{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:11Z","timestamp":1790802791384,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.beem.2015.09.001","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T15:08:32Z","timestamp":1442070512000},"page":"761-772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Corticosteroid-binding globulin: Modulating mechanisms of bioavailability of cortisol and its clinical implications"],"prefix":"10.1016","volume":"29","author":[{"given":"Yoon Ju","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Kratzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beem.2015.09.001_bib1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cccn.2005.03.044","article-title":"Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin","volume":"359","author":"Lewis","year":"2005","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1210\/edrv-10-3-232","article-title":"The free hormone hypothesis: a physiologically based mathematical model","volume":"10","author":"Mendel","year":"1989","journal-title":"Endocr Rev"},{"key":"10.1016\/j.beem.2015.09.001_bib3","first-page":"457","article-title":"The serum transport of steroid hormones","volume":"38","author":"Siiteri","year":"1982","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.beem.2015.09.001_bib4","doi-asserted-by":"crossref","first-page":"e113402","DOI":"10.1371\/journal.pone.0113402","article-title":"Towards engineering hormone-binding globulins as drug delivery agents","volume":"9","author":"Chan","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.beem.2015.09.001_bib5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jmb.2008.05.012","article-title":"The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release","volume":"380","author":"Zhou","year":"2008","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.beem.2015.09.001_bib6","doi-asserted-by":"crossref","first-page":"29594","DOI":"10.1074\/jbc.M705014200","article-title":"Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release","volume":"282","author":"Klieber","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib7","doi-asserted-by":"crossref","first-page":"16163","DOI":"10.1074\/jbc.M110.171082","article-title":"Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins","volume":"286","author":"Qi","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0960-0760(91)90305-O","article-title":"Interaction of human CBG with cell membranes","volume":"40","author":"Strel'chyonok","year":"1991","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2015.09.001_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1749-6632.1988.tb48859.x","article-title":"Are corticosteroid-binding globulin and sex hormone-binding globulin hormones?","volume":"538","author":"Rosner","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.beem.2015.09.001_bib10","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0006-291X(88)81329-9","article-title":"Induction of adenylate cyclase in a mammary carcinoma cell line by human corticosteroid-binding globulin","volume":"153","author":"Nakhla","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.beem.2015.09.001_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2265.2007.02890.x","article-title":"Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders","volume":"67","author":"Torpy","year":"2007","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib12","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.84.15.5153","article-title":"Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors","volume":"84","author":"Hammond","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.beem.2015.09.001_bib13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1074\/jbc.M807376200","article-title":"Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage","volume":"284","author":"Lin","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0022-4731(84)90142-0","article-title":"Human corticosteroid binding globulin is secreted by a hepatoma-derived cell line","volume":"20","author":"Khan","year":"1984","journal-title":"J\u00a0Steroid Biochem"},{"key":"10.1016\/j.beem.2015.09.001_bib15","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1210\/endo.132.2.8425503","article-title":"Corticosteroid-binding globulin biosynthesis in the mouse liver and kidney during postnatal development","volume":"132","author":"Scrocchi","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2015.09.001_bib16","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1210\/endo.132.2.7916682","article-title":"Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice","volume":"132","author":"Scrocchi","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2015.09.001_bib17","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1172\/JCI104931","article-title":"Transcortin: a corticosteroid-binding protein of plasma. VII. Half-life in normal and estrogen-treated subjects","volume":"43","author":"Sandberg","year":"1964","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.beem.2015.09.001_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1749-6632.1988.tb48857.x","article-title":"Physiology of corticosteroid-binding globulin in humans","volume":"538","author":"Heyns","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.beem.2015.09.001_bib19","article-title":"Steroid-protein interactions","volume":"4","author":"Westphal","year":"1971","journal-title":"Monogr Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0022-4731(72)90100-8","article-title":"Recent studies on the binding of cortisol in serum","volume":"3","author":"Rosner","year":"1972","journal-title":"J\u00a0Steroid Biochem"},{"key":"10.1016\/j.beem.2015.09.001_bib21","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1210\/mend-3-9-1448","article-title":"Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region","volume":"3","author":"Underhill","year":"1989","journal-title":"Mol Endocrinol (Baltimore, Md.)"