{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:49Z","timestamp":1786985089236,"version":"build-2736575974"},"reference-count":126,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"am","delay-in-days":456,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-CE14-0017-03"],"award-info":[{"award-number":["ANR-15-CE14-0017-03"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00c3\u00a9dicale","doi-asserted-by":"publisher","award":["DEQ20140329556"],"award-info":[{"award-number":["DEQ20140329556"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00c3\u00a9 et de la Recherche M\u00c3\u00a9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.beem.2020.101375","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T12:03:01Z","timestamp":1579694581000},"page":"101375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Old and new genes in primary aldosteronism"],"prefix":"10.1016","volume":"34","author":[{"given":"Sheerazed","family":"Boulkroun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Luiz","family":"Fernandes-Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Christina","family":"Zennaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beem.2020.101375_bib1","doi-asserted-by":"crossref","first-page":"T35","DOI":"10.1530\/JOE-16-0669","article-title":"30 years OF the mineralocorticoid receptor: mineralocorticoid receptor and NaCl transport mechanisms in the renal distal nephron","volume":"234","author":"Shibata","year":"2017","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1124\/pr.115.011106","article-title":"Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology","volume":"68","author":"Jaisser","year":"2016","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.beem.2020.101375_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.1.06017","article-title":"The new biology of aldosterone","volume":"186","author":"Connell","year":"2005","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1055\/s-0029-1243601","article-title":"TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation","volume":"42","author":"Bandulik","year":"2010","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.beem.2020.101375_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mce.2003.10.011","article-title":"The regulation of aldosterone synthase expression","volume":"217","author":"Bassett","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.mce.2008.12.015","article-title":"Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells","volume":"302","author":"Szekeres","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mce.2011.07.034","article-title":"Acute and chronic regulation of aldosterone production","volume":"350","author":"Hattangady","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0303-7207(83)90204-6","article-title":"Induction of cultured bovine adrenocortical zona glomerulosa cell 17-hydroxylase activity by ACTH","volume":"30","author":"Crivello","year":"1983","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib9","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1210\/endo-95-5-1240","article-title":"Functional and morphological observations on rat adrenal zona glomerulosa cells in monolayer culture","volume":"95","author":"Hornsby","year":"1974","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2020.101375_bib10","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1210\/jcem.86.10.7917","article-title":"Production and metabolism of serotonin (5-HT) by the human adrenal cortex: paracrine stimulation of aldosterone secretion by 5-HT","volume":"86","author":"Lefebvre","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib11","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1749-6632.2000.tb05428.x","article-title":"Possible function of IL-6 and TNF as intraadrenal factors in the regulation of adrenal steroid secretion","volume":"917","author":"Judd","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.beem.2020.101375_bib12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3346\/jkms.1998.13.6.629","article-title":"EGF-stimulated aldosterone secretion is mediated by tyrosine phosphorylation but not by phospholipase C in cultured porcine adrenal glomerulosa cells","volume":"13","author":"Kim","year":"1998","journal-title":"J\u00a0Kor Med Sci"},{"key":"10.1016\/j.beem.2020.101375_bib13","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1210\/endo.132.3.8440178","article-title":"Transforming growth factor-beta 1 inhibits aldosterone biosynthesis in cultured bovine zona glomerulosa cells","volume":"132","author":"Gupta","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2020.101375_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1172\/JCI109450","article-title":"Dopamine inhibits angiotensin-stimulated aldosterone biosynthesis in bovine adrenal cells","volume":"64","author":"McKenna","year":"1979","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2020.101375_bib15","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/bs.vh.2018.10.001","article-title":"Paracrine regulation of aldosterone secretion in physiological and pathophysiological conditions","volume":"109","author":"Lefebvre","year":"2019","journal-title":"Vitam Horm"},{"key":"10.1016\/j.beem.2020.101375_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/bs.vh.2018.09.003","article-title":"Leptin and aldosterone","volume":"109","author":"Faulkner","year":"2019","journal-title":"Vitam Horm"},{"key":"10.1016\/j.beem.2020.101375_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-0031-1295438","article-title":"Prevalence of primary aldosteronism in patient's cohorts and in population-based studies-a review of the current