{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:32:13Z","timestamp":1793291533124,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.beem.2018.05.008","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T12:36:59Z","timestamp":1527338219000},"page":"343-354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"title":["Central precocious puberty: From genetics to treatment"],"prefix":"10.1016","volume":"32","author":[{"given":"Rebecca Schneider","family":"Aguirre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica A.","family":"Eugster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib1","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1210\/jc.2013-1024","article-title":"Treatment and outcomes of precocious puberty: an update","volume":"98","author":"Fuqua","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S2213-8587(15)00418-0","article-title":"Pubertal development and regulation","volume":"4","author":"Abreu","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1542\/peds.2005-0012","article-title":"Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries","volume":"116","author":"Teilmann","year":"2005","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.beem.2018.05.008_bib4","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1210\/jc.2010-1025","article-title":"Central precocious puberty in children living in Spain: incidence, prevalence, and influence of adoption and immigration","volume":"95","author":"Soriano-Guillen","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/03014467400000031","article-title":"Interrelationships of skeletal maturation, sexual development and somatic growth in man","volume":"1","author":"Marshall","year":"1974","journal-title":"Ann Hum Biol"},{"issue":"10","key":"10.1016\/j.beem.2018.05.008_bib6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.tem.2015.07.008","article-title":"There is kisspeptin \u2013 and then there is kisspeptin","volume":"26","author":"Hussain","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.beem.2018.05.008_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fendo.2012.00149","article-title":"A\u00a0potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals","volume":"3","author":"Bianco","year":"2012","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.beem.2018.05.008_bib8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-1-4614-6199-9_15","article-title":"Interactions between kisspeptins and neurokinin B","volume":"784","author":"Navarro","year":"2013","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib9","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1542\/peds.2008-1783","article-title":"Consensus statement on the use of gonadotropin-releasing hormone analogs in children","volume":"123","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib10","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3732","article-title":"Section on endocrinology, evaluation and referral of children with signs of early puberty","volume":"137","author":"Kaplowitz","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.beem.2018.05.008_bib11","doi-asserted-by":"crossref","first-page":"184502","DOI":"10.1155\/2011\/184502","article-title":"Gonadotropin-dependent precocious puberty: neoplastic causes and endocrine considerations","volume":"2011","author":"Stephen","year":"2011","journal-title":"Int J Pediatr Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jpeds.2012.05.014","article-title":"Hypothalamic-pituitary lesions in pediatric patients: endocrine symptoms often precede neuro-ophthalmic presenting symptoms","volume":"161","author":"Taylor","year":"2012","journal-title":"J\u00a0Pediatr"},{"issue":"7","key":"10.1016\/j.beem.2018.05.008_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJMoa073443","article-title":"A\u00a0GPR54-activating mutation in a patient with central precocious puberty","volume":"358","author":"Teles","year":"2008","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib14","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1210\/jc.2009-2421","article-title":"Mutations of the KISS1 gene in disorders of puberty","volume":"95","author":"Silveira","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.beem.2018.05.008_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.6065\/apem.2016.21.2.66","article-title":"An update on the genetic causes of central precocious puberty","volume":"21","author":"Shin","year":"2016","journal-title":"Ann Pediatr Endocrinol Metab"},{"issue":"26","key":"10.1016\/j.beem.2018.05.008_bib16","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1302160","article-title":"Central precocious puberty caused by mutations in the imprinted gene MKRN3","volume":"368","author":"Abreu","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"49","key":"10.1016\/j.beem.2018.05.008_bib17","doi-asserted-by":"crossref","first-page":"85102","DOI":"10.18632\/oncotarget.19347","article-title":"Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000366282","article-title":"New causes of central precocious puberty: the role of genetic factors","volume":"100","author":"Bulcao Macedo","year":"2014","journal-title":"Neuroendocrinology"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000446963","article-title":"High frequency of MKRN3 mutations in male central precocious puberty previously classified as idiopathic","volume":"105","author":"Bessa","year":"2017","journal-title":"Neuroendocrinology"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib20","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1210\/jc.2016-3677","article-title":"Paternally inherited DLK1 deletion associated with familial central precocious puberty","volume":"102","author":"Dauber","year":"2017","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib21","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbadis.2012.02.003","article-title":"Possible roles of DLK1 in the Notch pathway during development and disease","volume":"1822","author":"Falix","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2015.07.048","article-title":"Notch signaling: an emerging therapeutic target for cancer treatment","volume":"369","author":"Yuan","year":"2015","journal-title":"Cancer Lett"},{"issue":"3\u20134","key":"10.1016\/j.beem.2018.05.008_bib23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000477441","article-title":"Molecular screening of MKRN3, DLK1, and KCNK9 genes in girls with idiopathic central precocious puberty","volume":"88","author":"Grandone","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"Suppl 2","key":"10.1016\/j.beem.2018.05.008_bib24","first-page":"33","article-title":"A\u00a0critical appraisal of the effect of gonadotropin-releasing hormon analog treatment on adult height of girls with central precocious puberty","volume":"9","author":"Bereket","year":"2017","journal-title":"J\u00a0Clin Res Pediatr Endocrinol"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archpedi.1994.02170040035006","article-title":"Laboratory