{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:20Z","timestamp":1791181520540,"version":"4.1.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Haematology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.beha.2011.02.006","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T04:33:08Z","timestamp":1305693188000},"page":"147-163","source":"Crossref","is-referenced-by-count":144,"title":["Transformation of follicular lymphoma"],"prefix":"10.1016","volume":"24","author":[{"given":"Izidore S.","family":"Lossos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Gascoyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beha.2011.02.006_bib1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/1097-0142(195607\/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B","article-title":"Follicular lymphoma; a re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases","volume":"9","author":"Hicks","year":"1956","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib2","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/1097-0142(197604)37:4<1923::AID-CNCR2820370443>3.0.CO;2-D","article-title":"The natural history of nodular lymphoma","volume":"37","author":"Qazi","year":"1976","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/1097-0142(197908)44:2<645::AID-CNCR2820440234>3.0.CO;2-Y","article-title":"Histological transformation of non-Hodgkin\u2019s lymphoma: a prospective study","volume":"44","author":"Cullen","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/1097-0142(197908)44:2<529::AID-CNCR2820440222>3.0.CO;2-Y","article-title":"Non-Hodgkin\u2019s lymphoma: a study of the evolution of the disease based upon 92 autopsied cases","volume":"44","author":"Risdall","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib5","first-page":"929","article-title":"Nodular poorly differentiated lymphocytic lymphoma: changes in histology and survival","volume":"65","author":"Ostrow","year":"1981","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/j.beha.2011.02.006_bib6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1182\/blood.V59.2.258.258","article-title":"Histologic progression in non-Hodgkin\u2019s lymphoma","volume":"59","author":"Hubbard","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1200\/JCO.1983.1.1.11","article-title":"Histologic conversion in the non-Hodgkin\u2019s lymphomas","volume":"1","author":"Acker","year":"1983","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/1097-0142(19830801)52:3<393::AID-CNCR2820520302>3.0.CO;2-M","article-title":"An autopsy study of histologic progression in non-Hodgkin\u2019s lymphomas. 192 cases from the National Cancer Institute","volume":"52","author":"Garvin","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib9","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1056\/NEJM198412063112303","article-title":"The natural history of initially untreated low-grade non-Hodgkin\u2019s lymphomas","volume":"311","author":"Horning","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1016\/j.beha.2011.02.006_bib10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/1097-0142(19840301)53:5<1109::AID-CNCR2820530516>3.0.CO;2-O","article-title":"Malignant lymphomas of follicular center cell origin in humans. V. Incidence, clinical features, and prognostic implications of transformation of small cleaved cell nodular lymphoma","volume":"53","author":"Oviatt","year":"1984","journal-title":"Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib11","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1200\/JCO.1986.4.10.1470","article-title":"Follicular lymphoma: prognostic factors for response and survival","volume":"4","author":"Gallagher","year":"1986","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0609.1989.tb01205.x","article-title":"Follicular low-grade non-Hodgkin\u2019s lymphoma: long-term outcome with or without tumor progression","volume":"42","author":"Ersboll","year":"1989","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.beha.2011.02.006_bib13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1200\/JCO.1997.15.4.1587","article-title":"Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients","volume":"15","author":"Bastion","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib14","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1200\/JCO.2006.09.3260","article-title":"Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma","volume":"25","author":"Montoto","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib15","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1200\/JCO.2008.16.0283","article-title":"Population-based analysis of incidence and outcome of transformed non-Hodgkin\u2019s lymphoma","volume":"26","author":"Al-Tourah","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib16","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.beha.2011.02.006_bib17","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJM198805263182106","article-title":"Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma","volume":"318","author":"De Jong","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.beha.2011.02.006_bib18","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1073\/pnas.85.22.8548","article-title":"Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene","volume":"85","author":"Gauwerky","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.beha.2011.02.006_bib19","first-page":"413","article-title":"Diffuse histiocytic lymphoma after histologic conversion: a poor prognostic variant","volume":"65","author":"Armitage","year":"1981","journal-title":"Cancer Treat Rep"},{"key":"10.1016\/j.beha.2011.02.006_bib20","first-page":"381","article-title":"Malignant lymphoma: a clinico-pathologic survey of 618 cases","volume":"18","author":"Gall","year":"1942","journal-title":"Am J Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib21","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/sj.leu.2403801","article-title":"Higher-grade transformation of follicular lymphoma \u2013 a continuous