{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:09:23Z","timestamp":1761498563090,"version":"build-2065373602"},"reference-count":95,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Haematology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.beha.2019.06.003","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T21:56:44Z","timestamp":1559771804000},"page":"196-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genomics of LGL leukemia and select other rare leukemia\/lymphomas"],"prefix":"10.1016","volume":"32","author":[{"given":"Katharine B.","family":"Moosic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umadevi","family":"Paila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine C.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Dziewulska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Tiffany","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakrosh","family":"Ratan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Feith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Thomas P.","family":"Loughran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/10428194.2017.1339880","article-title":"Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL)","volume":"59","author":"Sanikommu","year":"2018","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.thj.6200212","article-title":"T-cell large granular lymphocyte leukemia is characterized by massive TCRBV-restricted clonal CD8 expansion and a generalized overexpression of the effector cell marker CD57","volume":"4","author":"Melenhorst","year":"2003","journal-title":"Hematol J"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211","article-title":"Clonal diseases of large granular lymphocytes","volume":"82","author":"Loughran","year":"1993","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib4","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1182\/blood-2016-08-692590","article-title":"LGL leukemia: from pathogenesis to treatment","volume":"129","author":"Lamy","year":"2017","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.beha.2019.06.003_bib5","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1182\/blood-2010-07-296962","article-title":"How I treat LGL leukemia","volume":"117","author":"Lamy","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.beha.2019.06.003_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.blre.2014.02.001","article-title":"The pathogenesis and treatment of large granular lymphocyte leukemia","volume":"28","author":"Steinway","year":"2014","journal-title":"Blood Rev"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2217\/fon.12.75","article-title":"Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets","volume":"8","author":"Leblanc","year":"2012","journal-title":"Future Oncol"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7326\/0003-4819-102-2-169","article-title":"Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia","volume":"102","author":"Loughran","year":"1985","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.beha.2019.06.003_bib9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/leu.2014.298","article-title":"Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998)","volume":"29","author":"Loughran","year":"2015","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib10","first-page":"136","article-title":"Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors","volume":"1845","author":"Siveen","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMra1202117","article-title":"JAKs and STATs in immunity, immunodeficiency, and cancer","volume":"368","author":"O'Shea","year":"2013","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.beha.2019.06.003_bib12","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/ng.3040","article-title":"Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease","volume":"46","author":"Flanagan","year":"2014","journal-title":"Nat Genet"},{"issue":"20","key":"10.1016\/j.beha.2019.06.003_bib13","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1056\/NEJMoa1114885","article-title":"Somatic STAT3 mutations in large granular lymphocytic leukemia","volume":"366","author":"Koskela","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.beha.2019.06.003_bib14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.humpath.2017.12.014","article-title":"STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia","volume":"73","author":"Shi","year":"2018","journal-title":"Hum Pathol"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib15","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/leu.2012.350","article-title":"STAT3 mutations are highly specific for large granular lymphocytic leukemia","volume":"27","author":"Fasan","year":"2013","journal-title":"Leukemia"},{"issue":"15","key":"10.1016\/j.beha.2019.06.003_bib16","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1182\/blood-2012-06-435297","article-title":"STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia","volume":"120","author":"Jerez","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.beha.2019.06.003_bib17","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1038\/bcj.2013.65","article-title":"Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation","volume":"3","author":"Andersson","year":"2013","journal-title":"Blood Canc J"},{"issue":"15","key":"10.1016\/j.beha.2019.06.003_bib18","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1073\/pnas.1700682114","article-title":"Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1\/STAT3 