{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:37:12Z","timestamp":1792874232295,"version":"4.5.0"},"reference-count":261,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.bcp.2026.118551","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:40:42Z","timestamp":1792230042000},"page":"118551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P3","title":["Citicoline in cardiovascular protection: mechanistic roles of choline and acetylcholine"],"prefix":"10.1016","volume":"254","author":[{"given":"Wylly Rams\u00e9s","family":"Garc\u00eda-Ni\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Gonz\u00e1lez-Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Zazueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bcp.2026.118551_b0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0021-9258(19)50785-2","article-title":"The function of cytidine coenzymes in the biosynthesis of phospholipides","volume":"222","author":"Kennedy","year":"1956","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0010","first-page":"523","article-title":"Phosphatidylcholine and the CDP-choline cycle","volume":"1831","author":"Fagone","year":"2013","journal-title":"BBA"},{"key":"10.1016\/j.bcp.2026.118551_b0015","doi-asserted-by":"crossref","first-page":"25658","DOI":"10.1038\/s41598-025-11098-4","article-title":"The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation","volume":"15","author":"Abdel-Aziz","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118551_b0020","first-page":"1045","article-title":"Bioavailability of methyl-14C CDP-choline by oral route","volume":"33","author":"Agut","year":"1983","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bcp.2026.118551_b0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1037\/pha0000418","article-title":"The acute dose and baseline amplitude-dependent effects of CDP-choline on deviance detection (MMN) in chronic schizophrenia: A pilot study","volume":"30","author":"Aidelbaum","year":"2022","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0030","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400823R","article-title":"Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders","volume":"38","author":"Cavalu","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2026.118551_b0035","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1161\/CIRCULATIONAHA.121.053575","article-title":"Altered cardiac energetics and mitochondrial dysfunction in hypertrophic cardiomyopathy","volume":"144","author":"Ranjbarvaziri","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2026.118551_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105391","article-title":"Citicoline ameliorates arsenic-induced hepatotoxicity and diabetes in mice by overexpression of VAMP2, PPAR-gamma, As3MT, and SIRT3","volume":"192","author":"Nikravesh","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1139\/bcb-2014-0116","article-title":"Cardioprotective properties of citicoline against hyperthyroidism-induced reperfusion damage in rat hearts","volume":"93","author":"Hernandez-Esquivel","year":"2015","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118551_b0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2018.10.013","article-title":"The non-neuronal cholinergic system in the heart: a comprehensive review","volume":"125","author":"Saw","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.lfs.2013.12.026","article-title":"Citicoline (CDP-choline) protects myocardium from ischemia\/reperfusion injury via inhibiting mitochondrial permeability transition","volume":"96","author":"Hernandez-Esquivel","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12576-020-00787-6","article-title":"Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart","volume":"71","author":"Oikawa","year":"2021","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12933-021-01231-8","article-title":"Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications","volume":"20","author":"Saw","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bcp.2026.118551_b0070","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s11481-015-9601-5","article-title":"Activation of the macrophage alpha7 nicotinic acetylcholine receptor and control of inflammation","volume":"10","author":"Baez-Pagan","year":"2015","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0075","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvy217","article-title":"Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway","volume":"115","author":"Xu","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0080","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1139\/Y08-094","article-title":"Choline produces antiarrhythmic actions in animal models by cardiac M3 receptors: improvement of intracellular Ca2+ handling as a common mechanism","volume":"86","author":"Liu","year":"2008","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0085","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3389\/fphar.2019.01386","article-title":"Choline attenuates cardiac fibrosis by inhibiting p38MAPK signaling possibly by acting on M(3) muscarinic acetylcholine receptor","volume":"10","author":"Zhao","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yjmcc.2014.01.017","article-title":"Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner","volume":"69","author":"Ranek","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b0095","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032079","article-title":"Gestational hypoxia impaired endothelial nitric oxide synthesis via miR-155-5p\/NADPH oxidase\/reactive oxygen species axis in male offspring vessels","volume":"13","author":"Zhao","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bcp.2026.118551_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/ph15080925","article-title":"Citicoline modifies the expression of specific miRNAs related to cardioprotection in patients with ST-segment elevation myocardial infarction subjected to coronary angioplasty","volume":"15","author":"Silva-Palacios","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.bcp.2026.118551_b0105","first-page":"H1289","article-title":"Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms","volume":"314","author":"Buchholz","year":"2018","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0110","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0024-3205(94)00427-T","article-title":"Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline","volume":"56","author":"Weiss","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0197-0186(87)90049-0","article-title":"Metabolism of cytidine (5?)-diphosphocholine (cdp-choline) following oral and intravenous administration to the human and the rat","volume":"11","author":"L\u00f3pez","year":"1987","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bcp.2026.118551_b0120","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/s42003-025-08901-3","article-title":"TNAP dephosphorylates phosphocholine and phosphoethanolamine and participates in triglyceride transport from the liver to the bloodstream","volume":"8","author":"Drevet Mulard","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bcp.2026.118551_b0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/bj1460309","article-title":"Biosynthesis of phosphatidylethanolamines and phosphatidylcholines from ethanolamine and choline in rat liver","volume":"146","author":"Sundler","year":"1975","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2026.118551_b0130","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1021\/bi0517537","article-title":"Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde","volume":"45","author":"Fan","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2026.118551_b0135","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/geno.2000.6319","article-title":"Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes","volume":"70","author":"Chadwick","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.bcp.2026.118551_b0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.gene.2010.11.015","article-title":"Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase -2 genes","volume":"473","author":"Ganu","year":"2011","journal-title":"Gene"},{"key":"10.1016\/j.bcp.2026.118551_b0145","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0021-9258(19)57144-7","article-title":"Choline phosphokinase","volume":"202","author":"Wittenberg","year":"1953","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0150","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1042\/bj3630777","article-title":"Expression and characterization of the active molecular forms of choline\/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver","volume":"363","author":"Aoyama","year":"2002","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2026.118551_b0155","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0969-2126(03)00094-7","article-title":"The crystal structure of choline kinase reveals a eukaryotic protein kinase fold","volume":"11","author":"Peisach","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.bcp.2026.118551_b0160","doi-asserted-by":"crossref","first-page":"17801","DOI":"10.1074\/jbc.M401382200","article-title":"Identification of critical residues of choline kinase A2 from Caenorhabditis