{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:07:58Z","timestamp":1788815278713,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003996","name":"Kunming Medical University","doi-asserted-by":"publisher","award":["2025535Q09"],"award-info":[{"award-number":["2025535Q09"]}],"id":[{"id":"10.13039\/501100003996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202501AT070116"],"award-info":[{"award-number":["202501AT070116"]}],"id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["82360050"],"award-info":[{"award-number":["82360050"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bcp.2026.118383","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:38:09Z","timestamp":1787438289000},"page":"118383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Oxytocin suppresses endothelial-to-mesenchymal transition to mitigate cardiac fibrosis via the eNOS\/cGMP\/PKG pathway"],"prefix":"10.1016","volume":"253","author":[{"given":"Yu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiao","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-6093","authenticated-orcid":false,"given":"Yuqiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118383_b0005","volume":"103","author":"Elendu","year":"2024","journal-title":"Medicine"},{"key":"10.1016\/j.bcp.2026.118383_b0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/eurheartj\/ehaf524","article-title":"Left ventricular hypertrophy and myocardial fibrosis in heart failure with preserved ejection fraction: mechanisms and treatment","volume":"47","author":"Peikert","year":"2026","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bcp.2026.118383_b0015","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 heart disease and stroke statistics: a report of US and global data from the American heart association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2026.118383_b0020","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.15420\/cfr.2023.05","article-title":"Global public health burden of heart failure: an updated review","volume":"9","author":"Shahim","year":"2023","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.bcp.2026.118383_b0025","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cardfail.2025.07.007","article-title":"HF STATS 2025: heart failure epidemiology and outcomes statistics an updated 2025 report from the heart failure society of america","volume":"32","author":"Writing committee members","year":"2026","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.bcp.2026.118383_b0030","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41569-024-01046-6","article-title":"Global epidemiology of heart failure","volume":"21","author":"Khan","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bcp.2026.118383_b0035","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/CD9.0000000000000173","article-title":"Epidemiology and burden of heart failure","volume":"5","author":"Jia","year":"2025","journal-title":"Cardiology Discovery"},{"key":"10.1016\/j.bcp.2026.118383_b0040","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2026.118383_b0045","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.118383_b0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bcp.2019.06.021","article-title":"Endothelial-to-mesenchymal transition: pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases","volume":"168","author":"Lu","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118383_b0055","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.3390\/ijms25116180","article-title":"Endothelial-to-mesenchymal transition in cardiovascular pathophysiology","volume":"25","author":"Singh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118383_b0060","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/ars.2020.8169","article-title":"Endothelial-to-mesenchymal transition in pulmonary arterial hypertension","volume":"34","author":"Gorelova","year":"2021","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.bcp.2026.118383_b0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2174\/1573403X15666190808100336","article-title":"Endothelial to mesenchymal transition in the cardiogenesis and cardiovascular diseases","volume":"16","author":"Anbara","year":"2020","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.bcp.2026.118383_b0070","first-page":"153","article-title":"Endothelial nitric oxide synthase (eNOS) and the cardiovascular system: In physiology and in disease states","volume":"15","author":"Tran","year":"2022","journal-title":"Am J Biomed Sci Res"},{"key":"10.1016\/j.bcp.2026.118383_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2025.1682471","article-title":"NO\/NOS system dysregulation as a key molecular mechanism in chemotherapy-induced cardiotoxicity: a review","volume":"12","author":"Nagy","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bcp.2026.118383_b0080","article-title":"Pathological mechanisms and clinical research progress of endothelial dysfunction","volume":"13","author":"Wang","year":"2026","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bcp.2026.118383_b0085","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3390\/ijms27020629","article-title":"Nitric oxide signaling in cardiovascular physiology and pathology: mechanisms, dysregulation, and therapeutic frontiers","volume":"27","author":"Venkatesan","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118383_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004822","article-title":"Systems pharmacology and rational polypharmacy: Nitric oxide-cyclic GMP signaling pathway as an illustrative example and derivation of the general case","volume":"12","author":"Garmaroudi","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bcp.2026.118383_b0095","first-page":"947","article-title":"Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds. Braz J Med Biol Res = Rev Bras Pesqui","volume":"44","author":"Pereira","year":"2011","journal-title":"Med. Biol."