{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T09:59:04Z","timestamp":1792835944214,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Haematology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.beha.2008.02.002","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T16:50:22Z","timestamp":1212598222000},"page":"139-148","source":"Crossref","is-referenced-by-count":128,"title":["Vascular endothelium as \u2018novel\u2019 target of graft-versus-host disease"],"prefix":"10.1016","volume":"21","author":[{"given":"Andr\u00e9","family":"Tichelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Gratwohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beha.2008.02.002_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/sj.bmt.1705104","article-title":"Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in Europe: a report of the EBMT activity survey 2003","volume":"36","author":"Gratwohl","year":"2005","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib2","doi-asserted-by":"crossref","unstructured":"Gratwohl A, Baldomero H, Frauendorfer K, et\u00a0al. Results of the EBMT activity survey 2005 on haematopoietic stem cell transplantation: focus on increasing use of unrelated donors. Bone Marrow Transplantation 0 AD;39:71\u201387.","DOI":"10.1038\/sj.bmt.1705555"},{"key":"10.1016\/j.beha.2008.02.002_bib3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nri2000","article-title":"Graft-versus-host disease","volume":"7","author":"Shlomchik","year":"2007","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.beha.2008.02.002_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/sj.bmt.1705123","article-title":"Survival after reduced-intensity conditioning is not inferior to standard high-dose conditioning before allogeneic haematopoietic cell transplantation in acute leukaemias","volume":"36","author":"Massenkeil","year":"2005","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib5","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0140-6736(02)08907-9","article-title":"Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease","volume":"359","author":"Biedermann","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.beha.2008.02.002_bib6","first-page":"1097","article-title":"Endothelial-cell injury in cutaneous acute graft-versus-host disease","volume":"135","author":"Dumler","year":"1989","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.beha.2008.02.002_bib7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0002-9343(80)90380-0","article-title":"Chronic graft-versus-host syndrome in man. A long-term\u00a0clinicopathologic study of 20 Seattle patients","volume":"69","author":"Shulman","year":"1980","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/j.beha.2008.02.002_bib8","first-page":"35","article-title":"Endothelial changes in cutaneous graft-versus-host disease: a comparison between HLA matched and mismatched recipients of bone marrow transplantation","volume":"7","author":"Sviland","year":"1991","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3324\/haematol.10699","article-title":"Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group","volume":"92","author":"Ruutu","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2008.02.002_bib10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.bbmt.2004.03.002","article-title":"Thrombotic microangiopathy after allogeneic stem cell transplantation in the era of reduced-intensity conditioning: the incidence is not reduced","volume":"10","author":"Shimoni","year":"2004","journal-title":"Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/01.tp.0000230373.82376.46","article-title":"Risk factors and severe outcome in thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation","volume":"82","author":"Uderzo","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","article-title":"Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients","volume":"118","author":"McDonald","year":"1993","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.beha.2008.02.002_bib13","first-page":"3599","volume":"92","author":"Carreras","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.beha.2008.02.002_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bmt.1705835","article-title":"Risk factors and mortality predictors of hepatic veno-occlusive disease after pediatric hematopoietic stem cell transplantation","author":"Cheuk","year":"2007","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib15","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.bbmt.2006.06.002","article-title":"Diffuse alveolar hemorrhage and infection-associated alveolar hemorrhage following hematopoietic stem cell transplantation: related and high-risk clinical syndromes","volume":"12","author":"Majhail","year":"2006","journal-title":"Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00007890-199401000-00016","article-title":"Pulmonary hemorrhage as a cause of death in allogeneic bone marrow recipients with severe acute graft-versus-host disease","volume":"57","author":"Wojno","year":"1994","journal-title":"Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib17","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/sj.bmt.1703015","article-title":"Engraftment syndrome following hematopoietic stem cell transplantation","volume":"27","author":"Spitzer","year":"2001","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbmt.2005.04.009","article-title":"Engraftment syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation: incidence and effects on survival","volume":"11","author":"Gorak","year":"2005","journal-title":"Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib19","first-page":"520a","article-title":"Engraftment syndrome following myeloablative conditioning therapy and HLA-matched bone marrow transplantation (BMT) for hematological malignancy","volume":"96","author":"Colby","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.beha.2008.02.002_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00277-004-0946-8","article-title":"Granulocyte colony-stimulating factor-induced capillary leak syndrome confirmed by extravascular lung water measurements","volume":"84","author":"Deeren","year":"2005","journal-title":"Annals of Hematology"},{"key":"10.1016\/j.beha.2008.02.002_bib21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s002770050288","article-title":"Risk