{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:01:44Z","timestamp":1790866904382,"version":"4.1.0"},"reference-count":116,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Haematology"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.beha.2005.07.012","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T13:25:13Z","timestamp":1150377913000},"page":"571-593","source":"Crossref","is-referenced-by-count":48,"title":["Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined"],"prefix":"10.1016","volume":"19","author":[{"suffix":"MD","given":"Michelle A.","family":"Elliott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beha.2005.07.012_bib1","series-title":"World Health Organization classification of Tumours: Pathology and Genetics of Tumours and Lymphoid Tissue","year":"2001"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib2","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1182\/blood-2002-04-1199","article-title":"The World Health Organization (WHO) classification of the myeloid neoplasms","volume":"100","author":"Vardiman","year":"2002","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ajcp\/72.2.233","article-title":"Chronic neutrophilic leukemia. Report of two cases and review of the literature","volume":"72","author":"You","year":"1979","journal-title":"American Journal of Clinical Pathology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1046\/j.1365-2141.2002.03234.x","article-title":"Chronic neutrophilic leukaemia: a distinct clinical entity?","volume":"116","author":"Reilly","year":"2002","journal-title":"British Journal of Haematology"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/jcp.56.4.292","article-title":"Evidence of clonality in chronic neutrophilic leukaemia","volume":"56","author":"Bohm","year":"2003","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.beha.2005.07.012_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00000441-192007000-00003","article-title":"A case of splenomegaly with polymorphonuclearneutrophil hyperleukocytosis","volume":"160","author":"Tuohy","year":"1920","journal-title":"American Journal of Medical Science"},{"issue":"12","key":"10.1016\/j.beha.2005.07.012_bib7","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1200\/JCO.1999.17.12.3835","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting-Airlie House, Virginia, November 1997","volume":"17","author":"Harris","year":"1997","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib8","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2141.1994.tb06734.x","article-title":"The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Proposals by the French\u2013American-British cooperative leukaemia group","volume":"87","author":"Bennett","year":"1994","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.beha.2005.07.012_bib9","first-page":"291b","article-title":"Chronic neutrophilic leukemia(CNL): a true leukemia? a new classification","volume":"90","author":"Ben-Tal","year":"1997","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000205367","article-title":"Chronic neutrophilic leukemia with dysplastic features. A new variant of the myelodysplastic syndromes. [comment]","volume":"82","author":"Zoumbos","year":"1989","journal-title":"Acta Haematologica"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ajh.2830310419","article-title":"Chronic neutrophilic leukemia associated with polycythemia vera. [comment]","volume":"31","author":"Lugassy","year":"1989","journal-title":"American Journal of Hematology"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01715131","article-title":"Chronic neutrophilic leukemia. A study of four cases","volume":"68","author":"Zittoun","year":"1994","journal-title":"Annals of Hematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/1097-0142(19900701)66:1<162::AID-CNCR2820660129>3.0.CO;2-Z","article-title":"Chronic neutrophilic leukemia and multiple myeloma. An association with lambda light chain expression","volume":"66","author":"Standen","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2005.07.012_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.leu.2403562","article-title":"WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature","volume":"19","author":"Elliott","year":"2005","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/ajh.2830410424","article-title":"Chronic neutrophilic leukemia: case report documenting the absence of bcr-abl rearrangement","volume":"41","author":"Storek","year":"1992","journal-title":"American Journal of Hematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ajh.2830410110","article-title":"Elevated neutrophil function in chronic neutrophilic leukemia","volume":"41","author":"Ohtsuki","year":"1992","journal-title":"American Journal of Hematology"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib17","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1182\/blood.V82.3.1035b.1035b","article-title":"Clonal nature of chronic neutrophilic