{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:05:22Z","timestamp":1790885122914,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.beem.2008.10.012","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T04:23:52Z","timestamp":1236831832000},"page":"87-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["The role of the pancreatic endocannabinoid system in glucose metabolism"],"prefix":"10.1016","volume":"23","author":[{"given":"Francisco J.","family":"Berm\u00fadez-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Su\u00e1rez P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Nadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beem.2008.10.012_bib1","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1056\/NEJMoa072515","article-title":"Childhood body-mass index and the risk of coronary heart disease in adulthood","volume":"357","author":"Baker","year":"2007","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.beem.2008.10.012_bib2","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1056\/NEJMsa073166","article-title":"Adolescent overweight and future adult coronary heart disease","volume":"357","author":"Bibbins-Domingo","year":"2007","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.beem.2008.10.012_bib3","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jhep.2007.03.003","article-title":"Pediatric nonalcoholic fatty liver disease (NAFLD): a \u2018growing\u2019 problem?","volume":"46","author":"Roberts","year":"2007","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.beem.2008.10.012_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/138955707779317812","article-title":"Cannabinoid receptor antagonists and the metabolic syndrome: novel promising therapeutical approaches","volume":"7","author":"Cervino","year":"2007","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.beem.2008.10.012_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tem.2006.11.006","article-title":"Endocannabinoids and the control of energy balance","volume":"18","author":"Matias","year":"2007","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"key":"10.1016\/j.beem.2008.10.012_bib6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nn1457","article-title":"Endocannabinoid control of food intake and energy balance","volume":"8","author":"Di Marzo","year":"2005","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.beem.2008.10.012_bib7","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(05)66374-X","article-title":"Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study","volume":"365","author":"Van Gaal","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.beem.2008.10.012_bib8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1001\/jama.295.7.761","article-title":"Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial","volume":"295","author":"Pi-Sunyer","year":"2006","journal-title":"JAMA: The\u00a0Journal of the American Medical Association"},{"key":"10.1016\/j.beem.2008.10.012_bib9","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa044537","article-title":"Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia","volume":"353","author":"Despr\u00e9s","year":"2005","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.beem.2008.10.012_bib10","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/S0140-6736(06)69571-8","article-title":"Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study","volume":"368","author":"Scheen","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.beem.2008.10.012_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cmet.2007.11.012","article-title":"The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake","volume":"7","author":"Addy","year":"2008","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.beem.2008.10.012_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/er.2006-0007","article-title":"Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains","volume":"28","author":"Gromada","year":"2007","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.beem.2008.10.012_bib13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1469-7793.2000.00509.x","article-title":"Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels","volume":"528","author":"G\u00f6pel","year":"2000","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.beem.2008.10.012_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1469-7793.1999.0085z.x","article-title":"Homologous and heterologous asynchronicity between identified alpha-, beta- and delta-cells within intact islets of Langerhans in the mouse","volume":"517","author":"Nadal","year":"1999","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.beem.2008.10.012_bib15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ncb1563","article-title":"R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion","volume":"9","author":"Zhang","year":"2007","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.beem.2008.10.012_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1113\/jphysiol.2003.059675","article-title":"Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans","volume":"556","author":"G\u00f6pel","year":"2004","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.beem.2008.10.012_bib17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1007\/s00125-005-1878-0","article-title":"Alpha cell function in health and disease: influence of glucagon-like peptide-1","volume":"48","author":"Dunning","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.beem.2008.10.012_bib18","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/BF02221678","article-title":"Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats. A study with the isolated perfused rat pancreas in vitro","volume":"35","author":"Kurose","year":"1992","journal-title":"Diabetologia"},{"key":"10.1016\/j.beem.2008.10.012_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0079-6107(89)90013-8","article-title":"Electrophysiology of the pancreatic beta-cell","volume":"54","author":"Ashcroft","year":"1989","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"10.1016\/j.beem.2008.10.012_bib20","first-page":"72","article-title":"The Cell Physiology of Biphasic Insulin Secretion","volume":"15","author":"Rorsman","year":"2000","journal-title":"News in Physiological Sciences"},{"key":"10.1016\/j.beem.2008.10.012_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0014-5793(00)01631-8","article-title":"Synchronous glucose-dependent [Ca(2+)](i) oscillations in mouse pancreatic islets of Langerhans recorded in vivo","volume":"477","author":"Fernandez","year":"2000","journal-title":"FEBS Letters"},{"key":"10.1016\/j.beem.2008.10.012_bib22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00550880","article-title":"Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets","volume":"418","author":"Santos","year":"1991","journal-title":"Pfl\u00fcgers