mutations","volume":"114","author":"Chen","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.beha.2019.06.003_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ccell.2015.03.006","article-title":"Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma","volume":"27","author":"Crescenzo","year":"2015","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.beha.2019.06.003_bib20","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1038\/leu.2013.104","article-title":"STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia","volume":"27","author":"Ohgami","year":"2013","journal-title":"Leukemia"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib21","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.3324\/haematol.2013.101543","article-title":"STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression","volume":"99","author":"Ohgami","year":"2014","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.beha.2019.06.003_bib22","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/bjh.14487","article-title":"STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice","volume":"180","author":"Dutta","year":"2018","journal-title":"Br J Haematol"},{"issue":"22","key":"10.1016\/j.beha.2019.06.003_bib23","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1182\/blood-2012-12-474577","article-title":"Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia","volume":"121","author":"Rajala","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib24","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1172\/JCI94509","article-title":"STAT5BN642H is a driver mutation for T cell neoplasia","volume":"128","author":"Pham","year":"2018","journal-title":"J Clin Investig"},{"issue":"20","key":"10.1016\/j.beha.2019.06.003_bib25","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1182\/blood-2016-06-724856","article-title":"High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia","volume":"128","author":"Andersson","year":"2016","journal-title":"Blood"},{"issue":"37","key":"10.1016\/j.beha.2019.06.003_bib26","doi-asserted-by":"crossref","first-page":"61876","DOI":"10.18632\/oncotarget.18711","article-title":"STAT3 mutation impacts biological and clinical features of T-LGL leukemia","volume":"8","author":"Teramo","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1182\/asheducation-2017.1.181","article-title":"Chronic neutropenia in LGL leukemia and rheumatoid arthritis","volume":"2017","author":"Gazitt","year":"2017","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.beha.2019.06.003_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clim.2016.11.018","article-title":"A novel class of somatic mutations in blood detected preferentially in CD8+ cells","volume":"175","author":"Valori","year":"2017","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3324\/haematol.2014.113142","article-title":"The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia","volume":"100","author":"Rajala","year":"2015","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3324\/haematol.2017.175729","article-title":"Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia","volume":"103","author":"Savola","year":"2018","journal-title":"Haematologica"},{"issue":"20","key":"10.1016\/j.beha.2019.06.003_bib31","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1182\/bloodadvances.2018022723","article-title":"Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia","volume":"2","author":"Kawakami","year":"2018","journal-title":"Blood Adv"},{"issue":"14","key":"10.1016\/j.beha.2019.06.003_bib32","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1182\/blood-2013-04-494930","article-title":"STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients","volume":"122","author":"Jerez","year":"2013","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.beha.2019.06.003_bib33","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1182\/bloodadvances.2017011197","article-title":"Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia","volume":"1","author":"Morgan","year":"2017","journal-title":"Blood Adv"},{"issue":"3","key":"10.1016\/j.beha.2019.06.003_bib34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.immuni.2016.07.018","article-title":"Interleukin-15-Dependent T-cell-like innate intraepithelial lymphocytes develop in the intestine and transform into lymphomas in celiac disease","volume":"45","author":"Ettersperger","year":"2016","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.beha.2019.06.003_bib35","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1053\/j.gastro.2012.08.028","article-title":"Large granular lymphocytic leukemia: a treatable form of refractory celiac disease","volume":"143","author":"Malamut","year":"2012","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.beha.2019.06.003_bib36","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1172\/JCI9940","article-title":"Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression","volume":"107","author":"Epling-Burnette","year":"2001","journal-title":"J Clin Investig"},{"issue":"5","key":"10.1016\/j.beha.2019.06.003_bib37","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/leu.2017.49","article-title":"Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach","volume":"31","author":"Coppe","year":"2017","journal-title":"Leukemia"},{"issue":"Suppl 3","key":"10.1016\/j.beha.2019.06.003_bib38","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.3816\/CLM.2009.s.019","article-title":"Never say