{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T12:01:48Z","timestamp":1792929708105,"version":"4.5.0"},"reference-count":103,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.beem.2016.02.012","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T04:06:08Z","timestamp":1456891568000},"page":"277-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Renal aquaporins and water balance disorders"],"prefix":"10.1016","volume":"30","author":[{"given":"Hanne B.","family":"Moeller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H.","family":"Fuglsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beem.2016.02.012_bib1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.mam.2012.01.001","article-title":"The role of renal water channels in health and disease","volume":"33","author":"Holmes","year":"2012","journal-title":"Mol aspects Med"},{"key":"10.1016\/j.beem.2016.02.012_bib2","series-title":"Brenner and Rector's the kidney, urine concentration and dilution","first-page":"326","volume":"2","author":"Sands","year":"2012"},{"key":"10.1016\/j.beem.2016.02.012_bib3","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1681\/ASN.2007010056","article-title":"Aquaporin-1 is not expressed in descending thin limbs of short-loop nephrons","volume":"18","author":"Zhai","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib4","first-page":"F587","article-title":"Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta","volume":"272","author":"Pallone","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib5","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.1073\/pnas.92.16.7212","article-title":"Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells","volume":"92","author":"Katsura","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.beem.2016.02.012_bib6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.00053.2006","article-title":"Mouse models and the urinary concentrating mechanism in the new millennium","volume":"87","author":"Fenton","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.beem.2016.02.012_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1056\/NEJM200107193450304","article-title":"Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1","volume":"345","author":"King","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.beem.2016.02.012_bib8","first-page":"H234","article-title":"Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum","volume":"275","author":"Devuyst","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MNH.0000000000000151","article-title":"Water and solute transport across the peritoneal membrane","volume":"24","author":"Morelle","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.beem.2016.02.012_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/361549a0","article-title":"Cloning and expression of apical membrane water channel of rat kidney collecting tubule","volume":"361","author":"Fushimi","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.beem.2016.02.012_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00424-012-1129-4","article-title":"Cell biology of vasopressin-regulated aquaporin-2 trafficking","volume":"464","author":"Moeller","year":"2012","journal-title":"Pflugers Archiv Eur J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib12","doi-asserted-by":"crossref","first-page":"F1062","DOI":"10.1152\/ajprenal.00721.2010","article-title":"Regulation of the water channel aquaporin-2 by posttranslational modification","volume":"300","author":"Moeller","year":"2011","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib13","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1073\/pnas.91.14.6269","article-title":"Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells","volume":"91","author":"Ishibashi","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.beem.2016.02.012_bib14","doi-asserted-by":"crossref","first-page":"20782","DOI":"10.1074\/jbc.272.33.20782","article-title":"Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea","volume":"272","author":"Ishibashi","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2016.02.012_bib15","first-page":"F775","article-title":"Distribution of aquaporin-4 water channel expression within rat kidney","volume":"269","author":"Terris","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib16","series-title":"Long-term vasopressin-V2-receptor stimulation induces regulation of aquaporin 4 protein in renal inner medulla and cortex of Brattleboro rats","first-page":"2058","volume":"28","author":"Poulsen","year":"2013"},{"key":"10.1016\/j.beem.2016.02.012_bib17","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00018-009-0218-9","article-title":"Differential water permeability and regulation of three aquaporin 4 isoforms","volume":"67","author":"Fenton","year":"2010","journal-title":"Cell Mol Life Sci CMLS"},{"key":"10.1016\/j.beem.2016.02.012_bib18","doi-asserted-by":"crossref","first-page":"F1195","DOI":"10.1152\/ajprenal.00133.2005","article-title":"Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice","volume":"289","author":"Sohara","year":"2005","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2012-1044","article-title":"Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment","volume":"34","author":"Moeller","year":"2013","journal-title":"Endocr Rev"},{"key":"10.1016\/j.beem.2016.02.012_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/nrneph.2015.89","article-title":"Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus","volume":"11","author":"Bockenhauer","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.advms.2015.07.002","article-title":"Copeptin: pathophysiology and potential clinical