elegans","volume":"279","author":"Yuan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0165","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1021\/bi00060a005","article-title":"Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor","volume":"32","author":"Zheng","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2026.118551_b0170","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1110\/ps.8.12.2728","article-title":"Influence of key residues on the reaction mechanism of the cAMP-dependent protein kinase","volume":"8","author":"Hutter","year":"1999","journal-title":"Protein Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0175","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","article-title":"Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification","volume":"9","author":"Hanks","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.bcp.2026.118551_b0180","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1432-1327.1998.2550227.x","article-title":"The role of histidine residues in the HXGH site of CTP:phosphocholine cytidylyltransferase in CTP binding and catalysis","volume":"255","author":"Veitch","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0185","doi-asserted-by":"crossref","first-page":"19613","DOI":"10.1074\/jbc.M414028200","article-title":"Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry","volume":"280","author":"Bogan","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0190","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1016\/S0021-9258(17)34092-9","article-title":"Identification of phosphorylation sites in rat liver CTP: phosphocholine cytidylyltransferase","volume":"269","author":"MacDonald","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0195","doi-asserted-by":"crossref","unstructured":"Cornell RB, Kalmar GB, Kay RJ, Johnson MA, Sanghera JS and Pelech SL (1995) Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potential. Biochem J 310 (Pt 2):699-708. doi: 10.1042\/bj3100699.","DOI":"10.1042\/bj3100699"},{"key":"10.1016\/j.bcp.2026.118551_b0200","first-page":"847","article-title":"Membrane lipid compositional sensing by the inducible amphipathic helix of CCT","volume":"1861","author":"Cornell","year":"2016","journal-title":"BBA"},{"key":"10.1016\/j.bcp.2026.118551_b0205","doi-asserted-by":"crossref","first-page":"15531","DOI":"10.1074\/jbc.RA119.009850","article-title":"Remodeling of the interdomain allosteric linker upon membrane binding of CCTalpha pulls its active site close to the membrane surface","volume":"294","author":"Knowles","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0210","first-page":"222","article-title":"Studies on enzyme-substrate interactions of cholinephosphotransferase from rat liver","volume":"836","author":"Pontoni","year":"1985","journal-title":"BBA"},{"key":"10.1016\/j.bcp.2026.118551_b0215","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1038\/ncomms5068","article-title":"Structural basis for catalysis in a CDP-alcohol phosphotransferase","volume":"5","author":"Sciara","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0220","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1038\/ncomms5169","article-title":"X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism","volume":"5","author":"Nogly","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0225","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41467-024-55673-1","article-title":"Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase","volume":"16","author":"Roberts","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0230","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/s41467-023-38003-9","article-title":"Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0235","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1016\/S0021-9258(17)40126-8","article-title":"Re-evaluation of the kinetic mechanism of the choline acetyltransferase reaction","volume":"252","author":"Hersh","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0240","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/sj.emboj.7600221","article-title":"Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders","volume":"23","author":"Cai","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118551_b0245","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1021\/bi061536l","article-title":"Substrate binding and catalytic mechanism of human choline acetyltransferase","volume":"45","author":"Kim","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bcp.2026.118551_b0250","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1471-4159.1978.tb12401.x","article-title":"A fluorometric assay for choline acetyltransferase and its use in the purification of the enzyme from human placenta","volume":"30","author":"Hersh","year":"1978","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2026.118551_b0255","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1471-4159.1993.tb03561.x","article-title":"Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis","volume":"61","author":"Carbini","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2026.118551_b0260","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0361-9230(90)90295-B","article-title":"Kinetic and inactivation studies of recombinant Drosophila choline acetyltransferase","volume":"24","author":"Carbini","year":"1990","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bcp.2026.118551_b0265","doi-asserted-by":"crossref","first-page":"11988","DOI":"10.1016\/S0021-9258(19)86415-3","article-title":"The reaction of choline acetyltransferase with sulfhydryl reagents. Methoxycarbonyl-CoA disulfide as an active site-directed reagent","volume":"254","author":"Hersh","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0270","doi-asserted-by":"crossref","first-page":"29111","DOI":"10.1074\/jbc.270.49.29111","article-title":"Identification of an active site arginine in rat choline acetyltransferase by alanine scanning mutagenesis","volume":"270","author":"Wu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0275","doi-asserted-by":"crossref","first-page":"22244","DOI":"10.1074\/jbc.M011702200","article-title":"Functional characterization of phosphorylation of 69-kDa human choline acetyltransferase at serine 440 by protein kinase C","volume":"276","author":"Dobransky","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0280","unstructured":"Park CH, Kim YS, Cheon EW, Noh HS, Cho CH, Chung IY, Yoo JM, Kang SS, Choi WS and Cho CJ (2022) Action of citicoline on rat retinal expression of extracellular-signal-regulated kinase (ERK1\/2). Brain Res:584-589."},{"key":"10.1016\/j.bcp.2026.118551_b0285","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000071116","article-title":"Long-term citicoline (cytidine diphosphate choline) use in patients with vascular dementia: neuroimaging and neuropsychological outcomes","volume":"16","author":"Cohen","year":"2003","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.bcp.2026.118551_b0290","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2147\/CIA.S409994","article-title":"Citicoline may prevent cognitive decline in patients with cerebrovascular disease","volume":"18","author":"Almeria","year":"2023","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.bcp.2026.118551_b0295","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3233\/JAD-160808","article-title":"The Citicholinage Study: Citicoline plus cholinesterase inhibitors in aged patients affected with Alzheimer's disease study","volume":"56","author":"Gareri","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bcp.2026.118551_b0300","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16081048","article-title":"Dopamine and citicoline-co-loaded solid lipid nanoparticles as multifunctional nanomedicines for Parkinson's disease treatment by intranasal administration","volume":"16","author":"Castellani","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bcp.2026.118551_b0305","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1089\/jop.2022.0005","article-title":"The effect of citicoline on ethambutol optic neuropathy: histopathology and immunohistochemistry analysis of retina ganglion cell damage level in rat model","volume":"38","author":"Nusanti","year":"2022","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.bcp.2026.118551_b0310","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1177\/02698811211029752","article-title":"Increasing dietary choline attenuates spatial memory deficits resulting from exposure to the chemotherapeutic agents cyclophosphamide and doxorubicin","volume":"35","author":"Johns","year":"2022","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0315","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13063-024-08155-0","article-title":"SCARLET (Supplemental citicoline administration to reduce lung injury efficacy trial): study protocol for a single-site, double blinded, placebo-controlled and randomized phase 1\/2 trial of i.v citicoline (CDP-choline) in hospitalized SARS CoV-2 infected","volume":"25","author":"Pannu","year":"2024","journal-title":"Trials"},{"key":"10.1016\/j.bcp.2026.118551_b0320","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1177\/1091581809349452","article-title":"Single- and repeated-dose oral toxicity studies of citicoline free-base (choline cytidine 5'-pyrophosphate) in Sprague-Dawley rats","volume":"28","author":"Schauss","year":"2009","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.bcp.2026.118551_b0325","first-page":"1033","article-title":"CDP-choline: