{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:51:12Z","timestamp":1791910272208,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N41A670374"],"award-info":[{"award-number":["N41A670374"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N35A650038"],"award-info":[{"award-number":["N35A650038"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118528","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:00:46Z","timestamp":1791388846000},"page":"118528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["ECDD-S16 exhibits broad-spectrum antiviral activity and inhibits an early, pH-dependent step of influenza virus entry"],"prefix":"10.1016","volume":"254","author":[{"given":"Rattatammanoon","family":"Saengfak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwimon","family":"Manopwisedjaroen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bumrung","family":"Munyoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napason","family":"Chabang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparerk","family":"Borwornpinyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suradej","family":"Hongeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitthivut","family":"Charoensutthivarakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunee","family":"Thitithanyanont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.bcp.2026.118528_b0005","doi-asserted-by":"crossref","first-page":"12244","DOI":"10.3390\/ijms232012244","article-title":"Evolution of influenza viruses\u2014drug resistance, treatment options, and prospects","volume":"23","author":"Smyk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bcp.2026.118528_b0010","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/v17050722","article-title":"Evolution of antiviral drug resistance in SARS-CoV-2","volume":"17","author":"Dinata","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.bcp.2026.118528_b0015","article-title":"Broad-spectrum antiviral strategy: Host-targeting antivirals against emerging and re-emerging viruses","volume":"259","author":"He","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bcp.2026.118528_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116356","article-title":"Antiviral strategies targeting host factors and mechanisms obliging ssRNA viral pathogens","volume":"46","author":"Mahajan","year":"2021","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.bcp.2026.118528_b0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/mmi.15133","article-title":"Respiratory syncytial virus entry mechanism in host cells: A general overview","volume":"120","author":"Cadena-Cruz","year":"2023","journal-title":"Mol. Microbiol."},{"issue":"6","key":"10.1016\/j.bcp.2026.118528_b0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/tra.12389","article-title":"Fusion of enveloped viruses in endosomes","volume":"17","author":"White","year":"2016","journal-title":"Traffic"},{"issue":"5","key":"10.1016\/j.bcp.2026.118528_b0035","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s11101-020-09735-z","article-title":"Arylnaphthalene lactones: Structures and pharmacological potentials","volume":"20","author":"Park","year":"2021","journal-title":"Phytochem. Rev."},{"issue":"3","key":"10.1016\/j.bcp.2026.118528_b0040","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/microorganisms9030471","article-title":"Antiviral activity of vacuolar ATPase blocker diphyllin against SARS-CoV-2","volume":"9","author":"Stefanik","year":"2021","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.bcp.2026.118528_b0045","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3390\/v14020354","article-title":"Diphyllin shows broad-spectrum antiviral activity against medically important enveloped viruses","volume":"14","author":"\u0160tef\u00e1nik","year":"2022","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.bcp.2026.118528_b0050","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/cbdd.12538","article-title":"Synthesis and evaluation of cleistanthin A derivatives as potent vacuolar H+-ATPase inhibitors","volume":"86","author":"Zhao","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bcp.2026.118528_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173604","article-title":"Cleistanthin A induces apoptosis and suppresses motility of colorectal cancer cells","volume":"889","author":"Jearawuttanakul","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118528_b0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1055\/s-2005-873141","article-title":"Cytotoxic arylnaphthalide lignan glycosides from Phyllanthus taxodiifolius","volume":"72","author":"Tuchinda","year":"2006","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.bcp.2026.118528_b0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.antiviral.2013.06.014","article-title":"Inhibitory and combinatorial effect of diphyllin, a V-ATPase blocker, on influenza viruses","volume":"99","author":"Chen","year":"2013","journal-title":"Antiviral Res."