{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:55:01Z","timestamp":1780055701849,"version":"3.54.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.beem.2019.04.006","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T10:41:01Z","timestamp":1555152061000},"page":"101272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Polycystic ovary syndrome in adolescents"],"prefix":"10.1016","volume":"33","author":[{"given":"Preeti","family":"Dabadghao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 2","key":"10.1016\/j.beem.2019.04.006_bib1","first-page":"S389","article-title":"Prevalence of polycystic ovary syndrome in young women from North India: a Community-based study","volume":"16","author":"Gill","year":"2012","journal-title":"Indian J EndocrinolMetab"},{"key":"10.1016\/j.beem.2019.04.006_bib2","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.beem.2019.04.006_bib3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/jc.2003-031122","article-title":"Androgen excess in women: experience with over 1,000 consecutive patients","volume":"89","author":"Azziz","year":"2004","journal-title":"J\u00a0ClinEndocrinol Metab"},{"key":"10.1016\/j.beem.2019.04.006_bib4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1210\/jc.2005-1457","article-title":"Extensive clinical experience: relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism","volume":"91","author":"Carmina","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2019.04.006_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women's health aspects of polycysticovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.beem.2019.04.006_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med"},{"key":"10.1016\/j.beem.2019.04.006_bib7","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","volume":"vol. 4","author":"Zawadzki","year":"1992"},{"key":"10.1016\/j.beem.2019.04.006_bib8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.beem.2019.04.006_bib9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.beem.2019.04.006_bib10","first-page":"1","volume":"vol. 1","author":"Johnson","year":"2012"},{"issue":"3","key":"10.1016\/j.beem.2019.04.006_bib11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cen.13795","article-title":"International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"89","author":"Teede","year":"2018","journal-title":"ClinEndocrinol (Oxf)."},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib12","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.fertnstert.2016.07.1121","article-title":"Phenotypes and body mass in women with polycystic ovary syndrome identified in referral versus unselected populations: systematic review and meta-analysis","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil Steril"},{"issue":"5","key":"10.1016\/j.beem.2019.04.006_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"definition, aetiology, diagnosis and treatment","volume":"14","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.beem.2019.04.006_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/er.2004-0004","article-title":"The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome","volume":"26","author":"Escobar-Morreale","year":"2005","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/mend.13.6.0311","article-title":"Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries","volume":"13","author":"Nelson","year":"1999","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.beem.2019.04.006_bib16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mce.2016.07.029","article-title":"Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome","volume":"441","author":"Marti","year":"2017","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"10.1016\/j.beem.2019.04.006_bib17","first-page":"840","article-title":"11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome","volume":"102","author":"O'Reilly","year":"2017","journal-title":"J\u00a0ClinEndocrinolMetab"},{"key":"10.1016\/j.beem.2019.04.006_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jsbmb.2014.06.003","article-title":"DHEA, DHEAS and PCOS","volume":"145","author":"Goodarzi","year":"2015","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2019.04.006_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12958-015-0134-9","article-title":"Role of anti-m\u00fcllerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: a review","volume":"13","author":"Dumont","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib21","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"issue":"5","key":"10.1016\/j.beem.2019.04.006_bib22","doi-asserted-by":"crossref","first-page":"E1047","DOI":"10.1152\/ajpendo.00361.2004","article-title":"Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling","volume":"288","author":"Corbould","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib23","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/humrep\/der102","article-title":"Clinical, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis","volume":"26","author":"Hickey","year":"2011","journal-title":"Hum Reprod"},{"issue":"1","key":"10.1016\/j.beem.2019.04.006_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1399-5448.2012.00902.x","article-title":"Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI","volume":"14","author":"Flannery","year":"2013","journal-title":"Pediatr Diabetes"},{"key":"10.1016\/j.beem.2019.04.006_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mce.2013.09.012","article-title":"GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression","volume":"385","author":"Thompson","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2019.04.006_bib26","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00037.2010","article-title":"Kisspeptins and reproduction: