{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:29:45Z","timestamp":1790785785859,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK133392"],"award-info":[{"award-number":["DK133392"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK110770"],"award-info":[{"award-number":["DK110770"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.beem.2023.101824","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:10:46Z","timestamp":1695877846000},"page":"101824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differences between bone health parameters in adults with acromegaly and growth hormone deficiency: A systematic review"],"prefix":"10.1016","volume":"37","author":[{"given":"Pamela U.","family":"Freda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.2007-0036","article-title":"Growth hormone, insulin-like growth factors, and the skeleton","volume":"29","author":"Giustina","year":"2008","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib2","first-page":"55","article-title":"Growth hormone and bone","volume":"19","author":"Ohlsson","year":"1998","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/jcb.22322","article-title":"Growth factor control of bone mass","volume":"108","author":"Canalis","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.beem.2023.101824_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2265.2009.03626.x","article-title":"Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006; Acromegaly remains under-recognized and under-diagnosed","volume":"72","author":"Reid","year":"2010","journal-title":"Clin Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000375450","article-title":"Giustina A. bone and joint disorders in acromegaly","volume":"103","author":"Claessen","year":"2016","journal-title":"Neuroendocrinology"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1530\/EJE-12-0147","article-title":"Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study","volume":"167","author":"Claessen","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"10.1016\/j.beem.2023.101824_bib7","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1359\/jbmr.2003.18.7.1254","article-title":"Association between vertebral fracture and increased mortality in osteoporotic patients","volume":"18","author":"Jalava","year":"2003","journal-title":"J Bone Min Res"},{"issue":"10","key":"10.1016\/j.beem.2023.101824_bib8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.7326\/0003-4819-128-10-199805150-00001","article-title":"et alR. The association of radiographically detected vertebral fractures with back pain and function: a prospective study","volume":"128","author":"Nevitt","year":"1998","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s11102-022-01256-6","article-title":"Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis","volume":"25","author":"Ribeiro de Moura","year":"2022","journal-title":"Pituitary"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2265.2002.01624.x","article-title":"Effects of a growth hormone receptor antagonist on bone markers in acromegaly","volume":"57","author":"Fairfield","year":"2002","journal-title":"Clin Endocrinol"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/BF00298716","article-title":"Serum levels of bone Gla protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in acromegaly: effects of long-term octreotide treatment","volume":"52","author":"Terzolo","year":"1993","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1210\/jc.2014-2937","article-title":"Bone turnover, bone mineral density, and fracture risk in acromegaly: a meta-analysis","volume":"100","author":"Mazziotti","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1530\/eje.1.02285","article-title":"Serum GH and IGF-I are significant determinants of bone turnover but not bone mineral density in active acromegaly: a prospective study of more than 70 consecutive patients","volume":"155","author":"Ueland","year":"2006","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib14","first-page":"18","article-title":"Iliac crest bone mass and remodelling in acromegaly","volume":"97","author":"Halse","year":"1981","journal-title":"Acta Endocrinol"},{"issue":"10","key":"10.1016\/j.beem.2023.101824_bib15","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1210\/jc.2009-0474","article-title":"A link between bone mineral density and serum adiponectin and visfatin levels in acromegaly","volume":"94","author":"Sucunza","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12010164","article-title":"Vertebral fractures in acromegaly: a systematic review","volume":"12","author":"Sorohan","year":"2022","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib17","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1210\/jc.2012-4073","article-title":"Acromegaly has a negative influence on trabecular bone, but not on cortical bone, as assessed by high-resolution peripheral quantitative computed tomography","volume":"98","author":"Madeira","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.beem.2023.101824_bib18","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1359\/JBMR.050603","article-title":"Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women","volume":"20","author":"Bonadonna","year":"2005","journal-title":"J Bone Min Res"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/eje.1.01820","article-title":"Long-term maintenance of the anabolic effects of GH on the skeleton in successfully treated patients with acromegaly","volume":"152","author":"Biermasz","year":"2005","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF01622293","article-title":"Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine","volume":"7","author":"Kayath","year":"1997","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib21","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00198-015-3344-2","article-title":"Trabecular bone score as a skeletal fragility index in acromegaly