{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:53:48Z","timestamp":1791057228723,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2025LZXNYDJC15"],"award-info":[{"award-number":["2025LZXNYDJC15"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2024LCYXZX06"],"award-info":[{"award-number":["2024LCYXZX06"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000052"],"award-info":[{"award-number":["82000052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118453","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:34:26Z","timestamp":1788849266000},"page":"118453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["The FOXA2\/ST3GAL4 axis regulates airway mucus hypersecretion by modulating the ERK\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"254","author":[{"given":"Danli","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-4223","authenticated-orcid":false,"given":"Jing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118453_b0005","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118453_b0010","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.cell.2020.03.047","article-title":"Regenerative metaplastic clones in COPD lung drive inflammation and fibrosis","volume":"181","author":"Rao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118453_b0015","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1172\/JCI73469","article-title":"Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure","volume":"124","author":"Henderson","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2026.118453_b0020","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9539218","article-title":"Guifu Dihuang pills ameliorated mucus hypersecretion by suppressing Muc5ac expression and inactivating the ERK-SP1 pathway in lipopolysaccharide\/cigarette smoke-induced mice","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.bcp.2026.118453_b0025","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2478\/jtim-2023-0094","article-title":"Mucus hypersecretion in chronic obstructive pulmonary disease: from molecular mechanisms to treatment","volume":"11","author":"Yang","year":"2023","journal-title":"J. Transl. Intern. Med."},{"key":"10.1016\/j.bcp.2026.118453_b0030","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.3390\/molecules25194437","article-title":"The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease","volume":"25","author":"Li","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bcp.2026.118453_b0035","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S2213-2600(21)00079-5","article-title":"Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort","volume":"9","author":"Radicioni","year":"2021","journal-title":"Lancet Resp. Med."},{"key":"10.1016\/j.bcp.2026.118453_b0040","first-page":"E20","volume":"381","author":"Boyton","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118453_b0045","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1164\/rccm.201804-0734OC","article-title":"Localization of secretory mucins MUC5AC and MUC5B in normal\/healthy human airways","volume":"199","author":"Okuda","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bcp.2026.118453_b0050","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1164\/rccm.202208-1459ED","article-title":"Mucins MUC5AC and MUC5B in the airways: MUCing around together","volume":"206","author":"Kesimer","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bcp.2026.118453_b0055","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/alr.22907","article-title":"Ivacaftor restores delayed mucociliary transport caused by P. aeruginosa-induced acquired cystic fibrosis transmembrane conductance regulator dysfunction in rabbit nasal epithelia","volume":"12","author":"Cho","year":"2022","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.bcp.2026.118453_b0060","article-title":"Modulation of pulmonary immune functions by the P. aeruginosa secondary metabolite pyocyanin","volume":"16","author":"Lew","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118453_b0065","doi-asserted-by":"crossref","DOI":"10.1172\/JCI120901","article-title":"Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease","volume":"132","author":"Singanayagam","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2026.118453_b0070","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41579-025-01193-8","article-title":"P. aeruginosa: ecology, evolution, pathogenesis and antimicrobial susceptibility","volume":"23","author":"Letizia","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bcp.2026.118453_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152634","article-title":"Insights into the effects of inhaled drugs on airway epithelium with human airway basal cells","volume":"783","author":"Ogawa","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118453_b0080","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ccell.2022.10.011","article-title":"FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer","volume":"40","author":"Han","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bcp.2026.118453_b0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.890781","article-title":"The Pioneer transcription factor Foxa2 modulates T helper differentiation to reduce mouse allergic airway disease","volume":"13","author":"Yanez","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118453_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116319","article-title":"Dictamnus dasycarpus Turcz. attenuates airway inflammation and mucus hypersecretion by modulating the STAT6-STAT3\/FOXA2 