{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:34:44Z","timestamp":1790220884194,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PROEX 1734-2015"],"award-info":[{"award-number":["PROEX 1734-2015"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008132","name":"Universidade Federal de Pernambuco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["\\u201C Universal 421752\/2016-5"],"award-info":[{"award-number":["\\u201C Universal 421752\/2016-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Processes"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.beproc.2019.103981","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T06:57:31Z","timestamp":1572677851000},"page":"103981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Early weaning disrupts feeding patterns in female juvenile rats through 5HT-system modulations"],"prefix":"10.1016","volume":"170","author":[{"given":"Gabriel Ara\u00fajo","family":"Tavares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Cavalcanti do Amaral","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julliet Ara\u00fajo","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauber Rud\u00e1 Feitosa","family":"Braz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde Cesiana","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Jacques","family":"Lagranha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Lopes","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.beproc.2019.103981_bib0005","doi-asserted-by":"crossref","DOI":"10.1046\/j.1471-4159.2001.00550.x","article-title":"The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain","author":"Adell","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.beproc.2019.103981_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/S0893-133X(02)00300-7","article-title":"Spontaneous Novelty seeking and Amphetamine-induced conditioning and sensitization in adult mice: evidence of dissociation as a function of age at weaning","author":"Adriani","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.beproc.2019.103981_bib0015","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.bjp.0706935","article-title":"In vivo evidence that 5-HT2Creceptors inhibit 5-HT neuronal activity via a GABAergic mechanism","volume":"149","author":"Boothman","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.beproc.2019.103981_bib0020","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1004587107","article-title":"Central serotonin neurons are required for arousal to CO2","author":"Buchanan","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.beproc.2019.103981_bib0025","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.113.116137","article-title":"Tissue-specific changes in molecular clocks during the transition from pregnancy to lactation in Mice1","author":"Casey","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.beproc.2019.103981_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097412","article-title":"Pet-1 deficiency alters the circadian clock and its temporal organization of behavior","author":"Ciarleglio","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.beproc.2019.103981_bib0035","first-page":"657","article-title":"The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn","volume":"26","author":"Cubero","year":"2005","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.beproc.2019.103981_bib0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.beproc.2010.09.005","article-title":"Early weaning programs rats to have a dietary preference for fat and palatable foods in adulthood","volume":"86","author":"dos Santos Oliveira","year":"2011","journal-title":"Behav. Processes"},{"key":"10.1016\/j.beproc.2019.103981_bib0045","doi-asserted-by":"crossref","DOI":"10.1210\/er.2013-1051","article-title":"The effects of light at night on circadian clocks and metabolism","author":"Fonken","year":"2014","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.beproc.2019.103981_bib0050","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsw077","article-title":"Development of circadian sleep regulation in the rat: a longitudinal study under constant conditions","author":"Frank","year":"2017","journal-title":"Sleep"},{"key":"10.1016\/j.beproc.2019.103981_bib0055","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.23-20-07451.2003","article-title":"Midbrain raphe modulation of nonphotic circadian clock resetting and 5-HT release in the mammalian suprachiasmatic nucleus","author":"Glass","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.beproc.2019.103981_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2006.06.004","article-title":"Serotonin reciprocally regulates melanocortin neurons to modulate food intake","author":"Heisler","year":"2006","journal-title":"Neuron."},{"key":"10.1016\/j.beproc.2019.103981_bib0065","first-page":"R262","article-title":"Restricted daily feeding during nursing period resets circadian locomotor rhythm of infant rats","volume":"252","author":"Honma","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.beproc.2019.103981_bib0070","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jchemneu.2003.10.002","article-title":"The human raphe nuclei and the serotonergic system","author":"Hornung","year":"2003","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.beproc.2019.103981_bib0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbr.2004.05.008","article-title":"Multidimensional structure of anxiety-related behavior in early-weaned rats","volume":"156","author":"Kanari","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.beproc.2019.103981_bib0080","doi-asserted-by":"crossref","first-page":"NP105","DOI":"10.1177\/0890334415625217","article-title":"Melatonin concentrations and antioxidative capacity of human breast milk according to gestational age and the time of day","volume":"32","author":"Katzer","year":"2016","journal-title":"J. Hum. Lact."},{"key":"10.1016\/j.beproc.2019.103981_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2008.12.009","article-title":"Maternal deprivation by early weaning increases corticosterone and decreases hippocampal BDNF and neurogenesis in mice","author":"Kikusui","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.beproc.2019.103981_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2006.11.031","article-title":"Deprivation of mother-pup interaction by early weaning alters myelin formation in male, but not female, ICR mice","author":"Kikusui","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.beproc.2019.103981_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2003.12.016","article-title":"Early weaning induces anxiety and aggression in adult mice","author":"Kikusui","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.beproc.2019.103981_bib0100","doi-asserted-by":"crossref","DOI":"10.3758\/BF03331923","article-title":"Precocious weaning and changes in social variables during prepuberty affect cocaine reinforcing properties in adult