acute toxicity study","volume":"33","author":"Grau","year":"1983","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bcp.2026.118551_b0330","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jpba.2012.07.003","article-title":"A rapid LC-ESI-MS\/MS method for the quantitation of choline, an active metabolite of citicoline: application to in vivo pharmacokinetic and bioequivalence study in Indian healthy male volunteers","volume":"71","author":"Sarkar","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bcp.2026.118551_b0335","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1007\/s13346-024-01556-3","article-title":"OX26-cojugated gangliosilated liposomes to improve the post-ischemic therapeutic effect of CDP-choline","volume":"14","author":"d'Avanzo","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0340","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0345","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","article-title":"Reperfusion ijury in patients with acute myocardial infarction: JACC Scientific Statement","volume":"83","author":"Welt","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b0350","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2174\/092986710791331077","article-title":"Pharmacological strategies to contend against myocardial reperfusion damage: diverse chemicals for multiple targets","volume":"17","author":"Correa","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0355","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11845-013-1046-3","article-title":"Protective effect of CDP-choline on ischemia-reperfusion-induced myocardial tissue injury in rats","volume":"183","author":"Coskun","year":"2014","journal-title":"Ir. J. Med. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0360","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00210-008-0300-0","article-title":"CDP-choline prevents cardiac arrhythmias and lethality induced by short-term myocardial ischemia-reperfusion injury in the rat: involvement of central muscarinic cholinergic mechanisms","volume":"378","author":"Yilmaz","year":"2008","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0365","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/187071","article-title":"Pre-conditioning with CDP-choline attenuates oxidative stress-induced cardiac myocyte death in a hypoxia\/reperfusion model","volume":"2014","author":"Gonzalez-Pacheco","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.bcp.2026.118551_b0370","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/152308603770310329","article-title":"Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia","volume":"5","author":"Adibhatla","year":"2003","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bcp.2026.118551_b0375","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1038\/s41467-025-63813-4","article-title":"Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1","volume":"16","author":"Thatavarthy","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0380","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/bph.12468","article-title":"Targeting mitochondrial cardiolipin and the cytochrome c\/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis","volume":"171","author":"Birk","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0385","doi-asserted-by":"crossref","first-page":"10672","DOI":"10.1074\/jbc.M117.783068","article-title":"The phospholipase iPLA(2)gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling","volume":"292","author":"Liu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0390","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ajem.2013.03.018","article-title":"Cytidine diphosphate choline improves the outcome of cardiac arrest vs epinephrine in rat model","volume":"31","author":"Yu","year":"2013","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0395","article-title":"Citicoline improved cardiovascular function in animal model of dysautonomia","volume":"72","author":"Amin","year":"2021","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0400","first-page":"47","article-title":"Choline and citicoline ameliorate oxidative stress in acute kidney injury in rats","volume":"124","author":"Baris","year":"2023","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.bcp.2026.118551_b0405","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/lt.25179","article-title":"Cytidine-5'-diphosphocholine protects the liver from ischemia\/reperfusion injury preserving mitochondrial function and reducing oxidative stress","volume":"24","author":"Zazueta","year":"2018","journal-title":"Liver Transpl."},{"key":"10.1016\/j.bcp.2026.118551_b0410","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1038\/s41598-017-04620-w","article-title":"Common lipid features of lethal ventricular tarchyarrhythmias (LVTAs) induced by myocardial infarction and myocardial ion channel diseases","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118551_b0415","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/metabo9060109","article-title":"Characterization of bulk phosphatidylcholine compositions in human plasma using side-chain resolving lipidomics","volume":"9","author":"Quell","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.bcp.2026.118551_b0420","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12944-023-01832-0","article-title":"Serum lipidomics reveals phosphatidylethanolamine and phosphatidylcholine disorders in patients with myocardial infarction and post-myocardial infarction-heart failure","volume":"22","author":"Rong","year":"2023","journal-title":"Lipid Health Dis"},{"key":"10.1016\/j.bcp.2026.118551_b0425","doi-asserted-by":"crossref","unstructured":"M. Zhu, Y H, Zhang Y, Zhang S, Wei C, Cong Z and Du W (2018) Metabolomics Study of the Biochemical Changes in the Plasma of Myocardial Infarction Patients. Front Physiol 11:1017.","DOI":"10.3389\/fphys.2018.01017"},{"key":"10.1016\/j.bcp.2026.118551_b0430","doi-asserted-by":"crossref","first-page":"16944","DOI":"10.3389\/fmed.2021.716944","article-title":"Increase in Plasma Oxidized Phosphatidylcholines (OxPCs) in Patients Presenting With ST-Elevation Myocardial Infarction (STEMI)","volume":"8","author":"Solati","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0435","doi-asserted-by":"crossref","first-page":"H1170","DOI":"10.1152\/ajpheart.00237.2020","article-title":"Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury","volume":"320","author":"Stamenkovic","year":"2021","journal-title":"Am J Physiol Heart Circ"},{"key":"10.1016\/j.bcp.2026.118551_b0440","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/BF00169447","article-title":"Protective effects of phosphatidylcholine against mechanisms of ischemia and reperfusion-induced arrhythmias in isolated guinea pig ventricular tissues","volume":"342","author":"Duan","year":"1990","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0445","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/cbf.290110210","article-title":"Effect of exogenous CDP-choline on choline metabolism in isolated adult rat ventricular myocytes under normoxic and hypoxic conditions","volume":"11","author":"Rabkin","year":"1993","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.bcp.2026.118551_b0450","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-70410-6","article-title":"Cardiomyocyte Cyclin-dependent kinase 9 directly binds to and phosphorylates NF-kappaB p65 subunit to drive cardiac inflammation and remodeling","volume":"17","author":"Ye","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0455","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nri2423","article-title":"New regulators of NF-kappaB in inflammation","volume":"8","author":"Ghosh","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bcp.2026.118551_b0460","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/sj.emboj.7601622","article-title":"Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways","volume":"26","author":"Shambharkar","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118551_b0465","doi-asserted-by":"crossref","unstructured":"Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C and Ghosh G (2016) The NF-kappaB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100. Sci Signal 9:ra96. doi: 10.1126\/scisignal.aad9413.","DOI":"10.1126\/scisignal.aad9413"},{"key":"10.1016\/j.bcp.2026.118551_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106448","article-title":"Protective effect of citicoline on random flap survival in a rat mode","volume":"83","author":"Feng","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0475","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1007\/s11356-020-11101-7","article-title":"The impact of citicoline on brain injury in rats subjected to head irradiation","volume":"28","author":"Abdel-Aziz","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.bcp.2026.118551_b0480","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jss.2012.11.032","article-title":"CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis","volume":"183","author":"Cetinkaya","year":"2013","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0485","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1161\/hs1001.096010","article-title":"Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia","volume":"32","author":"Adibhatla","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.bcp.2026.118551_b0490","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s11064-014-1299-x","article-title":"Citicoline