{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:26:40Z","timestamp":1792193200874,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.beem.2005.07.004","type":"journal-article","created":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T08:49:43Z","timestamp":1133254183000},"page":"471-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":316,"title":["Human fat cell lipolysis: Biochemistry, regulation and clinical role"],"prefix":"10.1016","volume":"19","author":[{"given":"Peter","family":"Arner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beem.2005.07.004_bib1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/sj.ijo.0802326","article-title":"Integrative physiology of human adipose tissue","volume":"27","author":"Frayn","year":"2003","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1016\/j.beem.2005.07.004_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S1043-2760(03)00024-9","article-title":"The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones","volume":"14","author":"Arner","year":"2003","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"supplement 8A","key":"10.1016\/j.beem.2005.07.004_bib3","doi-asserted-by":"crossref","first-page":"29S","DOI":"10.1016\/j.amjmed.2003.09.004","article-title":"Free fatty acids and type 2 diabetes mellitus","volume":"115","author":"Wyne","year":"2003","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/j.beem.2005.07.004_bib4","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1042\/bst0311115","article-title":"The glucose-fatty acid cycle: a physiological perspective","volume":"31","author":"Frayn","year":"2003","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.beem.2005.07.004_bib5","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1042\/bst0311125","article-title":"Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase","volume":"31","author":"Forest","year":"2003","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.beem.2005.07.004_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.tem.2003.10.001","article-title":"Conversion from white to brown adipocytes: a strategy for the control of fat mass?","volume":"14","author":"Tiraby","year":"2003","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.beem.2005.07.004_bib7","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1042\/bst0311120","article-title":"Molecular mechanisms regulating hormone-sensitive lipase and lipolysis","volume":"31","author":"Holm","year":"2003","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.beem.2005.07.004_bib8","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.beem.2005.07.004_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-4899-1928-1_15","article-title":"Mechanisms regulating adipocyte lipolysis","volume":"441","author":"Carey","year":"1998","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.beem.2005.07.004_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1055\/s-2007-978670","article-title":"Millennium fat-cell lipolysis reveals unsuspected novel tracks","volume":"32","author":"Langin","year":"2000","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.beem.2005.07.004_bib11","first-page":"86","article-title":"Recent data on the regulation of lipolysis by catecholamines and natriuretic peptides","volume":"63","author":"Lafontan","year":"2002","journal-title":"Annales D'endocrinologie(Paris)"},{"key":"10.1016\/j.beem.2005.07.004_bib12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1262-3636(07)70121-0","article-title":"Metabolism of lipids in human white adipocyte","volume":"30","author":"Large","year":"2004","journal-title":"Diabetes and Metabolism"},{"key":"10.1016\/j.beem.2005.07.004_bib13","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00125-002-0945-z","article-title":"Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans","volume":"45","author":"Bjornholm","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.beem.2005.07.004_bib14","first-page":"167","article-title":"Methods to study phosphorylation and activation of the hormone-sensitive adipocyte phosphodiesterase type 3B in rat adipocytes","volume":"155","author":"Degerman","year":"2001","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.beem.2005.07.004_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0952-3278(92)90235-B","article-title":"Release and effects of prostaglandins in adipose tissue","volume":"47","author":"Richelsen","year":"1992","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"issue":"supplement 1","key":"10.1016\/j.beem.2005.07.004_bib16","first-page":"S57","article-title":"Adenosine, prostaglandins and phosphodiesterase as targets for obesity pharmacotherapy","volume":"17","author":"Arner","year":"1993","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"10.1016\/j.beem.2005.07.004_bib17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1210\/jc.2003-031005","article-title":"Adipocytokines and insulin resistance","volume":"89","author":"Pittas","year":"2004","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.beem.2005.07.004_bib18","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2174\/1566524053766022","article-title":"Insulin resistance in type 2 diabetes\u2014role of the adipokines","volume":"5","author":"Arner","year":"2005","journal-title":"Current Molecular Medicine"},{"key":"10.1016\/j.beem.2005.07.004_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/15216540400009968","article-title":"The central role of perilipin a in lipid metabolism and adipocyte lipolysis","volume":"56","author":"Tansey","year":"2004","journal-title":"IUBMB Life"},{"key":"10.1016\/j.beem.2005.07.004_bib20","doi-asserted-by":"crossref","first-page":"B135","DOI":"10.1093\/geronj\/49.4.B135","article-title":"Aging and hormone-sensitive lipolysis: reconciling the literature","volume":"49","author":"Gregerman","year":"1994","journal-title":"The Journals of Gerontology"},{"key":"10.1016\/j.beem.2005.07.004_bib21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1520-7560(200005\/06)16:3<202::AID-DMRR116>3.0.CO;2-#","article-title":"Lipid metabolism in the fetus and the newborn","volume":"16","author":"Herrera","year":"2000","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"10.1016\/j.beem.2005.07.004_bib22","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1038\/sj.ejcn.1601033","article-title":"Lipid metabolism in the elderly","volume":"54","author":"Toth","year":"2000","journal-title":"European Journal of Clinical Nutrition"},{"key":"10.1016\/j.beem.2005.07.004_bib23","first-page":"499","article-title":"Gender differences in