impact","volume":"60","author":"Lukaszyk","year":"2015","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.beem.2016.02.012_bib22","doi-asserted-by":"crossref","first-page":"F1037","DOI":"10.1152\/ajprenal.00639.2012","article-title":"Inherited secondary nephrogenic diabetes insipidus: concentrating on humans","volume":"304","author":"Bockenhauer","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/359233a0","article-title":"Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus","volume":"359","author":"Rosenthal","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.beem.2016.02.012_bib24","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1152\/ajprenal.00491.2005","article-title":"Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus","volume":"291","author":"Robben","year":"2006","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib25","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/ajmg.a.32386","article-title":"Nephrogenic diabetes insipidus in a patient with L1 syndrome: a new report of a contiguous gene deletion syndrome including L1CAM and AVPR2","volume":"146A","author":"Knops","year":"2008","journal-title":"Am J Med Genet Part A"},{"key":"10.1016\/j.beem.2016.02.012_bib26","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00467-013-2526-4","article-title":"Urinary concentration: different ways to open and close the tap","volume":"29","author":"Bockenhauer","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib27","doi-asserted-by":"crossref","first-page":"F801","DOI":"10.1152\/ajprenal.00253.2011","article-title":"Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors","volume":"302","author":"Saigusa","year":"2012","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib28","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200309017","article-title":"Reversed polarized delivery of an aquaporin-2 mutant causes dominant nephrogenic diabetes insipidus","volume":"163","author":"Kamsteeg","year":"2003","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.beem.2016.02.012_bib29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/pgmj.60.705.493","article-title":"Idiopathic hypergammaglobulinaemia associated with nephrogenic diabetes insipidus and distal renal tubular acidosis","volume":"60","author":"Spruce","year":"1984","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.beem.2016.02.012_bib30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40345-015-0028-y","article-title":"Lithium nephrotoxicity","volume":"3","author":"Azab","year":"2015","journal-title":"Int J bipolar Disord"},{"key":"10.1016\/j.beem.2016.02.012_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0002-9343(94)90308-5","article-title":"Clinical manifestations and management of acute lithium intoxication","volume":"97","author":"Okusa","year":"1994","journal-title":"Am J Med"},{"key":"10.1016\/j.beem.2016.02.012_bib32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ki.2009.91","article-title":"Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus","volume":"76","author":"Kortenoeven","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib33","doi-asserted-by":"crossref","first-page":"F552","DOI":"10.1152\/ajprenal.2000.279.3.F552","article-title":"Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI","volume":"279","author":"Kwon","year":"2000","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib34","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1046\/j.1523-1755.2002.00210.x","article-title":"Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats","volume":"61","author":"Klein","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib35","doi-asserted-by":"crossref","first-page":"C952","DOI":"10.1152\/ajpcell.00266.2003","article-title":"Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI","volume":"286","author":"Christensen","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib36","doi-asserted-by":"crossref","first-page":"F919","DOI":"10.1152\/ajprenal.00152.2012","article-title":"Evaluation of cellular plasticity in the collecting duct during recovery from lithium-induced nephrogenic diabetes insipidus","volume":"305","author":"Trepiccione","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib37","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1681\/ASN.2013090988","article-title":"Lithium causes G2 arrest of renal principal cells","volume":"25","author":"de Groot","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib38","doi-asserted-by":"crossref","first-page":"F1201","DOI":"10.1152\/ajprenal.00153.2013","article-title":"Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells","volume":"305","author":"Gao","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib39","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1073\/pnas.0800001105","article-title":"Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation","volume":"105","author":"Nielsen","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.beem.2016.02.012_bib40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/MNH.0b013e32835571d4","article-title":"Glycogen synthase kinase-3 regulation of urinary concentrating ability","volume":"21","author":"Rao","year":"2012","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.beem.2016.02.012_bib41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1681\/ASN.2012020217","article-title":"Is there a role for PGE2 in urinary concentration?","volume":"24","author":"Olesen","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib42","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2007.03.038","article-title":"Urine osmolality, cyclic AMP and aquaporin-2 in urine of patients under lithium treatment in response to water loading followed by vasopressin