leukemia. [comment]","volume":"82","author":"Kwong","year":"1993","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajh.2830430416","article-title":"Successful alpha-2b-interferon therapy for chronic neutrophilic leukemia","volume":"43","author":"Meyer","year":"1993","journal-title":"American Journal of Hematology"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1046\/j.1365-2141.1996.7082329.x","article-title":"Chronic neutrophil leukaemia in adolescence and young adulthood","volume":"94","author":"Hasle","year":"1996","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/(SICI)1096-8652(199701)54:1<72::AID-AJH11>3.0.CO;2-C","article-title":"Deletion of the long arm of chromosome 20 in a patient with chronic neutrophilic leukemia: cytogenetic findings in chronic neutrophilic leukemia","volume":"54","author":"Matano","year":"1997","journal-title":"American Journal of Hematology"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/(SICI)1096-8652(199803)57:3<221::AID-AJH7>3.0.CO;2-X","article-title":"Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia","volume":"57","author":"Yanagisawa","year":"1998","journal-title":"American Journal of Hematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0165-4608(98)00177-0","article-title":"A case of chronic neutrophilic leukemia with deletion (11)(q23)","volume":"110","author":"Terre","year":"1999","journal-title":"Cancer Genetics and Cytogenetics"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib23","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1999.01348.x","article-title":"Familial occurrence of chronic neutrophilic leukaemia","volume":"105","author":"Kojima","year":"1999","journal-title":"British Journal of Haematology"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/1096-8652(200007)64:3<229::AID-AJH18>3.0.CO;2-9","article-title":"Chimeric del20q in a case of chronic neutrophilic leukemia","volume":"64","author":"Frank","year":"2000","journal-title":"American Journal of Hematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.leu.2401993","article-title":"Chronic neutrophilic leukemia (CNL): a clinical, pathologic and cytogenetic study","volume":"15","author":"Elliott","year":"2001","journal-title":"Leukemia"},{"issue":"supplement 2","key":"10.1016\/j.beha.2005.07.012_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1067\/mjd.2001.103996","article-title":"Leukemia cutis in a patient with chronic neutrophilic leukemia","volume":"44","author":"Willard","year":"2001","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"10","key":"10.1016\/j.beha.2005.07.012_bib27","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1080\/1042819021000016087","article-title":"Allogeneic bone marrow transplantation in the management of chronic neutrophilic leukemia","volume":"43","author":"Piliotis","year":"2002","journal-title":"Leukemia and Lymphoma"},{"issue":"37","key":"10.1016\/j.beha.2005.07.012_bib28","doi-asserted-by":"crossref","first-page":"33968","DOI":"10.1074\/jbc.M203350200","article-title":"Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia","volume":"277","author":"Kobayashi","year":"2002","journal-title":"Journal of Biological Chemistry"},{"issue":"11","key":"10.1016\/j.beha.2005.07.012_bib29","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1136\/jcp.55.11.862","article-title":"Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferative disease","volume":"55","author":"Bohm","year":"2002","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.beha.2005.07.012_bib30","series-title":"Disorders of Phagocyte Function and Number. Haematology: Basic Principles and Practice","first-page":"720","author":"TD, C.J.a.C.","year":"2000"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib31","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/1097-0142(20011101)92:9<2399::AID-CNCR1588>3.0.CO;2-W","article-title":"Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma","volume":"92","author":"Kasuga","year":"2001","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1200\/JCO.2003.21.1.168","article-title":"Uncommon syndromes and treatment manifestations of malignancy: Case 2. Metastatic non-small-cell lung cancer presenting with leukocytosis","volume":"21","author":"Ganti","year":"2003","journal-title":"Journal of Clinical Oncology"},{"issue":"8","key":"10.1016\/j.beha.2005.07.012_bib33","doi-asserted-by":"crossref","first-page":"813","DOI":"10.4065\/77.8.813","article-title":"Current therapy for multiple myeloma. [see comment]","volume":"77","author":"Rajkumar","year":"2002","journal-title":"Mayo Clinic Proceedings"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000203863","article-title":"Chronic neutrophilic leukemia associated with monoclonal gammopathy of undetermined significance","volume":"95","author":"Ito","year":"1996","journal-title":"Acta Haematologica"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000204241","article-title":"Coexistence of chronic neutrophilic leukemia with light chain myeloma","volume":"91","author":"Cehreli","year":"1994","journal-title":"Acta