enigma","volume":"19","author":"Lossos","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2011.02.006_bib22","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","first-page":"265","article-title":"B-cell lymphoma, unclassifiable, with features intermediate between large B-cell lymphoma and Burkitt lymphoma","author":"Kluin","year":"2008"},{"key":"10.1016\/j.beha.2011.02.006_bib23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1046\/j.1365-2559.2001.01120.x","article-title":"Pathology of lymphoma progression","volume":"38","author":"Muller-Hermelink","year":"2001","journal-title":"Histopathology"},{"key":"10.1016\/j.beha.2011.02.006_bib24","doi-asserted-by":"crossref","first-page":"8886","DOI":"10.1073\/pnas.132253599","article-title":"Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes","volume":"99","author":"Lossos","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.beha.2011.02.006_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1044-579X(03)00015-4","article-title":"Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions","volume":"13","author":"Lossos","year":"2003","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.beha.2011.02.006_bib26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1080\/10428190290021623","article-title":"Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma","volume":"43","author":"Lossos","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.beha.2011.02.006_bib27","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/sj.leu.2402578","article-title":"BCL-6 mRNA expression in higher grade transformation of follicle center lymphoma: correlation with somatic mutations in the 5\u2019 regulatory region of the BCL-6 gene","volume":"16","author":"Lossos","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2011.02.006_bib28","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1182\/blood-2002-07-2119","article-title":"Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations","volume":"101","author":"Martinez-Climent","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib29","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1080\/1042819031000090228","article-title":"Analysis of FAS (CD95) gene mutations in higher-grade transformation of follicle center lymphoma","volume":"44","author":"Do","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.beha.2011.02.006_bib30","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1182\/blood.V83.5.1363.1363","article-title":"Molecular genetic demonstration of the diverse evolution of Richter\u2019s syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma)","volume":"83","author":"Matolcsy","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib31","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1349-7006.2008.00873.x","article-title":"Diffuse large B-cell lymphoma after transformation from low-grade follicular lymphoma: morphological, immunohistochemical, and FISH analyses","volume":"99","author":"Maeshima","year":"2008","journal-title":"Cancer Sci"},{"key":"10.1016\/j.beha.2011.02.006_bib32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/sj.bjc.6601006","article-title":"Outcome of follicular lymphoma grade 3: is anthracycline necessary as front-line therapy?","volume":"89","author":"Chau","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib33","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1182\/blood-2002-07-2298","article-title":"A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival","volume":"101","author":"Hans","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib34","doi-asserted-by":"crossref","DOI":"10.1097\/PAS.0b013e3181e9343d","article-title":"Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components","author":"Younes","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib35","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1097\/01.pas.0000172191.87176.3b","article-title":"Low histologic grade follicular lymphoma with high proliferation index: morphologic and clinical features","volume":"29","author":"Wang","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib36","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1182\/blood.V85.12.3671.bloodjournal85123671","article-title":"Prognostic value of cellular proliferation and histologic grade in follicular lymphoma","volume":"85","author":"Martin","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib37","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1440-1827.2006.02072.x","article-title":"Bcl2-negative follicular lymphomas frequently have Bcl6 translocation and\/or Bcl6 or p53 expression","volume":"57","author":"Guo","year":"2007","journal-title":"Pathol Int"},{"key":"10.1016\/j.beha.2011.02.006_bib38","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1182\/blood-2006-09-045989","article-title":"CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features","volume":"109","author":"Karube","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3324\/haematol.10682","article-title":"MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes","volume":"92","author":"Naresh","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2011.02.006_bib40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/gcc.1103","article-title":"Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18)","volume":"30","author":"Horsman","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib41","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1182\/blood.V84.4.1043.1043","article-title":"Prognostic value of chromosomal abnormalities in follicular lymphoma","volume":"84","author":"Tilly","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1044-579X(03)00014-2","article-title":"Cytogenetic evolution of follicular lymphoma","volume":"13","author":"Viardot","year":"2003","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.beha.2011.02.006_bib43","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1200\/JCO.2002.12.006","article-title":"Clinicopathologic correlations of genomic gains and losses in follicular lymphoma","volume":"20","author":"Viardot","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib44","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1158\/1078-0432.CCR-07-0456","article-title":"Comprehensive