{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:19:54Z","timestamp":1788466794231,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["23KJA350003"],"award-info":[{"award-number":["23KJA350003"]}],"id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32570462"],"award-info":[{"award-number":["32570462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2308200"],"award-info":[{"award-number":["2023YFC2308200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118404","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:02:55Z","timestamp":1787922175000},"page":"118404","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Targeting PKM2 by (+)-homocrepidine A restrains glycolytic reprogramming and reshapes macrophage fate to alleviate acute lung injury"],"prefix":"10.1016","volume":"254","author":[{"given":"Rongrong","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinque","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-1473","authenticated-orcid":false,"given":"Yinan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-5085","authenticated-orcid":false,"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118404_b0005","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.7150\/thno.69533","article-title":"AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages","volume":"6","author":"Xia","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bcp.2026.118404_b0010","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1038\/s41467-022-35492-y","article-title":"Locally organised and activated Fth1(hi) neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner","volume":"1","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118404_b0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13287-026-04903-y","article-title":"Fndc5 modification optimizes the therapeutic effect of rat MSCs on sepsis-induced ALI\/ARDS via activating the PI3K\/AKT signaling pathway","volume":"17","author":"Luo","year":"2026","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bcp.2026.118404_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102655","article-title":"miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury","volume":"62","author":"Shen","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.118404_b0025","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.actbio.2022.06.024","article-title":"ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment","volume":"148","author":"Muhammad","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bcp.2026.118404_b0030","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.immuni.2025.05.005","article-title":"A brain-to-lung signal from GABAergic neurons to ADRB2+ interstitial macrophages promotes pulmonary inflammatory responses","volume":"58","author":"Li","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.bcp.2026.118404_b0035","doi-asserted-by":"crossref","first-page":"292","DOI":"10.14348\/molcells.2021.0058","article-title":"Development and functions of alveolar macrophages","volume":"5","author":"Woo","year":"2021","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bcp.2026.118404_b0040","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41423-025-01268-9","article-title":"Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming","volume":"22","author":"Xu","year":"2025","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bcp.2026.118404_b0045","article-title":"Endothelial-derived CCL7 promotes macrophage polarization and aggravates septic acute lung injury via CCR1-mediated STAT1 succinylation","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bcp.2026.118404_b0050","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ymthe.2021.09.017","article-title":"Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation","volume":"2","author":"Song","year":"2022","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bcp.2026.118404_b0055","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jconrel.2025.02.005","article-title":"Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1\/M2 balance for osteoarthritis therapy","volume":"380","author":"Chen","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bcp.2026.118404_b0060","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.molimm.2021.10.007","article-title":"The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner","volume":"140","author":"Cai","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bcp.2026.118404_b0065","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74690","article-title":"Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses","volume":"11","author":"Lundahl","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.bcp.2026.118404_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2017.11.003","article-title":"The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP\/ADP homeostasis","volume":"324","author":"Chen","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bcp.2026.118404_b0075","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jcmgh.2023.01.004","article-title":"Gut microbiota-derived glutamine attenuates liver ischemia\/reperfusion injury via macrophage metabolic reprogramming","volume":"5","author":"Lu","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bcp.2026.118404_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118455","article-title":"Octahydroindolizine alkaloid Homocrepidine a from Dendrobium crepidatum attenuate P. acnes-induced inflammatory in vitro and in vivo","volume":"333","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118404_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103809","article-title":"Anti-inflammatory octahydroindolizine alkaloid enantiomers from Dendrobium crepidatum","volume":"100","author":"Hu","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bcp.2026.118404_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107126","article-title":"CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer","volume":"202","author":"Lv","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bcp.2026.118404_b0095","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41590-023-01430-3","article-title":"CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions","volume":"3","author":"Liu","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bcp.2026.118404_b0100","article-title":"Inflammatory fibroblast-like synoviocyte-derived exosomes aggravate osteoarthritis via enhancing macrophage glycolysis","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bcp.2026.118404_b0105","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.1021\/acsami.4c21635","article-title":"Controlled