die: survival signaling in large granular lymphocyte leukemia","volume":"9","author":"Shah","year":"2009","journal-title":"Clin Lymphoma Myeloma"},{"issue":"42","key":"10.1016\/j.beha.2019.06.003_bib39","doi-asserted-by":"crossref","first-page":"16308","DOI":"10.1073\/pnas.0806447105","article-title":"Network model of survival signaling in large granular lymphocyte leukemia","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.beha.2019.06.003_bib40","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1182\/bloodadvances.2018027862","article-title":"Subclonal STAT3 mutations solidify clonal dominance","volume":"3","author":"Kerr","year":"2019","journal-title":"Blood Adv"},{"issue":"8","key":"10.1016\/j.beha.2019.06.003_bib41","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nrc.2016.63","article-title":"The genetics and mechanisms of T cell acute lymphoblastic leukaemia","volume":"16","author":"Belver","year":"2016","journal-title":"Nat Rev Canc"},{"issue":"11","key":"10.1016\/j.beha.2019.06.003_bib42","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1182\/blood-2014-06-580480","article-title":"Efficacy of JAK\/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia","volume":"125","author":"Maude","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","article-title":"Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia","volume":"1","author":"Ferrando","year":"2002","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1182\/blood-2016-10-706465","article-title":"The genetics and molecular biology of T-ALL","volume":"129","author":"Girardi","year":"2017","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.beha.2019.06.003_bib45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood-2014-03-562751","article-title":"PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events","volume":"124","author":"Mendes","year":"2014","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.beha.2019.06.003_bib46","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1038\/leu.2016.100","article-title":"Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling","volume":"30","author":"Tremblay","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.beha.2019.06.003_bib47","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1038\/ncomms6794","article-title":"ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling","volume":"6","author":"Goossens","year":"2015","journal-title":"Nat Commun"},{"issue":"26","key":"10.1016\/j.beha.2019.06.003_bib48","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1182\/blood-2010-10-314286","article-title":"PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia","volume":"117","author":"Kleppe","year":"2011","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib49","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2014-03-559542","article-title":"Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia","volume":"124","author":"Kiel","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.beha.2019.06.003_bib50","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/leu.2017.252","article-title":"Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling","volume":"32","author":"Andersson","year":"2018","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib51","first-page":"2475","article-title":"MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha\/delta locus in mature T cell proliferations","volume":"8","author":"Stern","year":"1993","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib52","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V92.2.368","article-title":"Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia","volume":"92","author":"Gritti","year":"1998","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib53","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1073\/pnas.95.7.3885","article-title":"Deregulated expression of TCL1 causes T cell leukemia in mice","volume":"95","author":"Virgilio","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"61","key":"10.1016\/j.beha.2019.06.003_bib54","doi-asserted-by":"crossref","first-page":"104664","DOI":"10.18632\/oncotarget.22272","article-title":"Advances in the understanding and management of T-cell prolymphocytic leukemia","volume":"8","author":"Laribi","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib55","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/gcc.22313","article-title":"Genetic characterization of T-PLL reveals two major biologic subgroups and JAK3 mutations as prognostic marker","volume":"55","author":"Stengel","year":"2016","journal-title":"Genes Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib56","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/bjh.13952","article-title":"Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia","volume":"173","author":"L\u00f3pez","year":"2016","journal-title":"Br J Haematol"},{"issue":"12","key":"10.1016\/j.beha.2019.06.003_bib57","doi-asserted-by":"crossref","first-page":"e0145880","DOI":"10.1371\/journal.pone.0145880","article-title":"Dual-specificity phosphatase 4 regulates STAT5 protein stability and helper T cell polarization","volume":"10","author":"Hsiao","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib58","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/eji.201041295","article-title":"DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development","volume":"42","author":"Huang","year":"2012","journal-title":"Eur J