monitoring of children with precocious puberty","volume":"148","author":"Lee","year":"1994","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"22","key":"10.1016\/j.beem.2018.05.008_bib26","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","article-title":"Clinical practice. Precocious puberty","volume":"358","author":"Carel","year":"2008","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s40272-015-0130-8","article-title":"Central precocious puberty: update on diagnosis and treatment","volume":"17","author":"Chen","year":"2015","journal-title":"Paediatr Drugs"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1687-9856-2012-23","article-title":"A\u00a0single sample GnRHa stimulation test in the diagnosis of precocious puberty","volume":"2012","author":"Yazdani","year":"2012","journal-title":"Int J Pediatr Endocrinol"},{"issue":"12","key":"10.1016\/j.beem.2018.05.008_bib29","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1515\/JPEM.2008.21.12.1113","article-title":"The diagnostic value of a brief GnRH analogue stimulation test in girls with central precocious puberty: a single 30-minute post-stimulation LH sample is adequate","volume":"21","author":"Houk","year":"2008","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"issue":"13","key":"10.1016\/j.beem.2018.05.008_bib30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1055\/s-0034-1387790","article-title":"The usefulness of the leuprolide stimulation test as a diagnostic method of idiopathic central precocious puberty in girls","volume":"46","author":"Carretto","year":"2014","journal-title":"Horm Metab Res"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib31","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1210\/jcem-71-5-1251","article-title":"Gonadotropin secretory dynamics during puberty in normal girls and boys","volume":"71","author":"Oerter","year":"1990","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/adc.88.5.414","article-title":"Cranial MRI scans are indicated in all girls with central precocious puberty","volume":"88","author":"Ng","year":"2003","journal-title":"Arch Dis Child"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib33","doi-asserted-by":"crossref","first-page":"e29829","DOI":"10.1371\/journal.pone.0029829","article-title":"Pathological and incidental findings on brain MRI in a single-center study of 229 consecutive girls with early or precocious puberty","volume":"7","author":"Mogensen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.beem.2018.05.008_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13633-016-0027-5","article-title":"Do 6-8 year old girls with central precocious puberty need routine brain imaging?","volume":"2016","author":"Kaplowitz","year":"2016","journal-title":"Int J Pediatr Endocrinol"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S2213-8587(15)00380-0","article-title":"Causes, diagnosis, and treatment of central precocious puberty","volume":"4","author":"Latronico","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib36","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/adc.86.5.320","article-title":"Precocious puberty: a parent's perspective","volume":"86","author":"O'Sullivan","year":"2002","journal-title":"Arch Dis Child"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib37","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0277-9536(02)00480-X","article-title":"Early puberty is associated with mental health problems in middle adolescence","volume":"57","author":"Kaltiala-Heino","year":"2003","journal-title":"Soc Sci Med"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13633-015-0001-7","article-title":"Psychological assessment of mothers and their daughters at the time of diagnosis of precocious puberty","volume":"2015","author":"Schoelwer","year":"2015","journal-title":"Int J Pediatr Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000479688","article-title":"One-year follow-up of girls with precocious puberty and their mothers: do psychological assessments change over time or with treatment?","volume":"88","author":"Schoelwer","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"9","key":"10.1016\/j.beem.2018.05.008_bib40","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1210\/jc.2007-0321","article-title":"Growth pattern and final height after cessation of gonadotropin-suppressive therapy in girls with central sexual precocity","volume":"92","author":"Lazar","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.beem.2018.05.008_bib41","first-page":"4583","article-title":"Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function","volume":"84","author":"Heger","year":"1999","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.beem.2018.05.008_bib42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1530\/eje.0.1410140","article-title":"Analysis of the factors affecting auxological response to GnRH agonist treatment and final height outcome in girls with idiopathic central precocious puberty","volume":"141","author":"Arrigo","year":"1999","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"10.1016\/j.beem.2018.05.008_bib43","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1210\/jcem.86.10.7915","article-title":"Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience","volume":"86","author":"Klein","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.beem.2018.05.008_bib44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/eje.1.02056","article-title":"Three-month sustained-release triptorelin (11.25 mg) in the treatment of central precocious puberty","volume":"154","author":"Carel","year":"2006","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib45","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1210\/jc.2011-2704","article-title":"Efficacy and safety of leuprolide acetate 3-month depot 11.25 milligrams or 30 milligrams for the treatment of central precocious puberty","volume":"97","author":"Lee","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2011.05.036","article-title":"A\u00a0randomized trial of 1- and 3-month depot leuprolide doses in the treatment of central precocious puberty","volume":"159","author":"Fuld","year":"2011","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib47","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000456545","article-title":"Meta-analysis of paediatric patients with central precocious puberty treated with intramuscular triptorelin 11.25 mg 3-month prolonged-release formulation","volume":"87","author":"Duarnd","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"11","key":"10.1016\/j.beem.2018.05.008_bib48","first-page":"1241","article-title":"Efficacy and safety of triptorelin 6-month formulation in patients with central precocious puberty","volume":"29","author":"Klein","year":"2016","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.beem.2018.05.008_bib49","first-page":"1","article-title":"Experience with the once-yearly histrelin (GnRHa) subcutaneous implant in the treatment of central