{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:50:31Z","timestamp":1791654631292,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["26JS2810100"],"award-info":[{"award-number":["26JS2810100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020196","name":"Shandong Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["SDZZ-ZR-202501330"],"award-info":[{"award-number":["SDZZ-ZR-202501330"]}],"id":[{"id":"10.13039\/501100020196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MB013"],"award-info":[{"award-number":["ZR2023MB013"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22378230"],"award-info":[{"award-number":["22378230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307066"],"award-info":[{"award-number":["22307066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118524","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:36:15Z","timestamp":1791329775000},"page":"118524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Chemical proteomics and phenotypic profiling identify \u03b1FOD as a podophyllotoxin-derived PGK1 inhibitor that suppresses glycolysis and proliferation in hepatocellular carcinoma"],"prefix":"10.1016","volume":"254","author":[{"given":"Run-Hua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-2854","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-9338","authenticated-orcid":false,"given":"Jian-Jiang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bcp.2026.118524_b0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3350\/cmh.2023.0070","article-title":"The latest global burden of liver cancer: a past and present threat","volume":"29","author":"Oh","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118524_b0010","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.bcp.2026.118524_b0015","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/ijc.31963","article-title":"Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma","volume":"144","author":"Augello","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118524_b0020","article-title":"Advances in the treatment of hepatocellular carcinoma: an overview of the current and evolving therapeutic landscape for clinicians","author":"Moris","year":"2025","journal-title":"CA Cancer J. Clin."},{"issue":"Suppl 1","key":"10.1016\/j.bcp.2026.118524_b0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.31310","article-title":"Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: from Molecular Genetics to Targeted Therapies","volume":"1","author":"Lu","year":"2021","journal-title":"Hepatology 73 Suppl"},{"key":"10.1016\/j.bcp.2026.118524_b0030","article-title":"A new treatment combination for liver cancer","author":"O'Leary","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.bcp.2026.118524_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2025.156321","article-title":"Ganoderic acid T, a novel activator of pyruvate carboxylase, exhibits potent anti-liver cancer activity","volume":"170","author":"Lei","year":"2025","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0040","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1038\/s41467-023-38753-6","article-title":"Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase","volume":"14","author":"Zhan","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.bcp.2026.118524_b0045","doi-asserted-by":"crossref","first-page":"10647","DOI":"10.1021\/jacs.5c00919","article-title":"Identification of a Selective Anticancer Agent from a Collection of Complex-and-Diverse Compounds Synthesized from Stevioside","volume":"147","author":"Schaaf","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"10.1016\/j.bcp.2026.118524_b0050","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.bcp.2026.118524_b0060","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/S0962-8924(01)02104-3","article-title":"In silico analysis of cancer through the Cancer Genome Anatomy Project","volume":"11","author":"Strausberg","year":"2001","journal-title":"Trends Cell Biol."},{"issue":"7","key":"10.1016\/j.bcp.2026.118524_b0065","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1101\/gr.10.7.1051","article-title":"SAGEmap: a public gene expression resource","volume":"10","author":"Lash","year":"2000","journal-title":"Genome Res."},{"issue":"14","key":"10.1016\/j.bcp.2026.118524_b0070","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1080\/15384101.2016.1179037","article-title":"PGK1 is a new member of the protein kinome","volume":"15","author":"Li","year":"2016","journal-title":"Cell Cycle"},{"issue":"15","key":"10.1016\/j.bcp.2026.118524_b0075","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1016\/j.cell.2024.06.026","article-title":"100 years of the Warburg effect: a cancer metabolism endeavor","volume":"187","author":"Fendt","year":"2024","journal-title":"Cell"},{"issue":"3191","key":"10.1016\/j.bcp.2026.118524_b0080","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bcp.2026.118524_b0085","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.28887","article-title":"Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis","volume":"65","author":"Hu","year":"2017","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0090","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12964-023-01256-4","article-title":"Regulation of phosphoglycerate kinase 1 and its critical role in cancer","volume":"21","author":"Zhang","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"4","key":"10.1016\/j.bcp.2026.118524_b0095","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.molcel.2018.09.007","article-title":"Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication","volume":"72","author":"Li","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bcp.2026.118524_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116209","article-title":"Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo","volume":"267","author":"He","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"10.1016\/j.bcp.2026.118524_b0105","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1016\/j.apsb.2022.05.012","article-title":"A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1\u03b2 and IL-6","volume":"12","author":"Liao","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.bcp.2026.118524_b0110","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41401-020-0465-8","article-title":"Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"23","key":"10.1016\/j.bcp.2026.118524_b0115","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1021\/jm970839y","article-title":"Highly potent bisphosphonate ligands for phosphoglycerate