fat metabolism","volume":"4","author":"Blaak","year":"2001","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.beem.2005.07.004_bib24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2002.tb04267.x","article-title":"Modulation of lipid metabolism by energy status of adipocytes: implications for insulin sensitivity","volume":"967","author":"Kopecky","year":"2002","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.beem.2005.07.004_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1600-0838.2004.381.x","article-title":"Fat metabolism in exercise\u2014with special reference to training and growth hormone administration","volume":"14","author":"Lange","year":"2004","journal-title":"Scandinavian Journal of Medicine and Science in Sports"},{"key":"10.1016\/j.beem.2005.07.004_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0733-8651(05)70229-0","article-title":"Exercise in weight management of obesity","volume":"19","author":"Poirier","year":"2001","journal-title":"Cardiology Clinics"},{"key":"10.1016\/j.beem.2005.07.004_bib27","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(05)79052-8","article-title":"Not all fat is alike","volume":"351","author":"Arner","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.beem.2005.07.004_bib28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1055\/s-2002-38256","article-title":"Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome","volume":"34","author":"Wajchenberg","year":"2002","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.beem.2005.07.004_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0165-6147(03)00132-9","article-title":"Do regional differences in adipocyte biology provide new pathophysiological insights?","volume":"24","author":"Lafontan","year":"2003","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.beem.2005.07.004_bib30","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2337\/diabetes.51.7.2029","article-title":"Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes","volume":"51","author":"van Harmelen","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.beem.2005.07.004_bib31","first-page":"239","article-title":"Cultures of human adipose precursor cells","volume":"155","author":"Hauner","year":"2001","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.beem.2005.07.004_bib32","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3109\/07853890108995964","article-title":"Genetic variance and lipolysis regulation: implications for obesity","volume":"33","author":"Arner","year":"2001","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.beem.2005.07.004_bib33","first-page":"409","article-title":"Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia","volume":"24","author":"Large","year":"1998","journal-title":"Diabetes and Metabolism"},{"issue":"supplement","key":"10.1016\/j.beem.2005.07.004_bib34","first-page":"26","article-title":"Lipolysis in human adipocytes, effects of cell size, age and of regional differences","volume":"19","author":"Engfeldt","year":"1988","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.beem.2005.07.004_bib35","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/BF03344051","article-title":"Metabolic impact of body fat distribution","volume":"25","author":"Gasteyger","year":"2002","journal-title":"Journal of Endocrinological Investigation"},{"key":"10.1016\/j.beem.2005.07.004_bib36","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0899-9007(02)01003-1","article-title":"Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots","volume":"19","author":"Misra","year":"2003","journal-title":"Nutrition"},{"key":"10.1016\/j.beem.2005.07.004_bib37","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1172\/JCI21047","article-title":"Splanchnic lipolysis in human obesity","volume":"113","author":"Nielsen","year":"2004","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.beem.2005.07.004_bib38","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/07853890410035296","article-title":"Insulin resistance in patients with polycystic ovary syndrome","volume":"36","author":"Schroder","year":"2004","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.beem.2005.07.004_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biochi.2004.11.012","article-title":"Effects of testosterone on fat cell lipolysis. Species differences and possible role in polycystic ovarian syndrome","volume":"87","author":"Arner","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.beem.2005.07.004_bib40","first-page":"1291","article-title":"Molecular defects of insulin action in the polycystic ovary syndrome: possible tissue specificity","volume":"13","author":"Ciaraldi","year":"2000","journal-title":"Journal of Pediatric Endocrinology and Metabolism"},{"key":"10.1016\/j.beem.2005.07.004_bib41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2310\/6650.2001.34108","article-title":"Central role of the adipocyte in the metabolic syndrome","volume":"49","author":"Bergman","year":"2001","journal-title":"Journal of Investigative Medicine"},{"key":"10.1016\/j.beem.2005.07.004_bib42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00041433-199704000-00006","article-title":"Is familial combined hyperlipidaemia a genetic disorder of adipose tissue?","volume":"8","author":"Arner","year":"1997","journal-title":"Current Opinion in Lipidology"},{"key":"10.1016\/j.beem.2005.07.004_bib43","first-page":"271","article-title":"Identification of a nicotinic acid receptor: is this the molecular target for the oldest lipid-lowering drug?","volume":"5","author":"Pike","year":"2004","journal-title":"Current Opinion in Investigational Drugs"},{"key":"10.1016\/j.beem.2005.07.004_bib44","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1002\/dmrr.249","article-title":"The mode of action of thiazolidinediones","volume":"18","author":"Hauner","year":"2002","journal-title":"Diabetes\/Metabolism Research and Reviews"}],"container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X0500045X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X0500045X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:37:29Z","timestamp":1761496649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X0500045X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S1521690X0500045X"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2005.07.004","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human fat cell lipolysis: Biochemistry, regulation and clinical role","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2005.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}