Haematologica"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000205176","article-title":"Chronic neutrophilic leukaemia preceding for seven years the development of multiple myeloma","volume":"83","author":"Rovira","year":"1990","journal-title":"Acta Haematologica"},{"issue":"5","key":"10.1016\/j.beha.2005.07.012_bib37","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1182\/blood-2002-07-2341","article-title":"Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia","volume":"101","author":"Reeder","year":"2003","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/jcp.46.4.297","article-title":"Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta","volume":"46","author":"Standen","year":"1993","journal-title":"Journal of Clinical Pathology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1096-8652(199809)59:1<79::AID-AJH15>3.0.CO;2-X","article-title":"Analysis of clonality using X-linked polymorphisms in a patient with multiple myeloma and myelofibrosis","volume":"59","author":"Stevenson","year":"1998","journal-title":"American Journal of Hematology"},{"key":"10.1016\/j.beha.2005.07.012_bib40","series-title":"World Health Organization classification of Tumours: Pathology and Genetics of Tumours and Lymphoid Tissue","article-title":"Essential thrombocythemia","author":"Imbert","year":"2001"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000046517","article-title":"Evolution to acute myeloblastic leukemia from chronic neutrophilic leukemia with dysplastic features in granulocytic lineage","volume":"104","author":"Ota","year":"2000","journal-title":"Acta Haematologica"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000203613","article-title":"Chronic neutrophilic leukemia evolving from a myelodysplastic syndrome","volume":"98","author":"Pascucci","year":"1997","journal-title":"Acta Haematologica"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/sj.leu.2400938","article-title":"Demonstration of clonality in neutrophils using FISH in a case of chronic neutrophilic leukemia","volume":"12","author":"Froberg","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2005.07.012_bib44","first-page":"262b","article-title":"Clonal evolution from a 5q- myelodysplastic syndrome to a chronic neutrohilic leukemia","volume":"96","author":"Merlat","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0165-4608(01)00603-3","article-title":"Acquired gain of an X chromosome as the sole abnormality in the blast crisis of chronic neutrophilic leukemia","volume":"134","author":"Yamamoto","year":"2002","journal-title":"Cancer Genetics and Cytogenetics"},{"issue":"11","key":"10.1016\/j.beha.2005.07.012_bib46","first-page":"1329","article-title":"[A case of chronic neutrophilic leukemia accompanied with severe bone marrow fibrosis which was effectively treated by hydroxyurea]","volume":"35","author":"Hirayama","year":"1994","journal-title":"Rinsho Ketsueki\u2014Japanese Journal of Clinical Hematology"},{"issue":"1-2","key":"10.1016\/j.beha.2005.07.012_bib47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/10428199909093744","article-title":"Transition of polycythemia vera to chronic neutrophilic leukemia","volume":"33","author":"Higuchi","year":"1999","journal-title":"Leukemia and Lymphoma"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF02982088","article-title":"Severe bleeding tendency caused by leukemic infiltration and destruction of vascular walls in chronic neutrophilic leukemia","volume":"74","author":"Noguchi","year":"2001","journal-title":"International Journal of Hematology"},{"issue":"17","key":"10.1016\/j.beha.2005.07.012_bib49","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1056\/NEJM200004273421706","article-title":"Myelofibrosis with myeloid metaplasia. [see comment]","volume":"342","author":"Tefferi","year":"2000","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4065\/78.2.174","article-title":"Polycythemia vera: a comprehensive review and clinical recommendations","volume":"78","author":"Tefferi","year":"2003","journal-title":"Mayo Clinic Proceedings"},{"issue":"11","key":"10.1016\/j.beha.2005.07.012_bib51","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1038\/sj.leu.2401553","article-title":"Initial (prefibrotic) stages of idiopathic (primary) myelofibrosis (IMF)\u2014a clinicopathological study","volume":"13","author":"Thiele","year":"1999","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.beha.2005.07.012_bib52","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","article-title":"The molecular biology of chronic myeloid leukemia","volume":"96","author":"Deininger","year":"2000","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib53","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1182\/blood.V95.9.2913.009k32_2913_2921","article-title":"Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases","volume":"95","author":"Quackenbush","year":"2000","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib54","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1182\/blood.V88.7.2410.bloodjournal8872410","article-title":"Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR\/ABL