{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:10:46Z","timestamp":1790107846293,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["2020M28"],"award-info":[{"award-number":["2020M28"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118462","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:07:05Z","timestamp":1788995225000},"page":"118462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["MEX3A mediates DHRS3 instability to relieve G0\/G1 arrest and facilitate hepatocellular carcinoma tumorigenesis and progression"],"prefix":"10.1016","volume":"254","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2550-2937","authenticated-orcid":false,"given":"Weihan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl","key":"10.1016\/j.bcp.2026.118462_b0005","doi-asserted-by":"crossref","first-page":"S228","DOI":"10.3350\/cmh.2024.0824","article-title":"Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment","volume":"31","author":"Hwang","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12943-024-02101-z","article-title":"Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma","volume":"23","author":"Chan","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.118462_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cytogfr.2024.08.006","article-title":"Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis","volume":"79","author":"Yu","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.bcp.2026.118462_b0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jhep.2019.08.017","article-title":"Advances in molecular classification and precision oncology in hepatocellular carcinoma","volume":"72","author":"Rebouissou","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0025","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13046-025-03395-7","article-title":"Exploring RNA binding proteins in hepatocellular carcinoma: insights into mechanisms and therapeutic potential","volume":"44","author":"Ren","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"15","key":"10.1016\/j.bcp.2026.118462_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155209","article-title":"The role of the RNA-binding protein family MEX-3 in tumorigenesis","volume":"21","author":"Jasinski-Bergner","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2026.118462_b0035","article-title":"Oncogenic potential of the dual-function protein MEX3A","volume":"10","author":"Lederer","year":"2021","journal-title":"Biology (Basel)"},{"issue":"6","key":"10.1016\/j.bcp.2026.118462_b0040","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/cac2.12149","article-title":"Mex3a promotes oncogenesis through the RAP1\/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p","volume":"41","author":"Li","year":"2021","journal-title":"Cancer Commun. (Lond)"},{"issue":"2","key":"10.1016\/j.bcp.2026.118462_b0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1158\/0008-5472.CAN-22-1159","article-title":"MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis","volume":"83","author":"Wang","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.bcp.2026.118462_b0050","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.cbi.2014.10.018","article-title":"Molecular and biochemical characterisation of human short-chain dehydrogenase\/reductase member 3","volume":"234","author":"Lundova","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bcp.2026.118462_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.624871","article-title":"Hypermethylation of DHRS3 as a novel tumor suppressor involved in tumor growth and prognosis in gastric cancer","volume":"9","author":"Sumei","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.bcp.2026.118462_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054885","article-title":"Translational control of metabolism and cell cycle progression in hepatocellular carcinoma","volume":"24","author":"Scagliola","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bcp.2026.118462_b0065","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/cac2.12482","article-title":"Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-alpha signaling","volume":"43","author":"Qi","year":"2023","journal-title":"Cancer Commun. (Lond)"},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0070","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41419-025-07482-7","article-title":"PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma","volume":"16","author":"Ding","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13046-019-1058-6","article-title":"FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41419-025-08320-6","article-title":"CUL4B promotes hepatocellular carcinoma progression and oxaliplatin resistance by facilitating FUS degradation","volume":"17","author":"Wei","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13020-022-00671-y","article-title":"Nitidine chloride induces caspase 3\/GSDME-dependent pyroptosis by inhibting PI3K\/Akt pathway in lung cancer","volume":"17","author":"Yu","year":"2022","journal-title":"Chin. Med."},{"issue":"6","key":"10.1016\/j.bcp.2026.118462_b0090","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s12072-023-10565-2","article-title":"MEX3A determines in vivo hepatocellular carcinoma progression and induces resistance to sorafenib in a Hippo-dependent way","volume":"17","author":"Fang","year":"2023","journal-title":"Hepatol. Int."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0095","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12885-023-11703-7","article-title":"A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma","volume":"24","author":"Ai","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bcp.2026.118462_b0100","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.canlet.2021.07.044","article-title":"Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma","volume":"518","author":"Jing","year":"2021","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tcb.2021.07.001","article-title":"Cell cycle on the crossroad of tumorigenesis and cancer therapy","volume":"32","author":"Liu","year":"2022","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118462_b0110","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41419-022-05000-7","article-title":"MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41392-024-01787-3","article-title":"Mex-3 RNA binding family member a (MEX3A)\/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.bcp.2026.118462_b0120","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1093\/nar\/gkt087","article-title":"CDX2 regulation by the RNA-binding protein MEX3A: impact on intestinal differentiation and stemness","volume":"41","author":"Pereira","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bcp.2026.118462_b0125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.omtn.2021.11.026","article-title":"RNA-binding protein MEX3A controls G1\/S transition via regulating the RB\/E2F pathway in clear cell renal cell carcinoma","volume":"27","author":"Qiu","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"10","key":"10.1016\/j.bcp.2026.118462_b0130","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41419-020-03031-6","article-title":"Epigenetic silencing of CDKN1A and CDKN2B by SNHG1 promotes the cell cycle, migration and epithelial-mesenchymal transition progression of hepatocellular carcinoma","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.bcp.2026.118462_b0135","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41419-020-02858-3","article-title":"Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K\/AKT pathway","volume":"11","author":"Liang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010592","article-title":"RNA-binding protein MEX3A interacting with DVL3 stabilizes Wnt\/beta-catenin signaling in endometrial carcinoma","volume":"24","author":"Yang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"48","key":"10.1016\/j.bcp.2026.118462_b0145","doi-asserted-by":"crossref","first-page":"20252","DOI":"10.1073\/pnas.0907916106","article-title":"RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3","volume":"106","author":"Pagano","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bcp.2026.118462_b0150","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13058-018-1068-x","article-title":"Induction of cell cycle arrest and inflammatory genes by combined treatment with epigenetic, differentiating, and chemotherapeutic agents in triple-negative breast cancer","volume":"20","author":"Merino","year":"2018","journal-title":"Breast Cancer Res."},{"issue":"19","key":"10.1016\/j.bcp.2026.118462_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193171","article-title":"In vitro transfection of up-regulated genes identified in favorable-outcome neuroblastoma into cell lines","volume":"11","author":"Hiyama","year":"2022","journal-title":"Cells"},{"issue":"16","key":"10.1016\/j.bcp.2026.118462_b0160","doi-asserted-by":"crossref","first-page":"6865","DOI":"10.7150\/thno.76619","article-title":"Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state","volume":"12","author":"Yang","year":"2022","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.bcp.2026.118462_b0165","first-page":"747","article-title":"ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma","volume":"39","author":"Yang","year":"2024","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bcp.2026.118462_b0170","article-title":"ZKSCAN5 Activates VEGFC Expression by Recruiting SETD7 to Promote the lymphangiogenesis, tumour growth, and metastasis of breast cancer","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118462_b0175","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180570","article-title":"Hyaluronan network remodeling by ZEB1 and ITIH2 enhances the motility and invasiveness of cancer cells","volume":"135","author":"Lee","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"1\u20133","key":"10.1016\/j.bcp.2026.118462_b0180","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-5793(03)00669-0","article-title":"Three novel spermatogenesis-specific zinc finger genes","volume":"547","author":"Weissig","year":"2003","journal-title":"FEBS Lett."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:49:56Z","timestamp":1790106596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226008014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S0006295226008014"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118462","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MEX3A mediates DHRS3 instability to relieve G0\/G1 arrest and facilitate hepatocellular carcinoma tumorigenesis and progression","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118462"}}