{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:19:41Z","timestamp":1788261581791,"version":"build-2803163510"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","award":["XZR2024169"],"award-info":[{"award-number":["XZR2024169"]}],"id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["X10642"],"award-info":[{"award-number":["X10642"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["J0325094"],"award-info":[{"award-number":["J0325094"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118409","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T14:25:22Z","timestamp":1788099922000},"page":"118409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Wogonoside: Pharmacology, molecular targets and therapeutic potential"],"prefix":"10.1016","volume":"254","author":[{"given":"Ming","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6511-2614","authenticated-orcid":false,"given":"Rui","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiandeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bcp.2026.118409_b0005","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1248\/bpb.22.1015","article-title":"Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, berberine, coptisine, palmatine, jateorrhizine and glycyrrhizin in Kampo medicines by ion-pair high-performance liquid chromatography","volume":"22","author":"Okamura","year":"1999","journal-title":"Biol. Pharm. Bull."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118409_b0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.chroma.2005.01.054","article-title":"Separation and purification of baicalin and wogonoside from the chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography","volume":"1066","author":"Wu","year":"2005","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/mrc.2165","article-title":"Solid-state NMR studies and DFT calculations of flavonoids: baicalein, baicalin and wogonoside","volume":"46","author":"Wolniak","year":"2008","journal-title":"Magn. Reson. Chem."},{"issue":"24","key":"10.1016\/j.bcp.2026.118409_b0020","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.jchromb.2010.06.021","article-title":"Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats","volume":"878","author":"Zhu","year":"2010","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"20\u201321","key":"10.1016\/j.bcp.2026.118409_b0025","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.jchromb.2009.05.035","article-title":"Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry","volume":"877","author":"Wang","year":"2009","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"10","key":"10.1016\/j.bcp.2026.118409_b0030","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/bmc.649","article-title":"High-performance liquid chromatographic method for the determination and pharmacokinetic study of wogonoside in rat serum after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction","volume":"20","author":"Deng","year":"2006","journal-title":"Biomed. Chromatogr."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0035","first-page":"399","article-title":"Comparative pharmacokinetics of baicalin, wogonoside, baicalein and wogonin in plasma after oral administration of pure baicalin, radix scutellariae and scutellariae-paeoniae couple extracts in normal and ulcerative colitis rats","volume":"12","author":"Zhang","year":"2013","journal-title":"Iran J. Pharm. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0040","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jep.2014.05.033","article-title":"Comparative pharmacokinetic investigation on baicalin and wogonoside in type 2 diabetic and normal rats after oral administration of traditional Chinese medicine Huanglian Jiedu decoction","volume":"155","author":"He","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121723","article-title":"A preliminary exploratory clinical study of Xiao-Chai-Hu-Tang co-administered with irinotecan-based chemotherapy in advanced colorectal cancer","volume":"367","author":"Zhou","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(02)00257-X","article-title":"Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical mediator production in peritoneal exduate cells and immunoglobulin E of rat mesenteric lymph node lymphocytes","volume":"84","author":"Lim","year":"2003","journal-title":"J. Ethnopharmacol."},{"issue":"1\u20132","key":"10.1016\/j.bcp.2026.118409_b0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2009.01.010","article-title":"Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction","volume":"259","author":"Chen","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.bcp.2026.118409_b0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fct.2012.09.012","article-title":"Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway","volume":"51","author":"Sun","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0065","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3892\/or.2014.3294","article-title":"Wogonoside induces autophagy-related apoptosis in human glioblastoma cells","volume":"32","author":"Zhang","year":"2014","journal-title":"Oncol. Rep."