kinase","volume":"41","author":"Jakeman","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bcp.2026.118524_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114343","article-title":"Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products","volume":"183","author":"Wang","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"7728","key":"10.1016\/j.bcp.2026.118524_b0125","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-018-0622-0","article-title":"A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling","volume":"562","author":"Bollong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118524_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114115","article-title":"A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma","volume":"158","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0135","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1038\/s41467-021-25341-9","article-title":"Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers","volume":"12","author":"Mao","year":"2021","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.bcp.2026.118524_b0140","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203144","article-title":"Conjugating 4\u03b2-NH-(5-Aminoindazole)-podophyllotoxin and Galectin-1-Targeted Aptamer for Synergistic Chemo-Immunotherapy of Hepatocellular Carcinoma","volume":"12","author":"Cong","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"2","key":"10.1016\/j.bcp.2026.118524_b0145","first-page":"148","article-title":"Photoaffinity labeling and Quantitative Chemical Proteomics Identify LXR\u03b2 as the Functional Target of Enhancers of Astrocytic apoE, Cell","volume":"28","author":"Seneviratne","year":"2021","journal-title":"Chem. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118524_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100593","article-title":"Protocol for clickable photoaffinity labeling and quantitative chemical proteomics","volume":"2","author":"Lee","year":"2021","journal-title":"STAR Protoc."},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nchembio.1657","article-title":"Terazosin activates Pgk1 and Hsp90 to promote stress resistance","volume":"11","author":"Chen","year":"2015","journal-title":"Nat. Chem. Biol."},{"issue":"17","key":"10.1016\/j.bcp.2026.118524_b0160","doi-asserted-by":"crossref","first-page":"11944","DOI":"10.1021\/jacs.4c01028","article-title":"Protein Tyrosine Amination: Detection, Imaging, and Chemoproteomic Profiling with Synthetic Probes","volume":"146","author":"Chen","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0165","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1038\/s41467-025-58107-8","article-title":"Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against \u03b1PD1-induced cardiotoxicity in mice","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118524_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.120999","article-title":"Gelsedine-type alkaloids: Discovery of natural neurotoxins presented in toxic honey","volume":"381","author":"Yang","year":"2020","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.bcp.2026.118524_b0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12943-025-02338-2","article-title":"Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025","volume":"24","author":"Allgayer","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bcp.2026.118524_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112830","article-title":"Recent advances of podophyllotoxin\/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: an update (2010-2020)","volume":"208","author":"Xiao","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bcp.2026.118524_b0185","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.molcel.2016.02.009","article-title":"Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis","volume":"61","author":"Li","year":"2016","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.bcp.2026.118524_b0190","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2318956121","article-title":"A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1","volume":"121","author":"Riley","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bcp.2026.118524_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112555","article-title":"Podophyllum hexandrum and its active constituents: Novel radioprotectants","volume":"146","author":"Anand","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bcp.2026.118524_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.709075","article-title":"Insight into the Molecular Mechanism of Podophyllotoxin Derivatives as Anticancer Drugs","volume":"9","author":"Fan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.bcp.2026.118524_b0205","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1080\/15548627.2021.1899682","article-title":"Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1(G93A) astrocytes","volume":"17","author":"Granatiero","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.bcp.2026.118524_b0210","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002722","article-title":"IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms","volume":"9","author":"Wu","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"5","key":"10.1016\/j.bcp.2026.118524_b0215","article-title":"Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy","volume":"5","author":"Dheeraj","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"5","key":"10.1016\/j.bcp.2026.118524_b0220","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41589-022-01236-8","article-title":"Topoisomerase II and etoposide - a tangled tale","volume":"19","author":"Le","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bcp.2026.118524_b0225","doi-asserted-by":"crossref","unstructured":"Y. Gao, M. Ma, W. Li, X. Lei, Chemoproteomics, A Broad Avenue to Target Deconvolution, Adv Sci (Weinh) 11(8) (2024) e2305608.","DOI":"10.1002\/advs.202305608"},{"key":"10.1016\/j.bcp.2026.118524_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117863","article-title":"Phosphoglycerate kinase 1 (PGK1) in cancer: a promising target for diagnosis and therapy","volume":"256","author":"Fu","year":"2020","journal-title":"Life Sci."},{"issue":"23","key":"10.1016\/j.bcp.2026.118524_b0235","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1021\/jm0604833","article-title":"Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation","volume":"49","author":"Kotsikorou","year":"2006","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.bcp.2026.118524_b0240","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.amjmed.2023.03.033","article-title":"The FDA Modernization Act 2.0: Drug Testing in animals is Rendered Optional","volume":"136","author":"Adashi","year":"2023","journal-title":"Am. J. Med."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600866X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000629522600866X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:46:45Z","timestamp":1791654405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000629522600866X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":48,"alternative-id":["S000629522600866X"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118524","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical proteomics and phenotypic profiling identify \u03b1FOD as a podophyllotoxin-derived PGK1 inhibitor that suppresses glycolysis and proliferation in hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118524","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118524"}}