},{"key":"10.1016\/j.bcp.2026.118383_b0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/ijms27010057","article-title":"NO-cGMP signaling in endothelial function of the healthy and inflamed dental pulp","volume":"27","author":"Korkmaz","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118383_b0105","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/cells14171400","article-title":"Targeting the NO-sGC-cGMP pathway: mechanisms of action of vericiguat in chronic heart failure","volume":"14","author":"Bajec","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118383_b0110","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.3389\/fpsyg.2020.02139","article-title":"The role of oxytocin in cardiovascular protection","volume":"11","author":"Jankowski","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bcp.2026.118383_b0115","first-page":"206","article-title":"The role of oxytocin in cardiovascular regulation. Braz J Med Biol Res = Rev Bras Pesqui","volume":"47","author":"Gutkowska","year":"2014","journal-title":"Med. Biol."},{"key":"10.1016\/j.bcp.2026.118383_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2026.112605","article-title":"Oxytocin modulates glucose metabolism to protect against cardiac remodeling via the STAT3\/eNOS axis","volume":"145","author":"Zhao","year":"2026","journal-title":"Cell. Signalling"},{"key":"10.1016\/j.bcp.2026.118383_b0125","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/sj.bjp.0707609","article-title":"Oxytocin stimulates migration and invasion in human endothelial cells","volume":"153","author":"Cattaneo","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118383_b0130","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1210\/endo.140.3.6546","article-title":"Human vascular endothelial cells express oxytocin receptors","volume":"140","author":"Thibonnier","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bcp.2026.118383_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.766024","article-title":"Oxytocin protects against isoproterenol-induced cardiac hypertrophy by inhibiting PI3K\/AKT pathway via a lncRNA GAS5\/miR-375-3p\/KLF4-dependent mechanism","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118383_b0140","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.585163","article-title":"Galangin attenuates isoproterenol-induced inflammation and fibrosis in the cardiac tissue of albino wistar rats","volume":"11","author":"Thangaiyan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118383_b0145","article-title":"Heart failure induced by isoproterenol: a comparison of two doses and two delivery methods in C57BL\/6J mice","volume":"20","author":"Wang","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118383_b0150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2018.01.010","article-title":"A metabolic basis for endothelial-to-mesenchymal transition","volume":"69","author":"Xiong","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.118383_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115705","article-title":"Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway","volume":"300","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118383_b0160","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1165\/rcmb.2020-0434OC","article-title":"Decreased cyclic guanosine monophosphate-protein kinase G signaling impairs angiogenesis in a lamb model of persistent pulmonary hypertension of the newborn","volume":"65","author":"Sharma","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bcp.2026.118383_b0165","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s12276-020-0439-4","article-title":"Endothelial-to-mesenchymal transition in anticancer therapy and normal tissue damage","volume":"52","author":"Choi","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118383_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.985298","article-title":"Oxytocin promotes epicardial cell activation and heart regeneration after cardiac injury","volume":"10","author":"Wasserman","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bcp.2026.118383_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113498","article-title":"Oxytocin ameliorates high glucose- and ischemia\/reperfusion-induced myocardial injury by suppressing pyroptosis via AMPK signaling pathway","volume":"153","author":"Yao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118383_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110358","article-title":"Oxytocin ameliorates ischemia\/reperfusion-induced injury by inhibiting mast cell degranulation and inflammation in the rat heart","volume":"128","author":"Xiong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118383_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2024.171323","article-title":"Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR\/JAK2\/STAT3 