analysis of copy number and allele status identifies multiple chromosome defects underlying follicular lymphoma pathogenesis","volume":"13","author":"Ross","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.beha.2011.02.006_bib45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/gcc.10314","article-title":"Identification of cytogenetic subgroups and karyotypic pathways of clonal evolution in follicular lymphomas","volume":"39","author":"Hoglund","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib46","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","article-title":"LAZ3 rearrangements in non-Hodgkin\u2019s lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients","volume":"83","author":"Bastard","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib47","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1182\/blood.V79.10.2527.2527","article-title":"Translocations involving band 3q27 and Ig gene regions in non-Hodgkin\u2019s lymphoma","volume":"79","author":"Bastard","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib48","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1365-2141.2003.04086.x","article-title":"Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypes","volume":"120","author":"Horsman","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.beha.2011.02.006_bib49","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood-2008-07-168682","article-title":"A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36","volume":"113","author":"Katzenberger","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9440(10)63313-5","article-title":"Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-Cell component","volume":"165","author":"Katzenberger","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib51","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/gcc.20246","article-title":"BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B","volume":"44","author":"Bosga-Bouwer","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib52","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.humpath.2005.12.005","article-title":"Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma?","volume":"37","author":"Bosga-Bouwer","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib53","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1182\/blood.V101.3.1149","article-title":"Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive","volume":"101","author":"Bosga-Bouwer","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10428190701742472","article-title":"Frequency of BCL2 and BCL6 translocations in follicular lymphoma: relation with histological and clinical features","volume":"49","author":"Diaz-Alderete","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.beha.2011.02.006_bib55","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1182\/blood-2009-01-198580","article-title":"Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations","volume":"114","author":"Leich","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib56","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1182\/blood.V97.12.3713","article-title":"The Burkitt-like lymphomas: a Southwest Oncology Group study delineating phenotypic, genotypic, and clinical features","volume":"97","author":"Braziel","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib57","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1097\/01.pas.0000180442.87022.08","article-title":"Adult B-cell lymphomas with Burkitt-like morphology are phenotypically and genotypically heterogeneous with aggressive clinical behavior","volume":"29","author":"McClure","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib58","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.humpath.2009.10.027","article-title":"B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology","volume":"41","author":"Carbone","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib59","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3324\/haematol.2009.008128","article-title":"Novel lymphoid neoplasms\u2013the borderland between diffuse large B-cell lymphoma and Burkitt\u2019s lymphoma","volume":"94","author":"de Jong","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2011.02.006_bib60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1309\/AJCP7YLDTJPLCE5F","article-title":"\u201cDouble-Hit\u201d mature B-cell lymphomas show a common immunophenotype by flow cytometry that includes decreased CD20 expression","volume":"134","author":"Wu","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib61","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/10428190701836845","article-title":"C-MYC translocation in t(14;18) positive follicular lymphoma at presentation: an adverse prognostic indicator?","volume":"49","author":"Christie","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.beha.2011.02.006_bib62","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3324\/haematol.11305","article-title":"The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24\/c-MYC rearrangement","volume":"92","author":"Le Gouill","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2011.02.006_bib63","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3324\/haematol.11263","article-title":"High-grade B-cell lymphoma\/leukemia associated with t(14;18) and 8q24\/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis","volume":"92","author":"Lin","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2011.02.006_bib64","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1200\/JCO.1999.17.5.1558","article-title":"Small noncleaved, non-Burkitt\u2019s (Burkitt-like) lymphoma: cytogenetics predict outcome and reflect clinical presentation","volume":"17","author":"Macpherson","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/leu.2008.344","article-title":"Clinical features and prognosis of de novo diffuse large B-cell lymphoma with t(14;18) and 8q24\/c-MYC