Immunol"},{"issue":"5","key":"10.1016\/j.beha.2019.06.003_bib59","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5114\/pdia.2015.54749","article-title":"Primary cutaneous lymphomas: diagnosis and treatment","volume":"32","author":"Soko\u0142owska-Wojdy\u0142o","year":"2015","journal-title":"Postepy Dermatol Alergol"},{"issue":"10","key":"10.1016\/j.beha.2019.06.003_bib60","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze","year":"2005","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib61","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ng.3356","article-title":"Genomic landscape of cutaneous T cell lymphoma","volume":"47","author":"Choi","year":"2015","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib62","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21037\/cco.2018.11.02","article-title":"S\u00e9zary Syndrome, recent biomarkers and new drugs","volume":"8","author":"Cristofoletti","year":"2019","journal-title":"Chin Clin Oncol"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib63","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1182\/blood-2008-04-153031","article-title":"Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome","volume":"113","author":"van Doorn","year":"2009","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.beha.2019.06.003_bib64","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1182\/blood-2017-02-768234","article-title":"Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)","volume":"130","author":"Park","year":"2017","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.beha.2019.06.003_bib65","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.4161\/15384101.2014.965061","article-title":"Deregulation in STAT signaling is important for cutaneous T-cell lymphoma (CTCL) pathogenesis and cancer progression","volume":"13","author":"Netchiporouk","year":"2014","journal-title":"Cell Cycle"},{"issue":"12","key":"10.1016\/j.beha.2019.06.003_bib66","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/gcc.22679","article-title":"Genomic analysis reveals recurrent deletion of JAK-STAT signaling inhibitors HNRNPK and SOCS1 in mycosis fungoides","volume":"57","author":"Bastidas Torres","year":"2018","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.beha.2019.06.003_bib67","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1038\/ncomms9470","article-title":"Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in S\u00e9zary syndrome","volume":"6","author":"Kiel","year":"2015","journal-title":"Nat Commun"},{"issue":"13","key":"10.1016\/j.beha.2019.06.003_bib68","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","article-title":"PLCG1 mutations in cutaneous T-cell lymphomas","volume":"123","author":"Vaqu\u00e9","year":"2014","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.beha.2019.06.003_bib69","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.4161\/cc.24987","article-title":"STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma","volume":"12","author":"Kopp","year":"2013","journal-title":"Cell Cycle"},{"issue":"22","key":"10.1016\/j.beha.2019.06.003_bib70","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1182\/blood-2011-06-358382","article-title":"Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)","volume":"118","author":"Ralfkiaer","year":"2011","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib71","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood-2009-12-256719","article-title":"MicroRNA expression in Sezary syndrome: identification, function, and diagnostic potential","volume":"116","author":"Ballabio","year":"2010","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib72","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2016-09-692541","article-title":"Angioimmunoblastic T-cell lymphoma: the many-faced lymphoma","volume":"129","author":"Lunning","year":"2017","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.beha.2019.06.003_bib73","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1182\/blood-2013-10-531509","article-title":"A targeted mutational landscape of angioimmunoblastic T-cell lymphoma","volume":"123","author":"Odejide","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib74","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41408-017-0047-2","article-title":"Mutational heterogeneity of angioimmunoblastic T-cell lymphoma indicates distinct lymphomagenic pathways","volume":"8","author":"Willemsen","year":"2018","journal-title":"Blood Canc J"},{"issue":"11","key":"10.1016\/j.beha.2019.06.003_bib75","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2016-02-698977","article-title":"Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas","volume":"128","author":"Vallois","year":"2016","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.beha.2019.06.003_bib76","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.18632\/oncotarget.14503","article-title":"The heterogeneous landscape of ALK negative ALCL","volume":"8","author":"Mereu","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.beha.2019.06.003_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10040107","article-title":"The pathological spectrum of systemic anaplastic large cell lymphoma (ALCL)","volume":"10","author":"Montes-Mojarro","year":"2018","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.beha.2019.06.003_bib78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1182\/blood-2006-06-028969","article-title":"Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK\u03e9 