},{"issue":"6","key":"10.1016\/j.bcp.2026.118409_b0070","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1007\/s10753-014-9932-z","article-title":"Wogonoside ameliorates lipopolysaccharide-induced acute lung injury in mice","volume":"37","author":"Zhang","year":"2014","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.bcp.2026.118409_b0075","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bcp.2015.02.002","article-title":"Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-\u03baB and NLRP3 inflammasome activation","volume":"94","author":"Sun","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118409_b0080","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s00204-015-1552-3","article-title":"Wogonoside induces growth inhibition and cell cycle arrest via promoting the expression and binding activity of GATA-1 in chronic myelogenous leukemia cells","volume":"90","author":"Li","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118409_b0085","doi-asserted-by":"crossref","first-page":"e2768","DOI":"10.1038\/cddis.2017.175","article-title":"PLSCR1\/IP3R1\/Ca(2+) axis contributes to differentiation of primary AML cells induced by wogonoside","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.bcp.2026.118409_b0090","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.chembiol.2019.05.004","article-title":"A systems pharmacology approach uncovers wogonoside as an angiogenesis inhibitor of triple-negative breast cancer by targeting hedgehog signaling","volume":"26","author":"Huang","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bcp.2026.118409_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156406","article-title":"Targeting the NF-\u03baB p65-MMP28 axis: Wogonoside as a novel therapeutic agent for attenuating podocyte injury in diabetic nephropathy","volume":"138","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118409_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114481","article-title":"Wogonoside ameliorates oxidative damage in tubular epithelial cells of diabetic nephropathy by modulating the HNF4A-NRF2 axis","volume":"152","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0105","doi-asserted-by":"crossref","unstructured":"H.S. Kim, J.Y. Kim, M.S. Park, H. Zheng, G.E. Ji, Cloning and expression of beta-glucuronidase from Lactobacillus brevis in E. coli and application in the bioconversion of baicalin and wogonoside, J. Microbiol. Biotechnol. 19(12) (2009) 1650-5. https:\/\/doi.org\/10.4014\/jmb.0904.04053.","DOI":"10.4014\/jmb.0904.04053"},{"key":"10.1016\/j.bcp.2026.118409_b0110","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jchromb.2015.11.049","article-title":"Oral pharmacokinetics of baicalin, wogonoside, oroxylin a 7-O-\u03b2-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat","volume":"1026","author":"Cai","year":"2016","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"5","key":"10.1016\/j.bcp.2026.118409_b0115","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3892\/or.2013.2726","article-title":"Pretreatment of baicalin and wogonoside with glycoside hydrolase: a promising approach to enhance anticancer potential","volume":"30","author":"Yu","year":"2013","journal-title":"Oncol. Rep."},{"issue":"6","key":"10.1016\/j.bcp.2026.118409_b0120","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1248\/cpb.60.706","article-title":"Formation and conformation of baicalin-berberine and wogonoside-berberine complexes","volume":"60","author":"Wang","year":"2012","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.bcp.2026.118409_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119791","article-title":"Study on the compatibility of japonica rice in Xie-Bai-San decoction based on characterization, multi components quantification, and pharmacokinetics","volume":"348","author":"Dong","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155259","article-title":"Unraveling spatial metabolome of the aerial and underground parts of Scutellaria baicalensis by matrix-assisted laser desorption\/ionization mass spectrometry imaging","volume":"123","author":"Zhou","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118409_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.plaphy.2024.109362","article-title":"Effects of drought stress on the secondary metabolism of Scutellaria baicalensis Georgi and the function of SbWRKY34 in drought resistance","volume":"219","author":"Zhang","year":"2025","journal-title":"Plant Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0140","doi-asserted-by":"crossref","DOI":"10.1093\/plphys\/kiae607","article-title":"microRNA858 represses the transcription factor gene SbMYB47 and regulates flavonoid biosynthesis in Scutellaria baicalensis","volume":"197","author":"Yang","year":"2024","journal-title":"Plant Physiol."