pathway","volume":"173","author":"Jung","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118453_b0095","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12957","article-title":"FOXA2 depletion leads to mucus hypersecretion in canine airways with respiratory diseases","volume":"21","author":"Choi","year":"2019","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bcp.2026.118453_b0100","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1172\/JCI79422","article-title":"Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation","volume":"125","author":"Rajavelu","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bcp.2026.118453_b0105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3389\/fimmu.2020.00515","article-title":"Inactivation of FOXA2 by respiratory bacterial pathogens and dysregulation of pulmonary mucus homeostasis","volume":"11","author":"Choi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bcp.2026.118453_b0110","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1165\/rcmb.2018-0199OC","article-title":"The club cell marker SCGB1A1 downstream of FOXA2 is reduced in Asthma","volume":"60","author":"Zhu","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bcp.2026.118453_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103712","article-title":"Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress","volume":"85","author":"Yang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.118453_b0120","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41467-021-21550-4","article-title":"Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118453_b0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13148-021-01015-7","article-title":"5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells","volume":"13","author":"Greville","year":"2021","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bcp.2026.118453_b0130","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41375-024-02454-w","article-title":"The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9","volume":"39","author":"Krishnamoorthy","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.bcp.2026.118453_b0135","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1093\/ibd\/izad092","article-title":"Deletion of endogenous neuregulin-4 limits adaptive immunity during interleukin-10 receptor-neutralizing colitis","volume":"29","author":"Bernard","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.bcp.2026.118453_b0140","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2319057121","article-title":"CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV","volume":"121","author":"Immler","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bcp.2026.118453_b0145","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1021\/acs.biochem.7b00211","article-title":"Structure of the Forkhead domain of FOXA2 bound to a complete DNA consensus site","volume":"56","author":"Li","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2026.118453_b0150","doi-asserted-by":"crossref","first-page":"L82","DOI":"10.1152\/ajplung.00049.2019","article-title":"MUC1 contributes to goblet cell metaplasia and MUC5AC expression in response to cigarette smoke in vivo","volume":"319","author":"Kato","year":"2020","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bcp.2026.118453_b0155","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1038\/s41598-018-20444-8","article-title":"ATP12A promotes mucus dysfunction during Type 2 airway inflammation","volume":"8","author":"Lennox","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118453_b0160","doi-asserted-by":"crossref","unstructured":"D.J. Thornton, K. Rousseau, M.A. McGuckin, Structure and function of the polymeric mucins in airways mucus, in: Annual Review of Physiology, Annual Reviews, Palo Alto, 2008: pp. 459\u2013486. https:\/\/doi.org\/10.1146\/annurev.physiol.70.113006.100702.","DOI":"10.1146\/annurev.physiol.70.113006.100702"},{"key":"10.1016\/j.bcp.2026.118453_b0165","article-title":"Molecular and therapeutic significance of sNASP-TRAF6 axis in DEP-exacerbated airway allergic asthma","volume":"64","author":"Yang","year":"2024","journal-title":"Eur. Resp. J."},{"key":"10.1016\/j.bcp.2026.118453_b0170","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3390\/toxins13110773","article-title":"Bee venom prevents Mucin 5AC production through inhibition of AKT and SPDEF activation in airway epithelia cells","volume":"13","author":"Kim","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.bcp.2026.118453_b0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13148-017-0341-7","article-title":"Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD","volume":"9","author":"Song","year":"2017","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bcp.2026.118453_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117658","article-title":"TRPV1 mediates oxidative stress and autophagy pathways to regulate airway MUC5AC secretion","volume":"245","author":"Huang","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118453_b0185","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1164\/rccm.202306-1060OC","article-title":"Accelerated lung function decline and mucus-microbe evolution in chronic obstructive pulmonary disease","volume":"210","author":"Meldrum","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bcp.2026.118453_b0190","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1164\/rccm.202307-1266OC","article-title":"Increased Muc5AC and decreased ciliated cells in severe asthma partially restored by inhibition of IL-4R\u03b1 