physiological roles and regulatory mechanisms","volume":"92","author":"Pinilla","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.beem.2019.04.006_bib27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nrendo.2011.147","article-title":"Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility","volume":"8","author":"Navarro","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"10.1016\/j.beem.2019.04.006_bib28","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1073\/pnas.1415038112","article-title":"Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome","volume":"112","author":"Moore","year":"2015","journal-title":"Proc Natl AcadSci U S A"},{"key":"10.1016\/j.beem.2019.04.006_bib29","doi-asserted-by":"crossref","first-page":"10055","DOI":"10.1038\/ncomms10055","article-title":"Novel role for anti-M\u00fcllerian hormone in the regulation of GnRH neuron excitability and hormone secretion","volume":"7","author":"Cimino","year":"2016","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib30","first-page":"2100","article-title":"Heritability of polycystic ovary syndrome in a Dutch twin-family study","volume":"91","author":"Vink","year":"2006","journal-title":"J\u00a0ClinEndocrinolMetab"},{"issue":"1","key":"10.1016\/j.beem.2019.04.006_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","article-title":"Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16. 3, 2p21 and 9q33. 3","volume":"43","author":"Chen","year":"2011","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.beem.2019.04.006_bib32","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","article-title":"Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome","volume":"44","author":"Shi","year":"2012","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.beem.2019.04.006_bib33","first-page":"E2006","article-title":"Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome","volume":"98","author":"Louwers","year":"2013","journal-title":"J\u00a0ClinEndocrinolMetab"},{"issue":"3","key":"10.1016\/j.beem.2019.04.006_bib34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tem.2014.12.004","article-title":"Functional genomics of PCOS: from GWAS to molecular mechanisms","volume":"26","author":"McAllister","year":"2015","journal-title":"Trends EndocrinolMetab"},{"issue":"1","key":"10.1016\/j.beem.2019.04.006_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fertnstert.2016.04.040","article-title":"Genetic determinants of polycystic ovary syndrome: progress and future directions","volume":"106","author":"Jones","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.beem.2019.04.006_bib36","doi-asserted-by":"crossref","first-page":"51-64","DOI":"10.1093\/humupd\/dmp024","article-title":"Visually scoring hirsutism","volume":"16","author":"Yildiz","year":"2010","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.beem.2019.04.006_bib37","first-page":"1105","article-title":"Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline","volume":"93","author":"Martin","year":"2008","journal-title":"J\u00a0ClinEndocrinolMetab"},{"key":"10.1016\/j.beem.2019.04.006_bib38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejogrb.2012.03.023","article-title":"Epidemiology of hirsutism among women of reproductive age in the community: a simplified scoring system","volume":"163","author":"Li","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.beem.2019.04.006_bib39","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1067\/mpd.2001.109790","article-title":"The prevalence of upper lip hair in black and white girls during puberty: a new standard","volume":"138","author":"Lucky","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.beem.2019.04.006_bib40","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1542\/peds.2013-0490B","article-title":"Evidence-based recommendations for the diagnosis and treatment of pediatric acne","volume":"131","author":"Eichenfield","year":"2013","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.beem.2019.04.006_bib41","first-page":"1021","article-title":"Rapid maturation of the reproductive axis during perimenarche independent of body composition","volume":"85","author":"Legro","year":"2000","journal-title":"J\u00a0ClinEndocrinolMetab"},{"issue":"2","key":"10.1016\/j.beem.2019.04.006_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1043-2760(98)00020-4","article-title":"Endocrine and metabolic abnormalities in adolescents with a PCOS-like condition: consequences for adult reproduction","volume":"9","author":"Apter","year":"1998","journal-title":"Trends EndocrinolMetab"},{"issue":"5","key":"10.1016\/j.beem.2019.04.006_bib43","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1542\/peds.2006-2481","article-title":"Using the menstrual cycle as a vital sign","volume":"118","author":"Diaz","year":"2006","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000375530","article-title":"The diagnosis of polycystic ovary syndrome during adolescence","volume":"83","author":"Witchel","year":"2015","journal-title":"Horm Res Paediatr"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000479371","article-title":"An international consortium update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence","volume":"88","author":"Ib\u00e1\u00f1ez","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib46","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/humupd\/dmg044","article-title":"Ultrasound assessment of the polycystic ovary: international consensus definitions","volume":"9","author":"Balen","year":"2003","journal-title":"Hum Reprod Update"},{"issue":"3","key":"10.1016\/j.beem.2019.04.006_bib47","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/humupd\/dmt061","article-title":"Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"20","author":"Dewailly","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"6","key":"10.1016\/j.beem.2019.04.006_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000481532","article-title":"New