literature","volume":"44","author":"Hannemann","year":"2012","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.beem.2020.101375_bib18","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A\u00a0prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.beem.2020.101375_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11906-002-0011-8","article-title":"Resistant hypertension","volume":"4","author":"Calhoun","year":"2002","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.beem.2020.101375_bib20","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The Management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib21","first-page":"661","article-title":"Primary aldosteronism","volume":"45","author":"Conn","year":"1955","journal-title":"J\u00a0Lab Clin Med"},{"key":"10.1016\/j.beem.2020.101375_bib22","first-page":"19","article-title":"Man's endocrine and metabolic responses to stressing circumstances: clinical implications","volume":"14","author":"Conn","year":"1954","journal-title":"Hawaii Med J"},{"key":"10.1016\/j.beem.2020.101375_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tem.2008.01.006","article-title":"Primary aldosteronism: cardiovascular, renal and metabolic implications","volume":"19","author":"Rossi","year":"2008","journal-title":"Trends Endocrinol Metabol: TEM (Trends Endocrinol Metab)"},{"key":"10.1016\/j.beem.2020.101375_bib24","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism","volume":"45","author":"Milliez","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.beem.2020.101375_bib25","first-page":"1297","article-title":"LVH in primary aldosteronism","volume":"30","author":"Rossi","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib26","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.CIR.95.6.1471","article-title":"Remodeling of the left ventricle in primary aldosteronism due to Conn's adenoma","volume":"95","author":"Rossi","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.beem.2020.101375_bib27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/HYPERTENSIONAHA.113.01060","article-title":"Cardiovascular complications associated with primary aldosteronism: a controlled cross-sectional study","volume":"62","author":"Savard","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib28","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline","volume":"93","author":"Funder","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1161\/HYPERTENSIONAHA.111.175083","article-title":"Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms)","volume":"58","author":"Mulatero","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib30","first-page":"1109","article-title":"Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone","volume":"95","author":"Sutherland","year":"1966","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.beem.2020.101375_bib31","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/jcem-71-5-1151","article-title":"Defective fasciculata zone function as the mechanism of glucocorticoid-remediable aldosteronism","volume":"71","author":"Ulick","year":"1990","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0960-0760(01)00097-8","article-title":"Familial hyperaldosteronism","volume":"78","author":"Stowasser","year":"2001","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.beem.2020.101375_bib33","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1172\/JCI118279","article-title":"Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree","volume":"96","author":"Pascoe","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2020.101375_bib34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/355262a0","article-title":"A\u00a0chimaeric 11 beta-hydroxylase\/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension","volume":"355","author":"Lifton","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.beem.2020.101375_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng0992-66","article-title":"Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase","volume":"2","author":"Lifton","year":"1992","journal-title":"Nat Genet"},{"key":"10.1016\/j.beem.2020.101375_bib36","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1161\/HYPERTENSIONAHA.110.168740","article-title":"Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: clinical and biochemical presentation","volume":"57","author":"Aglony","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.1991.tb01446.x","article-title":"Clinical and pathological diversity of primary aldosteronism, including a new familial variety","volume":"18","author":"Gordon","year":"1991","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.beem.2020.101375_bib38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/00004872-200018090-00002","article-title":"Primary aldosteronism: learning from the study of familial varieties","volume":"18","author":"Stowasser","year":"2000","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.beem.2020.101375_bib39","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1046\/j.1440-1681.2001.03574.x","article-title":"Familial varieties of primary aldosteronism","volume":"28","author":"Stowasser","year":"2001","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.beem.2020.101375_bib40","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0003-4266(05)81756-1","article-title":"Familial aspect of primary hyperaldosteronism: analysis of families compatible with primary hyperaldosteronism type 2","volume":"66","author":"Medeau","year":"2005","journal-title":"Ann Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1136\/jmg.37.11.831","article-title":"A\u00a0novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22)","volume":"37","author":"Lafferty","year":"2000","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.beem.2020.101375_bib42","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1440-1681.2008.04882.x","article-title":"Examination of chromosome 7p22 candidate