{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:20:23Z","timestamp":1788542423567,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160763"],"award-info":[{"award-number":["82160763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2025GXNSFBA069154"],"award-info":[{"award-number":["2025GXNSFBA069154"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118399","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:25:13Z","timestamp":1787786713000},"page":"118399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Genistein inhibits colorectal cancer progression via regulating the LINC00355\/miR-150\/SGK1 axis and downstream EGFR\/PI3K\/AKT and MAPK signaling pathways"],"prefix":"10.1016","volume":"254","author":[{"given":"Xing","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzhi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bcp.2026.118399_b0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0010","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1186\/s12885-020-07656-w","article-title":"Prediction of mortality in metastatic colorectal cancer in a real-life population: a multicenter explorative analysis","volume":"20","author":"Rumpold","year":"2020","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0015","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0020","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"issue":"2","key":"10.1016\/j.bcp.2026.118399_b0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/jcm7020022","article-title":"Evaluation of Colorectal Cancer Incidence Trends in the United States (2000-2014)","volume":"7","author":"Ansa","year":"2018","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0030","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/cam4.2673","article-title":"Metastatic patterns and survival outcomes in patients with stage IV colon cancer: a population-based analysis","volume":"9","author":"Wang","year":"2020","journal-title":"Cancer Med."},{"issue":"21","key":"10.1016\/j.bcp.2026.118399_b0035","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1001\/jama.294.21.2758","article-title":"Progress in the adjuvant treatment of colon cancer: has it influenced clinical practice?","volume":"294","author":"Van Cutsem","year":"2005","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.bcp.2026.118399_b0040","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2174\/1386207320666170112141833","article-title":"Phytochemicals - a novel and prominent source of anti-cancer drugs against colorectal cancer","volume":"20","author":"Mahadevappa","year":"2017","journal-title":"Comb. Chem. High Throughput Screen."},{"issue":"3","key":"10.1016\/j.bcp.2026.118399_b0045","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","article-title":"Curcumin and Health","volume":"21","author":"Pulido-Moran","year":"2016","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.bcp.2026.118399_b0050","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3390\/molecules22030395","article-title":"Cancer chemoprevention by phytochemicals: nature's healing touch","volume":"22","author":"Zubair","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2026.118399_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.11.007","article-title":"Plant flavonoids in cancer chemoprevention: role in genome stability","volume":"45","author":"George","year":"2017","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0060","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/annonc\/mdx688","article-title":"Phase II study of nab-paclitaxel in refractory small bowel adenocarcinoma and CpG island methylator phenotype (CIMP)-high colorectal cancer","volume":"29","author":"Overman","year":"2018","journal-title":"Ann. Oncol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118399_b0065","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1007\/s00210-023-02550-1","article-title":"Genistein: a promising modulator of apoptosis and survival signaling in cancer","volume":"396","author":"Joshi","year":"2023","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118399_b0070","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3390\/ijms26031114","article-title":"Cellular and molecular mechanisms modulated by genistein in cancer","volume":"26","author":"Naponelli","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.bcp.2026.118399_b0075","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.3390\/ijms25105569","article-title":"Apigenin: molecular mechanisms and therapeutic potential against cancer spreading","volume":"25","author":"Naponelli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bcp.2026.118399_b0080","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/antiox8090327","article-title":"Induction of G2\/M cell cycle arrest and apoptosis by genistein in human bladder cancer T24 cells through inhibition of the ROS-dependent PI3k\/AKT signal transduction pathway","volume":"8","author":"Park","year":"2019","journal-title":"Antioxidants (basel)."},{"issue":"7","key":"10.1016\/j.bcp.2026.118399_b0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/ng.848","article-title":"Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters","volume":"43","author":"Hung","year":"2011","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.bcp.2026.118399_b0090","first-page":"15903","article-title":"MALAT1 is an oncogenic long non-coding RNA associated with tumor invasion in non-small cell lung cancer regulated by DNA methylation","volume":"8","author":"Guo","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bcp.2026.118399_b0095","doi-asserted-by":"crossref","unstructured":"Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014 Jan 16;505(7483):344-52.","DOI":"10.1038\/nature12986"},{"key":"10.1016\/j.bcp.2026.118399_b0100","doi-asserted-by":"crossref","unstructured":"Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell. 2011;146(3):353-358.","DOI":"10.1016\/j.cell.2011.07.014"},{"key":"10.1016\/j.bcp.2026.118399_b0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.omtn.2019.11.002","article-title":"LINC00355 promotes tumor progression in HNSCC by hindering microRNA-195-mediated suppression of HOXA10 expression","volume":"19","author":"Lu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"2","key":"10.1016\/j.bcp.2026.118399_b0110","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbrc.2018.11.151","article-title":"Comprehensive analysis of lncRNA-associated ceRNA network in colorectal cancer","volume":"508","author":"Yuan","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0115","doi-asserted-by":"crossref","first-page":"12988","DOI":"10.1038\/s41598-025-97556-5","article-title":"MiR- 150 deletion promotes lung tumor growth by upregulating P-STAT3 and ROS in MDSCs","volume":"15","author":"Qin","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bcp.2026.118399_b0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jhep.2025.01.027","article-title":"Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity","volume":"83","author":"Zhang","year":"2025","journal-title":"J. Hepatol."