13659","DOI":"10.3390\/ijms222413659","article-title":"Molecular Targets of natural compounds with anti-cancer properties","volume":"22","author":"Kubczak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0410","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s10637-014-0189-z","article-title":"A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer","volume":"33","author":"Alumkal","year":"2015","journal-title":"Invest. New Drugs"},{"issue":"7","key":"10.1016\/j.bcp.2026.118363_b0415","doi-asserted-by":"crossref","first-page":"13593","DOI":"10.1038\/ncomms13593","article-title":"NQO1 inhibits proteasome-mediated degradation of HIF-1\u03b1","volume":"14","author":"Oh","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0420","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1756-9966-33-14","article-title":"Clinical implications of high NQO1 expression in breast cancers","volume":"33","author":"Yang","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0425","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10549-010-1023-8","article-title":"Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer","volume":"124","author":"Yao","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.bcp.2026.118363_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116375","article-title":"Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer","volume":"460","author":"Xie","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118363_b0435","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.biopha.2018.09.159","article-title":"NQO1 induction mediated by photodynamic therapy synergizes with \u03b2-Lapachone-halogenated derivative against melanoma","volume":"108","author":"Lamberti","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118363_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102272","article-title":"UBIAD1 and CoQ10 protect melanoma cells from lipid peroxidation-mediated cell death","volume":"51","author":"Arslanbaeva","year":"2022","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153181","article-title":"NAD(P)H:quinone oxidoreductase-1 expression sensitizes malignant melanoma cells to the HSP90 inhibitor 17-AAG","volume":"11","author":"Kasai","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0450","first-page":"1124","article-title":"Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival","volume":"7","author":"Ji","year":"2014","journal-title":"Int. J. Clin. Exp. Path."},{"issue":"9","key":"10.1016\/j.bcp.2026.118363_b0455","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1349-7006.1998.tb00648.x","article-title":"Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase","volume":"89","author":"Mikami","year":"1998","journal-title":"Jpn. J. Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030566","article-title":"A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.bcp.2026.118363_b0465","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1186\/1471-2407-14-414","article-title":"NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix","volume":"9","author":"Ma","year":"2014","journal-title":"BMC Cancer"},{"issue":"15","key":"10.1016\/j.bcp.2026.118363_b0470","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12885-015-1271-4","article-title":"High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma","volume":"9","author":"Cui","year":"2015","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.bcp.2026.118363_b0475","doi-asserted-by":"crossref","first-page":"7839","DOI":"10.3390\/ijms24097839","article-title":"The role of NQO1 in ovarian cancer","volume":"24","author":"Tossetta","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118363_b0480","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1383-5718(03)00041-X","article-title":"An association between NQO1 genetic polymorphism and risk of bladder cancer","volume":"536","author":"Park","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bcp.2026.118363_b0485","article-title":"NQO1-mediated anoikis resistance and immune evasion define a high-risk multi-omic subtype for precision management of T1 high-grade bladder cancer","author":"Guo","year":"2026","journal-title":"Adv. Sci. (Weinh)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0490","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1038\/s41467-020-17873-3","article-title":"HIF-1\u03b1 and HIF-2\u03b1 differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice","volume":"11","author":"Hoefflin","year":"2020","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.bcp.2026.118363_b0495","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1158\/0008-5472.CAN-14-0562","article-title":"NQO1 suppresses NF-\u03baB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis","volume":"74","author":"Thapa","year":"2014","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0500","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccr.2010.05.026","article-title":"Integrative genomic profiling of human prostate cancer","volume":"18","author":"Taylor","year":"2010","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0505","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1073\/pnas.0304146101","article-title":"Gene expression profiling identifies clinically relevant subtypes of prostate cancer","volume":"101","author":"Lapointe","year":"2004","journal-title":"PNAS"},{"issue":"7","key":"10.1016\/j.bcp.2026.118363_b0510","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2407-7-64","article-title":"Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process","volume":"12","author":"Chandran","year":"2007","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.bcp.2026.118363_b0515","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s42003-019-0720-z","article-title":"Attenuation of NAD[P]H:quinone oxidoreductase 1 aggravates prostate cancer and tumor cell plasticity through enhanced TGF\u03b2 signaling","volume":"3","author":"Thapa","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2026.118363_b0520","unstructured":"https:\/\/www.cancer.gov\/tcga."},{"key":"10.1016\/j.bcp.2026.118363_b0525","unstructured":"Human Protein Atlas www.proteinatlas.org."},{"issue":"12","key":"10.1016\/j.bcp.2026.118363_b0530","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1158\/1940-6207.CAPR-14-0127","article-title":"Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer","volume":"7","author":"Khor","year":"2014","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"5","key":"10.1016\/j.bcp.2026.118363_b0535","doi-asserted-by":"crossref","first-page":"818","DOI":"10.3945\/jn.111.153114","article-title":"A \u03b3-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation","volume":"142","author":"Huang","year":"2012","journal-title":"J. Nutr."