receptor","volume":"210","author":"Boomer","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bcp.2026.118453_b0195","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/jmv.26406","article-title":"Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID-19 patients","volume":"93","author":"Lu","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bcp.2026.118453_b0200","first-page":"196","article-title":"Mucus plugs and small airway dysfunction in asthma, COPD, and asthma-COPD overlap, allergy asthma","volume":"14","author":"Tamura","year":"2022","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bcp.2026.118453_b0205","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1164\/rccm.200811-1768OC","article-title":"Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma","volume":"180","author":"Park","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bcp.2026.118453_b0210","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/jcm6120112","article-title":"Airway mucus and asthma: the Role of MUC5AC and MUC5B","volume":"6","author":"Bonser","year":"2017","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bcp.2026.118453_b0215","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1158\/0008-5472.CAN-22-2805","article-title":"FOXA2 Cooperates with mutant KRAS to drive invasive mucinous adenocarcinoma of the lung","volume":"83","author":"Tomoshige","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118453_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216762","article-title":"Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer","volume":"588","author":"Han","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bcp.2026.118453_b0225","article-title":"The role of ST3GAL4 in glioma malignancy, macrophage infiltration, and prognostic outcomes","volume":"10","author":"Zheng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bcp.2026.118453_b0230","article-title":"Sialyltransferase ST3GAL4 directs a dual mechanism to promote pancreatic ductal adenocarcinoma progression by regulating endoplasmic reticulum stress and mitochondrial homeostasis","volume":"1871","author":"Zeng","year":"2025","journal-title":"Biochim. Biophys. Acta-Mol. Basis Dis."},{"key":"10.1016\/j.bcp.2026.118453_b0235","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1513\/AnnalsATS.201802-128AW","article-title":"Airway epithelial differentiation and mucociliary clearance","volume":"15","author":"Whitsett","year":"2018","journal-title":"Ann. Am. Thoracic Society"},{"key":"10.1016\/j.bcp.2026.118453_b0240","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1056\/NEJMc1014719","article-title":"Airway mucus function and dysfunction","volume":"364","author":"Johnson","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118453_b0245","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1152\/physiol.2024.39.S1.2053","article-title":"Sex\u2011dependent regulation of mucin gene transcription and goblet cell secretion machinery following intra\u2011airway IL\u201113 in mice with conditional loss of club cell Creb1","volume":"39","author":"Sponchiado","year":"2024","journal-title":"Physiology"},{"key":"10.1016\/j.bcp.2026.118453_b0250","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41385-020-0262-1","article-title":"Exendin\u20114 restores airway mucus homeostasis through the GLP1R\u2011PKA\u2011PPAR\u03b3\u2011FOXA2\u2011phosphatase signaling","volume":"13","author":"Choi","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bcp.2026.118453_b0255","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1128\/IAI.01989-14","article-title":"M. pneumoniae modulates STAT3\u2011STAT6\/EGFR\u2011FOXA2 signaling to induce overexpression of airway mucins","volume":"82","author":"Hao","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bcp.2026.118453_b0260","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/BJ20130989","article-title":"TNF induces the expression of the sialyltransferase ST3Gal IV in human bronchial mucosa via MSK1\/2 protein kinases and increases FliD\/sialyl-Lewisx-mediated adhesion of P. aeruginosa","volume":"457","author":"Colomb","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.bcp.2026.118453_b0265","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.intimp.2016.08.033","article-title":"Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1\/2 pathway in human airway epithelial cells","volume":"40","author":"Qin","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2026.118453_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111857","article-title":"Benzo(a)pyrene induces MUC5AC expression through the AhR\/mitochondrial ROS\/ERK pathway in airway epithelial cells","volume":"210","author":"Sun","year":"2021","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.bcp.2026.118453_b0275","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jgr.2021.12.008","article-title":"Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo","volume":"46","author":"Lee","year":"2022","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.bcp.2026.118453_b0280","article-title":"Research progress on the mechanisms of high mucus secretion in the airway: a scoping review","volume":"21","author":"Ying","year":"2026","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:29:29Z","timestamp":1791055769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":56,"alternative-id":["S0006295226007926"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118453","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The FOXA2\/ST3GAL4 axis regulates airway mucus hypersecretion by modulating the ERK\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118453"}}