{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:51:18Z","timestamp":1791481878197,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577095"],"award-info":[{"award-number":["22577095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118514","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:41:45Z","timestamp":1790782905000},"page":"118514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["A bis(benzimidazolyl)-based anion transporter triggers chloride-initiated pyroptosis of MDA-MB-468 and 4T1 triple-negative breast cancer cells in vitro and in vivo"],"prefix":"10.1016","volume":"254","author":[{"given":"Li","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5008-5485","authenticated-orcid":false,"given":"Wen-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bcp.2026.118514_b0005","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/procel\/pwaf011","article-title":"Amino acid metabolism in breast cancer: pathogenic drivers and therapeutic opportunities","volume":"16","author":"Liu","year":"2025","journal-title":"Protein Cell"},{"issue":"10","key":"10.1016\/j.bcp.2026.118514_b0010","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/oncolo\/oyad233","article-title":"The evolving landscape of immune checkpoint inhibitors and antibody drug conjugates in the treatment of early-stage breast cancer","volume":"28","author":"Bhardwaj","year":"2023","journal-title":"Oncologist"},{"issue":"16","key":"10.1016\/j.bcp.2026.118514_b0015","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1200\/JCO.19.02474","article-title":"Adjuvant capecitabine with docetaxel and cyclophosphamide plus epirubicin for triple-negative breast cancer (CBCSG010): an open-label, randomized, multicenter, phase III trial","volume":"38","author":"Li","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bcp.2026.118514_b0020","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jconrel.2022.05.029","article-title":"Molecular design of a pathogen-activated, self-assembling mechanopharmaceutical device","volume":"347","author":"Willmer","year":"2022","journal-title":"J. Control. Release"},{"issue":"13","key":"10.1016\/j.bcp.2026.118514_b0025","doi-asserted-by":"crossref","first-page":"8398","DOI":"10.1021\/acs.analchem.9b01250","article-title":"Monitoring the changes of pH in lysosomes during autophagy and apoptosis by plasmon enhanced raman imaging","volume":"91","author":"Li","year":"2019","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.bcp.2026.118514_b0030","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202003205","article-title":"Inhibition of lysosomal degradation of clusterin by protein kinase D3 promotes triple-negative breast cancer tumor growth","volume":"8","author":"Liu","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bcp.2026.118514_b0035","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.2147\/IJN.S413217","article-title":"Glutathione-programmed mitochondria-targeted delivery of lonidamine for triple-negative breast cancer","volume":"18","author":"Wang","year":"2023","journal-title":"Int. J. Nanomedicine"},{"issue":"50","key":"10.1016\/j.bcp.2026.118514_b0040","doi-asserted-by":"crossref","first-page":"16443","DOI":"10.1021\/jacs.6b10379","article-title":"Chloride transport through supramolecular barrel-rosette ion channels: lipophilic control and apoptosis-inducing activity","volume":"138","author":"Saha","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"10.1016\/j.bcp.2026.118514_b0045","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.chempr.2019.05.001","article-title":"Determinants of ion-transporter cancer cell death","volume":"5","author":"Park","year":"2019","journal-title":"Chem"},{"key":"10.1016\/j.bcp.2026.118514_b0050","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejmech.2018.04.036","article-title":"Synthesis, anionophoric activity, and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters","volume":"152","author":"Yu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.bcp.2026.118514_b0055","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchem.2021","article-title":"Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells","volume":"6","author":"Ko","year":"2014","journal-title":"Nat. Chem."},{"issue":"7","key":"10.1016\/j.bcp.2026.118514_b0060","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nchem.2706","article-title":"A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations","volume":"9","author":"Busschaert","year":"2017","journal-title":"Nat. Chem."},{"issue":"17","key":"10.1016\/j.bcp.2026.118514_b0065","doi-asserted-by":"crossref","first-page":"9737","DOI":"10.1021\/jacs.3c01451","article-title":"A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy","volume":"145","author":"Mondal","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.bcp.2026.118514_b0070","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202523734","article-title":"Near-infrared triggered anion transport induces cancer cell death","volume":"65","author":"Ahmad","year":"2026","journal-title":"Angew. Chem. Int. Ed."},{"issue":"9","key":"10.1016\/j.bcp.2026.118514_b0075","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1039\/C6OB00002A","article-title":"Perenosins: a new class of anion transporter with anti-cancer activity","volume":"14","author":"Van Rossom","year":"2016","journal-title":"Org. Biomol. Chem."