{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:19:00Z","timestamp":1788023940094,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013414","name":"Conseil R\u00e9gional des Pays de la Loire","doi-asserted-by":"publisher","award":["PIRAMID"],"award-info":[{"award-number":["PIRAMID"]}],"id":[{"id":"10.13039\/501100013414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009371","name":"Universit\u00e9 de Nantes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019468","name":"Le Mans Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019468","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118393","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:29:42Z","timestamp":1787614182000},"page":"118393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin"],"prefix":"10.1016","volume":"254","author":[{"given":"Lucie","family":"Fonteneau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houda","family":"Benhelli-Mokrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line Robiou","family":"Du Pont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Marquis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Lebreton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Math\u00e9-Allainmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Ch\u00e9nais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-5060","authenticated-orcid":false,"given":"Fabrice","family":"Fleury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bcp.2026.118393_b0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118393_b0010","doi-asserted-by":"crossref","first-page":"63","DOI":"10.14740\/wjon1191","article-title":"Epidemiology of prostate cancer","volume":"10","author":"Rawla","year":"2019","journal-title":"World J Oncol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118393_b0015","first-page":"92","article-title":"The role of radiotherapy in metastatic prostate cancer","volume":"7","author":"Khullar","year":"2019","journal-title":"Am. J. Clin. Exp. Urol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118393_b0020","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.7150\/ijbs.11439","article-title":"Insights into chemoresistance of prostate cancer","volume":"11","author":"Zhang","year":"2015","journal-title":"Int. J. Biol. Sci."},{"issue":"22","key":"10.1016\/j.bcp.2026.118393_b0025","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.3390\/cancers14225697","article-title":"RAD51 is implicated in DNA damage, chemoresistance and immune dysregulation in solid tumors","volume":"14","author":"Liao","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.bcp.2026.118393_b0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/em.22087","article-title":"Mechanisms of DNA damage, repair, and mutagenesis","volume":"58","author":"Chatterjee","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.bcp.2026.118393_b0035","doi-asserted-by":"crossref","unstructured":"S. Qiu, J. Huang, MRN complex is an essential effector of DNA damage repair. J. Zhejiang Univ. Sci. B., 2021 15;22(1):31-37. doi: 10.1631\/jzus.B2000289. PMID: 33448185; PMCID: PMC7818010.","DOI":"10.1631\/jzus.B2000289"},{"issue":"5","key":"10.1016\/j.bcp.2026.118393_b0040","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/genes11050498","article-title":"The regulation of homologous recombination by helicases","volume":"11","author":"Huselid","year":"2020","journal-title":"Genes (Basel)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118393_b0045","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1038\/s41467-023-40672-5","article-title":"A RAD51-ADP double filament structure unveils the mechanism of filament dynamics in homologous recombination","volume":"14","author":"Luo","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bcp.2026.118393_b0050","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/abbs\/gmz076","article-title":"Pathways and assays for DNA double-strand break repair by homologous recombination","volume":"51","author":"Li","year":"2019","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"issue":"6913","key":"10.1016\/j.bcp.2026.118393_b0055","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature01230","article-title":"Insights into DNA recombination from the structure of a RAD51-BRCA2 complex","volume":"420","author":"Pellegrini","year":"2002","journal-title":"Nature"},{"issue":"54","key":"10.1016\/j.bcp.2026.118393_b0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genet-021920-092410","article-title":"RAD51 gene family structure and function","volume":"23","author":"Bonilla","year":"2020","journal-title":"Annu. Rev. Genet."},{"issue":"12","key":"10.1016\/j.bcp.2026.118393_b0065","article-title":"A pan-cancer bioinformatic analysis of RAD51 regarding the values for diagnosis, prognosis, and therapeutic prediction","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118393_b0070","article-title":"Recent advances in the development of non-PIKKs targeting small molecule inhibitors of DNA double-strand break repair","volume":"6","author":"Kelm","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118393_b0075","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/cb100428c","article-title":"Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening","volume":"6","author":"Huang","year":"2011","journal-title":"ACS Chem. Biol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118393_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100993","article-title":"A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bcp.2026.118393_b0085","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/genes12060920","article-title":"New RAD51 inhibitors to target homologous recombination in human cells","volume":"12","author":"Shkundina","year":"2021","journal-title":"Genes (Basel)"},{"issue":"15","key":"10.1016\/j.bcp.2026.118393_b0090","doi-asserted-by":"crossref","first-page":"7347","DOI":"10.1093\/nar\/gks353","article-title":"RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells","volume":"40","author":"Budke","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.bcp.2026.118393_b0095","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/emmm.201201760","article-title":"A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia","volume":"5","author":"Zhu","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bcp.2026.118393_b0100","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejmech.2015.04.021","article-title":"Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors","volume":"96","author":"Zhu","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2026.118393_b0105","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1093\/nar\/gkp200","article-title":"DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange","volume":"37","author":"Ishida","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.bcp.2026.118393_b0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1021\/cb800083a","article-title":"Discovery of potent CLC chloride channel inhibitors","volume":"3","author":"Matulef","year":"2008","journal-title":"ACS Chem. Biol."