mice","author":"Laviola","year":"1997","journal-title":"Psychobiology"},{"key":"10.1016\/j.beproc.2019.103981_bib0105","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1037\/h0077038","article-title":"Maternal influences on ontogeny of suckling and feeding rhythms in the rat","volume":"88","author":"Levin","year":"1975","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.beproc.2019.103981_bib0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.beproc.2019.103981_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2010.08.055","article-title":"Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity","author":"MacGillivray","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.beproc.2019.103981_bib0120","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.2008.05493.x","article-title":"Serotonergic potentiation of dark pulse-induced phase-shifting effects at midday in hamsters","author":"Mendoza","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.beproc.2019.103981_bib0125","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.16-06-02097.1996","article-title":"Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation","author":"Meyer-Bernstein","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1016\/j.beproc.2019.103981_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-8993(97)00111-X","article-title":"The serotonergic projection from the median raphe nucleus to the suprachiasmatic nucleus modulates activity phase onset, but not other circadian rhythm parameters","author":"Meyer-Bernstein","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.beproc.2019.103981_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-8993(02)03470-4","article-title":"Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region","author":"Montaez","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.beproc.2019.103981_bib0140","doi-asserted-by":"crossref","DOI":"10.1111\/j.1460-9568.2012.08077.x","article-title":"Novel biochemical manipulation of brain serotonin reveals a role of serotonin in the circadian rhythm of sleep-wake cycles","author":"Nakamaru-Ogiso","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.beproc.2019.103981_bib0145","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbr.2007.10.002","article-title":"Changes in social instigation- and food restriction-induced aggressive behaviors and hippocampal 5HT1B mRNA receptor expression in male mice from early weaning","volume":"187","author":"Nakamura","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.beproc.2019.103981_bib0150","doi-asserted-by":"crossref","DOI":"10.1038\/193280a0","article-title":"Effect of early and late weaning on learning in adult rats","author":"Novakov\u00e1","year":"1962","journal-title":"Nature"},{"key":"10.1016\/j.beproc.2019.103981_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0145376","article-title":"Milk leptin surge and biological rhythms of leptin and other regulatory proteins in breastmilk","volume":"10","author":"Nozhenko","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.beproc.2019.103981_bib0160","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1046\/j.1460-9568.2002.02016.x","article-title":"Effects of nursing mothers on rPer1 and rPer2 circadian expressions in the neonatal rat suprachiasmatic nuclei vary with developmental stage","volume":"15","author":"Ohta","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.beproc.2019.103981_bib0165","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.beproc.2010.10.001","article-title":"Effects of early weaning on the circadian rhythm and behavioral satiety sequence in rats","volume":"86","author":"Oliveira","year":"2011","journal-title":"Behav. Processes"},{"key":"10.1016\/j.beproc.2019.103981_bib0170","doi-asserted-by":"crossref","DOI":"10.3109\/07420528.2013.815198","article-title":"Photic and nonphotic responses of the circadian clock in serotonin-deficient Pet-1 knockout mice","author":"Paulus","year":"2013","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.beproc.2019.103981_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2011.08.032","article-title":"Developmental disruption of the serotonin system alters circadian rhythms","author":"Paulus","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.beproc.2019.103981_bib0180","series-title":"Animal","article-title":"Does the circadian system regulate lactation?","author":"Plaut","year":"2012"},{"key":"10.1016\/j.beproc.2019.103981_bib0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jchemneu.2004.03.010","article-title":"Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei","volume":"29","author":"Serrats","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.beproc.2019.103981_bib0190","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/dev.20202","article-title":"Early weaning decreases play-fighting behavior during the postweaning developmental period of wistar rats","volume":"49","author":"Shimozuru","year":"2007","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.beproc.2019.103981_bib0195","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.13971","article-title":"Serotonin transporter inhibition during neonatal period induces sex-dependent effects on mitochondrial bioenergetics in the rat brainstem","author":"Silva","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.beproc.2019.103981_bib0200","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1073\/pnas.1321576111","article-title":"Gq\/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice","volume":"111","author":"Spoida","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.beproc.2019.103981_bib0205","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0091-3057(93)90551-4","article-title":"Periodic mother deprivation during the light period reversed the phase of serotonin N-acetyltransferase activity rhythm of the pineal gland in rat pups","volume":"46","author":"Sugishita","year":"1993","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.beproc.2019.103981_bib0210","first-page":"R359","article-title":"Further evidence that circadian rhythm of blinded rat pups is entrained by the nursing dam","volume":"246","author":"Takahashi","year":"1984","journal-title":"Am. J. Physiol."}],"container-title":["Behavioural Processes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0376635719302402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0376635719302402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:10:16Z","timestamp":1778749816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0376635719302402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":42,"alternative-id":["S0376635719302402"],"URL":"https:\/\/doi.org\/10.1016\/j.beproc.2019.103981","relation":{},"ISSN":["0376-6357"],"issn-type":[{"value":"0376-6357","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early weaning disrupts feeding patterns in female juvenile rats through 5HT-system modulations","name":"articletitle","label":"Article Title"},{"value":"Behavioural Processes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.beproc.2019.103981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103981"}}