administration","volume":"566","author":"Wilting","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.beem.2016.02.012_bib43","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1172\/JCI118628","article-title":"Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex","volume":"97","author":"Marples","year":"1996","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib44","doi-asserted-by":"crossref","first-page":"F655","DOI":"10.1152\/ajprenal.2000.279.4.F655","article-title":"Early polyuria and urinary concentrating defect in potassium deprivation","volume":"279","author":"Amlal","year":"2000","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib45","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.bbagen.2013.12.002","article-title":"Renal aquaporins and water balance disorders","volume":"1840","author":"Kortenoeven","year":"2014","journal-title":"Biochimica biophysica acta"},{"key":"10.1016\/j.beem.2016.02.012_bib46","doi-asserted-by":"crossref","first-page":"F1313","DOI":"10.1152\/ajprenal.00040.2002","article-title":"AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors","volume":"283","author":"Wang","year":"2002","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib47","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI119299","article-title":"Apical extracellular calcium\/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct","volume":"99","author":"Sands","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1681\/ASN.2007010092","article-title":"Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism","volume":"19","author":"Bustamante","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib49","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/j.1523-1755.2004.66036.x","article-title":"Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells","volume":"66","author":"Procino","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib50","first-page":"F978","article-title":"Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats","volume":"274","author":"Sands","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib51","doi-asserted-by":"crossref","first-page":"e33145","DOI":"10.1371\/journal.pone.0033145","article-title":"Calcium-sensing receptor and aquaporin 2 interplay in hypercalciuria-associated renal concentrating defect in humans. An in\u00a0vivo and in\u00a0vitro study","volume":"7","author":"Procino","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.beem.2016.02.012_bib52","doi-asserted-by":"crossref","first-page":"F127","DOI":"10.1152\/ajprenal.90479.2008","article-title":"Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction","volume":"296","author":"Jensen","year":"2009","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib53","first-page":"F213","article-title":"Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction","volume":"273","author":"Frokiaer","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib54","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s12519-012-0378-9","article-title":"Decrease of renal aquaporins 1-4 is associated with renal function impairment in pediatric congenital hydronephrosis","volume":"8","author":"Li","year":"2012","journal-title":"World J Pediatr WJP"},{"key":"10.1016\/j.beem.2016.02.012_bib55","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3109\/00365590903127446","article-title":"Expression of renal aquaporins is down-regulated in children with congenital hydronephrosis","volume":"43","author":"Wen","year":"2009","journal-title":"Scand J urology Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib56","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.beem.2016.02.012_bib57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ckj\/sfv043","article-title":"From the nephrologist's point of view: diversity of causes and clinical features of acute kidney injury","volume":"8","author":"Bienholz","year":"2015","journal-title":"Clin kidney J"},{"key":"10.1016\/j.beem.2016.02.012_bib58","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ki.1982.65","article-title":"Renal concentration defect following nonoliguric acute renal failure in the rat","volume":"21","author":"Anderson","year":"1982","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib59","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1046\/j.1523-1755.2000.00008.x","article-title":"Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats","volume":"57","author":"Kim","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib60","first-page":"F413","article-title":"Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha-MSH","volume":"277","author":"Kwon","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib61","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s11255-014-0766-2","article-title":"Organ cross talk and remote organ damage following acute kidney injury","volume":"46","author":"Ologunde","year":"2014","journal-title":"Int urology Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib62","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","article-title":"Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline","volume":"158","author":"Stevens","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.beem.2016.02.012_bib63","first-page":"F724","article-title":"Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass","volume":"275","author":"Kwon","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib64","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1172\/JCI118044","article-title":"Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA","volume":"96","author":"Teitelbaum","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib65","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM196905222802101","article-title":"Vasopressin-resistant hyposthenuria in advanced chronic renal