},{"key":"10.1016\/j.beem.2015.09.001_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2009.07.015","article-title":"Corticosteroid-binding globulin: the clinical significance of altered levels and heritable mutations","volume":"316","author":"Gagliardi","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1210\/jc.2011-3090","article-title":"Cortisol binding globulin: more than just a carrier?","volume":"97","author":"Cizza","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib24","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1210\/jc.2001-011843","article-title":"Serum corticosteroid-binding globulin concentration and insulin resistance syndrome: a population study","volume":"87","author":"Fernandez-Real","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1210\/jcem-27-7-959","article-title":"Cortisol-binding capacity of plasma transcortin: a sex-linked trait?","volume":"27","author":"eDe Moor","year":"1967","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-8981(77)90395-3","article-title":"Simultaneous measurement of circulating cortisol, corticosteroid binding globulin (CBG) binding capacity and \u201capparent free cortisol concentration\u201d in human peripheral plasma using gel-exchange with Sephadex G-25","volume":"77","author":"Angeli","year":"1977","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1210\/jcem-24-10-1029","article-title":"Measurement of corticosteroid-binding globulin in man","volume":"24","author":"Doe","year":"1964","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib28","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1210\/jc.2010-0942","article-title":"Temperature-responsive release of cortisol from its binding globulin: a protein thermocouple","volume":"95","author":"Cameron","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.02.053","article-title":"New insights into corticosteroid-binding globulin and glucocorticoid delivery","volume":"180","author":"Henley","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.beem.2015.09.001_bib30","article-title":"N-glycans modulate the function of human corticosteroid-binding globulin","volume":"10","author":"Sumer-Bayraktar","year":"2011","journal-title":"Mol Cell Proteom MCP"},{"key":"10.1016\/j.beem.2015.09.001_bib31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0960-0760(95)00099-L","article-title":"Structure and function of corticosteroid-binding globulin: role of carbohydrates","volume":"53","author":"Avvakumov","year":"1995","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2015.09.001_bib32","doi-asserted-by":"crossref","first-page":"5636","DOI":"10.1016\/S0021-9258(18)99404-4","article-title":"Steroid-protein interactions. XV. Isolation and characterization of corticosteroid-binding globulin from human plasma","volume":"242","author":"Muldoon","year":"1967","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0304-4165(82)90142-8","article-title":"Structural organization of the carbohydrate moiety of human transcortin as determined by methylation analysis of the whole glycoprotein","volume":"714","author":"Akhrem","year":"1982","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.beem.2015.09.001_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0167-4838(82)90175-3","article-title":"Isolation and characterization of glycopeptides of human transcortin","volume":"705","author":"Strel'chyonok","year":"1982","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.beem.2015.09.001_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0010-7824(02)00436-5","article-title":"Effect of four different oral contraceptives on various sex hormones and serum-binding globulins","volume":"67","author":"Wiegratz","year":"2003","journal-title":"Contraception"},{"key":"10.1016\/j.beem.2015.09.001_bib36","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1210\/jc.2005-2157","article-title":"Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans","volume":"91","author":"Nader","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib37","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1210\/jcem-25-9-1163","article-title":"Elevation of certain plasma proteins in man following estrogen administration: a dose-response relationship","volume":"25","author":"Musa","year":"1965","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib38","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1172\/JCI103904","article-title":"Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effects of estrogens","volume":"38","author":"Sandberg","year":"1959","journal-title":"J\u00a0Clin Investig"},{"key":"10.1016\/j.beem.2015.09.001_bib39","doi-asserted-by":"crossref","first-page":"e110702","DOI":"10.1371\/journal.pone.0110702","article-title":"Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C\/EBP\u03b2","volume":"9","author":"Verhoog","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.beem.2015.09.001_bib40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1677\/joe.0.0270355","article-title":"Influence of various steroids on the specific binding of cortisol","volume":"27","author":"Demoor","year":"1963","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib41","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1210\/jcem-27-7-973","article-title":"Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay","volume":"27","author":"Murphy","year":"1967","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0009-8981(72)90430-5","article-title":"Determination of plasma corticosteroids and urinary cortisol by a competitive protein-binding method using dextran-coated charcoal","volume":"37","author":"Fiorelli","year":"1972","journal-title":"Clin Chim Acta; Int J Clin Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0021-9258(18)64465-5","article-title":"Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14","volume":"236","author":"Florini","year":"1961","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib44","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJMoa020266","article-title":"Measurements of serum free cortisol in critically ill patients","volume":"350","author":"Hamrahian","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.beem.2015.09.001_bib45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/jc.2005-0265","article-title":"Septic shock and sepsis: a comparison of total and free plasma cortisol levels","volume":"91","author":"Ho","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1210\/jcem-71-1-34","article-title":"A\u00a0role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils","volume":"71","author":"Hammond","year":"1990","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib47","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/clinchem\/35.8.1675","article-title":"Decreased immunoreactivity and binding activity of corticosteroid-binding globulin in serum in septic shock","volume":"35","author":"Pugeat","year":"1989","journal-title":"Clin Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib48","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/cen.12680","article-title":"Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications","volume":"82","author":"Nenke","year":"2015","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib49","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/00003246-199803000-00014","article-title":"Decreased