},{"issue":"11","key":"10.1016\/j.bcp.2026.118514_b0080","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1039\/C8SC04520H","article-title":"Inhibition of autophagic flux by cyclometalated iridium(iii) complexes through anion transportation","volume":"10","author":"Chen","year":"2019","journal-title":"Chem. Sci."},{"issue":"29","key":"10.1016\/j.bcp.2026.118514_b0085","doi-asserted-by":"crossref","first-page":"11584","DOI":"10.1039\/D4SC02115K","article-title":"Platinum-based metal complexes as chloride transporters that trigger apoptosis","volume":"15","author":"Wang","year":"2024","journal-title":"Chem. Sci."},{"issue":"11","key":"10.1016\/j.bcp.2026.118514_b0090","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1021\/acs.jmedchem.4c03227","article-title":"Ferroptosis of cancer cells via tubulin degradation and mitochondrial dysfunction: a novel mechanism of anticancer effect for small-molecule anion transporters","volume":"68","author":"Hong","year":"2025","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.bcp.2026.118514_b0095","doi-asserted-by":"crossref","first-page":"15006","DOI":"10.1021\/acs.jmedchem.3c01690","article-title":"Design, synthesis, and antitumor efficacy of substituted 2-amino[1,2,4] triazolopyrimidines and related heterocycles as dual inhibitors for microtubule polymerization and Janus kinase 2","volume":"66","author":"Chen","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2026.118514_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107421","article-title":"Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: design, synthesis, and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates","volume":"147","author":"Zhi","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bcp.2026.118514_b0105","doi-asserted-by":"crossref","unstructured":"L. Chen, Z.H. Lu, Y. F. Hu, L.Q. Li, J. Q. Wu, W.-H. Chen, et al. Dual induction of ferroptosis and apoptosis by triazolopyrimidinyl derivatives: design, synthesis, and biological evaluation for their anticancer efficacy via calcium\/calmodulin signaling and mitochondrial impairment, J. Med. Chem. 68 (21) (2025) 23024\u201323049. doi: 10.1021\/acs. jmedchem.5c01888.","DOI":"10.1021\/acs.jmedchem.5c01888"},{"issue":"1","key":"10.1016\/j.bcp.2026.118514_b0110","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ijc.32663","article-title":"In vitro elimination of epidermal growth factor receptor-overexpressing cancer cells by CD32A-chimeric receptor T cells in combination with cetuximab or panitumumab","volume":"146","author":"Caratelli","year":"2020","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.bcp.2026.118514_b0115","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41420-024-02196-9","article-title":"Targeting oncogenic MAGEA6 sensitizes triple negative breast cancer to doxorubicin through its autophagy and ferroptosis by stabling AMPK\u03b11","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bcp.2026.118514_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117519","article-title":"Design, synthesis, and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells","volume":"290","author":"Yang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2026.118514_b0125","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41418-025-01505-8","article-title":"GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis","volume":"32","author":"Chen","year":"2025","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.bcp.2026.118514_b0130","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/s41418-023-01117-0","article-title":"Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs","volume":"30","author":"Diepstraten","year":"2023","journal-title":"Cell Death Differ."},{"issue":"10","key":"10.1016\/j.bcp.2026.118514_b0135","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/s41418-024-01347-w","article-title":"Cell autonomous functions of CD47 in regulating cellular and metabolic plasticity","volume":"31","author":"Polara","year":"2024","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.bcp.2026.118514_b0140","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/b813797h","article-title":"Two-photon fluorescence lifetime imaging of intracellular chloride in cockroach salivary glands","volume":"8","author":"Hille","year":"2009","journal-title":"Photochem. Photobiol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2026.118514_b0145","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/jnc.12307","article-title":"Hypoosmotic and glutamate-induced swelling of bipolar cells in the rat retina: comparison with swelling of M\u00fcller glial cells","volume":"126","author":"Vogler","year":"2013","journal-title":"J. Neurochem."