translocations","author":"Niitsu","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2011.02.006_bib66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/leu.2008.281","article-title":"Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge","author":"Boerma","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2011.02.006_bib67","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa055351","article-title":"A biologic definition of Burkitt\u2019s lymphoma from transcriptional and genomic profiling","volume":"354","author":"Hummel","year":"2006","journal-title":"New Engl Journal Medicine"},{"key":"10.1016\/j.beha.2011.02.006_bib68","first-page":"473","article-title":"De novo acute B-cell leukemia with translocation t(14;18): an entity with a poor prognosis","volume":"5","author":"Kramer","year":"1991","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2011.02.006_bib69","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00000478-200004000-00006","article-title":"Blastic\/blastoid transformation of follicular lymphoma: immunohistologic and molecular analyses of five cases","volume":"24","author":"Natkunam","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib70","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1200\/JCO.2006.06.1648","article-title":"Gene-expression and immunohistochemical study of specific T-cell subsets and accessory cell types in the transformation and prognosis of follicular lymphoma","volume":"25","author":"Glas","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib71","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2006.06439.x","article-title":"Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms","volume":"136","author":"Davies","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.beha.2011.02.006_bib72","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood-2009-03-212191","article-title":"Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival","volume":"114","author":"Johnson","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib73","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1200\/JCO.2009.26.1693","article-title":"Prognostic factors in follicular lymphoma","volume":"28","author":"Relander","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib74","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1200\/JCO.2005.26.856","article-title":"Molecular pathogenesis of follicular lymphoma: a cross talk of genetic and immunologic factors","volume":"23","author":"de Jong","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib75","first-page":"1","article-title":"Predicting transformation in follicular lymphoma","author":"De Jong","year":"2009","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.beha.2011.02.006_bib76","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1182\/blood-2005-04-1565","article-title":"Analysis of multiple biomarkers shows that lymphoma-associated macrophage (LAM) content is an independent predictor of survival in follicular lymphoma (FL)","volume":"106","author":"Farinha","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib77","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib78","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1182\/blood-2008-08-174839","article-title":"Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone","volume":"113","author":"Carlotti","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib79","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1182\/blood-2007-11-124560","article-title":"S(mu) mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells","volume":"112","author":"Ruminy","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib80","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/MOH.0b013e328338ccab","article-title":"Molecular signatures in the diagnosis and management of follicular lymphoma","volume":"17","author":"Wrench","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.beha.2011.02.006_bib81","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1158\/1078-0432.CCR-08-0752","article-title":"Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways, and frequent Parallel clonal evolution","volume":"14","author":"d\u2019Amore","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.beha.2011.02.006_bib82","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1182\/blood-2009-08-236786","article-title":"Stem cell mimicry: key to transformation?","volume":"114","author":"Carlotti","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib83","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1182\/blood-2009-02-202465","article-title":"A pluripotency signature predicts histologic transformation and influences survival in follicular lymphoma patients","volume":"114","author":"Gentles","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib84","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1078\/0344-0338-00421","article-title":"Disappearance of CD21-positive follicular dendritic cells preceding the transformation of follicular lymphoma: immunohistological study of the transformation using CD21, p53, Ki-67, and P-glycoprotein","volume":"199","author":"Shiozawa","year":"2003","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.beha.2011.02.006_bib85","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2353\/ajpath.2010.100048","article-title":"Down-regulation of CD9 expression and its correlation to tumor progression in B lymphomas","volume":"177","author":"Yoon","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib86","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1182\/blood.V82.8.2289.2289","article-title":"p53 mutations are associated with histologic transformation of follicular lymphoma","volume":"82","author":"Lo Coco","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib87","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1182\/blood.V82.7.1994.1994","article-title":"p53 mutation is associated with progression in follicular lymphomas","volume":"82","author":"Sander","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib88","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1182\/blood.V91.12.4677","article-title":"Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma","volume":"91","author":"Elenitoba-Johnson","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib89","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1073\/pnas.1137463100","article-title":"Involvement