with C3\/A2 junction)[comment][erratum appears in Blood Jun 1;89(11):4244]","volume":"88","author":"Pane","year":"1996","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.beha.2005.07.012_bib55","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1200\/JCO.2001.19.11.2915","article-title":"BCR rearrangement-negative chronic myelogenous leukemia revisited","volume":"19","author":"Kurzrock","year":"2001","journal-title":"Journal of Clinical Oncology"},{"issue":"8","key":"10.1016\/j.beha.2005.07.012_bib56","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1182\/blood.V89.8.3064","article-title":"BCR-ABL transcript with an e19a2 (c3a2) junction in classical chronic myeloid leukemia. [comment]","volume":"89","author":"Wilson","year":"1997","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.beha.2005.07.012_bib57","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1182\/blood.V90.12.5024","article-title":"Typical chronic myelogenous leukemia with e19a2 junction BCR\/ABL transcript","volume":"90","author":"Briz","year":"1997","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.beha.2005.07.012_bib58","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2169\/internalmedicine.41.1183","article-title":"Philadelphia chromosome-positive chronic myeloid leukemia expressing p190(BCR-ABL). [see comment]","volume":"41","author":"Ohsaka","year":"2002","journal-title":"Internal Medicine"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib59","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1046\/j.1365-2141.1996.d01-1798.x","article-title":"Elevated platelet count features the variant type of BCR\/ABL junction in chronic myelogenous leukaemia","volume":"94","author":"Yamagata","year":"1996","journal-title":"British Journal of Haematology"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib60","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1182\/blood.V76.9.1819.1819","article-title":"New type of Bcr\/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia","volume":"76","author":"Saglio","year":"1990","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib61","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1046\/j.1365-2141.1999.01588.x","article-title":"Additional translocation (8;21)(q22;q22) in a patient with Philadelphia-positive chronic myelogenous leukaemia in the blastic phase. [see comment]","volume":"106","author":"Kojima","year":"1999","journal-title":"British Journal of Haematology"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib62","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1002\/cncr.10490","article-title":"Neutrophilic-chronic myeloid leukemia: low levels of p230 BCR\/ABL mRNA and undetectable BCR\/ABL protein may predict an indolent course","volume":"94","author":"Verstovsek","year":"2002","journal-title":"Cancer"},{"issue":"15","key":"10.1016\/j.beha.2005.07.012_bib63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.leu.2401993","article-title":"Chronic Neutrophilic Leukemia (CNL): a long-term clinical, pathologic, and cytogenetic study","volume":"94","author":"Elliott","year":"2001","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib64","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0950-3536(98)80041-3","article-title":"Molecular genetics and cytogenetics of myeloproliferative disorders","volume":"11","author":"Bench","year":"1998","journal-title":"Baillieres Clinical Haematology"},{"issue":"6","key":"10.1016\/j.beha.2005.07.012_bib65","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","article-title":"International scoring system for evaluating prognosis in myelodysplastic syndromes","volume":"89","author":"Greenberg","year":"1997","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib66","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V92.7.2322","article-title":"The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The medical research council adult and children's leukaemia working parties","volume":"92","author":"Grimwade","year":"1998","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib67","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2141.1996.d01-1896.x","article-title":"Deletions of chromosome 20q and the pathogenesis of myeloproliferative disorders","volume":"95","author":"Asimakopoulos","year":"1996","journal-title":"British Journal of Haematology"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib68","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1046\/j.1365-2141.2001.02796.x","article-title":"Cytogenetic findings and their clinical relevance in myelofibrosis with myeloid metaplasia","volume":"113","author":"Tefferi","year":"2001","journal-title":"British Journal of Haematology"},{"issue":"5777","key":"10.1016\/j.beha.2005.07.012_bib69","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/287049a0","article-title":"Involvement of the B-lymphoid system in chronic myelogenous