},{"key":"10.1016\/j.bcp.2026.118409_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2026.107038","article-title":"A novel endophytic fungus Fusarium oxysporum G-07 exhibits antagonism against Rhizoctonia solani and promotes growth in Scutellaria baicalensis","volume":"219","author":"Wang","year":"2026","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.bcp.2026.118409_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jchromb.2012.09.024","article-title":"Purification of baicalin and wogonoside from Scutellaria baicalensis extracts by macroporous resin adsorption chromatography","volume":"908","author":"Du","year":"2012","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bcp.2026.118409_b0155","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.chroma.2019.05.028","article-title":"Large-scale separation of baicalin and wogonoside from Scutellaria baicalensis Georgi by the combination of pH-zone-refining and conventional counter-current chromatography","volume":"1601","author":"Wang","year":"2019","journal-title":"J. Chromatogr. A"},{"issue":"19","key":"10.1016\/j.bcp.2026.118409_b0160","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1002\/jssc.202000455","article-title":"Retention mechanism of pH-peak-focusing in countercurrent chromatographic separation of baicalin and wogonoside from Scutellaria baicalensis Georgi","volume":"43","author":"Wang","year":"2020","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.bcp.2026.118409_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2025.107386","article-title":"Synergistic coupling of ultrasonic cavitation with tailored deep eutectic solvent systems for intensified extraction of Scutellaria Radix flavonoids: Modelling and optimization by genetic algorithm","volume":"119","author":"Cui","year":"2025","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.bcp.2026.118409_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465938","article-title":"Green extraction of bioactive flavonoids in Scutellariae Radix using deep eutectic solvents-based ultrasound-assisted matrix solid phase dispersion combined with computer-aided analysis","volume":"1751","author":"Gao","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bcp.2026.118409_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.127559","article-title":"Fluorescent distinguishing flavonoid glycosides against aglycones based on the selective recognization of boric acid-functional Eu(III)-organic framework","volume":"286","author":"Zhu","year":"2025","journal-title":"Talanta"},{"issue":"4","key":"10.1016\/j.bcp.2026.118409_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules31040680","article-title":"Origin identification of scutellariae radix based on multidimensional quality indicators and machine learning algorithms","volume":"31","author":"Liu","year":"2026","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0185","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1038\/s41598-026-37751-0","article-title":"Optimization of the extraction process of Sanhuang Qingre Formula by integrating response surface methodology, grey correlation analysis, and machine learning","volume":"16","author":"Chen","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118409_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2025.1632033","article-title":"UPLC fingerprinting combined with quantitative analysis of multicomponents by a single marker for quality evaluation of YiQing granules","volume":"13","author":"Li","year":"2025","journal-title":"Front. Chem."},{"key":"10.1016\/j.bcp.2026.118409_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117175","article-title":"Integrating offline 2D UHPLC-QTOF-MS\/MS-based automated analytical platform and UHPLC-QTRAP\u00ae-MS: the chemical profiling of modified Gegen Qinlian Decoction","volume":"267","author":"Shi","year":"2026","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0200","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jtcme.2024.04.006","article-title":"Integrating pharmacokinetics and network pharmacology to decipher the efficacy of Fufang Qinlan oral liquid on post infectious cough","volume":"15","author":"Huang","year":"2025","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.bcp.2026.118409_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155706","article-title":"Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota","volume":"129","author":"Luo","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0210","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13020-026-01341-z","article-title":"Interpretation of the efficacy-oriented components of decoction pieces in compounds based on the spectrum-effect relationship: Huangqin Qingfei decoction as an example","volume":"21","author":"Liu","year":"2026","journal-title":"Chin. Med."},{"key":"10.1016\/j.bcp.2026.118409_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155979","article-title":"Exploring the mechanisms of Huangqin Qingfei Decoction on acute lung injury by LC-MS combined network pharmacology analysis","volume":"134","author":"Liu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118409_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1671732","article-title":"Clinical efficacy and metabolomics profiling of dachaihu decoction for patients with septic liver injury: a randomized controlled trial","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0225","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpba.2012.03.051","article-title":"Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin a and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry","volume":"70","author":"Tong","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.bcp.2026.118409_b0230","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4083","article-title":"Simultaneous determination of baicalin, baicalein, wogonoside, wogonin, scutellarin, berberine, coptisine, ginsenoside Rb1 and ginsenoside Re of Banxia xiexin decoction in rat plasma by LC-MS\/MS and its application to a pharmacokinetic study","volume":"32","author":"Wang","year":"2018","journal-title":"Biomed. Chromatogr."