of multiple signaling pathways in follicular lymphoma transformation: p38-mitogen-activated protein kinase as a target for therapy","volume":"100","author":"Elenitoba-Johnson","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.beha.2011.02.006_bib90","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1046\/j.1365-2559.2002.01506.x","article-title":"Frequent alteration of MDM2 and p53 in the molecular progression of recurring non-Hodgkin\u2019s lymphoma","volume":"41","author":"Moller","year":"2002","journal-title":"Histopathology"},{"key":"10.1016\/j.beha.2011.02.006_bib91","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2141.1998.00733.x","article-title":"Gain of chromosome 7 marks the progression from indolent to aggressive follicle centre lymphoma and is a common finding in patients with diffuse large B-cell lymphoma: a study by FISH","volume":"101","author":"Bernell","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.beha.2011.02.006_bib92","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1054\/bjoc.2000.1638","article-title":"Copy number gain at 12q12-14 may be important in the transformation from follicular lymphoma to diffuse large B cell lymphoma","volume":"84","author":"Hough","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.beha.2011.02.006_bib93","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0046-8177(03)00350-2","article-title":"Identification of chromosomal copy number changes associated with transformation of follicular lymphoma to diffuse large B-cell lymphoma","volume":"34","author":"Boonstra","year":"2003","journal-title":"Hum Pathol"},{"key":"10.1016\/j.beha.2011.02.006_bib94","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1182\/blood-2002-08-2482","article-title":"BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma","volume":"102","author":"Akasaka","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib95","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1023\/A:1008259006476","article-title":"Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma","volume":"8","author":"Matolcsy","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib96","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/blood-2008-02-140616","article-title":"Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances","volume":"113","author":"Cheung","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib97","first-page":"1919","article-title":"TNFRSF14 is Mutated in a subset of follicular lymphoma and Correlated with inferior prognosis","volume":"114","author":"Cheung","year":"2009","journal-title":"ASH Annu Meet Abstr"},{"key":"10.1016\/j.beha.2011.02.006_bib98","first-page":"3967","article-title":"FAS mutations in follicular lymphoma are rare but associated with aggressive clinical behavior","volume":"114","author":"Johnson","year":"2009","journal-title":"ASH Annu Meet Abstr"},{"key":"10.1016\/j.beha.2011.02.006_bib99","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1182\/blood-2008-08-174953","article-title":"Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation","volume":"113","author":"O\u2019Shea","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib100","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa041869","article-title":"Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells","volume":"351","author":"Dave","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.beha.2011.02.006_bib101","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3324\/haematol.13574","article-title":"Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols","volume":"94","author":"de Jong","year":"2009","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2011.02.006_bib102","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1182\/blood-2006-04-018218","article-title":"High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma","volume":"108","author":"Carreras","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib103","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1182\/blood-2009-07-235598","article-title":"The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation","volume":"115","author":"Farinha","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib104","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1200\/JCO.2008.18.0513","article-title":"High numbers of tumor-infiltrating programmed cell death 1-Positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma","volume":"27","author":"Carreras","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib105","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1158\/1078-0432.CCR-07-0778","article-title":"A high tumor-associated macrophage content predicts favorable outcome in follicular lymphoma patients treated with rituximab and cyclophosphamide-doxorubicin-vincristine-prednisone","volume":"13","author":"Taskinen","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.beha.2011.02.006_bib106","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1182\/blood-2007-11-125823","article-title":"Prognostic influence of tumor-infiltrating mast cells in patients with follicular lymphoma treated with rituximab and CHOP","volume":"111","author":"Taskinen","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib107","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.3324\/haematol.2009.021766","article-title":"Vascularization predicts overall survival and risk of transformation in follicular lymphoma","volume":"95","author":"Farinha","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.beha.2011.02.006_bib108","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/annonc\/mdl162","article-title":"The Follicular Lymphoma International Prognostic Index (FLIPI) and the histological subtype are the most important factors to predict histological transformation in follicular lymphoma","volume":"17","author":"Gine","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib109","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1200\/JCO.1995.13.7.1726","article-title":"Long-term