{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:33:47Z","timestamp":1761597227316},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Haematology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.beha.2010.05.005","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T09:18:10Z","timestamp":1284628690000},"page":"283-290","source":"Crossref","is-referenced-by-count":21,"title":["Is there an impact of killer cell immunoglobulin-like receptors and KIR-ligand incompatibilities on outcomes after unrelated cord blood stem cell transplantation?"],"prefix":"10.1016","volume":"23","author":[{"given":"Roel","family":"Willemze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan","family":"Purtill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Arrais","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Gluckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.beha.2010.05.005_bib1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/00062752-200211000-00005","article-title":"Minor histocompatibility antigens as target of graft-versus-leukemia reactions","volume":"9","author":"Falkenburg","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.beha.2010.05.005_bib2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1182\/blood.V86.5.2041.bloodjournal8652041","article-title":"Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients","volume":"86","author":"Kolb","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib3","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1182\/blood-2002-02-0350","article-title":"Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect","volume":"100","author":"Farag","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib4","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.coi.2004.07.010","article-title":"Killer immunoglobulin-like receptors","volume":"16","author":"Moretta","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri1570","article-title":"MHC class I molecules and KIRs in human history, health and survival","volume":"5","author":"Parham","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"Lanier","year":"2005","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"10.1016\/j.beha.2010.05.005_bib7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.coi.2006.05.002","article-title":"Natural killer cells as an initial defense against pathogens","volume":"18","author":"Lodoen","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0065-2776(08)60664-1","article-title":"Biology of natural killer cells","volume":"47","author":"Trinchieri","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.immunol.17.1.189","article-title":"Natural killer cells in antiviral defense: function and regulation by innate cytokines","volume":"17","author":"Biron","year":"1999","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"10.1016\/j.beha.2010.05.005_bib10","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood-2009-08-238469","article-title":"Regulation of human NK-cell cytokine and chemokine production by target cell recognition","volume":"115","author":"Fauriat","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the \u201cmissing self\u201d: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/j.beha.2010.05.005_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/358066a0","article-title":"MHC class I alloantigen specificity of Ly-49+IL-2-activated natural killer cells","volume":"358","author":"Karlhofer","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.beha.2010.05.005_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nri1306","article-title":"Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future","volume":"4","author":"Vivier","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0952-7915(00)00241-7","article-title":"NK cells and NKT cells in innate defense against viral infections","volume":"13","author":"Biron","year":"2001","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib15","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1182\/blood-2007-09-077438","article-title":"Human natural killer cells","volume":"112","author":"Caligiuri","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1034\/j.1399-0039.2003.00072.x","article-title":"Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002","volume":"62","author":"Marsh","year":"2003","journal-title":"Tissue Antigens"},{"issue":"2","key":"10.1016\/j.beha.2010.05.005_bib17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.183.2.645","article-title":"The human leukocyte antigen (HLA)-C-specific \u201cactivatory\u201d or \u201cinhibitory\u201d natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions","volume":"183","author":"Biassoni","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.beha.2010.05.005_bib18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1182\/blood-2008-01-132902","article-title":"The reactivity of Bw4+ HLA-B and HLA-A alleles with KIR3DL1: implications for patient and donor suitability for haploidentical stem cell transplantation","volume":"112","author":"Foley","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1182\/blood-2008-02-137521","article-title":"Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1","volume":"112","author":"Stern","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib20","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/eji.200425089","article-title":"Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific","volume":"34","author":"Hansasuta","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2567.2009.03208.x","article-title":"The extensive polymorphism of KIR genes","volume":"129","author":"Middleton","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.beha.2010.05.005_bib22","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.4049\/jimmunol.174.10.6540","article-title":"Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors","volume":"174","author":"Leung","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib23","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4049\/jimmunol.172.1.644","article-title":"Determinants of antileukemia effects of allogeneic NK cells","volume":"172","author":"Leung","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1182\/blood-2006-07-038687","article-title":"Donor natural killer cell allorecognition of missing self in haploidentical hematopoieitc transplantation for acute myeloid leukemia: challenging its predictive