disease","volume":"280","author":"Tannen","year":"1969","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.beem.2016.02.012_bib66","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1471-2369-15-101","article-title":"Abnormal urinary excretion of NKCC2 and AQP2 in response to hypertonic saline in chronic kidney disease: an intervention study in patients with chronic kidney disease and healthy controls","volume":"15","author":"Jensen","year":"2014","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib67","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1210\/en.2014-1385","article-title":"Diabetes insipidus: celebrating a century of vasopressin therapy","volume":"155","author":"Qureshi","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2016.02.012_bib68","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.2215\/CJN.01640408","article-title":"Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride","volume":"3","author":"Bedford","year":"2008","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"10.1016\/j.beem.2016.02.012_bib69","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1136\/adc.80.6.548","article-title":"Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride","volume":"80","author":"Kirchlechner","year":"1999","journal-title":"Archives Dis Child"},{"key":"10.1016\/j.beem.2016.02.012_bib70","doi-asserted-by":"crossref","first-page":"F1103","DOI":"10.1152\/ajprenal.00337.2004","article-title":"Stimulation of AQP2 membrane insertion in renal epithelial cells in\u00a0vitro and in\u00a0vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)","volume":"288","author":"Bouley","year":"2005","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib71","doi-asserted-by":"crossref","first-page":"F216","DOI":"10.1152\/ajprenal.00439.2010","article-title":"Sildenafil reduces polyuria in rats with lithium-induced NDI","volume":"302","author":"Sanches","year":"2012","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib72","doi-asserted-by":"crossref","first-page":"14217","DOI":"10.1073\/pnas.0602331103","article-title":"Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation","volume":"103","author":"Sohara","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.beem.2016.02.012_bib73","doi-asserted-by":"crossref","first-page":"F309","DOI":"10.1152\/ajprenal.00001.2011","article-title":"Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase","volume":"301","author":"Li","year":"2011","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib74","doi-asserted-by":"crossref","first-page":"F266","DOI":"10.1152\/ajprenal.00359.2009","article-title":"Lovastatin-induced cholesterol depletion affects both apical sorting and endocytosis of aquaporin-2 in renal cells","volume":"298","author":"Procino","year":"2010","journal-title":"Am J Physiol Ren Physiol"},{"issue":"485","key":"10.1016\/j.beem.2016.02.012_bib75","first-page":"e415","article-title":"Atorvastatin prevents the downregulation of aquaporin-2 receptor after bilateral ureteral obstruction and protects renal function in a rat model","volume":"80","author":"Danilovic","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.beem.2016.02.012_bib76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/ki.2014.10","article-title":"Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice","volume":"86","author":"Procino","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib77","doi-asserted-by":"crossref","first-page":"12949","DOI":"10.1073\/pnas.1104691108","article-title":"Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus","volume":"108","author":"Olesen","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.beem.2016.02.012_bib78","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1172\/JCI39680","article-title":"A\u00a0selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus","volume":"119","author":"Li","year":"2009","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib79","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1210\/me.2004-0080","article-title":"Functional rescue of the constitutively internalized V2 vasopressin receptor mutant R137H by the pharmacological chaperone action of SR49059","volume":"18","author":"Bernier","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.beem.2016.02.012_bib80","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1681\/ASN.2005080854","article-title":"Pharmacologic chaperones as a potential treatment for X-linked nephrogenic diabetes insipidus","volume":"17","author":"Bernier","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib81","doi-asserted-by":"crossref","first-page":"12195","DOI":"10.1073\/pnas.0900130106","article-title":"Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists","volume":"106","author":"Robben","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl. 1","key":"10.1016\/j.beem.2016.02.012_bib82","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1530\/EJE-09-1063","article-title":"The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences","volume":"162","author":"Hannon","year":"2010","journal-title":"Eur J endocrinology\/Eur Fed Endocr Soc"},{"key":"10.1016\/j.beem.2016.02.012_bib83","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrneph.2012.246","article-title":"Hyponatraemia: more than just a marker of disease severity?","volume":"9","author":"Schrier","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib84","first-page":"F926","article-title":"Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats","volume":"269","author":"Fujita","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib85","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1200\/JCO.2013.49.1464","article-title":"Olfactory neuroblastoma with