leukaemia","volume":"287","author":"Martin","year":"1980","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib70","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-4608(95)00036-4","article-title":"Fluorescent in situ hybridization studies of lymphocytes and neutrophils in chronic granulocytic leukemia","volume":"83","author":"Tefferi","year":"1995","journal-title":"Cancer Genetics and Cytogenetics"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib71","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1172\/JCI111840","article-title":"Evidence for the involvement of B lymphoid cells in polycythemia vera and essential thrombocythemia","volume":"75","author":"Raskind","year":"1985","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib72","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.V88.1.59.59","article-title":"Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age","volume":"88","author":"Busque","year":"1996","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib73","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1046\/j.1365-2141.1997.1933010.x","article-title":"Clonal haemopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromes","volume":"97","author":"Champion","year":"1997","journal-title":"British Journal of Haematology"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett","year":"1982","journal-title":"British Journal of Haematology"},{"issue":"6","key":"10.1016\/j.beha.2005.07.012_bib75","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0145-2126(00)00159-4","article-title":"Myelodysplastic and myeloproliferative type of chronic myelomonocytic leukemia\u2014distinct subgroups or two stages of the same disease?","volume":"25","author":"Voglova","year":"2001","journal-title":"Leukemia Research"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib76","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1182\/blood.V99.3.840","article-title":"Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients","volume":"99","author":"Onida","year":"2002","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib77","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1200\/JCO.1988.6.9.1417","article-title":"Prognostic factors in adult chronic myelomonocytic leukemia: an analysis of 107 cases","volume":"6","author":"Fenaux","year":"1988","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib78","first-page":"324","article-title":"Prognosis of chronic myelomonocytic leukemia","volume":"81","author":"Catalano","year":"1996","journal-title":"Haematologica"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib79","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0145-2126(01)00014-5","article-title":"Dysplastic versus proliferative CMML\u2014a retrospective analysis of 91 patients from a single institution","volume":"25","author":"Nosslinger","year":"2001","journal-title":"Leukemia Research"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib80","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0145-2126(90)90133-T","article-title":"Prognostic factors of myelodysplastic syndromes\u2014a simplified 3-D scoring system","volume":"14","author":"Goasguen","year":"1990","journal-title":"Leukemia Research"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib81","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/bjc.1987.154","article-title":"Prognostic factors and survival in chronic myelomonocytic leukaemia (CMML)","volume":"56","author":"Stark","year":"1987","journal-title":"British Journal of Cancer"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib82","first-page":"203","article-title":"Juvenile myelomonocytic leukemia","volume":"3","author":"Emanuel","year":"2004","journal-title":"Current Hematology Reports"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib83","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0165-4608(91)90235-M","article-title":"Chronic myelomonocytic leukemia: single entity or heterogeneous disorder? a prospective multicenter study of 100 patients. Groupe Francais de Cytogenetique Hematologique","volume":"55","author":"anonymous","year":"1991","journal-title":"Cancer Genetics and Cytogenetics"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib84","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2141.1991.tb08616.x","article-title":"Prognostic factors in adult de novo myelodysplastic syndromes treated by intensive chemotherapy","volume":"77","author":"Fenaux","year":"1991","journal-title":"British Journal of Haematology"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib85","first-page":"324","article-title":"Prognosis of chronic myelomonocytic leukemia","volume":"81","author":"Catalano","year":"1996","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.beha.2005.07.012_bib86","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0145-2126(00)00078-3","article-title":"Pericardial effusion in chronic myelomonocytic leukemia (CMML): a case report and review of the literature","volume":"24","author":"Strupp","year":"2000","journal-title":"Leukemia