{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:52:34Z","timestamp":1790182354055,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Rheumatology"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1016\/j.berh.2003.09.004","type":"journal-article","created":{"date-parts":[[2004,3,4]],"date-time":"2004-03-04T10:24:58Z","timestamp":1078395898000},"page":"1063-1080","source":"Crossref","is-referenced-by-count":66,"title":["Musculoskeletal manifestations of osteomalacia and rickets"],"prefix":"10.1016","volume":"17","author":[{"given":"Antonio J","family":"Reginato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet Arambulo","family":"Coquia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.berh.2003.09.004_BIB1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0033-8389(22)02681-1","article-title":"Rickets and osteomalacia are still around","volume":"29","author":"Pitt","year":"1991","journal-title":"Radiologic Clinics of North America"},{"key":"10.1016\/j.berh.2003.09.004_BIB2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0049-0172(99)80013-4","article-title":"Musculoskeletal manifestations of osteomalacia: report of 26 cases and literature review","volume":"28","author":"Reginato","year":"1999","journal-title":"Seminars in Arthritis & Rheumatism"},{"key":"10.1016\/j.berh.2003.09.004_BIB3","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1136\/bmj.1.5337.1054","article-title":"Rickets in immigrant children in London","volume":"1","author":"Benson","year":"1963","journal-title":"British Medical Journal"},{"key":"10.1016\/j.berh.2003.09.004_BIB4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-2002-36714","article-title":"Vitamin D metabolism, rickets, and osteomalacia","volume":"6","author":"Berry","year":"2002","journal-title":"Seminars in Musculoskeletal Radiology"},{"issue":"supplement","key":"10.1016\/j.berh.2003.09.004_BIB5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00124743-199704001-00022","article-title":"Musculoskeletal manifestations of osteomalacia","volume":"3","author":"Reginato","year":"1997","journal-title":"Journal of Clinical Rheumatology"},{"key":"10.1016\/j.berh.2003.09.004_BIB6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1532-5415.1978.tb01341.x","article-title":"Nutritional hypovitaminosis D and the genesis of osteomalacia in the elderly","volume":"25","author":"Anwar","year":"1978","journal-title":"Journal of the American Geriatric Society"},{"key":"10.1016\/j.berh.2003.09.004_BIB7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0002-9343(93)90335-M","article-title":"Non-invasive testing in the diagnosis of osteomalacia","volume":"95","author":"Bingham","year":"1993","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jcb.10338","article-title":"Vitamin D: a millenium perspective","volume":"88","author":"Holick","year":"2003","journal-title":"Journal of Cell Biochemistry"},{"key":"10.1016\/j.berh.2003.09.004_BIB9","first-page":"267","article-title":"Immunhistochemical detection of FGF-23 protein in tumours that cause oncogenic osteomalacia","volume":"148","author":"Larsson","year":"2003","journal-title":"European Journal of Endcrinology"},{"key":"10.1016\/j.berh.2003.09.004_BIB10","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1056\/NEJMoa020881","article-title":"Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia","volume":"348","author":"Jonsson","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jbmr.5650100406","article-title":"Solar ultraviolet B radiation and photo production of vitamin D3 in Central and Southern areas of Argentina","volume":"10","author":"Ladizesky","year":"1995","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.berh.2003.09.004_BIB12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(73)91361-5","article-title":"Vitamin D deficiency among Asian immigrants to Britain","volume":"i","author":"Preece","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2003.09.004_BIB13","first-page":"439","article-title":"Clinical and histological spectrum of osteomalacia among Asians in South London","volume":"83","author":"Finch","year":"1992","journal-title":"Quarterly Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0140-6736(84)90553-1","article-title":"How common is osteomalacia in the elderly?","volume":"ii","author":"Campell","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2003.09.004_BIB15","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0140-6736(73)91362-7","article-title":"Sunlight, vitamin D and osteomalacia in the elderly","volume":"i","author":"Hodkinson","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2003.09.004_BIB16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/BF03040308","article-title":"Decreased cutaneous vitamin D-synthesis in heavily melanized individuals: a rare cause for pathologic fractures of the hip","volume":"11","author":"Berger","year":"2003","journal-title":"Wiener Klinische Wochenschrift"},{"key":"10.1016\/j.berh.2003.09.004_BIB17","first-page":"74","article-title":"Increased skin pigment reduces the capacity of skin to synthesize vitamin