subtypes","volume":"109","author":"Lamant","year":"2007","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib79","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.onc.1205152","article-title":"Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death","volume":"21","author":"Zamo","year":"2002","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.beha.2019.06.003_bib80","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1182\/blood-2007-04-060715","article-title":"Pathobiology of ALK+ anaplastic large-cell lymphoma","volume":"110","author":"Amin","year":"2007","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.beha.2019.06.003_bib81","first-page":"6517","article-title":"Role of signal transducer and activator of transcription 5 in nucleophosmin\/anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells","volume":"61","author":"Nieborowska-Skorska","year":"2001","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib82","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1182\/blood-2014-12-614503","article-title":"Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts","volume":"127","author":"Scarf\u00f2","year":"2016","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.beha.2019.06.003_bib83","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/10428194.2015.1064530","article-title":"Genetics of anaplastic large cell lymphoma","volume":"57","author":"Zeng","year":"2016","journal-title":"Leuk Lymphoma"},{"unstructured":"Khoury JD, Medeiros LJ, Rassidakis GZ, Yared MA, Tsioli P, Leventaki V, et al. Differential expression and clinical significance of tyrosine- phosphorylated STAT3 in ALK+ and ALK\u2212 anaplastic large cell lymphoma. :9.","key":"10.1016\/j.beha.2019.06.003_bib84"},{"issue":"12","key":"10.1016\/j.beha.2019.06.003_bib85","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/onc.2010.537","article-title":"Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy","volume":"30","author":"Matsuoka","year":"2011","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.beha.2019.06.003_bib86","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/ng.3428","article-title":"The genomic landscape of adult T cell leukemia\/lymphoma","volume":"47","author":"Vicente","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.beha.2019.06.003_bib87","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.3389\/fmicb.2018.01686","article-title":"HTLV-1-Mediated epigenetic pathway to adult T-cell leukemia-lymphoma","volume":"9","author":"Yamagishi","year":"2018","journal-title":"Front Microbiol"},{"issue":"3","key":"10.1016\/j.beha.2019.06.003_bib88","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells","volume":"103","author":"Satou","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.beha.2019.06.003_bib89","doi-asserted-by":"crossref","first-page":"e1001274","DOI":"10.1371\/journal.ppat.1001274","article-title":"HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo","volume":"7","author":"Satou","year":"2011","journal-title":"PLoS Pathog"},{"issue":"11","key":"10.1016\/j.beha.2019.06.003_bib90","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat Genet"},{"issue":"20","key":"10.1016\/j.beha.2019.06.003_bib91","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1182\/blood-2015-11-685032","article-title":"Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia","volume":"127","author":"Bellon","year":"2016","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.beha.2019.06.003_bib92","doi-asserted-by":"crossref","first-page":"13897","DOI":"10.1073\/pnas.94.25.13897","article-title":"Proliferation of adult T cell leukemia\/lymphoma cells is associated with the constitutive activation of JAK\/STAT proteins","volume":"94","author":"Takemoto","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.beha.2019.06.003_bib93","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.166.4.2602","article-title":"Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site","volume":"166","author":"Mariner","year":"2001","journal-title":"J Immunol"},{"issue":"13","key":"10.1016\/j.beha.2019.06.003_bib94","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1073\/pnas.87.13.5218","article-title":"Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy","volume":"87","author":"Tendler","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.beha.2019.06.003_bib95","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/s41375-018-0290-y","article-title":"IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective \u03b3-chain cytokines, decreases leukemic T-cell viability","volume":"33","author":"Wang","year":"2019","journal-title":"Leukemia"}],"container-title":["Best Practice &amp; Research Clinical Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692619300428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521692619300428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:05:24Z","timestamp":1761498324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521692619300428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":95,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1521692619300428"],"URL":"https:\/\/doi.org\/10.1016\/j.beha.2019.06.003","relation":{},"ISSN":["1521-6926"],"issn-type":[{"type":"print","value":"1521-6926"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomics of LGL leukemia and select other rare leukemia\/lymphomas","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Haematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beha.2019.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}