corticosteroid-binding globulin in burn patients: relationship with interleukin-6 and fat in nutritional support","volume":"26","author":"Bernier","year":"1998","journal-title":"Crit care Med"},{"key":"10.1016\/j.beem.2015.09.001_bib50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1210\/endo.133.1.8391424","article-title":"Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells","volume":"133","author":"Bartalena","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2015.09.001_bib51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.14310\/horm.2002.1203","article-title":"Pituitary-adrenal responses following major abdominal surgery","volume":"7","author":"Dimopoulou","year":"2008","journal-title":"Hormones (Athens, Greece)"},{"key":"10.1016\/j.beem.2015.09.001_bib52","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0009-9120(99)00009-0","article-title":"Corticosteroid-binding globulin and free cortisol in the early postoperative period after cardiac surgery","volume":"32","author":"Vogeser","year":"1999","journal-title":"Clin Biochem"},{"key":"10.1016\/j.beem.2015.09.001_bib53","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrendo.2012.134","article-title":"Regulation of cortisol bioavailability\u2013effects on hormone measurement and action","volume":"8","author":"Perogamvros","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib54","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00134-004-2306-5","article-title":"Cortisol dynamics following acute severe brain injury","volume":"30","author":"Savaridas","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.beem.2015.09.001_bib55","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1080\/00365520701416691","article-title":"Corticosteroid-binding globulin: a possible early predictor of infection in acute necrotizing pancreatitis","volume":"42","author":"Muller","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.beem.2015.09.001_bib56","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2265.2007.02826.x","article-title":"Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnancies","volume":"66","author":"Ho","year":"2007","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib57","first-page":"28","article-title":"Increased urinary free cortisol and decreased serum corticosteroid-binding globulin in polycystic ovary syndrome","volume":"125","author":"Invitti","year":"1991","journal-title":"Acta Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib58","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0009-9120(00)00051-5","article-title":"Corticosteroid-binding globulin and unbound serum cortisol in women with polycystic ovary syndrome","volume":"33","author":"Vogeser","year":"2000","journal-title":"Clin Biochem"},{"key":"10.1016\/j.beem.2015.09.001_bib59","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1210\/jcem-29-6-837","article-title":"Effects of testosteronereatment on plasma proteins and amino acids in men","volume":"29","author":"Dickinson","year":"1969","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib60","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1210\/jcem-24-10-1067","article-title":"Determination of the binding capacity of corticosteroid-binding globulin by paper electrophoresis","volume":"24","author":"Osorio","year":"1964","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1210\/jcem-26-1-71","article-title":"Data on transcortin activity in human plasma as studied by gel filtration","volume":"26","author":"De Moor","year":"1966","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib62","first-page":"1","article-title":"Determination of cortisol binding capacity in human peripheral plasma using a competitive protein binding technique and gel equilibration with Sephadex G-25","volume":"20","author":"Frajria","year":"1976","journal-title":"J\u00a0Nucl Biol Med"},{"key":"10.1016\/j.beem.2015.09.001_bib63","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1210\/jcem-22-7-704","article-title":"Measurement of the binding capacity of corticosteroid-binding globulin in human plasma","volume":"22","author":"Daughday","year":"1962","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"key":"10.1016\/j.beem.2015.09.001_bib64","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1210\/jcem-23-5-459","article-title":"A\u00a0study of the binding capacity of corticosteroid-binding globulin in plasma","volume":"23","author":"Murphy","year":"1963","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib65","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0009-8981(72)90426-3","article-title":"A\u00a0new method for estimation of corticosteroid-binding globulin with hydrophobic resin","volume":"37","author":"Usui","year":"1972","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib66","first-page":"515","article-title":"Eine einfache Methode zur Bestimmung der Kapazit\u00e4t des corticosteroidbindenden Globulins im Plasma","volume":"70","author":"Pirke","year":"1972","journal-title":"Acta Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib67","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0002-9378(78)90293-4","article-title":"An in\u00a0vivo system in man for quantitation of estrogenicity. I. Physiologic changes in binding capacity of serum corticosteroid-binding globulin","volume":"130","author":"Moore","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.beem.2015.09.001_bib68","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1210\/jcem-39-1-160","article-title":"Immunochemical quantitation of human transcortin","volume":"39","author":"van Baelen","year":"1974","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib69","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jsbmb.2011.08.006","article-title":"Corticosteroid-binding globulin reactive centre loop antibodies recognise only the intact natured protein: elastase cleaved and uncleaved CBG may coexist in circulation","volume":"127","author":"Lewis","year":"2011","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2015.09.001_bib70","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/336257a0","article-title":"Hormone binding globulins undergo serpin conformational change in inflammation","volume":"336","author":"Pemberton","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.beem.2015.09.001_bib71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0195-5616(79)50002-3","article-title":"Hyperadrenocorticism (hyperadrenocorticoidism, hyperadrenocorticalism, Cushing's disease, Cushing's syndrome)","volume":"9","author":"Scott","year":"1979","journal-title":"Vet Clin North Am Small Animal Pract"},{"key":"10.1016\/j.beem.2015.09.001_bib72","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1210\/jcem-28-3-422","article-title":"Overnight suppression test with dexamethasone in Cushing's syndrome","volume":"28","author":"Sawin","year":"1968","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clinbiochem.2008.09.115","article-title":"Validation of a simple method of estimating plasma free cortisol: role of cortisol binding to albumin","volume":"42","author":"Dorin","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1016\/j.beem.2015.09.001_bib74","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1373\/clinchem.2005.063354","article-title":"Calculation of bioavailable and free testosterone in men: a comparison of 5 published algorithms","volume":"52","author":"Ronde de","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.beem.2015.09.001_bib75","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jsbmb.2013.12.015","article-title":"Development of a formula for estimating plasma free cortisol concentration from a measured total cortisol concentration when elastase-cleaved and intact corticosteroid binding globulin coexist","volume":"141","author":"Nguyen","year":"2014","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2015.09.001_bib76","first-page":"39","article-title":"Comparison of the diagnostic accuracy of measured and calculated free cortisol in acutely ill patients using the Coolens equation","volume":"15","author":"Cohen","year":"2013","journal-title":"Crit care Resusc J Australas Acad Crit Care Med"},{"key":"10.1016\/j.beem.2015.09.001_bib77","article-title":"Comparison of total cortisol, free cortisol, and surrogate markers of free cortisol in diagnosis of adrenal insufficiency in patients with stable cirrhosis","volume":"12","author":"Fede","year":"2014","journal-title":"Clin Gastroenterol Hepatol official Clin Pract J Am Gastroenterol Assoc"},{"key":"10.1016\/j.beem.2015.09.001_bib78","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jhep.2010.05.020","article-title":"Characterising adrenal function using directly measured plasma free cortisol in stable severe liver disease","volume":"53","author":"Tan","year":"2010","journal-title":"J\u00a0hepatology"},{"key":"10.1016\/j.beem.2015.09.001_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinbiochem.2015.07.014","article-title":"Three calculations of free cortisol versus measured values in the critically ill","author":"Molenaar","year":"2015","journal-title":"Clin Biochem"},{"key":"10.1016\/j.beem.2015.09.001_bib80","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2265.2010.03897.x","article-title":"Corticosteroid-binding globulin regulates cortisol pharmacokinetics","volume":"74","author":"Perogamvros","year":"2011","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.beem.2015.09.001_bib81","first-page":"596","article-title":"Expression of corticosteroid-binding globulin CBG in the human heart","volume":"47","author":"Sch\u00e4fer","year":"2015","journal-title":"Horm Metab Res = Hormon- und Stoffwechselforschung = Hormoneset m\u00e9tabolisme"},{"key":"10.1016\/j.beem.2015.09.001_bib82","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.metabol.2004.11.015","article-title":"Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women","volume":"54","author":"Fernandez-Real","year":"2005","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.beem.2015.09.001_bib83","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1210\/jcem.86.8.7724","article-title":"Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension","volume":"86","author":"Torpy","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib84","doi-asserted-by":"crossref","first-page":"E678","DOI":"10.1210\/jc.2011-3141","article-title":"High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects","volume":"97","author":"Lin","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib85","doi-asserted-by":"crossref","first-page":"E151","DOI":"10.1210\/jc.2011-2022","article-title":"CBG Santiago: a novel CBG mutation","volume":"97","author":"Torpy","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib86","doi-asserted-by":"crossref","first-page":"E129","DOI":"10.1210\/jc.2014-3130","article-title":"Naturally occurring mutations of human corticosteroid-binding globulin","volume":"100","author":"Simard","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metabol"},{"key":"10.1016\/j.beem.2015.09.001_bib87","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0960-0760(92)90107-T","article-title":"A\u00a0Leu-His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol","volume":"42","author":"Smith","year":"1992","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2015.09.001_bib88","first-page":"361","article-title":"Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity","volume":"85","author":"Emptoz-Bonneton","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib89","doi-asserted-by":"crossref","first-page":"E142","DOI":"10.1210\/jc.2010-0746","article-title":"Novel corticosteroid-binding globulin variant that lacks steroid binding activity","volume":"95","author":"Perogamvros","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2015.09.001_bib90","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1210\/jc.2012-2467","article-title":"Two different corticosteroid-binding globulin variants that lack cortisol-binding activity in a greek woman","volume":"97","author":"Hill","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"}],"container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X15000901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X15000901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:51:26Z","timestamp":1761497486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X15000901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":90,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1521690X15000901"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2015.09.001","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corticosteroid-binding globulin: Modulating mechanisms of bioavailability of cortisol and its clinical implications","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2015.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}