genes RBaK, PMS2 and GNA12 in familial hyperaldosteronism type II","volume":"35","author":"Jeske","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.beem.2020.101375_bib43","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1440-1681.1996.tb02786.x","article-title":"PCR-SSCP analysis of the p53 gene in tumours of the adrenal gland","volume":"23","author":"Ballantine","year":"1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.beem.2020.101375_bib44","first-page":"611","article-title":"Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma","volume":"82","author":"Davies","year":"1997","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1440-1681.1992.tb00462.x","article-title":"Familial hyperaldosteronism type II: five families with a new variety of primary aldosteronism","volume":"19","author":"Stowasser","year":"1992","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.beem.2020.101375_bib46","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41588-018-0048-5","article-title":"CLCN2 chloride channel mutations in familial hyperaldosteronism type II","volume":"50","author":"Scholl","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.beem.2020.101375_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-018-0053-8","article-title":"A\u00a0gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism","author":"Fernandes-Rosa","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.beem.2020.101375_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/356057a0","article-title":"A\u00a0chloride channel widely expressed in epithelial and non-epithelial cells","volume":"356","author":"Thiemann","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.beem.2020.101375_bib49","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1474-4422(13)70053-X","article-title":"Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study","volume":"12","author":"Depienne","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.beem.2020.101375_bib50","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1212\/WNL.0000000000000812","article-title":"Subclinical leukodystrophy and infertility in a man with a novel homozygous CLCN2 mutation","volume":"83","author":"Di Bella","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.beem.2020.101375_bib51","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1523\/JNEUROSCI.0338-07.2007","article-title":"Leukoencephalopathy upon disruption of the chloride channel ClC-2","volume":"27","author":"Blanz","year":"2007","journal-title":"J\u00a0Neurosci : Off J Soc Neurosci"},{"key":"10.1016\/j.beem.2020.101375_bib52","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/emboj\/20.6.1289","article-title":"Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption","volume":"20","author":"Bosl","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.beem.2020.101375_bib53","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1038\/s41467-019-12113-9","article-title":"Pathogenesis of hypertension in a mouse model for human CLCN2 related hyperaldosteronism","volume":"10","author":"Goppner","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.beem.2020.101375_bib54","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1038\/s41467-019-13033-4","article-title":"Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation","volume":"10","author":"Schewe","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.beem.2020.101375_bib55","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1210\/jc.2008-0594","article-title":"A\u00a0novel form of human mendelian hypertension featuring nonglucocorticoid-remediable aldosteronism","volume":"93","author":"Geller","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib56","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archpedi.1959.02070020092012","article-title":"Primary aldosteronism due to adrenal hyperplasia; occurrence in a boy aged 10 years","volume":"98","author":"Therien","year":"1959","journal-title":"AMA J Dis Child"},{"key":"10.1016\/j.beem.2020.101375_bib57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mce.2016.10.025","article-title":"Disordered zonal and cellular CYP11B2 enzyme expression in familial hyperaldosteronism type 3","volume":"439","author":"Gomez-Sanchez","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib58","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.beem.2020.101375_bib59","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1073\/pnas.1121407109","article-title":"Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5","volume":"109","author":"Scholl","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.beem.2020.101375_bib60","doi-asserted-by":"crossref","first-page":"E1532","DOI":"10.1210\/jc.2012-1334","article-title":"A\u00a0novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension","volume":"97","author":"Charmandari","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib61","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.111.183996","article-title":"KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism","volume":"59","author":"Mulatero","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib62","doi-asserted-by":"crossref","first-page":"E1861","DOI":"10.1210\/jc.2013-2428","article-title":"A\u00a0Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III","volume":"98","author":"Monticone","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib63","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000358197","article-title":"Discordant genotype-phenotype correlation in familial hyperaldosteronism type III with KCNJ5 gene mutation: a patient report and review of the literature","volume":"82","author":"Adachi","year":"2014","journal-title":"Hormone Res Paediatr"},{"key":"10.1016\/j.beem.2020.101375_bib64","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1530\/EJE-17-0946","article-title":"Genetics