diagnostic criteria of polycystic ovarian morphology for adolescents: impact on prevalence and hormonal profile","volume":"88","author":"Merino","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"10.1016\/j.beem.2019.04.006_bib49","first-page":"405","article-title":"Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement","volume":"92","author":"Rosner","year":"2007","journal-title":"J\u00a0ClinEndocrinolMetab"},{"issue":"10","key":"10.1016\/j.beem.2019.04.006_bib50","first-page":"4542","article-title":"Toward excellence in testosterone testing: a consensus statement","volume":"95","author":"Rosner","year":"2010","journal-title":"J\u00a0ClinEndocrinolMetab"},{"key":"10.1016\/j.beem.2019.04.006_bib51","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1016\/j.ajog.2010.03.008","article-title":"The diagnosisof polycystic ovary syndrome in adolescents","volume":"203","author":"Carmina","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.beem.2019.04.006_bib52","first-page":"1641","article-title":"Prevalence of hyperandrogenic states in late adolescent and young women: epidemiological survey on Italian high-school students","volume":"98","author":"Gambineri","year":"2013","journal-title":"JClinEndocrinolMetab"},{"key":"10.1016\/j.beem.2019.04.006_bib53","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1210\/jc.2005-2076","article-title":"Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome","volume":"91","author":"Pigny","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2019.04.006_bib54","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1093\/humrep\/dep074","article-title":"Anti-Mullerian hormone concentrations in androgen-suppressed women with polycystic ovary syndrome","author":"Carlsen","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.beem.2019.04.006_bib55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/cen.13269","article-title":"Anti-Mullerian hormone reflects the severity of polycystic ovary syndrome","volume":"86","author":"Jacob","year":"2017","journal-title":"ClinEndocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.beem.2019.04.006_bib56","first-page":"723","article-title":"The measurement of anti-Mullerian hormone: a critical appraisal","volume":"99","author":"Rustamov","year":"2014","journal-title":"J\u00a0ClinEndocrinolMetab"},{"key":"10.1016\/j.beem.2019.04.006_bib57","doi-asserted-by":"crossref","unstructured":"Palmert MR, Gordon CM, Kartashov AI, et\u00a0al. Screening for abnormal glucosetolerance in adolescents with polycystic ovary syndrome. J Clin Endocrinol;87:1017\u20131023.","DOI":"10.1210\/jcem.87.3.8305"},{"key":"10.1016\/j.beem.2019.04.006_bib58","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/jc.2005-1666","article-title":"Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance","volume":"91","author":"Coviello","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2019.04.006_bib59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jpeds.2015.09.082","article-title":"Early biomarkers of subclinical atherosclerosis in obese adolescent girls with polycystic ovary syndrome","volume":"168","author":"Hughan","year":"2016","journal-title":"J\u00a0Pediatr"},{"issue":"11","key":"10.1016\/j.beem.2019.04.006_bib60","first-page":"3533","article-title":"Effect of lifestyle intervention on features of polycystic ovarian syndrome, metabolic syndrome, and intima-media thickness in obese adolescent girls","volume":"96","author":"Lass","year":"2011","journal-title":"J\u00a0ClinEndocrinolMetab"},{"issue":"11","key":"10.1016\/j.beem.2019.04.006_bib61","first-page":"4299e306","article-title":"The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials","volume":"93","author":"Hoeger","year":"2008","journal-title":"J\u00a0ClinEndocrinolMetab"},{"issue":"8","key":"10.1016\/j.beem.2019.04.006_bib62","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1089\/jwh.2016.5792","article-title":"Lifestyle and behavioral management of polycystic ovary syndrome","volume":"26","author":"Brennan","year":"2017","journal-title":"J\u00a0Womens Health (Larchmt)."},{"issue":"8","key":"10.1016\/j.beem.2019.04.006_bib63","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrendo.2010.119","article-title":"Therapy: low-dose flutamide for hirsutism: into the limelight, at last","volume":"6","author":"de Zegher","year":"2010","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"10.1016\/j.beem.2019.04.006_bib64","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.fertnstert.2011.05.048","article-title":"Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study","volume":"95","author":"Ladson","year":"2011","journal-title":"Fertil Steril"},{"issue":"11","key":"10.1016\/j.beem.2019.04.006_bib65","first-page":"3361","article-title":"Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin","volume":"96","author":"Ib\u00e1\u00f1ez","year":"2011","journal-title":"J\u00a0ClinEndocrinolMetab"}],"container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X19300156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X19300156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:55:45Z","timestamp":1761497745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X19300156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S1521690X19300156"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2019.04.006","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polycystic ovary syndrome in adolescents","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2019.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101272"}}