patients","volume":"27","author":"Hong","year":"2016","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.beem.2023.101824_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.738895","article-title":"The negative impacts of acromegaly on bone microstructure not fully Reversible","volume":"12","author":"Duan","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib23","first-page":"37","article-title":"Prevalence of osteoporosis and vertebral fractures in acromegalic patients","volume":"8","author":"Padova","year":"2011","journal-title":"Clin Cases Min Bone Metab"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1507\/endocrj.EJ13-0387","article-title":"Rapid decline in bone turnover markers but not bone mineral density in acromegalic patients after transsphenoidal surgery","volume":"61","author":"Tamada","year":"2014","journal-title":"Endocr J"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1530\/EJE-16-0340","article-title":"Treatment of acromegaly increases BMD but reduces trabecular bone score: a longitudinal study","volume":"175","author":"Godang","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"10.1016\/j.beem.2023.101824_bib26","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1210\/jc.2013-2695","article-title":"R. Progression of vertebral fractures despite long-term biochemical control of acromegaly: a prospective follow-up study","volume":"98","author":"Claessen","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1530\/EJE-10-1005","article-title":"High prevalence of vertebral fractures despite normal bone mineral density in patients with long-term controlled acromegaly","volume":"164","author":"Wassenaar","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"10.1016\/j.beem.2023.101824_bib28","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1210\/jc.2013-1460","article-title":"Vertebral fractures in patients with acromegaly: a 3-year prospective study","volume":"98","author":"Mazziotti","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1359\/jbmr.061206","article-title":"Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study","volume":"22","author":"Sornay-Rendu","year":"2007","journal-title":"J Bone Min Res"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jbmr.562","article-title":"Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements","volume":"27","author":"Liu","year":"2012","journal-title":"J Bone Min Res"},{"issue":"12","key":"10.1016\/j.beem.2023.101824_bib31","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1002\/jbmr.152","article-title":"Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures","volume":"25","author":"Stein","year":"2010","journal-title":"J Bone Min Res"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib32","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/jbmr.2796","article-title":"Microarchitecture and peripheral BMD are impaired in postmenopausal white women with fracture independently of total hip T-Score: an international multicenter study","volume":"31","author":"Boutroy","year":"2016","journal-title":"J Bone Min Res"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jbmr.3299","article-title":"Evaluation of radius microstructure and areal bone mineral density improves fracture prediction in postmenopausal women","volume":"33","author":"Biver","year":"2018","journal-title":"J Bone Min Res"},{"issue":"9","key":"10.1016\/j.beem.2023.101824_bib34","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1210\/clinem\/dgab260","article-title":"Impaired bone microarchitecture in premenopausal women with acromegaly: the possible role of Wnt signaling","volume":"106","author":"Silva","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1530\/EJE-17-0468","article-title":"Bone microarchitecture and estimated bone strength in men with active acromegaly","volume":"177","author":"Silva","year":"2017","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.beem.2023.101824_bib36","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvad121","article-title":"Persistent deficits in bone quality in treated acromegaly: evidence from assessments of microstructure","author":"Kuker","year":"2023","journal-title":"J Endocr Soc"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/EJE-15-0931","article-title":"Reduction of trabecular and cortical volumetric bone mineral density at the proximal femur in patients with acromegaly","volume":"174","author":"Valassi","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib38","first-page":"123","article-title":"Increased cortical bone content of insulin-like growth factors in acromegalic patients","volume":"84","author":"Ueland","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-2362.2002.00944.x","article-title":"J. Decreased trabecular bone biomechanical competence, apparent density, IGF-II and IGFBP-5 content in acromegaly","volume":"32","author":"Ueland","year":"2002","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11102-017-0847-1","article-title":"Bone histomorphometry in acromegaly patients with fragility vertebral fractures","volume":"21","author":"Dalle Carbonare","year":"2018","journal-title":"Pituitary"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib41","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s12020-016-1078-3","article-title":"High-resolution-cone beam tomography analysis of bone microarchitecture in patients with acromegaly and radiological vertebral fractures","volume":"54","author":"Maffezzoni","year":"2016","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib42","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1359\/jbmr.071108","article-title":"Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women","volume":"23","author":"Boutroy","year":"2008","journal-title":"J Bone Min Res"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib43","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2265.2008.03322.x","article-title":"Spinal volumetric trabecular bone mass in