IN endocrinology: the expanding genetic horizon of primary aldosteronism","volume":"178","author":"Monticone","year":"2018","journal-title":"Eur J Endocrinol\/Eur Fed Endocr Soc"},{"key":"10.1016\/j.beem.2020.101375_bib65","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jhh.2017.34","article-title":"Familial hyperaldosteronism type III","volume":"31","author":"Monticone","year":"2017","journal-title":"J\u00a0Hum Hypertens"},{"key":"10.1016\/j.beem.2020.101375_bib66","article-title":"Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism","volume":"4","author":"Scholl","year":"2015","journal-title":"ElifeTrends Endocrinol Metabol"},{"key":"10.1016\/j.beem.2020.101375_bib67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ebiom.2016.10.002","article-title":"CACNA1H mutations are associated with different forms of primary aldosteronism","volume":"13","author":"Daniil","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.beem.2020.101375_bib68","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ana.10607","article-title":"Association between genetic variation of CACNA1H and childhood absence epilepsy","volume":"54","author":"Chen","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.beem.2020.101375_bib69","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ana.21169","article-title":"Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants","volume":"62","author":"Heron","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.beem.2020.101375_bib70","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.1074\/jbc.C400006200","article-title":"Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy","volume":"279","author":"Khosravani","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2020.101375_bib71","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ana.20458","article-title":"Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy","volume":"57","author":"Khosravani","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.beem.2020.101375_bib72","doi-asserted-by":"crossref","first-page":"22085","DOI":"10.1074\/jbc.M603316200","article-title":"CACNA1H mutations in autism spectrum disorders","volume":"281","author":"Splawski","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.beem.2020.101375_bib73","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00424-015-1776-3","article-title":"Two heterozygous Cav3.2 channel mutations in a pediatric chronic pain patient: recording condition-dependent biophysical effects","volume":"468","author":"Souza","year":"2016","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.beem.2020.101375_bib74","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1210\/en.2016-1170","article-title":"CACNA1H(M1549V) mutant calcium channel causes autonomous aldosterone production in HAC15 cells and is inhibited by mibefradil","volume":"157","author":"Reimer","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2020.101375_bib75","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.beem.2020.101375_bib76","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ando.2016.05.001","article-title":"SFE\/SFHTA\/AFCE primary aldosteronism consensus: introduction and handbook","volume":"77","author":"Amar","year":"2016","journal-title":"Ann Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib77","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ando.2016.02.006","article-title":"SFE\/SFHTA\/AFCE consensus on primary aldosteronism, part 5: genetic diagnosis of primary aldosteronism","volume":"77","author":"Zennaro","year":"2016","journal-title":"Ann Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib78","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1210\/jc.2005-0681","article-title":"Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I","volume":"90","author":"Stowasser","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib79","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.2716","article-title":"Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension","volume":"45","author":"Azizan","year":"2013","journal-title":"Nat Genet"},{"issue":"440\u20134","key":"10.1016\/j.beem.2020.101375_bib80","first-page":"4e1","article-title":"Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.beem.2020.101375_bib81","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1210\/en.2015-1466","article-title":"Pathogenesis of adrenal aldosterone-producing adenomas carrying mutations of the Na(+)\/K(+)-ATPase","volume":"156","author":"Stindl","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2020.101375_bib82","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1210\/en.2015-2029","article-title":"Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3","volume":"157","author":"Tauber","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2020.101375_bib83","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/HYPERTENSIONAHA.111.186478","article-title":"Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism","volume":"59","author":"Boulkroun","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib84","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma","volume":"64","author":"Fernandes-Rosa","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib85","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/cen.12873","article-title":"Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype","volume":"83","author":"Scholl","year":"2015","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib86","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1530\/ERC-15-0321","article-title":"Novel somatic mutations and distinct molecular signature in aldosterone-producing adenomas","volume":"22","author":"Akerstrom","year":"2015","journal-title":"Endocr Relat