{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:39:51Z","timestamp":1790854791148,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Haematology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.beha.2006.11.001","type":"journal-article","created":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T21:29:55Z","timestamp":1172784595000},"page":"19-27","source":"Crossref","is-referenced-by-count":57,"title":["The stem cell niche in health and leukemic disease"],"prefix":"10.1016","volume":"20","author":[{"given":"David T.","family":"Scadden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beha.2006.11.001_bib1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/science.290.5490.328","article-title":"A niche maintaining germ line stem cells in the Drosophila ovary","volume":"290","author":"Xie","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.beha.2006.11.001_bib2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/35037606","article-title":"Somatic support cells restrict germline stem cell self-renewal and promote differentiation","volume":"407","author":"Kiger","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature754","article-title":"A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans","volume":"417","author":"Crittenden","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/35102160","article-title":"Stem cells find their niche","volume":"414","author":"Spradling","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/scd.2006.15.1","article-title":"The continuum of stem cell transdifferentiation: possibility of hematopoietic stem cell plasticity with concurrent CD45 expression","volume":"15","author":"Udani","year":"2006","journal-title":"Stem Cells and Development"},{"key":"10.1016\/j.beha.2006.11.001_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0092-8674(93)90251-K","article-title":"Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression","volume":"73","author":"Jones","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.beha.2006.11.001_bib7","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1242\/dev.126.11.2409","article-title":"The spatial relationship between stem cells and their progeny in the\u00a0basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis","volume":"126","author":"Jensen","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.beha.2006.11.001_bib8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1242\/dev.02252","article-title":"Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production","volume":"133","author":"Ormestad","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.beha.2006.11.001_bib9","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood-2004-11-4422","article-title":"Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells","volume":"106","author":"Nilsson","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.beha.2006.11.001_bib10","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1182\/blood.V89.11.4013","article-title":"Potential and distribution of transplanted hematopoietic stem cells in a nonablated mouse model","volume":"89","author":"Nilsson","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.beha.2006.11.001_bib11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.beha.2006.11.001_bib12","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nature02041","article-title":"Identification of the haematopoietic stem cell niche and control of the niche size","volume":"425","author":"Zhang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tcm.2005.03.002","article-title":"Regulation of hematopoietic stem cells by the niche","volume":"15","author":"Arai","year":"2005","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1016\/j.beha.2006.11.001_bib15","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1242\/jcs.00369","article-title":"Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow","volume":"116","author":"Gronthos","year":"2003","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.beha.2006.11.001_bib16","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1084\/jem.20041992","article-title":"Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size","volume":"201","author":"Stier","year":"2005","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.beha.2006.11.001_bib17","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1074\/jbc.273.2.1114","article-title":"Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium","volume":"273","author":"McNeil","year":"1998","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.beha.2006.11.001_bib18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature04247","article-title":"Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor","volume":"439","author":"Adams","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib19","doi-asserted-by":"crossref","first-page":"557a","DOI":"10.1182\/blood.V106.11.1968.1968","article-title":"Parathyroid hormone may improve autologous stem cell mobilization va the stem cell niche","volume":"106","author":"Ballen","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.beha.2006.11.001_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.beha.2006.11.001_bib21","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ijc.21038","article-title":"Parathyroid hormone-related protein (PTHrP) as a causative factor of cancer-associated wasting: possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts","volume":"116","author":"Onuma","year":"2005","journal-title":"International Journal of Cancer"}],"container-title":["Best Practice &amp; Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692606000818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692606000818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T09:08:50Z","timestamp":1628500130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692606000818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S1521692606000818"],"URL":"https:\/\/doi.org\/10.1016\/j.beha.2006.11.001","relation":{},"ISSN":["1521-6926"],"issn-type":[{"value":"1521-6926","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}