},{"issue":"7","key":"10.1016\/j.bcp.2026.118409_b0235","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1039\/C7RA08270C","article-title":"Mechanism in the existent difference in form of wogonin\/wogonoside between plasma and intestine\/liver in rats","volume":"8","author":"Wang","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.bcp.2026.118409_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119232","article-title":"Discovering the Q-marker of scutellaria baicalensis against viral pneumonia integrated chemical profile identification, pharmacokinetic, metabolomics and network pharmacology","volume":"340","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0245","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2014.03.033","article-title":"Development of a SPE-LC\/MS\/MS method for simultaneous quantification of baicalein, wogonin, oroxylin a and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies","volume":"97","author":"Fong","year":"2014","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bcp.2026.118409_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2026.117571","article-title":"Systematic characterization of active components and therapeutic mechanisms of Chaihu Guizhi Ganjiang Decoction in metabolic dysfunction-associated steatohepatitis","volume":"279","author":"Wu","year":"2026","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0255","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1186\/s12967-024-05955-5","article-title":"Multi-omics and experimental analysis unveil the key components in Scutellaria baicalensis Georgi to alleviate hepatic fibrosis via regulating cPLA2-mediated arachidonic acid metabolism","volume":"22","author":"Yang","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bcp.2026.118409_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155645","article-title":"Integrated pharmacokinetic properties and tissue distribution of multiple active constituents in Qing-Yi Recipe: a comparison between granules and decoction","volume":"129","author":"Ma","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118409_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156424","article-title":"Qingyi decoction and its active ingredients ameliorate acute pancreatitis by regulating acinar cells and macrophages via NF-\u03baB\/NLRP3\/Caspase-1 pathways","volume":"139","author":"An","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118409_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121624","article-title":"Sanhuang Xiexin decoction ameliorates acute lung injury by disrupting NEK7-NLRP3 inflammasome activation","volume":"366","author":"Wang","year":"2026","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118409_b0275","doi-asserted-by":"crossref","first-page":"13234","DOI":"10.1021\/acsami.3c18102","article-title":"Screening of CPT1A-targeting lipid metabolism modulators using mitochondrial membrane chromatography","volume":"16","author":"Su","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bcp.2026.118409_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.465775","article-title":"Cell-free synthesis of membrane receptors for preparation of NKG2A monolithic micro-affinity chromatography","volume":"1746","author":"Chen","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bcp.2026.118409_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176566","article-title":"Wogonoside alleviates microglia-mediated neuroinflammation via TLR4\/MyD88\/NF-\u03baB signaling axis after spinal cord injury","volume":"973","author":"Zhu","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153179","article-title":"Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK\/pMLC2 pathway","volume":"68","author":"Huang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118409_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118155","article-title":"The Scutellaria-Coptis herb couple and its active small-molecule ingredient wogonoside alleviate cytokine storm by regulating the CD39\/NLRP3\/GSDMD signaling pathway","volume":"329","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156142","article-title":"Lotus seed drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C\/SP1\/ZEB1 signaling pathway","volume":"135","author":"Xie","year":"2024","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.bcp.2026.118409_b0305","doi-asserted-by":"crossref","first-page":"919","DOI":"10.5650\/jos.ess23101","article-title":"Anti-lung cancer, anti-microbial, anti-\u03b1-glucosidase, anti-sorbitol dehydrogenase, and in silico studies of wogonoside and isoliquiritigenin as natural compounds","volume":"72","author":"Zeng","year":"2023","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.bcp.2026.118409_b0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2025.466164","article-title":"A multi-chamber membrane separation electrophoresis system supporting bio-affinity screening and evaluation of potential bioactive compounds in complex