Canc"},{"key":"10.1016\/j.beem.2020.101375_bib87","doi-asserted-by":"crossref","first-page":"e708","DOI":"10.1097\/MD.0000000000000708","article-title":"Prevalence and characterization of somatic mutations in Chinese aldosterone-producing adenoma patients","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.beem.2020.101375_bib88","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3389\/fendo.2019.00666","article-title":"Prevalence and histopathological characteristics of KCNJ5 mutant aldosterone-producing adenomas in a multi-ethnic Malaysian cohort","volume":"10","author":"Mohideen","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib89","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1210\/jc.2018-01004","article-title":"Targeted molecular characterization of aldosterone-producing adenomas in white Americans","volume":"103","author":"Nanba","year":"2018","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib90","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.118.12070","article-title":"Genetic characteristics of aldosterone-producing adenomas in blacks","volume":"73","author":"Nanba","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib91","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.119.14177","article-title":"Cellular and molecular heterogeneity in adrenals with aldosterone producing adenoma","volume":"75","author":"De Sousa","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib92","doi-asserted-by":"crossref","first-page":"E1089","DOI":"10.1210\/jc.2015-2149","article-title":"A\u00a0meta-analysis of somatic KCNJ5 K(+) channel mutations in 1636 patients with an aldosterone-producing adenoma","volume":"100","author":"Lenzini","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib93","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/jc.2011-2885","article-title":"Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas","volume":"97","author":"Taguchi","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib94","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/HYPERTENSIONAHA.114.03346","article-title":"Clinical characteristics of somatic mutations in Chinese patients with aldosterone-producing adenoma","volume":"65","author":"Zheng","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib95","doi-asserted-by":"crossref","first-page":"11396","DOI":"10.1038\/srep11396","article-title":"Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population","volume":"5","author":"Wu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.beem.2020.101375_bib96","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1038\/srep19546","article-title":"Activating mutations in CTNNB1 in aldosterone producing adenomas","volume":"6","author":"Akerstrom","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.beem.2020.101375_bib97","doi-asserted-by":"crossref","first-page":"39121","DOI":"10.1038\/srep39121","article-title":"The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.beem.2020.101375_bib98","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJMoa1504869","article-title":"Pregnancy, primary aldosteronism, and adrenal CTNNB1 mutations","volume":"373","author":"Teo","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.beem.2020.101375_bib99","doi-asserted-by":"crossref","first-page":"K37","DOI":"10.1530\/EJE-19-0377","article-title":"A somatic mutation in CLCN2 identified in a sporadic aldosterone-producing adenoma","volume":"181","author":"Dutta","year":"2019","journal-title":"Eur J Endocrinol\/Eur Fed Endocr Soc"},{"key":"10.1016\/j.beem.2020.101375_bib100","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1210\/jc.2016-1700","article-title":"PRKACA somatic mutations are rare findings in aldosterone-producing adenomas","volume":"101","author":"Rhayem","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib101","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/HYPERTENSIONAHA.111.186239","article-title":"Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas","volume":"59","author":"Azizan","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib102","doi-asserted-by":"crossref","first-page":"E155","DOI":"10.1210\/jc.2014-3009","article-title":"Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance","volume":"100","author":"Cheng","year":"2015","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib103","doi-asserted-by":"crossref","first-page":"E2307","DOI":"10.1210\/jc.2012-2342","article-title":"Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling","volume":"97","author":"Seccia","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib104","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1530\/EJE-13-0551","article-title":"Lack of influence of somatic mutations on steroid gradients during adrenal vein sampling in aldosterone-producing adenoma patients","volume":"169","author":"Osswald","year":"2013","journal-title":"Eur J Endocrinol\/Eur Fed Endocr Soc"},{"key":"10.1016\/j.beem.2020.101375_bib105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/HYPERTENSIONAHA.115.06186","article-title":"Genotype-specific steroid profiles associated with aldosterone-producing adenomas","volume":"67","author":"Williams","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib106","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"The lancet Diabetes endocrinolPfl\u00fcgers Archiv"},{"key":"10.1016\/j.beem.2020.101375_bib107","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1210\/jc.2019-00531","article-title":"KCNJ5 somatic mutation is a predictor of hypertension remission after adrenalectomy for unilateral primary aldosteronism","volume":"104","author":"Vilela","year":"2019","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib108","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1097\/HJH.0000000000000186","article-title":"KCNJ5 