survival after histologic transformation of low-grade follicular lymphoma","volume":"13","author":"Yuen","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib110","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/annonc\/mdn657","article-title":"The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL)","volume":"20","author":"Noy","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib111","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1200\/JCO.2001.19.19.3918","article-title":"Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin\u2019s lymphomas","volume":"19","author":"Kaminski","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib112","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1200\/JCO.2000.18.6.1316","article-title":"Multicenter phase II study of iodine-131 tositumomab for chemotherapy-relapsed\/refractory low-grade and transformed low-grade B-cell non-Hodgkin\u2019s lymphomas","volume":"18","author":"Vose","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib113","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1200\/JCO.2004.06.055","article-title":"Tositumomab and iodine I 131 tositumomab for recurrent indolent and transformed B-cell non-Hodgkin\u2019s lymphoma","volume":"22","author":"Davies","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib114","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1200\/JCO.2002.11.076","article-title":"Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin\u2019s lymphoma","volume":"20","author":"Witzig","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib115","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1182\/blood.V74.7.2579.2579","article-title":"Autologous bone marrow transplantation in follicular non-Hodgkin\u2019s lymphoma before and after histologic transformation","volume":"74","author":"Schouten","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib116","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1182\/blood.V77.11.2524.2524","article-title":"Autologous bone marrow transplantation in 69 patients with a history of low-grade B-cell non-Hodgkin\u2019s lymphoma","volume":"77","author":"Freedman","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib117","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1023\/A:1008349427337","article-title":"High-dose therapy with autologous haematopoietic support in patients with transformed follicular lymphoma: a study of 27 patients from a single centre","volume":"9","author":"Foran","year":"1998","journal-title":"Ann Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib118","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1034\/j.1600-0609.2000.90114.x","article-title":"Long-term follow-up of autologous stem-cell transplantation for follicular and transformed follicular lymphoma","volume":"65","author":"Berglund","year":"2000","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.beha.2011.02.006_bib119","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1046\/j.1365-2141.2001.02705.x","article-title":"Autotransplants for histologically transformed follicular non-Hodgkin\u2019s lymphoma","volume":"113","author":"Chen","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.beha.2011.02.006_bib120","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1200\/JCO.2001.19.3.727","article-title":"High-dose therapy and autologous stem-cell support for chemosensitive transformed low-grade follicular non-Hodgkin\u2019s lymphoma: a case-matched study from the European Bone Marrow Transplant Registry","volume":"19","author":"Williams","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.beha.2011.02.006_bib121","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1053\/bbmt.1999.v5.pm10465106","article-title":"Autologous bone marrow transplantation after histologic transformation of indolent B cell malignancies","volume":"5","author":"Friedberg","year":"1999","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.beha.2011.02.006_bib122","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/sj.bmt.1705178","article-title":"Long-term event-free survivors after high-dose therapy and autologous stem-cell transplantation for low-grade follicular lymphoma","volume":"36","author":"Andreadis","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.beha.2011.02.006_bib123","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bbmt.2007.04.009","article-title":"A 15-year analysis of early and late autologous hematopoietic stem cell transplant in relapsed, aggressive, transformed, and nontransformed follicular lymphoma","volume":"13","author":"Sabloff","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.beha.2011.02.006_bib124","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1182\/blood.V112.11.4459.4459","article-title":"Autologous stem cell transplantation is superior to myeloablative allogeneic SCT as a salvage therapy for patients with refractory\/relapsed transformed lymphoma","volume":"112","author":"Ramadan","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.beha.2011.02.006_bib125","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1200\/JCO.2007.11.5477","article-title":"Nonmyeloablative allogeneic hematopoietic cell transplantation in relapsed, refractory, and transformed indolent non-Hodgkin\u2019s lymphoma","volume":"26","author":"Rezvani","year":"2008","journal-title":"J Clin Oncol"}],"container-title":["Best Practice &amp; Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692611000132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692611000132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T06:29:22Z","timestamp":1592548162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692611000132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":125,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1521692611000132"],"URL":"https:\/\/doi.org\/10.1016\/j.beha.2011.02.006","relation":{},"ISSN":["1521-6926"],"issn-type":[{"value":"1521-6926","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}