Archiv: European Journal of Physiology"},{"key":"10.1016\/j.beem.2008.10.012_bib23","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/diab.42.8.1210","article-title":"Fluorescence digital image analysis of glucose-induced [Ca2+]i oscillations in mouse pancreatic islets of Langerhans","volume":"42","author":"Valdeolmillos","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.beem.2008.10.012_bib24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/bbrc.1996.1622","article-title":"Real time electrochemical detection of 5-HT\/insulin secretion from single pancreatic islets: effect of glucose and K+ depolarization","volume":"228","author":"Barbosa","year":"1996","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.beem.2008.10.012_bib25","doi-asserted-by":"crossref","first-page":"22265","DOI":"10.1016\/S0021-9258(18)41522-0","article-title":"Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets","volume":"268","author":"Gilon","year":"1993","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.beem.2008.10.012_bib26","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00268-006-0719-8","article-title":"Islet vasculature as a regulator of endocrine pancreas function","volume":"31","author":"Ballian","year":"2007","journal-title":"World Journal of Surgery"},{"key":"10.1016\/j.beem.2008.10.012_bib27","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1073\/pnas.0510790103","article-title":"The unique cytoarchitecture of human pancreatic islets has implications for islet cell function","volume":"103","author":"Cabrera","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.beem.2008.10.012_bib28","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/00006676-200408000-00019","article-title":"Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments","volume":"29","author":"Kiba","year":"2004","journal-title":"Pancreas"},{"key":"10.1016\/j.beem.2008.10.012_bib29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02784941","article-title":"Neural regulation of the endocrine pancreas","volume":"18","author":"Brunicardi","year":"1995","journal-title":"International Journal of Pancreatology"},{"key":"10.1016\/j.beem.2008.10.012_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00006676-199901000-00008","article-title":"Morphology and histochemistry of the rabbit pancreatic innervation","volume":"18","author":"Love","year":"1999","journal-title":"Pancreas"},{"key":"10.1016\/j.beem.2008.10.012_bib31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1177\/23.9.126256","article-title":"Enzymes of the cholinergic system in islets of Langerhans","volume":"23","author":"Godfrey","year":"1975","journal-title":"The Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.beem.2008.10.012_bib32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1292\/jvms.58.243","article-title":"Anatomical localization of sympathetic postganglionic and sensory neurons innervating the pancreas of the cat","volume":"58","author":"Furuzawa","year":"1996","journal-title":"The Journal of Veterinary Medical Science \/ The Japanese Society of Veterinary Science"},{"key":"10.1016\/j.beem.2008.10.012_bib33","first-page":"E785","article-title":"Nonadrenergic sympathetic neural influences on basal pancreatic hormone secretion","volume":"255","author":"Dunning","year":"1988","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/j.beem.2008.10.012_bib34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1210\/endo-121-1-332","article-title":"Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 2. Effects on basal release of somatostatin and pancreatic polypeptide","volume":"121","author":"Ahr\u00e9n","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2008.10.012_bib35","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/0006-2952(86)90733-1","article-title":"Pancreatic islet arachidonic acid turnover and metabolism and insulin release in response to delta-9-tetrahydrocannabinol","volume":"35","author":"Laychock","year":"1986","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.beem.2008.10.012_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ceca.2005.10.005","article-title":"Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell","volume":"39","author":"Juan-Pic\u00f3","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.beem.2008.10.012_bib37","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2005-2679","article-title":"Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia","volume":"91","author":"Matias","year":"2006","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.beem.2008.10.012_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.regpep.2007.08.009","article-title":"Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors","volume":"145","author":"Nakata","year":"2008","journal-title":"Regulatory Peptides"},{"key":"10.1016\/j.beem.2008.10.012_bib39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejphar.2007.02.066","article-title":"Role of cannabinoid CB2 receptors in glucose homeostasis in rats","volume":"565","author":"Bermudez-Silva","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.beem.2008.10.012_bib40","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/oby.2007.106","article-title":"Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet","volume":"16","author":"Starowicz","year":"2008","journal-title":"Obesity (Silver Spring, Md.)"},{"key":"10.1016\/j.beem.2008.10.012_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s00125-007-0890-y","article-title":"Presence of functional cannabinoid receptors in human endocrine pancreas","volume":"51","author":"Berm\u00fadez-Silva","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.beem.2008.10.012_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.bbrc.2008.05.077","article-title":"The cannabinoid CB1 receptor is expressed in pancreatic delta-cells","volume":"372","author":"Tharp","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.beem.2008.10.012_bib43","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jneumeth.2008.02.014","article-title":"Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!","volume":"171","author":"Grimsey","year":"2008","journal-title":"Journal of Neuroscience Methods"},{"key":"10.1016\/j.beem.2008.10.012_bib44","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00125-002-0827-4","article-title":"Graft vascular function after transplantation of pancreatic islets","volume":"45","author":"Jansson","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.beem.2008.10.012_bib45","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/gut.22.2.158","article-title":"The pancreas as a single organ: the influence of the endocrine upon the exocrine part of the gland","volume":"22","author":"Henderson","year":"1981","journal-title":"Gut"},{"key":"10.1016\/j.beem.2008.10.012_bib46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1160\/TH05-06-0413","article-title":"Regulation