gene somatic mutations affect cardiac remodelling but do not preclude cure of high blood pressure and regression of left ventricular hypertrophy in primary aldosteronism","volume":"32","author":"Rossi","year":"2014","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.beem.2020.101375_bib109","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5551\/jat.24455","article-title":"Comparison of cardiovascular complications in patients with and without KCNJ5 gene mutations harboring aldosterone-producing adenomas","volume":"22","author":"Kitamoto","year":"2015","journal-title":"J\u00a0Atherosclerosis Thromb"},{"key":"10.1016\/j.beem.2020.101375_bib110","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/en.2013-1944","article-title":"Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas","volume":"155","author":"Tauber","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.beem.2020.101375_bib111","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1172\/JCI91733","article-title":"Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma","volume":"127","author":"Scholl","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.beem.2020.101375_bib112","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1161\/HYPERTENSIONAHA.117.10226","article-title":"Macrolides blunt aldosterone biosynthesis: a proof-of-concept study in KCNJ5 mutated adenoma cells ex\u00a0vivo","volume":"70","author":"Caroccia","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib113","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/08037051.2018.1436961","article-title":"Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism","volume":"27","author":"Maiolino","year":"2018","journal-title":"Blood Pres"},{"key":"10.1016\/j.beem.2020.101375_bib114","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1210\/jc.2009-2010","article-title":"Adrenocortical zonation in humans under normal and pathological conditions","volume":"95","author":"Nishimoto","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib115","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.110.158543","article-title":"Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism","volume":"56","author":"Boulkroun","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib116","doi-asserted-by":"crossref","first-page":"E4591","DOI":"10.1073\/pnas.1505529112","article-title":"Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands","volume":"112","author":"Nishimoto","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.beem.2020.101375_bib117","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mce.2016.10.014","article-title":"Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism","volume":"441","author":"Nishimoto","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib118","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.118.11086","article-title":"Cellular and genetic causes of idiopathic hyperaldosteronism","volume":"72","author":"Omata","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib119","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041926","article-title":"Comprehensive Re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter","volume":"7","author":"Akerstrom","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.beem.2020.101375_bib120","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/HYPERTENSIONAHA.113.01733","article-title":"Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas","volume":"63","author":"Williams","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.beem.2020.101375_bib121","doi-asserted-by":"crossref","first-page":"E1765","DOI":"10.1210\/jc.2014-1927","article-title":"A\u00a0Novel KCNJ5-insT149 Somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium","volume":"99","author":"Kuppusamy","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib122","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1210\/jc.2015-3284","article-title":"Clinical and steroidogenic characteristics of aldosterone-producing adenomas with ATPase or CACNA1D gene mutations","volume":"101","author":"Kitamoto","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib123","doi-asserted-by":"crossref","first-page":"E819","DOI":"10.1210\/jc.2011-2965","article-title":"Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors","volume":"97","author":"Azizan","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2020.101375_bib124","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mce.2015.04.022","article-title":"Immunohistochemical, genetic and clinical characterization of sporadic aldosterone-producing adenomas","volume":"411","author":"Monticone","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.beem.2020.101375_bib125","article-title":"Genetics of aldosterone-producing adenoma in Korean patients","volume":"11","author":"Hong","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.beem.2020.101375_bib126","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/HYPERTENSIONAHA.119.13476","article-title":"Primary Aldosteronism: KCNJ5 mutations and adrenocortical cell growth","volume":"74","author":"Yang","year":"2019","journal-title":"Hypertension"}],"container-title":["Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X20300026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X20300026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T16:56:46Z","timestamp":1761497806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X20300026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1521690X20300026"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2020.101375","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Old and new genes in primary aldosteronism","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2020.101375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101375"}}