precocious puberty","volume":"3","author":"Lewis","year":"2009","journal-title":"Drug Des Dev Ther"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib50","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1210\/jc.2006-2479","article-title":"Efficacy and safety of histrelin subdermal implant in children with central precocious puberty: a multicenter trial","volume":"92","author":"Eugster","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib51","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jpeds.2013.05.033","article-title":"A\u00a0single histrelin implant is effective for 2 years for treatment of central precocious puberty","volume":"163","author":"Lewis","year":"2013","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib52","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jpeds.2012.08.038","article-title":"Random luteinizing hormone often remains pubertal in children treated with the histrelin implant for central precocious puberty","volume":"162","author":"Lewis","year":"2013","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.beem.2018.05.008_bib53","first-page":"546","article-title":"Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years","volume":"80","author":"Paul","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib54","first-page":"306","article-title":"Review of outcomes after cessation of gonadotropin-releasing hormone agonist treatment of girls with precocious puberty","volume":"11","author":"Thornton","year":"2014","journal-title":"Pediatr Endocrinol Rev"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2013.12.009","article-title":"Resumption of puberty in girls and boys following removal of the histrelin implant","volume":"164","author":"Fisher","year":"2014","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib56","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/cen.12319","article-title":"Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades","volume":"80","author":"Lazar","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib57","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1210\/jc.2004-1863","article-title":"Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese Study Group on central precocious puberty","volume":"90","author":"Tanaka","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib58","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s004310051289","article-title":"Final height, gonadal function and bone mineral density of adolescent males with central precocious puberty after therapy with gonadotropin-releasing hormone analogues","volume":"159","author":"Bertelloni","year":"2000","journal-title":"Eur J Pediatr"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib59","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/eje.0.1330403","article-title":"Early polycystic ovary-like syndrome in girls with central precocious puberty and exaggerated adrenal response","volume":"133","author":"Lazar","year":"1995","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib60","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1530\/EJE-15-0118","article-title":"Management of endocrine disease: secondary osteoporosis: pathophysiology and management","volume":"173","author":"Mirza","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib61","doi-asserted-by":"crossref","first-page":"591","DOI":"10.6061\/clinics\/2012(06)08","article-title":"Bone mineral density and body composition in girls with idiopathic central precocious puberty before and after treatment with a gonadotropin-releasing hormone agonist","volume":"67","author":"Alessandri","year":"2012","journal-title":"Clinics (Sao Paulo)"},{"issue":"3","key":"10.1016\/j.beem.2018.05.008_bib62","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1210\/jc.2002-021154","article-title":"Bone mass at final height in precocious puberty after gonadotropin-releasing hormone agonist with and without calcium supplementation","volume":"88","author":"Antoniazzi","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2018.05.008_bib63","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s004310050831","article-title":"Effect of central precocious puberty and gonadotropin-releasing hormone analogue treatment on peak bone mass and final height in females","volume":"157","author":"Bertelloni","year":"1998","journal-title":"Eur J Pediatr"},{"issue":"12","key":"10.1016\/j.beem.2018.05.008_bib64","doi-asserted-by":"crossref","first-page":"649","DOI":"10.11622\/smedj.2015183","article-title":"Kisspeptin signalling and its roles in humans","volume":"56","author":"Tng","year":"2015","journal-title":"Singap Med J"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib65","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/cr.2016.31","article-title":"Drugging the undruggables: exploring the ubiquitin system for drug development","volume":"26","author":"Huang","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.beem.2018.05.008_bib66","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.brainres.2010.08.087","article-title":"Impact of mutations in kisspeptin and neurokinin B signaling pathways on human reproduction","volume":"1364","author":"Silveira","year":"2010","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib67","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1210\/en.2010-0903","article-title":"KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation","volume":"152","author":"Bianco","year":"2011","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.beem.2018.05.008_bib68","doi-asserted-by":"crossref","first-page":"E647","DOI":"10.1210\/jc.2013-4084","article-title":"Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene","volume":"99","author":"Settas","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib69","doi-asserted-by":"crossref","first-page":"E1097","DOI":"10.1210\/jc.2013-3126","article-title":"Central precocious puberty that appears to be sporadic caused by paternally inherited mutations in the imprinted gene makorin ring finger 3","volume":"99","author":"Macedo","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2018.05.008_bib70","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/pr.2015.159","article-title":"A\u00a0missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty","volume":"78","author":"Kansakoski","year":"2015","journal-title":"Pediatr Res"}],"container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X18300769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X18300769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:52:51Z","timestamp":1761497571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X18300769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1521690X18300769"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2018.05.008","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central precocious puberty: From genetics to treatment","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2018.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}