{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:11:33Z","timestamp":1790107893941,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303887"],"award-info":[{"award-number":["82303887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371129"],"award-info":[{"award-number":["82371129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi'an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2024SF-ZDCYL-01-04"],"award-info":[{"award-number":["2024SF-ZDCYL-01-04"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2024SF2-GJHX-18"],"award-info":[{"award-number":["2024SF2-GJHX-18"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key Research and Development Projects","doi-asserted-by":"publisher","award":["2025SF-YBXM-087"],"award-info":[{"award-number":["2025SF-YBXM-087"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012023119"],"award-info":[{"award-number":["xzy012023119"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118457","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:05:02Z","timestamp":1789085102000},"page":"118457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Endothelial NLRP3 pyroptotic as a trigger for blood brain barrier disruption and neurotoxic Astrogenesis in chronic intermittent hypoxia"],"prefix":"10.1016","volume":"254","author":[{"given":"Xia","family":"Zihan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niu","family":"Xiaoxin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chendi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Yushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Chutong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chenxi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chanchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Haiqin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Weichao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Gulbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-267X","authenticated-orcid":false,"given":"Yewen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bcp.2026.118457_b0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir. Med."},{"issue":"9","key":"10.1016\/j.bcp.2026.118457_b0010","article-title":"The global burden of obstructive sleep apnea","volume":"15","author":"Iannella","year":"2025","journal-title":"Diagnostics (basel)"},{"key":"10.1016\/j.bcp.2026.118457_b0015","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2147\/NSS.S489232","article-title":"Impact of chronic intermittent hypoxia on cognitive function and hippocampal neurons in mice: a study of inflammatory and oxidative stress pathways","volume":"16","author":"Zhang","year":"2024","journal-title":"Nat. Sci. Sleep"},{"key":"10.1016\/j.bcp.2026.118457_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjmed.2026.05.038","article-title":"Sleep apnea and the ageing brain: bridging mechanisms and clinical outcomes","author":"Kosasih","year":"2026","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bcp.2026.118457_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2025.1628961","article-title":"Effectiveness of the sleep apnea-specific hypoxic burden and sleep breathing impairment index in assessing cognitive impairment in children with obstructive sleep apnea","volume":"13","author":"Zhu","year":"2025","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.bcp.2026.118457_b0030","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2147\/NSS.S522352","article-title":"Relationship between serum neurotransmitters and cognitive impairment in adults with obstructive sleep apnea","volume":"17","author":"Yang","year":"2025","journal-title":"Nat. Sci. Sleep"},{"issue":"7","key":"10.1016\/j.bcp.2026.118457_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076518","article-title":"Inflammatory processes in Alzheimer's disease-pathomechanism, diagnosis and treatment: a review","volume":"24","author":"Twarowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_b0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41419-021-04379-z","article-title":"NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood-brain barrier integrity in murine stroke","volume":"13","author":"Bellut","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.bcp.2026.118457_b0045","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jphs.2025.09.003","article-title":"Endothelial NLRP3-mediated pyroptosis induces blood-brain barrier and neuronal damage in Huntington's disease models","volume":"159","author":"Cai","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.118457_b0050","article-title":"NLRP3 deficiency protects against intermittent hypoxia-induced neuroinflammation and mitochondrial ROS by promoting the PINK1-parkin pathway of mitophagy in a murine model of sleep apnea","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_b0055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12868-022-00756-2","article-title":"NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia","volume":"23","author":"She","year":"2022","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bcp.2026.118457_b0060","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molimm.2025.01.003","article-title":"TRIM44 alleviates renal ischemia-reperfusion injury by inhibiting pyroptosis through the NLRP3 pathway","volume":"178","author":"Ning","year":"2025","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bcp.2026.118457_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177247","article-title":"Targeting the ALKBH5-NLRP3 positive feedback loop alleviates cardiomyocyte pyroptosis after myocardial infarction","volume":"989","author":"Cui","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.bcp.2026.118457_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103609","article-title":"Early reactive A1 astrocytes induction by the neurotoxin 3-nitropropionic acid in rat brain","volume":"21","author":"Lopez-Sanchez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7638","key":"10.1016\/j.bcp.2026.118457_b0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bcp.2026.118457_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/jfb16120454","article-title":"Three-dimensional human neurovascular unit modeling reveals cell-specific mechanisms of traumatic brain injury","volume":"16","author":"Power","year":"2025","journal-title":"J Funct Biomater"},{"issue":"11","key":"10.1016\/j.bcp.2026.118457_b0085","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20242403","article-title":"Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action","volume":"222","author":"Wilhelmsen","year":"2025","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118457_b0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bcp.2026.118457_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100954","article-title":"Isolation and culturing of primary mouse astrocytes for the analysis of focal adhesion dynamics","volume":"2","author":"G\u00fcler","year":"2021","journal-title":"STAR Protoc."