protects brain against closed head injury in rats through suppressing oxidative stress and calpain over-activation","volume":"39","author":"Qian","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108612","article-title":"Protective effects of citicoline-containing eye drops against UVB-Induced corneal oxidative damage in a rat model","volume":"208","author":"Tokuc","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bcp.2026.118551_b0500","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bcp.2026.118551_b0505","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0510","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1161\/ATVBAHA.120.315146","article-title":"Activation of M3AChR (type 3 muscarinic acetylcholine receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2) signaling by choline alleviates vascular smooth muscle cell phenotypic switching and vascular remodeling","volume":"40","author":"He","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2026.118551_b0515","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1471-4159.2009.06208.x","article-title":"The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection","volume":"110","author":"Espada","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bcp.2026.118551_b0520","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4740931","article-title":"Choline protects the heart from doxorubicin-induced cardiotoxicity through vagal activation and Nrf2\/HO-1 pathway","volume":"2022","author":"Guo","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2026.118551_b0525","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000343360","article-title":"Acetylcholine attenuates hypoxia\/ reoxygenation-induced mitochondrial and cytosolic ROS formation in H9c2 cells via M2 acetylcholine receptor","volume":"31","author":"Miao","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0530","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10495-010-0549-x","article-title":"Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells","volume":"16","author":"Liu","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.bcp.2026.118551_b0535","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1159\/000366364","article-title":"Acetylcholine promotes ROS detoxification against hypoxia\/reoxygenation-induced oxidative stress through FoxO3a\/PGC-1\u03b1 dependent superoxide dismutase","volume":"34","author":"Sun","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0540","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/ncpcardio0710","article-title":"Mechanisms of disease: apoptosis in heart failure\u2013seeing hope in death","volume":"3","author":"Narula","year":"2006","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0545","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.1073\/pnas.96.14.8144","article-title":"Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy","volume":"96","author":"Narula","year":"1999","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2026.118551_b0550","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.lfs.2004.11.029","article-title":"Involvement of death receptor signaling in mechanical stretch-induced cardiomyocyte apoptosis","volume":"77","author":"Liao","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0555","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cvr\/cvp261","article-title":"Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats","volume":"85","author":"Choudhury","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0560","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221838","article-title":"Apoptosis: A comprehensive overview of signaling pathways, morphological changes, and physiological significance and therapeutic implications","volume":"13","author":"Mustafa","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118551_b0565","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000538946","article-title":"Cytoprotection as an innovative therapeutic strategy to cardiogenic shock: exploring the potential of cytidine-5-diphosphocholine to mitigate target organ damage","volume":"61","author":"Gonzalez-Pacheco","year":"2024","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0570","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1139\/bcb-2018-0218","article-title":"Citicoline protects against lead-induced oxidative injury in neuronal PC12 cells","volume":"97","author":"Aminzadeh","year":"2019","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118551_b0575","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0006-8993(02)03605-3","article-title":"Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells","volume":"957","author":"Barrachina","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.bcp.2026.118551_b0580","doi-asserted-by":"crossref","first-page":"6286","DOI":"10.3390\/ijms15046286","article-title":"Neuroprotective effects of citicoline in in vitro models of retinal neurodegeneration","volume":"15","author":"Matteucci","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0585","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000089842","article-title":"Choline produces cytoprotective effects against ischemic myocardial injuries: evidence for the role of cardiac m3 subtype muscarinic acetylcholine receptors","volume":"16","author":"Yang","year":"2005","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0590","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1159\/000488049","article-title":"Choline inhibits ischemia-reperfusion-induced cardiomyocyte autophagy in rat myocardium by activating Akt\/mTOR signaling","volume":"45","author":"Hang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0595","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9979706","article-title":"Activation of the M3AChR and Notch1\/HSF1 signaling pathway by choline alleviates angiotensin II-induced cardiomyocyte apoptosis","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2026.118551_b0600","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1159\/000430157","article-title":"Acetylcholine attenuated TNF-alpha-induced apoptosis in H9c2 cells: role of calpain and the p38-MAPK pathway","volume":"36","author":"Zhao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0605","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jcp.22424","article-title":"Acetylcholine inhibits hypoxia-induced tumor necrosis factor-\u03b1 production via regulation of MAPKs phosphorylation in cardiomyocytes","volume":"226","author":"Li","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b0610","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.febslet.2005.02.065","article-title":"Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha","volume":"579","author":"Kakinuma","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bcp.2026.118551_b0615","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/hrt.67.6.482","article-title":"Decreased cardiac parasympathetic activity in chronic heart failure and its relation to left ventricular function","volume":"67","author":"Nolan","year":"1992","journal-title":"Br. Heart J."},{"key":"10.1016\/j.bcp.2026.118551_b0620","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jacbts.2020.07.004","article-title":"Cardiac sympathetic-parasympathetic interaction: the endless story of Yin and Yang","volume":"5","author":"Dusi","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.bcp.2026.118551_b0625","article-title":"The intrinsic cardiac nervous system: From pathophysiology to therapeutic implications","volume":"13","author":"Giannino","year":"2024","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.bcp.2026.118551_b0630","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1113\/jphysiol.1976.sp011414","article-title":"The location of cardiac vagal preganglionic motoneurones in the medulla of the cat","volume":"258","author":"McAllen","year":"1976","journal-title":"J. Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b0635","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1161\/01.RES.46.5.606","article-title":"Cardiac responses during stimulation of the dorsal motor nucleus and nucleus ambiguus in the cat","volume":"46","author":"Geis","year":"1980","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0640","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00210-008-0285-8","article-title":"The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles","volume":"378","author":"Myslivecek","year":"2008","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0645","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ar.25686","article-title":"Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy","volume":"309","author":"Hanna","year":"2026","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.bcp.2026.118551_b0650","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092466","article-title":"Revisiting the cardioprotective effects of acetylcholine receptor activation against myocardial ischemia\/reperfusion injury","volume":"19","author":"Intachai","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0655","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.104.525493","article-title":"Efferent vagal nerve stimulation protects heart against ischemia-induced arrhytmias by preserving connexin 43 protein","volume":"112","author":"Ando","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2026.118551_b0660","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1254\/jphs.FP0051023","article-title":"Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes","volume":"101","author":"Zhang","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0665","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jtcvs.2008.08.020","article-title":"Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect","volume":"137","author":"Katare","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.bcp.2026.118551_b0670","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00395-015-0508-3","article-title":"Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow","volume":"110","author":"Uitterdijk","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b0675","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jcin.2017.04.036","article-title":"Low-level tragus stimulation for the treatment of ischemia and reperfusion injury in patients with st-segment elevation myocardial infarction: a proof-of-concept study","volume":"10","author":"Yu","year":"2017","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"10.1016\/j.bcp.2026.118551_b0680","first-page":"H1289","article-title":"Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms","volume":"314","author":"Bucholz","year":"2018","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0685","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0009-9120(00)00084-9","article-title":"Effect of CDP-choline on brain acetylcholinesterase and Na(+), K(+)-ATPase in adult rats","volume":"33","author":"Plataras","year":"2000","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0690","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1476-5381.1991.tb12471.x","article-title":"Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice","volume":"104","author":"Gimenez","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0695","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1111\/j.1742-4658.2009.07208.x","article-title":"Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium","volume":"276","author":"Kakinuma","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.bcp.2026.118551_b0700","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12576-020-00787-6","article-title":"Non-neuronal cardiac acetylcholine system playing indispensable roles in cardiac homeostasis confers resiliency to the heart","volume":"71","author":"Oikawa","year":"2021","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0705","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cell of the adult human heart","volume":"588","author":"Litvi\u00f1ukov\u00e1","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118551_b0710","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1042\/CS20257026","article-title":"Impaired cardiac non-neuronal acetylcholine synthesis triggers mitochondrial dysfunction with the loss of nicotinic receptor-mediated calcium handling, causing the failing heart","volume":"139","author":"Sonobe","year":"2025","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bcp.2026.118551_b0715","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00011-023-01714-2","article-title":"Activating alpha7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway","volume":"72","author":"Niu","year":"2023","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0720","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091553","article-title":"Insight into the role of the PI3K\/Akt pathway in ischemic injury and post-infarct left ventricular remodeling in normal and diabetic heart","volume":"11","author":"Walkowski","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bcp.2026.118551_b0725","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2101496118","article-title":"Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation","volume":"118","author":"Truebestein","year":"2021","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2026.118551_b0730","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.118551_b0735","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1074\/jbc.RA119.012425","article-title":"Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)","volume":"295","author":"Balasuriya","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111736","article-title":"The emerging role of alpha7nAChRs\/caspase-3\/Nrf-2 signaling pathway in citicoline improved autistic behavior induced by thimerosal in mice","volume":"130","author":"Khattab","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0745","first-page":"H2322","article-title":"ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases","volume":"283","author":"Krieg","year":"2002","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0750","first-page":"H727","article-title":"Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase","volume":"284","author":"Qin","year":"2003","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0755","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0022-2828(03)00083-X","article-title":"Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening","volume":"35","author":"Oldenburg","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b0760","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1091\/mbc.01-08-0411","article-title":"Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling","volume":"13","author":"Yu","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bcp.2026.118551_b0765","first-page":"H2606","article-title":"Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS","volume":"287","author":"Krieg","year":"2004","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0770","first-page":"H1976","article-title":"Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart","volume":"288","author":"Krieg","year":"2005","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0775","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/hh1501.094266","article-title":"Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels","volume":"89","author":"Cohen","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0780","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0008-6363(02)00861-1","article-title":"Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals","volume":"58","author":"Krieg","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0785","first-page":"H2504","article-title":"Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes","volume":"277","author":"Yao","year":"1999","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.bcp.2026.118551_b0790","first-page":"19","article-title":"Ischemic postconditioning reduced myocardial ischemia-reperfusion injury: The roles of melatonin and uncoupling protein 3","volume":"23","author":"Aslan","year":"2020","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b0795","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2006.08.030","article-title":"Effects of postconditioning of adenosine and acetylcholine on the ischemic isolated rat ventricular myocytes","volume":"549","author":"Lu","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0800","first-page":"H1551","article-title":"Cardiac effects of postconditioning depend critically on the duration of index ischemia","volume":"292","author":"Manintveld","year":"2007","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b0805","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000491775","article-title":"VEGF-A and VEGF-B coordinate the arteriogenesis to repair the infarcted heart with vagus nerve stimulation","volume":"48","author":"Lv","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b0810","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/jcmm.12049","article-title":"Vagal nerve stimulation protects cardiac injury by attenuating mitochondrial dysfunction in a murine burn injury model","volume":"17","author":"Lu","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.115094","article-title":"Transcutaneous auricular vagus nerve stimulation attenuates stroke-heart syndrome: The role of parasympathetic activity","volume":"385","author":"Wang","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bcp.2026.118551_b0820","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10741-010-9180-8","article-title":"TNFalpha in myocardial ischemia\/reperfusion, remodeling and heart failure","volume":"16","author":"Kleinbongard","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.bcp.2026.118551_b0825","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/jcp.24800","article-title":"Acetylcholine inhibits tumor necrosis factor alpha activated endoplasmic reticulum apoptotic pathway via EGFR-PI3K signaling in cardiomyocytes","volume":"230","author":"Miao","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b0830","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/FJC.0b013e31826c1c13","article-title":"M3-mAChR stimulation exerts anti-apoptotic effect via activating the HIF-1alpha\/HO-1\/VEGF signaling pathway in H9c2 rat ventricular cells","volume":"60","author":"Hui","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0835","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1002\/ehf2.14475","article-title":"Vagus nerve stimulation-induced stromal cell-derived factor-l alpha participates