},{"issue":"11","key":"10.1016\/j.bcp.2026.118528_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0292340","article-title":"ECDD-S16 targets vacuolar ATPase: A potential inhibitor for pyroptosis-induced inflammation","volume":"18","author":"Ekchariyawat","year":"2023","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bcp.2026.118528_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0301330","article-title":"Infection kinetics, syncytia formation, and inflammatory biomarkers as predictive indicators for the pathogenicity of SARS-CoV-2 variants of concern in Calu-3 cells","volume":"19","author":"Purwono","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118528_b0075","first-page":"52065","article-title":"Viral concentration determination through plaque assays: Using traditional and novel overlay systems","volume":"93","author":"Baer","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"9","key":"10.1016\/j.bcp.2026.118528_b0080","doi-asserted-by":"crossref","first-page":"e2830","DOI":"10.21769\/BioProtoc.2830","article-title":"Time-of-addition and temperature-shift assays to determine particular step(s) in the viral life cycle that is blocked by antiviral substance(s)","volume":"8","author":"Aoki-Utsubo","year":"2018","journal-title":"Bio-protocol"},{"issue":"2","key":"10.1016\/j.bcp.2026.118528_b0150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.coviro.2012.02.005","article-title":"Broadly neutralizing antibodies against influenza virus and prospects for universal therapies","volume":"2","author":"Ekiert","year":"2012","journal-title":"Curr. Opin. Virol."},{"issue":"3","key":"10.1016\/j.bcp.2026.118528_b0160","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.enzmictec.2011.06.005","article-title":"A simple fluorescent labeling technique to study virus adsorption in Newcastle disease virus infected cells","volume":"49","author":"Balogh","year":"2011","journal-title":"Enzyme Microb. Technol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118528_b0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"10458","key":"10.1016\/j.bcp.2026.118528_b0085","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0140-6736(24)01716-1","article-title":"Severe respiratory syncytial virus infection in children: Burden, management, and emerging therapies","volume":"404","author":"Mazur","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bcp.2026.118528_b0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.abb.2008.03.025","article-title":"Function, structure and regulation of the vacuolar (H+)-ATPases","volume":"476","author":"Jefferies","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bcp.2026.118528_b0095","series-title":"In Influenza pathogenesis and control (Vol. I","first-page":"93","article-title":"Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology","author":"Russell","year":"2014"},{"issue":"4","key":"10.1016\/j.bcp.2026.118528_b0155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/v10040184","article-title":"Arbidol (Umifenovir): a broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses","volume":"10","author":"Haviernik","year":"2018","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.bcp.2026.118528_b0090","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.antiviral.2013.08.002","article-title":"Inhibition of influenza virus internalization by (\u2212)-epigallocatechin-3-gallate","volume":"100","author":"Kim","year":"2013","journal-title":"Antiviral Res."},{"issue":"1","key":"10.1016\/j.bcp.2026.118528_b0140","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/22221751.2021.2023329","article-title":"SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells","volume":"11","author":"Zhao","year":"2022","journal-title":"Emerging Microbes Infect."},{"issue":"8","key":"10.1016\/j.bcp.2026.118528_b0130","doi-asserted-by":"crossref","first-page":"e00851","DOI":"10.1128\/jvi.00851-23","article-title":"SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models","volume":"97","author":"Mykytyn","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.bcp.2026.118528_b0135","article-title":"SARS-CoV-2 evolution enhances endocytic uptake while preserving TMPRSS2-dependent fusion","volume":"16","author":"Magnus","year":"2025","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.bcp.2026.118528_b0105","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016972","article-title":"Endocytosis of viruses and bacteria","volume":"6","author":"Cossart","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.bcp.2026.118528_b0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jep.2005.07.021","article-title":"Anti-inflammatory activities of constituents isolated from Phyllanthus polyphyllus","volume":"103","author":"Rao","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bcp.2026.118528_b0120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.phymed.2010.04.001","article-title":"Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated K+ channels","volume":"18","author":"Leung","year":"2010","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bcp.2026.118528_b0125","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3389\/fimmu.2018.01509","article-title":"A synthetic disaccharide derivative of diphyllin, TAARD, activates human natural killer cells to secrete interferon-gamma via toll-like receptor-mediated NF-\u03baB and STAT3 signaling pathways","volume":"9","author":"Yi","year":"2018","journal-title":"Front. Immunol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:21:39Z","timestamp":1791908499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226008701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":32,"alternative-id":["S0006295226008701"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118528","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ECDD-S16 exhibits broad-spectrum antiviral activity and inhibits an early, pH-dependent step of influenza virus entry","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"118528"}}