axis","volume":"182","author":"Yang","year":"2024","journal-title":"Peptides"},{"key":"10.1016\/j.bcp.2026.118383_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2026.124281","article-title":"Oxytocin ameliorates cardiac hypertrophy by inhibiting mitochondrial dysfunction and pyroptosis via AMPK\/PGC-1\u03b1 \/TFAM pathway","volume":"391","author":"Wang","year":"2026","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2026.118383_b0195","doi-asserted-by":"crossref","first-page":"11724","DOI":"10.3390\/ijms262311724","article-title":"Endothelial-to-mesenchymal transition in health and disease: molecular insights and therapeutic implications","volume":"26","author":"Kim","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118383_b0200","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease","volume":"73","author":"Kovacic","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2026.118383_b0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1074248420952233","article-title":"Endothelial-to-mesenchymal transition: role in cardiac fibrosis","volume":"26","author":"Cheng","year":"2021","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2026.118383_b0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/bph.14522","article-title":"Endothelial NOS: perspective and recent developments","volume":"176","author":"Garcia","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118383_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106931","article-title":"Modulation of the nitric oxide\/cGMP pathway in cardiac contraction and relaxation: potential role in heart failure treatment","volume":"196","author":"Mollace","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2026.118383_b0220","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/cvr\/cvae202","article-title":"Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload","volume":"120","author":"Fukuma","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118383_b0225","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1538-7836.2010.03806.x","article-title":"Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition","volume":"8","author":"Dangel","year":"2010","journal-title":"J Thromb Haemost: JTH"},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2026.118383_b0230","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.rmed.2016.08.022","article-title":"Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: a review of the preclinical evidence","volume":"122","author":"Sandner","year":"2017","journal-title":"Respir. Med."},{"key":"10.1016\/j.bcp.2026.118383_b0235","doi-asserted-by":"crossref","first-page":"46","DOI":"10.14336\/AD.2022.0523","article-title":"The NO-cGMP-PKG axis in HFpEF: from pathological mechanisms to potential therapies","volume":"14","author":"Cai","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.bcp.2026.118383_b0240","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2026.118383_b0245","doi-asserted-by":"crossref","unstructured":"U. F\u00f6rstermann, W.C. Sessa, Nitric oxide synthases: regulation and function, Eur. Heart J. 33 (2012) 829-837,837a-837d.","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"10.1016\/j.bcp.2026.118383_b0250","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fphys.2013.00347","article-title":"Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium","volume":"4","author":"Qian","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bcp.2026.118383_b0255","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/bja\/aen071","article-title":"Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during caesarean section","volume":"100","author":"Svanstr\u00f6m","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bcp.2026.118383_b0260","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1681\/ASN.2007010029","article-title":"Molecular mechanisms of antidiuretic effect of oxytocin","volume":"19","author":"Li","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.bcp.2026.118383_b0265","doi-asserted-by":"crossref","first-page":"534","DOI":"10.5603\/GP.a2021.0104","article-title":"Water intoxication in the course of stimulation of labor with oxytocin","volume":"92","author":"Szadok","year":"2021","journal-title":"Ginekol. Pol."},{"key":"10.1016\/j.bcp.2026.118383_b0270","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1161\/ATVBAHA.118.311276","article-title":"Epigenetic regulation of endothelial-to-mesenchymal transition in chronic heart disease","volume":"38","author":"Hulshoff","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2026.118383_b0275","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.3390\/ijms18102157","article-title":"TGF-\u03b2-induced endothelial-mesenchymal transition in fibrotic diseases","volume":"18","author":"Pardali","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118383_b0280","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41419-021-03750-4","article-title":"Knockout RAGE alleviates cardiac fibrosis through repressing endothelial-to-mesenchymal transition (EndMT) mediated by autophagy","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:16:04Z","timestamp":1788812164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":56,"alternative-id":["S0006295226007227"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118383","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxytocin suppresses endothelial-to-mesenchymal transition to mitigate cardiac fibrosis via the eNOS\/cGMP\/PKG pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118383"}}