in angiogenesis and repair of infarcted hearts","volume":"10","author":"Wang","year":"2023","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.bcp.2026.118551_b0840","article-title":"Overexpression of SDF-1alpha enhanced migration and engraftment of cardiac stem cells and reduced infarcted size via CXCR4\/PI3K pathway","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118551_b0845","article-title":"Nicotinic agonist inhibits cardiomyocyte apoptosis in CVB3-induced myocarditis via alpha3beta4-nAChR\/PI3K\/Akt-dependent survivin upregulation","volume":"2019","author":"Li","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bcp.2026.118551_b0850","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3892\/etm.2022.11272","article-title":"Hypercholesterolemia attenuates cardioprotection of ischemic preconditioning and postconditioning with alpha7 nicotinic acetylcholine receptor agonist by enhancing inflammation and inhibiting the PI3K\/Akt\/eNOS pathway","volume":"23","author":"Wen","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0855","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(00)81166-6","article-title":"Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses","volume":"93","author":"Rodig","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bcp.2026.118551_b0860","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.aaw3242","article-title":"Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations","volume":"367","author":"Wilmes","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bcp.2026.118551_b0865","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41392-024-01934-w","article-title":"The JAK-STAT pathway: from structural biology to cytokine engineering","volume":"9","author":"Lv","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bcp.2026.118551_b0870","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/emboj\/20.1.91","article-title":"Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression","volume":"20","author":"Kovarik","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118551_b0875","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1016\/j.bpj.2011.10.006","article-title":"Activated STAT1 transcription factors conduct distinct saltatory movements in the cell nucleus","volume":"101","author":"Speil","year":"2011","journal-title":"Biophys. J ."},{"key":"10.1016\/j.bcp.2026.118551_b0880","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12872-025-04517-x","article-title":"Baricitinib represses the myocardial fibrosis via blocking JAK\/STAT and TGF-beta1 pathways in vivo and in vitro","volume":"25","author":"Feng","year":"2025","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.bcp.2026.118551_b0885","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/cvr\/cvx004","article-title":"JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate","volume":"113","author":"Chen","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0890","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejphar.2016.05.024","article-title":"Role of JAK-STAT pathway in reducing cardiomyocytes hypoxia\/reoxygenation injury induced by S1P postconditioning","volume":"784","author":"Wang","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0895","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10741-019-09822-0","article-title":"Pharmacological preconditioning with phosphodiestrase inhibitor: an answer to stem cell survival against ischemic injury through JAK\/STAT signaling","volume":"25","author":"Yadav","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.bcp.2026.118551_b0900","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/08923973.2024.2381759","article-title":"Citicoline modulates inflammatory signaling pathways in the spleen of rats exposed to gamma-radiation","volume":"46","author":"Abdel-Aziz","year":"2024","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.bcp.2026.118551_b0905","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.652767","article-title":"Dietary choline-enhanced skin immune response of juvenile grass carp might be related to the STAT3 and NF-kB signaling pathway (Ctenopharyngodon idella)","volume":"8","author":"Yuan","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bcp.2026.118551_b0910","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091150","article-title":"The cholinergic anti-inflammatory pathway attenuates the development of atherosclerosis in Apoe(-\/-) mice through modulating macrophage functions","volume":"9","author":"Qian","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bcp.2026.118551_b0915","doi-asserted-by":"crossref","first-page":"395a","DOI":"10.1016\/j.bpj.2023.11.2414","article-title":"Determinants for \u03b17nAChR-JAK2 coupling to enable cholinergic anti-inflammatory signaling","volume":"123","author":"Tillman","year":"2024","journal-title":"Biophys. J ."},{"key":"10.1016\/j.bcp.2026.118551_b0920","doi-asserted-by":"crossref","first-page":"C1294","DOI":"10.1152\/ajpcell.00160.2009","article-title":"Cholinergic agonists regulate JAK2\/STAT3 signaling to suppress endothelial cell activation","volume":"297","author":"Chatterjee","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b0925","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.hrthm.2017.09.039","article-title":"Sympathetic nerve blocks promote anti-inflammatory response by activating the JAK2-STAT3-mediated signaling cascade in rat myocarditis models: A novel mechanism with clinical implications","volume":"15","author":"Park","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bcp.2026.118551_b0930","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s10753-018-0759-x","article-title":"GTS-21 protected against LPS-induced sepsis myocardial injury in mice through alpha7nAChR","volume":"41","author":"Kong","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.bcp.2026.118551_b0935","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-026-03636-z","article-title":"Activation of alpha7nAChR prevents maladaptive right ventricular remodeling via inhibiting the recruitment of CCR2(+) macrophages in experimental pulmonary arterial hypertension","volume":"27","author":"Chen","year":"2026","journal-title":"Respir. Res."},{"key":"10.1016\/j.bcp.2026.118551_b0940","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/HYPERTENSIONAHA.110.160077","article-title":"Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension","volume":"57","author":"Li","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.bcp.2026.118551_b0945","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112719","article-title":"Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis","volume":"9","author":"Cheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118551_b0950","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fphar.2017.00025","article-title":"Right cervical vagotomy aggravates viral myocarditis in mice via the cholinergic anti-inflammatory pathway","volume":"8","author":"Li-Sha","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0955","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1080\/21505594.2018.1482179","article-title":"The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4(+) T cell differentiation","volume":"9","author":"De-Pu","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.bcp.2026.118551_b0960","doi-asserted-by":"crossref","first-page":"748","DOI":"10.7150\/ijbs.24576","article-title":"Activation of central alpha 7 nicotinic acetylcholine receptor reverses suppressed immune function of T lymphocytes and protects against sepsis lethality","volume":"14","author":"Ren","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b0965","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177983","article-title":"Ciprofol attenuates sepsis-induced cardiomyopathy via alpha7 nicotinic acetylcholine receptor-dependent modulation of myocardial inflammation and NF-kappaB\/STAT3 signaling","volume":"1003","author":"Zhou","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b0970","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/emmm.201201374","article-title":"Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype","volume":"4","author":"Cardilo-Reis","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b0975","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbrc.2021.12.094","article-title":"Activation of alpha7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition","volume":"590","author":"Wu","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b0980","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0293630","article-title":"GPER activation attenuates cardiac dysfunction by upregulating the SIRT1\/3-AMPK-UCP2 pathway in postmenopausal diabetic rats","volume":"18","author":"Azizian","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118551_b0985","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/CIRCULATIONAHA.115.018935","article-title":"SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction","volume":"133","author":"Lai","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.bcp.2026.118551_b0990","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118551_b0995","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00210-022-02284-6","article-title":"Citicoline and COVID-19: vis-\u00e0-vis