},{"issue":"2","key":"10.1016\/j.bcp.2026.118457_b0100","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bcp.2026.118457_b0105","series-title":"Pre-Clinical Models: Techniques and Protocols","first-page":"105","article-title":"The Y-maze for assessment of spatial working and reference memory in mice","author":"Kraeuter","year":"2019"},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_bib181","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1038\/s41598-022-15592-x","article-title":"Effects of intermittent hypoxia with thrombin in an in vitro model of human brain endothelial cells and their impact on PAR-1\/PAR-3 cleavage","volume":"12","author":"Zolotoff","year":"2022","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bcp.2026.118457_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25053065","article-title":"Early increase in blood-brain barrier permeability in a murine model exposed to fifteen days of intermittent hypoxia","volume":"25","author":"Roche","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bcp.2026.118457_b0115","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10787-023-01235-8","article-title":"The NLRP3 inflammasome: role in the pathobiology of chronic pain","volume":"31","author":"Chen","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_b0120","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.bcp.2026.118457_b0125","article-title":"High obstructive sleep apnea hypoxic burden associates with reduced lo cus coeruleus structural integrity on 7T MRI in older adults","volume":"49","author":"Kam","year":"2025","journal-title":"SLEEPJ"},{"issue":"9","key":"10.1016\/j.bcp.2026.118457_b0130","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz120","article-title":"Altered structural brain network resulting from white matter injury in obstructive sleep apnea","volume":"42","author":"Lee","year":"2019","journal-title":"Sleep"},{"key":"10.1016\/j.bcp.2026.118457_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.crad.2025.106939","article-title":"Diagnostic value of quantitative brain synthetic magnetic resonance imaging in patients with obstructive sleep apnoea","volume":"86","author":"Li","year":"2025","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.bcp.2026.118457_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.sleep.2025.106583","article-title":"Association between serum \u03b1-synuclein levels and neurocognitive deficits in patients with obstructive sleep apnea: a case-control study","volume":"132","author":"Zhou","year":"2025","journal-title":"Sleep Med."},{"key":"10.1016\/j.bcp.2026.118457_b0145","article-title":"Effectiveness of the sleep apnea-specific hypoxic burden and sleep breathing impairment index in assessing cognitive impairment in children with obstructive sleep apnea","volume":"13\u20132025","author":"Zhu","year":"2025","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.bcp.2026.118457_b0150","article-title":"Research progress on pyroptosis and its effect on the central nervous system","volume":"106333","author":"Hao","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_b0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41420-023-01440-y","article-title":"Targeting pyroptosis as a preventive and therapeutic approach for stroke","volume":"9","author":"Long","year":"2023","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_b0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12974-018-1245-y","article-title":"Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes","volume":"15","author":"Korotkov","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.bcp.2026.118457_b0165","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","article-title":"Microglia-derived TNF-\u03b1 mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.bcp.2026.118457_b0170","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1177\/0271678X241260526","article-title":"Novel intravital approaches to quantify deep vascular structure and perfusion in the aging mouse brain using ultrasound localization microscopy (ULM)","volume":"44","author":"Ny\u00fal-T\u00f3th","year":"2024","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"1","key":"10.1016\/j.bcp.2026.118457_b0175","article-title":"A minimally invasive framework reveals region-specific cerebrovascular remodeling in aging using intravital functional ultrasound imaging and ultrasound localization microscopy (fUS-ULM)","volume":"13","author":"Negri","year":"2026","journal-title":"Adv Sci (weinh)"},{"key":"10.1016\/j.bcp.2026.118457_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2026.104118","article-title":"LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia","volume":"92","author":"Ihuoma","year":"2026","journal-title":"Redox Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226007963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:51:15Z","timestamp":1790106675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226007963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":37,"alternative-id":["S0006295226007963"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118457","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial NLRP3 pyroptotic as a trigger for blood brain barrier disruption and neurotoxic Astrogenesis in chronic intermittent hypoxia","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118457"}}