},{"issue":"5","key":"10.1016\/j.bcp.2026.118363_b0540","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/pbc.24924","article-title":"A meta-analysis of the association between NQO1 C609T variation and acute myeloid leukemia risk","volume":"61","author":"Li","year":"2014","journal-title":"Pediatr. Blood Cancer"},{"issue":"10","key":"10.1016\/j.bcp.2026.118363_b0545","first-page":"4091","article-title":"Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia\/ myelodysplastic syndrome and de novo acute myeloid leukemia","volume":"6","author":"Naoe","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0550","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1182\/blood.V94.2.803","article-title":"Prevalence of the inactivating 609C\u2013>T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia","volume":"94","author":"Larson","year":"1999","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.bcp.2026.118363_b0555","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/bjc.2013.357","article-title":"The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis","volume":"109","author":"Lajin","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"12","key":"10.1016\/j.bcp.2026.118363_b0560","first-page":"1492","article-title":"NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms","volume":"89","author":"Kracht","year":"2004","journal-title":"Haematologica"},{"issue":"15","key":"10.1016\/j.bcp.2026.118363_b0565","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.7314\/APJCP.2015.16.15.6569","article-title":"Applicative value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis for patients with pancreatic cancer treated by concurrent chemoradiotherapy","volume":"16","author":"Gu","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"13","key":"10.1016\/j.bcp.2026.118363_b0570","doi-asserted-by":"crossref","first-page":"11151","DOI":"10.2147\/OTT.S269720","article-title":"Correlation between baseline serum tumor markers and clinical characteristic factors in patients with advanced pancreatic cancer","volume":"2","author":"Deng","year":"2020","journal-title":"Onco. Targets Ther."},{"issue":"2","key":"10.1016\/j.bcp.2026.118363_b0575","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/1354750X.2020.1725786","article-title":"Elevated CEA and CA19-9 serum levels independently predict advanced pancreatic cancer at diagnosis","volume":"25","author":"van Manen","year":"2020","journal-title":"Biomarkers"},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0580","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/s13046-024-03166-w","article-title":"Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer - a comprehensive review","volume":"43","author":"Reese","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"145","key":"10.1016\/j.bcp.2026.118363_b0585","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.lfs.2015.12.017","article-title":"Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones","volume":"15","author":"Glorieux","year":"2016","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.bcp.2026.118363_b0590","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3892\/or.2022.8293","article-title":"Molecular mechanisms of platinum\u2013based chemotherapy resistance in ovarian cancer (Review)","volume":"47","author":"Yang","year":"2022","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0595","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1038\/s41598-019-44111-8","article-title":"Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging","volume":"9","author":"Punganuru","year":"2019","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bcp.2026.118363_b0600","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3390\/cancers10120470","article-title":"Cancer-specific biomarker hNQO1-activatable fluorescent probe for imaging cancer cells in vitro and in vivo","volume":"10","author":"Punganuru","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.bcp.2026.118363_b0605","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3389\/fchem.2020.00756","article-title":"Covalent-assembly based fluorescent probes for detection of hNQO1 and imaging in living cells","volume":"26","author":"Han","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.bcp.2026.118363_b0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.112713","article-title":"Natural occurrence, physicochemical properties, biological activities, toxicity and synthesis","volume":"186","author":"Gomes","year":"2021","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bcp.2026.118363_b0615","unstructured":"www.cancer.gov\/publications\/dictionaries\/cancer-drug\/def\/lapachone."},{"issue":"8","key":"10.1016\/j.bcp.2026.118363_b0620","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41416-018-0278-4","article-title":"Phase 1 study of ARQ 761, a \u03b2-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis","volume":"119","author":"Gerber","year":"2018","journal-title":"Br. J. Cancer."},{"issue":"7","key":"10.1016\/j.bcp.2026.118363_b0625","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1158\/1535-7163.MCT-15-0765","article-title":"NQO1-mediated tumor-selective lethality and radiosensitization for head and neck cancer","volume":"15","author":"Li","year":"2016","journal-title":"Mol. Cancer Ther."},{"issue":"6","key":"10.1016\/j.bcp.2026.118363_b0630","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.ccell.2016.11.006","article-title":"Leveraging an NQO1 bioactivatable drug for tumor-selective use of poly(ADP-ribose) polymerase inhibitors","volume":"30","author":"Huang","year":"2016","journal-title":"Cancer Cell"},{"issue":"15","key":"10.1016\/j.bcp.2026.118363_b0635","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3390\/cells13151272","article-title":"Human NQO1 as a selective target for anticancer therapeutics and tumor imaging","volume":"13","author":"Khan","year":"2024","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.bcp.2026.118363_b0640","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1084\/jem.20172024","article-title":"NQO1 inhibits the TLR-dependent production of selective cytokines by promoting I\u03baB-\u03b6 degradation","volume":"215","author":"Kimura","year":"2018","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0645","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2024.2363000","article-title":"\u03b2-Lapachone promotes the recruitment and polarization of tumor-associated neutrophils (TANs) toward an antitumor (N1) phenotype in NQO1-positive cancers","volume":"13","author":"Tumbath","year":"2024","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.bcp.2026.118363_b0650","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1038\/s41467-019-11238-1","article-title":"NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118363_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101440","article-title":"Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to \u03b2-lapachone","volume":"30","author":"Torrente","year":"2020","journal-title":"Redox Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:13:40Z","timestamp":1788812020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":131,"alternative-id":["S0006295226007021"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118363","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NQO1 at the crossroads of oxidative stress, cancer, and therapeutic innovation","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118363","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118363"}}