conjectured","volume":"395","author":"Al-Kuraishy","year":"2022","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b1000","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrm.2017.110","article-title":"The mitochondrial UPR: mechanisms, physiological functions and implications in ageing","volume":"19","author":"Shpilka","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118551_b1005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2019.09.025","article-title":"Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy","volume":"145","author":"Xue","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1010","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1111\/jcmm.14363","article-title":"Eliciting alpha7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling","volume":"23","author":"Lin","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1015","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1111\/bph.14506","article-title":"Nicotinic ACh receptor alpha7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3","volume":"176","author":"Li","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b1020","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.redox.2017.11.012","article-title":"Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS\/NF\u03baB\/mTOR\/P70S6K signaling cascade","volume":"14","author":"Lu","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bcp.2026.118551_b1025","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1038\/s41598-017-12221-w","article-title":"Chebulinic acid inhibits smooth muscle cell migration by suppressing PDGF-Rbeta phosphorylation and inhibiting matrix metalloproteinase-2 expression","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118551_b1030","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0008-6363(98)00232-6","article-title":"Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases","volume":"41","author":"Cospedal","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bcp.2026.118551_b1035","first-page":"H369","article-title":"AMP-activated protein kinase inhibits vascular smooth muscle cell proliferation and migration and vascular remodeling following injury","volume":"304","author":"Stone","year":"2013","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b1040","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1016\/j.bpj.2023.06.004","article-title":"Modeling IP(3)-induced Ca(2+) signaling based on its interspike interval statistics","volume":"122","author":"Friedhoff","year":"2023","journal-title":"Biophys. J ."},{"key":"10.1016\/j.bcp.2026.118551_b1045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216857120","article-title":"Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors","volume":"120","author":"Fujii","year":"2023","journal-title":"PNAS"},{"key":"10.1016\/j.bcp.2026.118551_b1050","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41467-022-29073-2","article-title":"Structural basis for activation and gating of IP(3) receptors","volume":"13","author":"Schmitz","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b1055","first-page":"H95","article-title":"IP(3)-mediated Ca(2+) release regulates atrial Ca(2+) transients and pacemaker function by stimulation of adenylyl cyclases","volume":"320","author":"Capel","year":"2021","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b1060","doi-asserted-by":"crossref","first-page":"23961","DOI":"10.1074\/jbc.272.38.23961","article-title":"Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes","volume":"272","author":"Perez","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bcp.2026.118551_b1065","doi-asserted-by":"crossref","DOI":"10.3390\/biom14101334","article-title":"Potential roles of IP(3) receptors and calcium in programmed cell death and implications in cardiovascular diseases","volume":"14","author":"Piamsiri","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.bcp.2026.118551_b1070","first-page":"275","article-title":"Effects of CDP-choline administration on receptor-stimulated inositol phospholipid hydrolysis in brain slices and neuronal cultures","volume":"7","author":"Canonico","year":"1992","journal-title":"Funct. Neurol."},{"key":"10.1016\/j.bcp.2026.118551_b1075","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.celrep.2018.12.051","article-title":"Choline Is an intracellular messenger linking extracellular stimuli to IP3-evoked Ca2+ signals through sigma-1 receptors","volume":"26","author":"Brailoiu","year":"2019","journal-title":"Cell Rep."},{"issue":"Suppl 12","key":"10.1016\/j.bcp.2026.118551_b1080","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1097\/00005344-199204002-00034","article-title":"Calcium activation of hyperpolarization response to acetylcholine in coronary endothelial cells","volume":"20","author":"Cheung","year":"1992","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b1085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00424-007-0379-z","article-title":"Acetylcholine-induced Ca2+ oscillations are modulated by a Ca2+ regulation of InsP3R2 in rat portal vein myocytes","volume":"456","author":"Fritz","year":"2008","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.bcp.2026.118551_b1090","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.ATV.0000089013.82552.5D","article-title":"Crucial role of type 2 inositol 1,4,5-trisphosphate receptors for acetylcholine-induced Ca2+ oscillations in vascular myocytes","volume":"23","author":"Morel","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2026.118551_b1095","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ceca.2015.06.005","article-title":"CaMKII regulates intracellular Ca(2)(+) dynamics in native endothelial cells","volume":"58","author":"Toussaint","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcp.2026.118551_b1100","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1113\/JP271157","article-title":"Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium","volume":"593","author":"Wilson","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b1105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2019.102108","article-title":"Hydrogen peroxide depolarizes mitochondria and inhibits IP(3)-evoked Ca(2+) release in the endothelium of intact arteries","volume":"84","author":"Zhang","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bcp.2026.118551_b1110","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/ATVBAHA.115.305469","article-title":"Reduction of mitochondria-endoplasmic reticulum interactions by acetylcholine protects human umbilical vein endothelial cells from hypoxia\/reoxygenation injury","volume":"35","author":"He","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bcp.2026.118551_b1115","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3892\/etm.2012.573","article-title":"Role of acetylcholine and calcium ions in three vascular contraction models: Angiotensin II, phenylephrine and caffeine","volume":"4","author":"Szadujkis-Szadurska","year":"2012","journal-title":"Exp. Ther. Med."},{"issue":"Pt 2","key":"10.1016\/j.bcp.2026.118551_b1120","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj3320459","article-title":"Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs\/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart","volume":"332","author":"Lazou","year":"1998","journal-title":"Biochem. J"},{"key":"10.1016\/j.bcp.2026.118551_b1125","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/emboj\/16.8.1901","article-title":"Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase","volume":"16","author":"Fukuda","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bcp.2026.118551_b1130","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/msb.2010.121","article-title":"Substrate-dependent control of MAPK phosphorylation in vivo","volume":"7","author":"Kim","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bcp.2026.118551_b1135","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s11064-005-7201-0","article-title":"Citicoline inhibits MAP kinase signalling pathways after focal cerebral ischaemia","volume":"30","author":"Krupinski","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bcp.2026.118551_b1140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2045-824X-4-20","article-title":"Citicoline induces angiogenesis improving survival of vascular\/human brain microvessel endothelial cells through pathways involving ERK1\/2 and insulin receptor substrate-1","volume":"4","author":"Krupinski","year":"2012","journal-title":"Vasc. Cell"},{"key":"10.1016\/j.bcp.2026.118551_b1145","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8604723","article-title":"Combination of neuroprotective and regenerative agents for AGE-induced retinal degeneration: In vitro study","volume":"2017","author":"Bikbova","year":"2017","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.bcp.2026.118551_b1150","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00210-012-0740-4","article-title":"Choline inhibits angiotensin II-induced cardiac hypertrophy by intracellular calcium signal and p38 MAPK pathway","volume":"385","author":"Wang","year":"2012","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b1155","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1479-5876-11-209","article-title":"Upregulation of M(3) muscarinic receptor inhibits cardiac hypertrophy induced by angiotensin II","volume":"11","author":"Liu","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1160","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2119\/molmed.2017.00091","article-title":"Nicotinic