},{"issue":"27","key":"10.1016\/j.bcp.2026.118514_b0150","doi-asserted-by":"crossref","first-page":"17192","DOI":"10.1074\/jbc.273.27.17192","article-title":"Porcine spleen deoxyribonuclease II. Covalent structure, cDNA sequence, molecular cloning, and gene expression","volume":"273","author":"Wang","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.bcp.2026.118514_b0155","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.3390\/ijms26167895","article-title":"A review of pathophysiology, molecular mechanisms, and omics approaches of spinal cord injury","volume":"26","author":"Patel","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bcp.2026.118514_b0160","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1021\/acscentsci.4c02156","article-title":"Synergistic antitumor immunotherapy via mitochondria regulation in macrophages and tumor cells by an iridium photosensitizer","volume":"11","author":"Li","year":"2025","journal-title":"ACS Cent. Sci."},{"issue":"35","key":"10.1016\/j.bcp.2026.118514_b0165","doi-asserted-by":"crossref","first-page":"21354","DOI":"10.1073\/pnas.2002126117","article-title":"Yeast ATM and ATR kinases use different mechanisms to spread histone H2A phosphorylation around a DNA double-strand break","volume":"117","author":"Li","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.bcp.2026.118514_b0170","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/s41401-023-01109-3","article-title":"Activated SIRT1 contributes to DPT-induced glioma cell parthanatos by upregulation of NOX2 and NAT10","volume":"44","author":"Liang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bcp.2026.118514_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101215","article-title":"STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis, and pyroptosis by activating NLRP3","volume":"24","author":"Li","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118514_b0180","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2024.11.017","article-title":"The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance","volume":"58","author":"Xu","year":"2025","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.bcp.2026.118514_b0185","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41401-024-01369-7","article-title":"Cyclic GMP-AMP synthase recognizes the physical features of DNA","volume":"46","author":"Dong","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.bcp.2026.118514_b0190","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.immuni.2021.03.011","article-title":"Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING","volume":"54","author":"Fang","year":"2021","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.bcp.2026.118514_b0195","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3390\/ijms26051941","article-title":"TANK-binding kinase 1 in the pathogenesis and treatment of inflammation-related diseases","volume":"26","author":"Hui","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118514_b0200","doi-asserted-by":"crossref","first-page":"109153","DOI":"10.1016\/j.bioelechem.2025.109153","article-title":"Investigations of potential therapeutic targets from high-throughput, label-free, quantitative proteomic studies in MDA-MB-468 cells treated with metformin and electrical pulses","volume":"168","author":"Sahu","year":"2026","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.bcp.2026.118514_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107496","article-title":"Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting caspase-1-induced pyroptosis","volume":"94","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.bcp.2026.118514_b0210","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.tibs.2025.08.010","article-title":"The interplay of the cGAS\u2013STING pathway with the lysosome","volume":"50","author":"Xu","year":"2025","journal-title":"Trends Biochem. Sci"},{"issue":"1","key":"10.1016\/j.bcp.2026.118514_b0215","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12951-021-00943-z","article-title":"Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation","volume":"19","author":"Zhu","year":"2021","journal-title":"J Nanobiotechnology."},{"key":"10.1016\/j.bcp.2026.118514_b0220","article-title":"Uncoupled pyroptosis and IL-1\u03b2 secretion downstream of inflammasome signaling","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118514_b0225","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.bcp.2026.118514_b0230","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s13048-025-01887-w","article-title":"Bushen Huatan formula alleviates polycystic ovary syndrome in rats by activating the PI3K\/Akt pathway to inhibit GSDMD-mediated pyroptosis and mitochondrial damage","volume":"18","author":"Xiong","year":"2025","journal-title":"J Ovarian Res."},{"issue":"9","key":"10.1016\/j.bcp.2026.118514_b0235","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS\u2013STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118514_b0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7575","key":"10.1016\/j.bcp.2026.118514_b0245","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:05:09Z","timestamp":1791479109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226008567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":49,"alternative-id":["S0006295226008567"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118514","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A bis(benzimidazolyl)-based anion transporter triggers chloride-initiated pyroptosis of MDA-MB-468 and 4T1 triple-negative breast cancer cells in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118514","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118514"}}