factors for capillary leakage syndrome after bone marrow transplantation","volume":"74","author":"Nurnberger","year":"1997","journal-title":"Annals of Hematology"},{"key":"10.1016\/j.beha.2008.02.002_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.bmt.1704730","article-title":"Vascular leak syndrome and serositis as an unusual manifestation of chronic graft-versus-host disease in nonmyeloablative transplants","volume":"35","author":"Gyger","year":"2004","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib23","first-page":"177","article-title":"Marrow engraftment and clinical manifestations of capillary leak syndrome","volume":"18","author":"Cahill","year":"1996","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib24","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1210\/jc.81.8.3051","article-title":"Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome","volume":"81","author":"Talvensaari","year":"1996","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.beha.2008.02.002_bib25","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/cncr.2820690528","article-title":"Coronary artery disease mortality in patients treated for Hodgkin's disease","volume":"69","author":"Boivin","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2008.02.002_bib26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0140-6736(00)02717-3","article-title":"Impaired glucose tolerance and dyslipidaemia as late effects after bone-marrow transplantation in childhood","volume":"356","author":"Taskinen","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.beha.2008.02.002_bib27","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1182\/blood-2006-05-022335","article-title":"Diabetes, hypertension and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplant survivor study","volume":"109","author":"Baker","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.beha.2008.02.002_bib28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2141.2005.05616.x","article-title":"Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease","volume":"130","author":"Couriel","year":"2005","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.beha.2008.02.002_bib29","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1182\/blood-2006-10-054080","article-title":"Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation","volume":"110","author":"Tichelli","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.beha.2008.02.002_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1053-2498(99)00128-X","article-title":"Intravascular ultrasound imaging after cardiac transplantation: advantage of multi-vessel imaging","volume":"19","author":"Kapadia","year":"2000","journal-title":"The Journal of Heart and Lung Transplantation: the Official Publication of the International Society for Heart Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.RES.0000246086.93555.f3","article-title":"Allograft vasculopathy versus atherosclerosis","volume":"99","author":"Rahmani","year":"2006","journal-title":"Circulation Research"},{"key":"10.1016\/j.beha.2008.02.002_bib32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1681\/ASN.V71158","article-title":"Cardiovascular disease after renal transplantation","volume":"7","author":"Kasiske","year":"1996","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.beha.2008.02.002_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-6143.2005.01165.x","article-title":"Endothelial apoptosis and chronic transplant vasculopathy: recent results, novel mechanisms","volume":"6","author":"Cailhier","year":"2006","journal-title":"American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons"},{"issue":"Suppl. 1","key":"10.1016\/j.beha.2008.02.002_bib34","first-page":"269","article-title":"Late vascular complications after haematopoietic stem cell transplantation: a retrospective multicentre study of the Late Effect Working Party EBMT","volume":"37","author":"Wojcik","year":"2006","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vph.2006.11.005","article-title":"Endothelial injury in the initiation and progression of vascular disorders","volume":"46","author":"Tesfamariam","year":"2007","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.beha.2008.02.002_bib36","first-page":"531","article-title":"Circulating endothelial cells: markers of vascular dysfunction","volume":"51","author":"Goon","year":"2005","journal-title":"Clinical Laboratory"},{"key":"10.1016\/j.beha.2008.02.002_bib37","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/01.tp.0000209218.24916.ba","article-title":"Endothelial cell-derived microparticles in allogeneic hematopoietic stem cell recipients","volume":"81","author":"Pihusch","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/sj.bmt.1700767","article-title":"Endothelial cell markers in bone marrow transplant recipients with and without acute graft-versus-host disease","volume":"19","author":"Salat","year":"1997","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib39","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/sj.bmt.1704258","article-title":"Combining altered levels of effector transcripts in circulating T cells with a marker of endothelial injury is specific for active graft-versus-host disease","volume":"32","author":"Biedermann","year":"2003","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.beha.2008.02.002_bib40","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.bmt.1703026","article-title":"Serum levels of soluble adhesion molecules in stem cell transplantation-related complications","volume":"27","author":"Matsuda","year":"2001","journal-title":"Bone Marrow Transplantation"}],"container-title":["Best Practice &amp; Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692608000042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692608000042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T16:18:09Z","timestamp":1631377089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692608000042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1521692608000042"],"URL":"https:\/\/doi.org\/10.1016\/j.beha.2008.02.002","relation":{},"ISSN":["1521-6926"],"issn-type":[{"value":"1521-6926","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}