D3","volume":"i","author":"Clellans","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2003.09.004_BIB18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/art.1780210619","article-title":"Atypical axial osteomalacia, report of four cases with two having features of ankylosing spondylitis","volume":"21","author":"Nelson","year":"1978","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.berh.2003.09.004_BIB19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198507043130101","article-title":"Calcification of entheses associated with X-linked hypophosphatemic osteomalacia","volume":"313","author":"Polisson","year":"1985","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB20","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/art.1780290516","article-title":"Adult sporadic hypophosphatemic osteomalacia presenting as regional migratory osteoporosis","volume":"29","author":"Gerster","year":"1986","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.berh.2003.09.004_BIB21","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/art.1780290717","article-title":"Reflex sympatheic dytrophy syndrome: an unusual mode of presentation of osteomalacia","volume":"29","author":"Huaux","year":"1986","journal-title":"Arthritis & Rheumatism."},{"key":"10.1016\/j.berh.2003.09.004_BIB22","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1001\/archinte.152.8.1720a","article-title":"Can vitamin D deficiency produce an unusual pain syndrome","volume":"152","author":"Reginato","year":"1992","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB23","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1001\/archinte.151.8.1662","article-title":"Can vitamin D deficiency produce an unusual pain syndrome?","volume":"151","author":"Gloth","year":"1991","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB24","first-page":"597","article-title":"Joint lesion of hyperparathyroidism","volume":"25","author":"Bywaters","year":"1971","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.berh.2003.09.004_BIB25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archinte.134.3.565","article-title":"Gluten-induced enteropathy; osteomalacia as a principal manifestation","volume":"134","author":"Haijar","year":"1974","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1365-2796.1992.tb00554.x","article-title":"A patient with osteomalacia as single presenting symptom of gluten-sensitive enteropathy","volume":"232","author":"De-Boer","year":"1992","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/ard.39.1.1","article-title":"Osteomalacia in rheumatoid arthritis","volume":"39","author":"O'Driscoll","year":"1980","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.berh.2003.09.004_BIB28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/bmj.4.5942.433","article-title":"Vitamin D deficiency, spontaneous fractures, and osteopenia in rheumatoid arthritis","volume":"4","author":"Maddison","year":"1974","journal-title":"British Medical Journal"},{"key":"10.1016\/j.berh.2003.09.004_BIB29","first-page":"117","article-title":"Intraspinal new bone formation and spinal cord compression in familial hypophosphatemic vitamin D resistant osteomalacia","volume":"61","author":"Adams","year":"1986","journal-title":"Quarterly Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB30","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1097\/00042737-200211000-00018","article-title":"Disabling osteomalacic myopathy as the only presenting feature of coeliac disease","volume":"14","author":"Byrne","year":"2002","journal-title":"European Journal of Gastroenterology & Hepatology"},{"key":"10.1016\/j.berh.2003.09.004_BIB31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/jcp.36.3.245","article-title":"Osteomalacia and osteoporosis; evaluation of a diagnostic index","volume":"36","author":"McKenna","year":"1983","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.berh.2003.09.004_BIB32","series-title":"Manual de enfermedados oseous metabolicas","first-page":"114","article-title":"Clinical evaluation of metabolic bone disease\u2014bone biopsy and histomorphometry","author":"Maldonado","year":"2003"},{"key":"10.1016\/j.berh.2003.09.004_BIB33","series-title":"Vitamin D","first-page":"645","article-title":"Vitamin D and the pathogenesis of rickets and osteomalacia","author":"Parfitt","year":"1997"},{"key":"10.1016\/j.berh.2003.09.004_BIB34","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/0016-5085(78)90150-6","article-title":"Oral 25-hydroxyvitamin D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy","volume":"74","author":"Compston","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.berh.2003.09.004_BIB35","first-page":"715","article-title":"Bone disease induced by anticonvulsant therapy and treatment with calcitriol (1,25 dihydroxyvitamin D3)","volume":"140","author":"Hunt","year":"1986","journal-title":"American Journal of Diseases of Children"},{"key":"10.1016\/j.berh.2003.09.004_BIB36","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1210\/jc.80.7.2255","article-title":"Pseudo-vitamin D deficiency absence of 25-hydroxyvitamin D 1-hydroxylase activity in human