chinese medicine","volume":"1757","author":"Shang","year":"2025","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.bcp.2026.118409_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119295","article-title":"Integrating lipid metabolomics, serum medicinal chemistry, network pharmacology and experimental validation to explore the mechanism of Sanmiao wan in the treatment of rheumatoid arthritis","volume":"340","author":"Wan","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"Pt 3","key":"10.1016\/j.bcp.2026.118409_b0320","article-title":"UPLC-Q-Exactive\/MS based analysis explore the correlation between components variations and anti-influenza virus effect of four quantified extracts of Chaihu Guizhi decoction","volume":"319","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0325","doi-asserted-by":"crossref","unstructured":"Y.Z. Yang, Y.Z. Tang, Y.H. Liu, Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells, J Ethnopharmacol 148(1) (2013) 271-6. https:\/\/doi.org\/10.1016\/j.jep.2013.04.025.","DOI":"10.1016\/j.jep.2013.04.025"},{"issue":"9","key":"10.1016\/j.bcp.2026.118409_b0330","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100370RR","article-title":"Qing-Fei-Pai-Du decoction and wogonoside exert anti-inflammatory action through down-regulating USP14 to promote the degradation of activating transcription factor 2","volume":"35","author":"Xu","year":"2021","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0335","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jtcme.2025.12.003","article-title":"Chemical characterization of Jing Guan Fang and its application in alleviating coronavirus envelope protein-induced proinflammatory responses in vitro and in vivo","volume":"16","author":"Yeh","year":"2026","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.bcp.2026.118409_b0340","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2016.02.040","article-title":"Protective mechanisms of wogonoside against Lipopolysaccharide\/D-galactosamine-induced acute liver injury in mice","volume":"780","author":"Gao","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bcp.2026.118409_b0345","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.3892\/etm.2017.4904","article-title":"Wogonoside alleviates inflammation induced by traumatic spinal cord injury by suppressing NF-\u03baB and NLRP3 inflammasome activation","volume":"14","author":"Zhu","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0350","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/08923973.2021.1913503","article-title":"Wogonoside attenuates the articular cartilage injury and the infiltration of Th1\/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-\u03baB and ERK1\/2 activation","volume":"43","author":"Liu","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"13","key":"10.1016\/j.bcp.2026.118409_b0355","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.1021\/acs.jafc.3c04082","article-title":"Wogonoside ameliorates airway inflammation and mucus hypersecretion via NF-\u03baB\/STAT6 signaling in ovalbumin-induced murine acute asthma","volume":"72","author":"Yu","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0360","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3892\/ol.2015.3408","article-title":"Wogonoside induces apoptosis in Bel-7402, a hepatocellular carcinoma cell line, by regulating Bax\/Bcl-2","volume":"10","author":"Li","year":"2015","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0365","first-page":"63","article-title":"Wogonoside induces cell cycle arrest and mitochondrial mediated apoptosis by modulation of Bcl-2 and Bax in osteosarcoma cancer cells","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bcp.2026.118409_b0370","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.biopha.2018.06.077","article-title":"Wogonoside induces apoptosis in human non-small cell lung cancer A549 cells by promoting mitochondria dysfunction","volume":"106","author":"Luo","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.bcp.2026.118409_b0375","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3892\/etm.2021.9842","article-title":"Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1\u03b1 pathway","volume":"21","author":"Gu","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.118409_b0380","first-page":"4463","article-title":"Wogonoside inhibits cell growth and induces mitochondrial-mediated autophagy-related apoptosis in human colon cancer cells through the PI3K\/AKT\/mTOR\/p70S6K signaling pathway","volume":"15","author":"Han","year":"2018","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.bcp.2026.118409_b0385","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/abbs\/gmz109","article-title":"Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis","volume":"51","author":"Chen","year":"2019","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"issue":"11","key":"10.1016\/j.bcp.2026.118409_b0390","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/mc.22412","article-title":"Wogonoside inhibits angiogenesis in breast cancer via suppressing Wnt\/\u03b2-catenin pathway","volume":"55","author":"Huang","year":"2016","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.bcp.2026.118409_b0395","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.21037\/jtd-20-1555","article-title":"Effects of wogonoside on invasion and migration of lung cancer A549 cells and angiogenesis in xenograft tumors of nude mice","volume":"12","author":"Yan","year":"2020","journal-title":"J. Thorac. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0400","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13046-017-0574-5","article-title":"Wogonoside inhibits invasion and migration through suppressing TRAF2\/4 expression in breast cancer","volume":"36","author":"Yao","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bcp.2026.118409_b0405","doi-asserted-by":"crossref","first-page":"10097","DOI":"10.2147\/OTT.S251806","article-title":"Wogonoside Attenuates cutaneous squamous cell carcinoma by reducing epithelial-mesenchymal transition\/invasion and cancer stem-like cell property","volume":"13","author":"Wang","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"47","key":"10.1016\/j.bcp.2026.118409_b0410","doi-asserted-by":"crossref","first-page":"64322","DOI":"10.1021\/acsami.5c19127","article-title":"Self-assembling nanoparticles orchestrate cuproptosis-immunotherapy synergy to suppress postoperative glioma recurrence","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"18","key":"10.1016\/j.bcp.2026.118409_b0415","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1182\/blood-2012-11-466219","article-title":"Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells","volume":"121","author":"Chen","year":"2013","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bcp.2026.118409_b0420","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1111\/jcmm.13481","article-title":"Wogonoside induces depalmitoylation and translocation of PLSCR1 and N-RAS in primary acute myeloid leukaemia cells","volume":"22","author":"Li","year":"2018","journal-title":"J. Cell Mol. Med."},{"issue":"11","key":"10.1016\/j.bcp.2026.118409_b0425","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1177\/0960327116679716","article-title":"Wogonoside exerts growth-suppressive effects against T acute lymphoblastic leukemia through the STAT3 pathway","volume":"36","author":"Xiao","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118409_b0430","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/jcp.27067","article-title":"Wogonoside impedes the progression of acute myeloid leukemia through inhibiting bone marrow angiogenesis","volume":"234","author":"Lin","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118409_b0435","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s10620-015-3751-4","article-title":"Wogonoside shows antifibrotic effects in an experimental regression model of hepatic fibrosis","volume":"60","author":"Wang","year":"2015","journal-title":"Dig. Dis. Sci."},{"issue":"11","key":"10.1016\/j.bcp.2026.118409_b0440","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1002\/ptr.7558","article-title":"Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1\/P53\/SLC7A11 pathway","volume":"36","author":"Liu","year":"2022","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0445","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1080\/13880209.2020.1845747","article-title":"Effects of wogonoside on the inflammatory response and oxidative stress in mice with nonalcoholic fatty liver disease","volume":"58","author":"Jiang","year":"2020","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0450","doi-asserted-by":"crossref","DOI":"10.3390\/biom16010064","article-title":"Scutellaria baicalensis georgi: a promising source of bioactive molecules for kidney disease therapy","volume":"16","author":"Yang","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2026.118409_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115670","article-title":"Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects","volume":"168","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.bcp.2026.118409_b0460","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/08923973.2022.2090955","article-title":"Wogonoside preserves against ischemia\/reperfusion-induced myocardial injury by suppression of apoptosis, inflammation, and fibrosis via modulating Nrf2\/HO-1 pathway","volume":"44","author":"Zhang","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.bcp.2026.118409_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116871","article-title":"Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Wogonoside in acute myocardial ischemia rats","volume":"317","author":"Feng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2026.110383","article-title":"Therapeutic potential of wogonoside in hypertension-induced cardiac injury: Targeting apoptosis and MAPK signaling pathway","volume":"155","author":"Chen","year":"2026","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0475","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12906-025-04760-x","article-title":"Mechanisms of wogonoside in the treatment of atherosclerosis based on network pharmacology, molecular docking, and experimental validation","volume":"25","author":"Gong","year":"2025","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.bcp.2026.118409_b0480","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.921250","article-title":"Treatment of