Research"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib87","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000040713","article-title":"Pleural effusion in chronic myelomonocytic leukemia","volume":"99","author":"Bourantas","year":"1998","journal-title":"Acta Haematologica"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib88","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0145-2126(96)00117-8","article-title":"Fatal hyperleukocytic syndrome in a patient with chronic myelomonocytic leukemia","volume":"21","author":"Aul","year":"1997","journal-title":"Leukemia Research"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib89","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1080\/1042819022386671","article-title":"Leukapheresis in chronic myelomonocytic leukemia with leukostasis syndrome: elevated serum lactate levels as an early sign of microcirculation failure","volume":"43","author":"Stemmler","year":"2002","journal-title":"Leukemia and Lymphoma"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib90","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1080\/1042819042000207271","article-title":"Risk assessment in chronic myelomonocytic leukemia (CMML)","volume":"45","author":"Germing","year":"2004","journal-title":"Leukemia and Lymphoma"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib91","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1182\/blood-2002-01-0330","article-title":"New prognostic parameters for chronic myelomonocytic leukemia","volume":"100","author":"Germing","year":"2002","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.beha.2005.07.012_bib92","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0145-2126(97)00192-6","article-title":"Problems in the classification of CMML\u2014dysplastic versus proliferative type","volume":"22","author":"Germing","year":"1998","journal-title":"Leukemia Research"},{"issue":"suppliment 1","key":"10.1016\/j.beha.2005.07.012_bib93","first-page":"2607","article-title":"The dysplastic versusproliferative classificationdilemma of chronic myelomonocytic leukemia: a retrospective single institution analysis of 273 patients","volume":"98","author":"Onida","year":"2001","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib94","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0145-2126(02)00021-8","article-title":"Two groups of chronic myelomonocytic leukaemia: myelodysplastic and myeloproliferative. Prognostic implications in a series of a single center","volume":"26","author":"Gonzalez-Medina","year":"2002","journal-title":"Leukemia Research"},{"issue":"3","key":"10.1016\/j.beha.2005.07.012_bib95","first-page":"218","article-title":"Chronic myelomonocytic leukemia: myeloproliferative variant","volume":"3","author":"Onida","year":"2004","journal-title":"Current Hematology Reports"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib96","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2141.1988.tb04173.x","article-title":"Prognostic features of chronic myelomonocytic leukaemia: a modified Bournemouth score gives the best prediction of survival","volume":"68","author":"Worsley","year":"1988","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib97","first-page":"52","article-title":"Primary myelodysplastic syndromes: analysis of prognostic factors in 235 patients and proposals for an improved scoring system","volume":"6","author":"Aul","year":"1992","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib98","first-page":"866","article-title":"Prognostic factors in myelodysplastic and Myeloproliferatve types of chronic myelomonocytic leukemia: a retrospctive analysis of 83 patients from a single institution","volume":"89","author":"Breccia","year":"2004","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib99","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0092-8674(94)90322-0","article-title":"Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation","volume":"77","author":"Golub","year":"1994","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.beha.2005.07.012_bib100","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1182\/blood.V91.12.4419","article-title":"Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2)","volume":"91","author":"Ross","year":"1998","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.beha.2005.07.012_bib101","doi-asserted-by":"crossref","first-page":"14845","DOI":"10.1073\/pnas.93.25.14845","article-title":"The TEL\/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways","volume":"93","author":"Carroll","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/j.beha.2005.07.012_bib102","first-page":"408","article-title":"Sensitivity to imatinib but low frequency of the TEL\/PDGFRbeta fusion protein in chronic myelomonocytic leukemia","volume":"88","author":"Gunby","year":"2003","journal-title":"Haematologica"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib103","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJMoa020150","article-title":"Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta","volume":"347","author":"Apperley","year":"2002","journal-title":"New