by cannabinoid receptors of anandamide transport across the blood-brain barrier and through other endothelial cells","volume":"95","author":"Maccarrone","year":"2006","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.beem.2008.10.012_bib47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.molbrainres.2004.08.025","article-title":"Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors","volume":"132","author":"Golech","year":"2004","journal-title":"Brain Research Molecular Brain Research"},{"key":"10.1016\/j.beem.2008.10.012_bib48","doi-asserted-by":"crossref","first-page":"9612","DOI":"10.1523\/JNEUROSCI.22-21-09612.2002","article-title":"A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding","volume":"22","author":"G\u00f3mez","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.beem.2008.10.012_bib49","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0306-4522(98)00524-7","article-title":"Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study","volume":"90","author":"Hohmann","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.beem.2008.10.012_bib50","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1172\/JCI17725","article-title":"The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis","volume":"112","author":"Cota","year":"2003","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.beem.2008.10.012_bib51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/sj.ijo.0802847","article-title":"Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)\/Lep(ob) mice","volume":"29","author":"Liu","year":"2005","journal-title":"International Journal of Obesity (2005)"},{"key":"10.1016\/j.beem.2008.10.012_bib52","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI200523057","article-title":"Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity","volume":"115","author":"Osei-Hyiaman","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.beem.2008.10.012_bib53","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.2337\/diabetes.54.10.2838","article-title":"Activation of the peripheral endocannabinoid system in human obesity","volume":"54","author":"Engeli","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.beem.2008.10.012_bib54","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2337\/dc08-0386","article-title":"The SERENADE Trial: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight and lipid profile in drug-naive type 2 diabetes","volume":"31","author":"Rosenstock","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.beem.2008.10.012_bib55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/abio.2000.4509","article-title":"Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry","volume":"280","author":"Giuffrida","year":"2000","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.beem.2008.10.012_bib56","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejphar.2005.12.016","article-title":"Activation of cannabinoid CB1 receptors induces glucose intolerance in rats","volume":"531","author":"Berm\u00fadez-Silva","year":"2006","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.beem.2008.10.012_bib57","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1021\/bi060163l","article-title":"Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids","volume":"45","author":"Leung","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.beem.2008.10.012_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/35102582","article-title":"An anorexic lipid mediator regulated by feeding","volume":"414","author":"Rodr\u00edguez de Fonseca","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.beem.2008.10.012_bib59","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1079\/BJN20041256","article-title":"Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide","volume":"92","author":"Cani","year":"2004","journal-title":"The British Journal of Nutrition"},{"key":"10.1016\/j.beem.2008.10.012_bib60","doi-asserted-by":"crossref","first-page":"E923","DOI":"10.1152\/ajpendo.00555.2004","article-title":"Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways","volume":"289","author":"Gonz\u00e1lez-Yanes","year":"2005","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.beem.2008.10.012_bib61","doi-asserted-by":"crossref","first-page":"27849","DOI":"10.1074\/jbc.M404087200","article-title":"Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha)","volume":"279","author":"Guzm\u00e1n","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.beem.2008.10.012_bib62","doi-asserted-by":"crossref","first-page":"8898","DOI":"10.1073\/pnas.95.15.8898","article-title":"Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells","volume":"95","author":"Zhou","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.beem.2008.10.012_bib63","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1210\/en.2004-0667","article-title":"Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation","volume":"146","author":"Gremlich","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2008.10.012_bib64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents","volume":"3","author":"Overton","year":"2006","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.beem.2008.10.012_bib65","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1210\/en.2006-1608","article-title":"A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release","volume":"148","author":"Chu","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2008.10.012_bib66","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbrc.2004.06.149","article-title":"Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats","volume":"321","author":"Akiba","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.beem.2008.10.012_bib67","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.bbrc.2004.11.120","article-title":"Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor","volume":"326","author":"Soga","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.beem.2008.10.012_bib68","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.0711278105","article-title":"GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current","volume":"105","author":"Lauckner","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X08001425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X08001425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:40:17Z","timestamp":1761496817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X08001425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S1521690X08001425"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2008.10.012","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of the pancreatic endocannabinoid system in glucose metabolism","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2008.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}