},{"issue":"18","key":"10.1016\/j.bcp.2026.118393_b0115","doi-asserted-by":"crossref","first-page":"5460","DOI":"10.3390\/molecules26185460","article-title":"Molecular determinant of DIDS analogs targeting RAD51 activity","volume":"26","author":"Velic","year":"2021","journal-title":"Molecules"},{"issue":"87","key":"10.1016\/j.bcp.2026.118393_b0120","article-title":"Synthesis and biological evaluation of DIDS analogues as efficient inhibitors of RAD51 involved in homologous recombination","volume":"1","author":"Demeyer","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bcp.2026.118393_b0205","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Ann. Appl. Biol."},{"key":"10.1016\/j.bcp.2026.118393_b0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0224137","article-title":"Statistical determination of synergy based on Bliss definition of drugs independence","volume":"14","author":"Demidenko","year":"2019","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.bcp.2026.118393_b0130","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1002\/1878-0261.13224","article-title":"Resistance to DNA repair inhibitors in cancer","volume":"16","author":"Baxter","year":"2022","journal-title":"Mol. Oncol."},{"issue":"7182","key":"10.1016\/j.bcp.2026.118393_b0135","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nature06548","article-title":"Resistance to therapy caused by intragenic deletion in BRCA2","volume":"451","author":"Edwards","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bcp.2026.118393_b0140","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1177\/01945998221083506","article-title":"RAD51 inhibitor and radiation toxicity in vestibular schwannoma","volume":"167","author":"Thielhelm","year":"2022","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"5","key":"10.1016\/j.bcp.2026.118393_b0145","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.dnarep.2007.12.008","article-title":"The consequences of Rad51 overexpression for normal and tumor cells","volume":"7","author":"Klein","year":"2008","journal-title":"DNA Repair (Amst)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118393_b0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1109\/TNB.2004.842503","article-title":"Unique structure and function of chloride transporting CLC proteins","volume":"4","author":"Pusch","year":"2005","journal-title":"IEEE Trans. Nanobioscience"},{"issue":"3","key":"10.1016\/j.bcp.2026.118393_b0155","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF00233668","article-title":"Stilbene disulfonates block ATP-sensitive K+ channels in guinea pig ventricular myocytes","volume":"136","author":"Furukawa","year":"1993","journal-title":"J. Membr. Biol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118393_b0160","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1021\/acs.jmedchem.5b01762","article-title":"Development of small molecules that specifically inhibit the D-loop activity of RAD51","volume":"59","author":"Lv","year":"2016","journal-title":"J. Med. Chem."},{"issue":"1441","key":"10.1016\/j.bcp.2026.118393_b0165","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1098\/rstb.2003.1368","article-title":"RAD51 localization and activation following DNA damage","volume":"359","author":"Tarsounas","year":"2004","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bcp.2026.118393_b0170","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2147\/OTT.S322297","article-title":"Targeting RAD51-mediated homologous recombination as a treatment for advanced solid and hematologic malignancies: opportunities and challenges ahead","volume":"15","author":"Tsang","year":"2022","journal-title":"Onco Targets Ther."},{"issue":"24","key":"10.1016\/j.bcp.2026.118393_b0175","doi-asserted-by":"crossref","first-page":"C14","DOI":"10.1158\/1538-7445.PANCA19-C14","article-title":"Abstract C14: a novel RAD51 inhibitor, CYT-0851, shows anticancer activity in preclinical models of pancreatic cancer","volume":"79","author":"Day","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118393_b0180","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fonc.2014.00289","article-title":"A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to doxorubicin","volume":"4","author":"Alagpulinsa","year":"2014","journal-title":"Front. Oncol."},{"issue":"6330","key":"10.1016\/j.bcp.2026.118393_b0185","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.aam7344","article-title":"PARP inhibitors: synthetic lethality in the clinic","volume":"355","author":"Lord","year":"2017","journal-title":"Science"},{"issue":"7612","key":"10.1016\/j.bcp.2026.118393_b0190","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature18325","article-title":"Replication fork stability confers chemoresistance in BRCA-deficient cells","volume":"535","author":"Ray Chaudhuri","year":"2016","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bcp.2026.118393_b0195","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tcb.2019.07.008","article-title":"PARP inhibitor resistance: a tug-of-war in BRCA-mutated cells","volume":"29","author":"Noordermeer","year":"2019","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118393_b0200","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1158\/1078-0432.CCR-15-1348","article-title":"RAD51 mediates resistance of cancer stem cells to PARP inhibition in triple-negative breast cancer","volume":"23","author":"Liu","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.118393_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnves.2026.100072","article-title":"Single-cell and multi-omics analyses implicate DDX39A as a candidate mediator of the LDHA-lactate-lactylation axis in castration-resistant prostate cancer","volume":"2","author":"Tian","year":"2026","journal-title":"Cell Investigation."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600732X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600732X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:51:28Z","timestamp":1788022288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522600732X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":42,"alternative-id":["S000629522600732X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118393","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel stilbene derivative targets RAD51 activity and sensitizes DU145 prostate cancer cells to cisplatin","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118393","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118393"}}