value","volume":"110","author":"Ruggeri","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","article-title":"Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib26","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer alloreactivity in mismatched haematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.beha.2010.05.005_bib27","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1182\/blood-2007-01-065383","article-title":"Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT","volume":"109","author":"Miller","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib28","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1182\/blood-2003-01-0091","article-title":"Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors","volume":"102","author":"Giebel","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib29","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1182\/blood-2004-04-1441","article-title":"Genotypic inhibitory killer immunoglobulin-like receptor ligand incompatibility enhances the long-term antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias","volume":"105","author":"Beelen","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib30","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1182\/blood-2004-12-4825","article-title":"Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes","volume":"105","author":"Hsu","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib31","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1182\/blood-2002-04-1197","article-title":"Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants","volume":"100","author":"Davies","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib32","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bbmt.2006.05.007","article-title":"The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the Center for International Blood and Bone Marrow Transplant Research, the European Blood and Bone Marrow Transplant Registry, and the Dutch registry","volume":"12","author":"Farag","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.beha.2010.05.005_bib33","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1182\/blood-2003-11-3893","article-title":"Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors","volume":"103","author":"Bornhauser","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib34","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1182\/blood-2003-02-0438","article-title":"The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia","volume":"103","author":"Cook","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbmt.2006.09.009","article-title":"Detrimental effect of natual killer cell alloreactivity in T-replete hematopoietic stem cell transplantation for leukaemia patients","volume":"13","author":"Sun","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.beha.2010.05.005_bib36","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.molimm.2007.11.014","article-title":"Activating KIRs exert a crucial role on relapse and overall survival after HLA-identical sibling transplantation","volume":"45","author":"Schellekens","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.beha.2010.05.005_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/sj.bmt.1705468","article-title":"Activating KIR genes are associated with CMV reactivation and survival after non-T cell depleted HLA-identical sibling bone marrow transplantation for malignant disorders","volume":"38","author":"Chen","year":"2006","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.beha.2010.05.005_bib38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1365-2141.2003.04604.x","article-title":"T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation","volume":"123","author":"Lowe","year":"2003","journal-title":"Brit J Haematol"},{"key":"10.1016\/j.beha.2010.05.005_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/14653240510027136","article-title":"History of the clinical use of umbilical cord blood hematopoietic cells","volume":"7","author":"Gluckman","year":"2005","journal-title":"Cytotherapy"},{"key":"10.1016\/j.beha.2010.05.005_bib40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.coi.2006.07.014","article-title":"Donor selection for unrelated cord blood transplants","volume":"18","author":"Gluckman","year":"2006","journal-title":"Curr Opin Immunol"},{"issue":"10","key":"10.1016\/j.beha.2010.05.005_bib41","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1182\/blood.V97.10.2962","article-title":"Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia","volume":"97","author":"Rocha","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib42","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1056\/NEJMoa041469","article-title":"Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia","volume":"351","author":"Rocha","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.beha.2010.05.005_bib43","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/S0140-6736(07)60915-5","article-title":"Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study","volume":"369","author":"Eapen","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.beha.2010.05.005_bib44","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1182\/blood-2008-12-197467","article-title":"Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity","volume":"113","author":"Brunstein","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2010.05.005_bib45","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/leu.2008.365","article-title":"KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia","volume":"23","author":"Willemze","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2010.05.005_bib46","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1182\/blood.V114.22.2301.2301","article-title":"Outcomes of unrelated cord blood transplantation for non-malignant diseases in children are not associated with KIR-ligand matching between donor and recipient: a study on behalf of Eurocord","volume":"114","author":"Ruggeri","year":"2009","journal-title":"Blood"}],"container-title":["Best Practice & Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692610000174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692610000174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T20:24:42Z","timestamp":1591907082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692610000174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S1521692610000174"],"URL":"https:\/\/doi.org\/10.1016\/j.beha.2010.05.005","relation":{},"ISSN":["1521-6926"],"issn-type":[{"value":"1521-6926","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}