acromegalic patients: a longitudinal study","volume":"70","author":"Battista","year":"2009","journal-title":"Clin Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00198-012-2188-2","article-title":"Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study","volume":"24","author":"Boutroy","year":"2013","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib45","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jocd.2013.01.006","article-title":"Manitoba bone density P. Clinical factors associated with trabecular bone score","volume":"16","author":"Leslie","year":"2013","journal-title":"J Clin Densitom"},{"issue":"8","key":"10.1016\/j.beem.2023.101824_bib46","doi-asserted-by":"crossref","first-page":"bvab090","DOI":"10.1210\/jendso\/bvab090","article-title":"Spine bone texture assessed by trabecular bone score in active and controlled acromegaly: a prospective study","volume":"5","author":"Sala","year":"2021","journal-title":"J Endocr Soc"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1530\/EJE-18-0881","article-title":"Non-invasive DXA-derived bone structure assessment of acromegaly patients: a cross-sectional study","volume":"180","author":"Kuzma","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cen.14439","article-title":"Trabecular bone score and bone mineral density in patients with long-term controlled acromegaly","volume":"95","author":"Calatayud","year":"2021","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib49","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11657-021-00986-7","article-title":"Trabecular bone score and bone mineral density in acromegalic osteopathy assessment: a cross-sectional study","volume":"16","author":"Sorohan","year":"2021","journal-title":"Arch Osteoporos"},{"issue":"21","key":"10.1016\/j.beem.2023.101824_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11216374","article-title":"Trabecular bone score as a reliable measure of lumbar spine bone microarchitecture in acromegalic patients","volume":"11","author":"Nazzari","year":"2022","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib51","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1159\/000528199","article-title":"Trabecular bone score as an index of bone fragility in patients with acromegaly: a systematic review and meta-analysis","volume":"113","author":"Bioletto","year":"2023","journal-title":"Neuroendocrinology"},{"issue":"12","key":"10.1016\/j.beem.2023.101824_bib52","first-page":"e5088","article-title":"Vertebral fractures occur despite control of acromegaly and are predicted by cortical volumetric bone mineral density","volume":"106","author":"Kuzma","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.beem.2023.101824_bib53","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1210\/jc.2008-0791","article-title":"Prevalence of vertebral fractures in men with acromegaly","volume":"93","author":"Mazziotti","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.beem.2023.101824_bib54","doi-asserted-by":"crossref","first-page":"e2843","DOI":"10.1210\/clinem\/dgac183","article-title":"High prevalence of vertebral fractures associated with preoperative GH levels in patients with recent diagnosis of acromegaly","volume":"107","author":"Frara","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib55","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1530\/EJE-20-0415","article-title":"Progression of vertebral fractures in long-term controlled acromegaly: a 9-year follow-up study","volume":"183","author":"Pelsma","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"10.1016\/j.beem.2023.101824_bib56","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa363","article-title":"Treatment of acromegalic osteopathy in real-life clinical practice: the BAAC (Bone Active Drugs in Acromegaly) study","volume":"105","author":"Mazziotti","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib57","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/jbmr.2734","article-title":"A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX","volume":"31","author":"McCloskey","year":"2016","journal-title":"J Bone Min Res"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib58","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S2213-8587(18)30333-4","article-title":"Improving fracture risk assessment in older adults","volume":"7","author":"Shane","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib59","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S2213-8587(18)30308-5","article-title":"Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study","volume":"7","author":"Samelson","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.beem.2017.02.002","article-title":"Focus on growth hormone deficiency and bone in adults","volume":"31","author":"Tritos","year":"2017","journal-title":"Best Pr Res Clin Endocrinol Metab"},{"key":"10.1016\/j.beem.2023.101824_bib61","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.pmbts.2015.10.008","article-title":"Effects of Growth Hormone on Bone","volume":"138","author":"Tritos","year":"2016","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"10058","key":"10.1016\/j.beem.2023.101824_bib62","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/S0140-6736(16)30053-8","article-title":"Hypopituitarism","volume":"388","author":"Higham","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib63","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1210\/jcem.82.6.3982","article-title":"The effect of growth hormone (GH) on histomorphometric indices of bone structure and bone turnover in GH-deficient men","volume":"82","author":"Bravenboer","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib64","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s42000-021-00275-5","article-title":"Update on vertebral fractures in pituitary diseases: from research to clinical practice","volume":"20","author":"Carrone","year":"2021","journal-title":"Horm (Athens)"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib65","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1210\/jc.2013-3921","article-title":"Effects of recombinant human growth hormone therapy on bone mineral density in adults with growth hormone deficiency: a meta-analysis","volume":"99","author":"Barake","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl B","key":"10.1016\/j.beem.2023.101824_bib66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1096-6374(98)80026-9","article-title":"Influence of gender and gonadal steroids on responsiveness to growth hormone replacement therapy in adults with growth hormone deficiency","volume":"8","author":"Johannsson","year":"1998","journal-title":"Growth Horm IGF Res"},{"issue":"8","key":"10.1016\/j.beem.2023.101824_bib67","first-page":"2865","article-title":"Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency","volume":"81","author":"Johannsson","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib68","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1359\/jbmr.2002.17.6.1081","article-title":"The effects of growth hormone replacement therapy on bone metabolism in adult-onset growth hormone deficiency: a 2-year open randomized controlled multicenter trial","volume":"17","author":"Bex","year":"2002","journal-title":"J Bone Min Res"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib69","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41574-022-00649-8","article-title":"Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis","volume":"18","author":"Mazziotti","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib70","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1210\/jc.2010-2662","article-title":"Unreplaced sex steroid deficiency, corticotropin deficiency, and lower IGF-I are associated with lower bone mineral density in adults with growth hormone deficiency: a KIMS database analysis","volume":"96","author":"Tritos","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF03343570","article-title":"Effects of two years of growth hormone (GH) replacement therapy on bone metabolism and mineral density in childhood and adulthood onset GH deficient patients","volume":"22","author":"Longobardi","year":"1999","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib72","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1359\/jbmr.060112","article-title":"Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy","volume":"21","author":"Mazziotti","year":"2006","journal-title":"J Bone Min Res"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib73","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1210\/jc.2005-0897","article-title":"A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency","volume":"91","author":"Murray","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib74","first-page":"1462","article-title":"Elderly patients with adult-onset growth hormone deficiency are not osteopenic","volume":"82","author":"Toogood","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib75","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1210\/jc.2003-030685","article-title":"Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly","volume":"89","author":"Murray","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib76","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s11102-020-01031-5","article-title":"Growth hormone therapy in adults with growth hormone deficiency: a critical assessment of the literature","volume":"23","author":"He","year":"2020","journal-title":"Pituitary"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib77","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11102-007-0069-z","article-title":"Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency","volume":"11","author":"Mazziotti","year":"2008","journal-title":"Pituitary"},{"issue":"12","key":"10.1016\/j.beem.2023.101824_bib78","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1359\/jbmr.070811","article-title":"Fracture incidence in GH-deficient patients on complete hormone replacement including GH","volume":"22","author":"Holmer","year":"2007","journal-title":"J Bone Min Res"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib79","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1359\/jbmr.2001.16.2.398","article-title":"The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density","volume":"16","author":"Wuster","year":"2001","journal-title":"J Bone Min Res"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib80","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ecl.2014.10.014","article-title":"Pituitary diseases and bone","volume":"44","author":"Mazziotti","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib81","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1365-2265.2004.01935.x","article-title":"Growth hormone replacement in adults and bone mineral density: a systematic review and meta-analysis","volume":"60","author":"Davidson","year":"2004","journal-title":"Clin Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib82","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/EJE-11-1072","article-title":"Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency","volume":"166","author":"Elbornsson","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib83","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/cen.12493","article-title":"Effects of up to 15 years of recombinant human GH (rhGH) replacement on bone metabolism in adults with growth hormone deficiency (GHD): the Leiden Cohort Study","volume":"81","author":"Appelman-Dijkstra","year":"2014","journal-title":"Clin Endocrinol"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib84","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/cen.12132","article-title":"Predictors of the effects of 4 years of growth hormone replacement on bone mineral density in patients with adult-onset growth hormone deficiency - a KIMS database analysis","volume":"79","author":"Tritos","year":"2013","journal-title":"Clin