England Journal of Medicine"},{"issue":"8","key":"10.1016\/j.beha.2005.07.012_bib104","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1182\/blood.V83.8.2248.2248","article-title":"Mutations of the N-ras gene in juvenile chronic myelogenous leukemia","volume":"83","author":"Miyauchi","year":"1994","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.beha.2005.07.012_bib105","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1182\/blood-2003-09-3287","article-title":"Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis","volume":"103","author":"Loh","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.beha.2005.07.012_bib106","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng1156","article-title":"Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia","volume":"34","author":"Tartaglia","year":"2003","journal-title":"Nature Genetics"},{"key":"10.1016\/j.beha.2005.07.012_bib107","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.leukres.2004.10.001","article-title":"Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia","volume":"29","author":"Loh","year":"2005","journal-title":"Leukemia Research"},{"issue":"7","key":"10.1016\/j.beha.2005.07.012_bib108","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1182\/blood.V88.7.2480.bloodjournal8872480","article-title":"A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe francais des myelodysplasies and European CMML group","volume":"88","author":"Wattel","year":"1996","journal-title":"Blood"},{"issue":"5-6","key":"10.1016\/j.beha.2005.07.012_bib109","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3109\/10428199809057611","article-title":"Results of topotecan single-agent therapy in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia","volume":"31","author":"Beran","year":"1998","journal-title":"Leukemia and Lymphoma"},{"issue":"9","key":"10.1016\/j.beha.2005.07.012_bib110","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1200\/JCO.1999.17.9.2819","article-title":"Topotecan and cytarabine is an active combination regimen in myelodysplastic syndromes and chronic myelomonocytic leukemia","volume":"17","author":"Beran","year":"1999","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.beha.2005.07.012_bib111","first-page":"624a","article-title":"Chemotherapy of increasing intensity in the treatment of chronic myelomonocytic leukemia","volume":"98","author":"Beran","year":"2001","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.beha.2005.07.012_bib112","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1182\/blood.V99.6.1943","article-title":"Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program","volume":"99","author":"Castro-Malaspina","year":"2002","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib113","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1365-2141.2000.02133.x","article-title":"Treatment of chronic myelomonocytic leukaemia by allogeneic marrow transplantation","volume":"110","author":"Zang","year":"2000","journal-title":"British Journal of Haematology"},{"issue":"1","key":"10.1016\/j.beha.2005.07.012_bib114","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2141.2002.03552.x","article-title":"Allogeneic stem cell transplantation of adult chronic myelomonocytic leukaemia. A report on behalf of the chronic leukaemia working party of the European group for Blood and Marrow Transplantation (EBMT)","volume":"118","author":"Kroger","year":"2002","journal-title":"British Journal of Haematology"},{"issue":"10","key":"10.1016\/j.beha.2005.07.012_bib115","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.bmt.1704472","article-title":"Allogeneic transplantation: a therapeutic option for myelofibrosis, chronic myelomonocytic leukemia and Philadelphia-negative\/BCR-ABL-negative chronic myelogenous leukemia","volume":"33","author":"Mittal","year":"2004","journal-title":"Bone Marrow Transplantation"},{"issue":"6","key":"10.1016\/j.beha.2005.07.012_bib116","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1182\/blood-2003-12-4207","article-title":"Reduced-intensity allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome and acute myeloid leukemia with multilineage dysplasia using fludarabine, busulphan, and alemtuzumab (FBC) conditioning","volume":"104","author":"Ho","year":"2004","journal-title":"Blood"}],"container-title":["Best Practice &amp; Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692605000988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692605000988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T14:08:43Z","timestamp":1586959723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692605000988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S1521692605000988"],"URL":"https:\/\/doi.org\/10.1016\/j.beha.2005.07.012","relation":{},"ISSN":["1521-6926"],"issn-type":[{"value":"1521-6926","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}