placenta decidual cells","volume":"80","author":"Glorieux","year":"1995","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.berh.2003.09.004_BIB37","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1056\/NEJM198106253042608","article-title":"A cellular defect in hereditary vitamin D-dependent rickets type II: defective nuclear uptake of 1,25-dihydroxyvitamin D in cultured skin fibroblasts","volume":"304","author":"Eil","year":"1981","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00041552-199807000-00004","article-title":"The role of the PHEX gene (PEX) in families with X-linked hypophosphatemic rickets","volume":"7","author":"Rowe","year":"1998","journal-title":"Current Opinion in Nephrology & Hypertension"},{"key":"10.1016\/j.berh.2003.09.004_BIB39","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1359\/jbmr.2003.18.7.1227","article-title":"Serum FGF-23 levels in normal and disordered phosphorous homeostasis","volume":"18","author":"Weber","year":"2003","journal-title":"Journal of Bone & Mineral Research"},{"key":"10.1016\/j.berh.2003.09.004_BIB40","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1210\/en.143.8.3179","article-title":"Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo","volume":"143","author":"Shimada","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.berh.2003.09.004_BIB41","doi-asserted-by":"crossref","DOI":"10.1097\/01.rhu.0000101906.15276.ed","article-title":"Oncogenic hypophosphatemic osteomalacia (OHO) associated with nasal hemangiopericytoma. Case report and update of the literature","author":"Fuentealba","year":"2003","journal-title":"Journal of Clinical Rheumatology"},{"key":"10.1016\/j.berh.2003.09.004_BIB42","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMe030037","article-title":"Oncogenic osteomalacia\u2014a complex dance of factors","volume":"348","author":"Carpenter","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB43","series-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","first-page":"340","article-title":"Fanconi syndrome and renal tubular acidosis","author":"Chesney","year":"1999"},{"key":"10.1016\/j.berh.2003.09.004_BIB44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJM198207223070403","article-title":"Incidence of radiographically evident bone disease, nephrocalcinosis and nephrolithiasis in various types of renal tubular acidosis","volume":"307","author":"Brenner","year":"1982","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB45","series-title":"Principles of Bone Biology","first-page":"1229","article-title":"Hypophosphatasia: nature's window on alkaline phosphatase function in man","author":"Whyte","year":"2002"},{"key":"10.1016\/j.berh.2003.09.004_BIB46","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0002-9343(84)90871-4","article-title":"Osteomalacia and osteitis fibrosa in a man ingesting aluminium hydroxide antacid","volume":"76","author":"Carmichael","year":"1984","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.berh.2003.09.004_BIB47","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/bmj.281.6245.910","article-title":"Osteomalacia developing during treatment of osteoporosis with sodium fluoride and vitamin D","volume":"281","author":"Compston","year":"1980","journal-title":"British Medical Journal"},{"key":"10.1016\/j.berh.2003.09.004_BIB48","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0140-6736(84)92272-4","article-title":"Focal osteomalacia due to low-dose bisphosphonate therapy in Paget's disease","volume":"i","author":"Boyce","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2003.09.004_BIB49","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/0140-6736(93)92935-M","article-title":"Mineralization defects with pamindronate therapy for Paget's disease","volume":"342","author":"Adamson","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2003.09.004_BIB50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/8756-3282(86)90202-4","article-title":"Fibrogenesis imperfecta ossium with early onset: observations after 20 years of illness","volume":"7","author":"Lang","year":"1986","journal-title":"Bone"},{"key":"10.1016\/j.berh.2003.09.004_BIB51","series-title":"Manual de enfermedades oseas metabolicas","first-page":"235","article-title":"Osteodistrofia renal","author":"Maldonado","year":"2003"},{"key":"10.1016\/j.berh.2003.09.004_BIB52","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1055\/s-2007-1004992","article-title":"Tumor-induced osteomalacia: pre- and postoperative biochemical findings","volume":"22","author":"Leicht","year":"1990","journal-title":"Hormone and Metabolic Research"}],"container-title":["Best Practice & Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694203001128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694203001128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:57:47Z","timestamp":1682647067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694203001128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S1521694203001128"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2003.09.004","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}