Endocrinol"},{"issue":"2","key":"10.1016\/j.beem.2023.101824_bib85","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/EJE-18-0711","article-title":"Bone microarchitecture and volumetric bone density impairment in young male adults with childhood-onset growth hormone deficiency","volume":"180","author":"Yang","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.beem.2023.101824_bib86","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/jcm10040657","article-title":"3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency","volume":"10","author":"Gracia-Marco","year":"2021","journal-title":"J Clin Med"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib87","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ghir.2013.12.001","article-title":"Impact of the growth hormone replacement on bone status in growth hormone deficient adults","volume":"24","author":"Kuzma","year":"2014","journal-title":"Growth Horm IGF Res"},{"issue":"8","key":"10.1016\/j.beem.2023.101824_bib88","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4158\/EP151183.OR","article-title":"Trabecular bone score change differs with regard to 25(Oh)D levels in patients treated for adult-onset growth hormone deficiency","volume":"22","author":"Kuzma","year":"2016","journal-title":"Endocr Pr"},{"issue":"Suppl 1","key":"10.1016\/j.beem.2023.101824_bib89","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.33549\/physiolres.934775","article-title":"The long-term effects of growth hormone replacement on bone mineral density and trabecular bone score: results of the 10-year prospective follow-up","volume":"70","author":"Vanuga","year":"2021","journal-title":"Physiol Res"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib90","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/2042018816643908","article-title":"Seven years of follow up of trabecular bone score, bone mineral density, body composition and quality of life in adults with growth hormone deficiency treated with rhGH replacement in a single center","volume":"7","author":"Allo Miguel","year":"2016","journal-title":"Ther Adv Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.beem.2023.101824_bib91","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1530\/eje.0.1370240","article-title":"Increased fracture frequency in adult patients with hypopituitarism and GH deficiency","volume":"137","author":"Rosen","year":"1997","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib92","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12020-015-0738-z","article-title":"Incidence of morphometric vertebral fractures in adult patients with growth hormone deficiency","volume":"52","author":"Mazziotti","year":"2016","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib93","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1530\/EJE-07-0523","article-title":"Morbidity and GH deficiency: a nationwide study","volume":"158","author":"Stochholm","year":"2008","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.beem.2023.101824_bib94","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/EJE-10-0125","article-title":"Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency","volume":"163","author":"Mazziotti","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib95","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1530\/EJE-14-0097","article-title":"Association between l-thyroxine treatment, GH deficiency, and radiological vertebral fractures in patients with adult-onset hypopituitarism","volume":"170","author":"Mazziotti","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.beem.2023.101824_bib96","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S2213-8587(15)00098-4","article-title":"Fracture risk in adult patients treated with growth hormone replacement therapy for growth hormone deficiency: a prospective observational cohort study","volume":"3","author":"Mo","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"10.1016\/j.beem.2023.101824_bib97","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/cen.12262","article-title":"FRAX score in acromegaly: does it tell the whole story?","volume":"80","author":"Brzana","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.beem.2023.101824_bib98","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/clinem\/dgz096","article-title":"A consensus on the diagnosis and treatment of acromegaly comorbidities: an update","volume":"105","author":"Giustina","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.beem.2023.101824_bib99","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/jc.2011-0179","article-title":"Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Molitch","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.beem.2023.101824_bib100","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4158\/GL-2019-0405","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinologyguidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care","volume":"25","author":"Yuen","year":"2019","journal-title":"Endocr Pr"}],"container-title":["Best Practice & Research Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X23000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521690X23000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:03:47Z","timestamp":1778616227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521690X23000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":100,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1521690X23000982"],"URL":"https:\/\/doi.org\/10.1016\/j.beem.2023.101824","relation":{},"ISSN":["1521-690X"],"issn-type":[{"value":"1521-690X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences between bone health parameters in adults with acromegaly and growth hormone deficiency: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Endocrinology & Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beem.2023.101824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101824"}}