acetylcholine receptor-mediated protection of the rat heart exposed to ischemia reperfusion","volume":"23","author":"Mavropoulos","year":"2017","journal-title":"Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1165","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijcard.2012.01.015","article-title":"Increase in cardiac M2-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats","volume":"167","author":"Mar","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b1170","first-page":"H810","article-title":"Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress","volume":"294","author":"LaCroix","year":"2008","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b1175","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neulet.2008.06.003","article-title":"Increase of cardiac M2-muscarinic receptor gene expression in type-1 but not in type-2 diabetic rats","volume":"441","author":"Lee","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bcp.2026.118551_b1180","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41580-018-0040-z","article-title":"Regulation of proteasome assembly and activity in health and disease","volume":"19","author":"Rousseau","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bcp.2026.118551_b1185","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1038\/s12276-023-01087-w","article-title":"Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases","volume":"55","author":"Jeong","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1190","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1208153","article-title":"The double-hit protocol induces HFpEF and impairs myocardial ubiquitin-proteasome system performance in FVB\/N mice","volume":"14","author":"Lira","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bcp.2026.118551_b1195","first-page":"H1385","article-title":"Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload","volume":"295","author":"Hedhli","year":"2008","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.bcp.2026.118551_b1200","first-page":"6","article-title":"Upregulation of proteasome activity rescues cardiomyocytes following pulse treatment with a proteasome inhibitor","volume":"4","author":"Wang","year":"2014","journal-title":"Am J Cardiovasc Dis"},{"key":"10.1016\/j.bcp.2026.118551_b1205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00395-021-00861-z","article-title":"Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning","volume":"116","author":"Hirschhauser","year":"2021","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bcp.2026.118551_b1210","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1476-5381.2009.00606.x","article-title":"Activation of cardiac muscarinic M3 receptors induces delayed cardioprotection by preserving phosphorylated connexin43 and up-regulating cyclooxygenase-2 expression","volume":"159","author":"Zhao","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bcp.2026.118551_b1215","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000092074","article-title":"Ischemia impairs the association between connexin 43 and M3 subtype of acetylcholine muscarinic receptor (M3-mAChR) in ventricular myocytes","volume":"17","author":"Yue","year":"2006","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bcp.2026.118551_b1220","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2025.102745","article-title":"MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases","volume":"36","author":"Alaei","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bcp.2026.118551_b1225","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature03049","article-title":"Processing of primary microRNAs by the Microprocessor complex","volume":"432","author":"Denli","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118551_b1230","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/s12276-024-01202-5","article-title":"Experimental capture of miRNA targetomes: disease-specific 3'UTR library-based miRNA targetomics for Parkinson's disease","volume":"56","author":"Hart","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1235","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41586-021-04234-3","article-title":"MicroRNA sequence codes for small extracellular vesicle release and cellular retention","volume":"601","author":"Garcia-Martin","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bcp.2026.118551_b1240","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ncrna.2025.08.001","article-title":"Stability of microRNAs in serum and plasma reveal promise as a circulating biomarker","volume":"15","author":"Katayama","year":"2025","journal-title":"Noncoding RNA Res"},{"key":"10.1016\/j.bcp.2026.118551_b1245","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/s41416-024-02831-3","article-title":"Circulating miRNA panels as a novel non-invasive diagnostic, prognostic, and potential predictive biomarkers in non-small cell lung cancer (NSCLC)","volume":"131","author":"Abdipourbozorgbaghi","year":"2024","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bcp.2026.118551_b1250","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12964-020-00624-8","article-title":"Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem\/stromal cells","volume":"18","author":"Li","year":"2020","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.bcp.2026.118551_b1255","doi-asserted-by":"crossref","first-page":"12239","DOI":"10.18632\/aging.103855","article-title":"Extracellular-vesicle containing miRNA-503-5p released by macrophages contributes to atherosclerosis","volume":"13","author":"Wang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bcp.2026.118551_b1260","article-title":"MicroRNA-221 protects myocardial contractility in myocardial ischemia\/reperfusion injury through phospholamban","volume":"20","author":"Li","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118551_b1265","doi-asserted-by":"crossref","first-page":"46259","DOI":"10.1038\/srep46259","article-title":"Over-expression of microRNA-1 causes arrhythmia by disturbing intracellular trafficking system","volume":"7","author":"Su","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bcp.2026.118551_b1270","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ncomms2090","article-title":"The miRNA-212\/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy","volume":"3","author":"Ucar","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bcp.2026.118551_b1275","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12872-022-02714-6","article-title":"MicroRNA expression profiles in familial hypertrophic cardiomyopathy with myosin-binding protein C3 (MYBPC3) gene mutations","volume":"22","author":"Lin","year":"2022","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.bcp.2026.118551_b1280","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12265-017-9750-4","article-title":"Various regulatory modes for circadian rhythmicity and sexual dimorphism in the non-neuronal cardiac cholinergic system","volume":"10","author":"Oikawa","year":"2017","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.bcp.2026.118551_b1285","article-title":"M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p","volume":"7","author":"Pan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bcp.2026.118551_b1290","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1111\/jcmm.14474","article-title":"miR-499 released during myocardial infarction causes endothelial injury by targeting alpha7-nAchR","volume":"23","author":"Zhou","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bcp.2026.118551_b1295","doi-asserted-by":"crossref","first-page":"143","DOI":"10.21037\/cdt-23-309","article-title":"M(3) subtype of muscarinic acetylcholine receptor inhibits cardiac fibrosis via targeting microRNA-29b\/beta-site app cleaving enzyme 1 axis","volume":"14","author":"Li","year":"2024","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.bcp.2026.118551_b1300","doi-asserted-by":"crossref","first-page":"295","DOI":"10.7150\/ijbs.5976","article-title":"Choline protects against cardiac hypertrophy induced by increased after-load","volume":"9","author":"Zhao","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bcp.2026.118551_b1305","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1161\/ATVBAHA.120.314333","article-title":"Aging-associated miR-217 aggravates atherosclerosis and promotes cardiovascular dysfunction","volume":"40","author":"de Yebenes","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Biochemical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006295226008944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T19:52:37Z","timestamp":1792871557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006295226008944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":261,"alternative-id":["S0006295226008944"],"URL":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118551","relation":{},"ISSN":["0006-2952"],"issn-type":[{"value":"0006-2952","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Citicoline in cardiovascular protection: mechanistic roles of choline and acetylcholine","name":"articletitle","label":"Article Title"},{"value":"Biochemical Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bcp.2026.118551","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118551"}}