},{"issue":"14","key":"10.1016\/j.bcp.2026.118399_b0125","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa0805019","article-title":"Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer","volume":"360","author":"Van Cutsem","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.bcp.2026.118399_b0130","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1056\/NEJMoa1305275","article-title":"Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer","volume":"369","author":"Douillard","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118399_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.608722","article-title":"SGK1 in human cancer: emerging roles and mechanisms","volume":"10","author":"Sang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bcp.2026.118399_b0140","doi-asserted-by":"crossref","DOI":"10.1177\/1758835920940946","article-title":"The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star","volume":"12","author":"Zhu","year":"2020","journal-title":"Ther Adv Med Oncol."},{"key":"10.1016\/j.bcp.2026.118399_b0145","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12964-026-02856-6","article-title":"An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB\/PI3K\/AKT\/mTOR\/MYC signaling axis","volume":"24","author":"Zuo","year":"2026","journal-title":"Cell Commun. Signal"},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118399_b0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11010-019-03505-y","article-title":"ER\u03b2 modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway","volume":"456","author":"Liu","year":"2019","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bcp.2026.118399_b0155","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3892\/or.2018.6468","article-title":"Genistein and AG1024 synergistically increase the radiosensitivity of prostate cancer cells","volume":"40","author":"Tang","year":"2018","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.bcp.2026.118399_b0160","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.5114\/aoms.2018.78742","article-title":"Genistein-triggered anticancer activity against liver cancer cell line HepG2 involves ROS generation, mitochondrial apoptosis, G2\/M cell cycle arrest and inhibition of cell migration","volume":"15","author":"Zhang","year":"2019","journal-title":"Arch. Med. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2026.118399_b0165","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/tox.22698","article-title":"Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo","volume":"34","author":"Hsiao","year":"2019","journal-title":"Environ. Toxicol."},{"issue":"4","key":"10.1016\/j.bcp.2026.118399_b0170","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/biof.1627","article-title":"Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer","volume":"46","author":"Chen","year":"2020","journal-title":"Biofactors"},{"key":"10.1016\/j.bcp.2026.118399_b0175","article-title":"Integrative multi-omics analysis reveals the LncRNA 60967.1-PLCD4-ATRA axis as a key regulator of colorectal cancer progression and immune response","volume":"24(1):164","author":"Chen","year":"2025","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2026.118399_b0180","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41392-025-02128-8","article-title":"The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis","volume":"10","author":"Meng","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.bcp.2026.118399_b0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41417-023-00700-4","article-title":"Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p\/CRKL axis","volume":"31","author":"Hu","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"9","key":"10.1016\/j.bcp.2026.118399_b0190","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.18632\/aging.203069","article-title":"Correction for: miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bcp.2026.118399_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155462","article-title":"Andrographolide sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the EGFR\/AKT and PDGFR\u03b2\/AKT signaling pathways","volume":"126","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"issue":"21","key":"10.1016\/j.bcp.2026.118399_b0200","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2423077122","article-title":"Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4 Suppl","key":"10.1016\/j.bcp.2026.118399_b0205","doi-asserted-by":"crossref","first-page":"1362S","DOI":"10.1093\/jn\/131.4.1362S","article-title":"Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements","volume":"131","author":"Setchell","year":"2001","journal-title":"J. Nutr."},{"issue":"8881","key":"10.1016\/j.bcp.2026.118399_b0210","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/0140-6736(93)92188-Y","article-title":"Plasma concentrations of phyto-oestrogens in Japanese men","volume":"342","author":"Adlercreutz","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.bcp.2026.118399_b0215","first-page":"58","article-title":"RCC1 knockdown sensitizes drug-resistant colorectal cancer to 5-fluorouracil or doxorubicin by impairing DNA repair","volume":"8","author":"Li","year":"2025","journal-title":"Cancer Drug Resist."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:10:02Z","timestamp":1788541802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":43,"alternative-id":["S0006295226007380"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118399","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genistein inhibits colorectal cancer progression via regulating the LINC00355\/miR-150\/SGK1 axis and downstream EGFR\/PI3K\/AKT and MAPK signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118399","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118399"}}