release of cold atmospheric plasma by gelatin scaffold enhances wound healing via macrophage modulation","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bcp.2026.118404_b0110","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41419-023-05937-3","article-title":"Effects of altered glycolysis levels on CD8(+) T cell activation and function","volume":"7","author":"Cao","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118404_b0115","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1136\/gutjnl-2021-325150","article-title":"FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2","volume":"12","author":"Rao","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.bcp.2026.118404_b0120","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.apsb.2024.04.024","article-title":"KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2","volume":"7","author":"Peng","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bcp.2026.118404_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101634","article-title":"Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH","volume":"36","author":"Xu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.118404_b0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41392-025-02307-7","article-title":"Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance","volume":"10","author":"Wang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2026.118404_b0135","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1161\/CIRCRESAHA.124.325049","article-title":"March2 alleviates aortic aneurysm\/dissection by regulating PKM2 polymerization","volume":"136","author":"Li","year":"2025","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2026.118404_b0140","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.cmet.2025.05.012","article-title":"Itaconate promotes inflammatory responses in tissue-resident alveolar macrophages and exacerbates acute lung injury","volume":"37","author":"Shan","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2026.118404_b0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s11658-025-00750-6","article-title":"Targeting alveolar macrophages: a promising intervention for pulmonary infection and acute lung injury","volume":"30","author":"Hou","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bcp.2026.118404_b0150","article-title":"The role of immunometabolism in macrophage polarization and its impact on acute lung injury\/acute respiratory distress syndrome","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118404_b0155","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2026.118404_b0160","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/biomedicines12030632","article-title":"Roles of macrophages and endothelial cells and their crosstalk in acute lung injury","volume":"12","author":"Osorio-Valencia","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bcp.2026.118404_b0165","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.apsb.2021.03.011","article-title":"Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation","volume":"11","author":"Lv","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bcp.2026.118404_b0170","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s40425-019-0817-4","article-title":"Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth","volume":"1","author":"Cao","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.bcp.2026.118404_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100754","article-title":"Therapeutic strategies to overcome taxane resistance in cancer","volume":"55","author":"Das","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.bcp.2026.118404_b0180","article-title":"Lactate supports a metabolic-epigenetic link in macrophage polarization","volume":"46","author":"Noe","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bcp.2026.118404_b0185","doi-asserted-by":"crossref","first-page":"22508","DOI":"10.1021\/acsnano.3c05998","article-title":"Precisely regulating M2 subtype macrophages for renal fibrosis resolution","volume":"22","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.bcp.2026.118404_b0190","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1089\/ars.2020.8203","article-title":"Macrophage regulation of granulopoiesis and neutrophil functions","volume":"3","author":"Schulz","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2026.118404_b0195","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1038\/s41418-023-01194-1","article-title":"TRAF3\/STAT6 axis regulates macrophage polarization and tumor progression","volume":"8","author":"Shi","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bcp.2026.118404_b0200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41419-023-05607-4","article-title":"Schwann cell-derived exosomes containing MFG-E8 modify macrophage\/microglial polarization for attenuating inflammation via the SOCS3\/STAT3 pathway after spinal cord injury","volume":"1","author":"Ren","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bcp.2026.118404_b0205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12943-024-01966-4","article-title":"Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p\/STAT6 axis to promote gastric cancer progression","volume":"23","author":"Deng","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.118404_b0210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2024.05.015","article-title":"TIPE1 limits virus replication by disrupting PKM2\/ HIF-1\u03b1\/ glycolysis feedback loop","volume":"221","author":"Ren","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2026.118404_b0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"1","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bcp.2026.118404_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157784","article-title":"Qishen Yiqi Dropping Pills ameliorate acute myocardial infarction by modulating PKM2\/STAT3 pathway-mediated metabolic reprogramming in macrophages","volume":"151","author":"Fan","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118404_b0225","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:57:46Z","timestamp":1788465466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":45,"alternative-id":["S0006295226007434"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118404","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting PKM2 by (+)-homocrepidine A restrains glycolytic reprogramming and reshapes macrophage fate to alleviate acute lung injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118404","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118404"}}