brain edema by wogonoside is associated with inhibition of neuronal apoptosis and SIRT1 activation in rats","volume":"26","author":"Cheng","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bcp.2026.118409_b0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2024.116206","article-title":"Exploring the anti-ischemic stroke potential of wogonoside: Insights from Nrf2\/Sirt3 signaling pathway and UPLC-TripleTOF-MS\/MS-based metabolomics","volume":"246","author":"Xu","year":"2024","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bcp.2026.118409_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117438","article-title":"Angong Niuhuang Wan inhibit ferroptosis on ischemic and hemorrhagic stroke by activating PPAR\u03b3\/AKT\/GPX4 pathway","volume":"321","author":"Bai","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0495","article-title":"Polyphenolic metabolites in Scutellaria baicalensis as potential candidate agents for the treatment of ischemic stroke","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"20","key":"10.1016\/j.bcp.2026.118409_b0500","article-title":"Ultrasmall nanoparticles mitigate tau hyperphosphorylation to restore synaptic integrity and boost cognitive function in Alzheimer's disease","volume":"14","author":"Xu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"Pt 1","key":"10.1016\/j.bcp.2026.118409_b0505","article-title":"Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico","volume":"337","author":"Tang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157240","article-title":"Wogonoside inhibits fibroblast activation and pulmonary fibrosis by dual regulation of Snail1 lactylation and PGC1\u03b1\/PINK1-mediated mitophagy","volume":"147","author":"Wu","year":"2025","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.bcp.2026.118409_b0515","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/bmc.3501","article-title":"Simultaneous determination of baicalin, oroxylin A-7-O-glucuronide and wogonoside in rat plasma by UPLC-DAD and its application in pharmacokinetics of pure baicalin, Radix Scutellariae and Yinhuang Granule","volume":"29","author":"Chen","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.bcp.2026.118409_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2020.113723","article-title":"Development and validation of an LC-MS\/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: Application to a portal vein infusion study","volume":"601","author":"Tu","year":"2020","journal-title":"Anal. Biochem."},{"issue":"3","key":"10.1016\/j.bcp.2026.118409_b0525","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.71660","article-title":"Ying-Huang oral liquid ameliorates oxidative stress in the liver of heat-stressed broilers via KEAP1-NRF2 and PINK1\/Parkin pathway","volume":"14","author":"Li","year":"2026","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.bcp.2026.118409_b0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.117169","article-title":"Antidepressant efficacy and Q-markers determination of Dachaihu decoction: Combining pharmacology, correlation analysis, and network pharmacology approaches","volume":"267","author":"Bing","year":"2026","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"8","key":"10.1016\/j.bcp.2026.118409_b0535","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26083703","article-title":"Flavonoids from scutellaria baicalensis: promising alternatives for enhancing swine production and health","volume":"26","author":"Wu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118409_b0540","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1691629","article-title":"Development and validation of a UHPLC-QqQ-MS\/MS method for simultaneous determination of fifteen major components from Oroxyli seed extract in rat plasma and its application in the pharmacokinetic study","volume":"16","author":"Lv","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118409_b0545","doi-asserted-by":"crossref","first-page":"23723","DOI":"10.1038\/s41598-025-04960-y","article-title":"Antae-eum, a herbal formula, relieves LPS-induced inflammatory response in macrophages via suppression of autophagic flux","volume":"15","author":"Oh","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118409_b0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117686","article-title":"Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1\u03b2 secretion from D-glucose and PA induced BV2 cells via autophagy\/NLRP3 signaling","volume":"323","author":"Tian","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bcp.2026.118409_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107570","article-title":"Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: implications for metabolic and transport interactions","volume":"212","author":"Liu","year":"2025","journal-title":"Pharmacol. Res."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:03:14Z","timestamp":1788260594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":111,"alternative-id":["S0006295226007483"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118409","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wogonoside: Pharmacology, molecular targets and therapeutic potential","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118409"}}