hyponatremia","volume":"33","author":"Hoorn","year":"2015","journal-title":"J\u00a0Clin Oncol official J Am Soc Clin Oncol"},{"key":"10.1016\/j.beem.2016.02.012_bib86","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1172\/JCI119352","article-title":"Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat","volume":"99","author":"Ecelbarger","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib87","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1046\/j.1523-1755.2001.00977.x","article-title":"Escape from antidiuresis: a good story","volume":"60","author":"Verbalis","year":"2001","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.beem.2016.02.012_bib88","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cellsig.2015.07.021","article-title":"Arginine vasopressin receptor signaling and functional outcomes in heart failure","volume":"28","author":"Wasilewski","year":"2016","journal-title":"Cell Signal"},{"key":"10.1016\/j.beem.2016.02.012_bib89","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.amjmed.2006.05.007","article-title":"Water and sodium retention in edematous disorders: role of vasopressin and aldosterone","volume":"119","author":"Schrier","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.beem.2016.02.012_bib90","doi-asserted-by":"crossref","first-page":"F1547","DOI":"10.1152\/ajprenal.00461.2012","article-title":"Congestive heart failure in rats is associated with increased collecting duct vasopressin sensitivity and vasopressin type 2 receptor reexternalization","volume":"305","author":"Brond","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib91","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1046\/j.1523-1755.2003.00858.x","article-title":"Urinary aquaporin-2 in healthy humans and patients with liver cirrhosis and chronic heart failure during baseline conditions and after acute water load","volume":"63","author":"Pedersen","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib92","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1681\/ASN.V10102165","article-title":"Selective V2-receptor vasopressin antagonism decreases urinary aquaporin-2 excretion in patients with chronic heart failure","volume":"10","author":"Martin","year":"1999","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib93","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1172\/JCI119312","article-title":"Upregulation of aquaporin-2 water channel expression in chronic heart failure rat","volume":"99","author":"Xu","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib94","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ki.1994.265","article-title":"Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats","volume":"46","author":"Tsuboi","year":"1994","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib95","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1681\/ASN.V1091950","article-title":"Renal expression of aquaporins in liver cirrhosis induced by chronic common bile duct ligation in rats","volume":"10","author":"Fernandez-Llama","year":"1999","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.beem.2016.02.012_bib96","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1523-1755.2000.00156.x","article-title":"Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis","volume":"58","author":"Fernandez-Llama","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.beem.2016.02.012_bib97","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s10620-009-0829-x","article-title":"Aquaporin-2 urinary excretion in cirrhosis: relationship to vasopressin and nitric oxide","volume":"55","author":"Chung","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.beem.2016.02.012_bib98","first-page":"F348","article-title":"Metabolic clearance of vasopressin and an analogue resistant to vasopressinase in human pregnancy","volume":"264","author":"Davison","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib99","first-page":"R1739","article-title":"Upregulation of endothelial and neuronal constitutive nitric oxide synthase in pregnant rats","volume":"271","author":"Xu","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib100","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI649","article-title":"Upregulation of aquaporin 2 water channel expression in pregnant rats","volume":"101","author":"Ohara","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2016.02.012_bib101","doi-asserted-by":"crossref","first-page":"679","DOI":"10.7326\/0003-4819-79-5-679","article-title":"Demeclocycline-induced nephrogenic diabetes insipidus. In-vivo and in-vitro studies","volume":"79","author":"Singer","year":"1973","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.beem.2016.02.012_bib102","doi-asserted-by":"crossref","first-page":"F1705","DOI":"10.1152\/ajprenal.00723.2012","article-title":"Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla","volume":"305","author":"Kortenoeven","year":"2013","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.beem.2016.02.012_bib103","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am J Med"}],"container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X16000397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X16000397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:50:58Z","timestamp":1761497458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X16000397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":103,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1521690X16000397"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2016.02.012","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renal aquaporins and water balance disorders","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2016.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}