{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:00:55Z","timestamp":1791356455631,"version":"4.3.1"},"reference-count":113,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Rheumatology"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.berh.2006.06.009","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T16:09:23Z","timestamp":1158682163000},"page":"829-848","source":"Crossref","is-referenced-by-count":80,"title":["Contemporary concepts of inflammation, damage and repair in rheumatic diseases"],"prefix":"10.1016","volume":"20","author":[{"given":"Frank P.","family":"Luyten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik J.U.","family":"Lories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Verschueren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"de Vlam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Westhovens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6937","key":"10.1016\/j.berh.2006.06.009_bib1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"Feldmann","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.berh.2003.09.010","article-title":"The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis","volume":"18","author":"Feldmann","year":"2004","journal-title":"Best Practice & Research in Clinical Rheumatology"},{"issue":"9","key":"10.1016\/j.berh.2006.06.009_bib4","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/rheumatology\/keh205","article-title":"Biological therapies in the spondyloarthritides \u2013 the current state","volume":"43","author":"Braun","year":"2004","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s100670170095","article-title":"Osteoprotegerin and osteoprotegerin-ligand balance: a new paradigm in bone metabolism providing new therapeutic targets","volume":"20","author":"Lories","year":"2001","journal-title":"Clinical Rheumatology"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cytogfr.2005.02.009","article-title":"Bone morphogenetic protein signaling in joint homeostasis and disease","volume":"16","author":"Lories","year":"2005","journal-title":"Cytokine and Growth Factor Reviews"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib7","first-page":"S44","article-title":"Healing of erosive changes in rheumatoid arthritis","volume":"22","author":"Rau","year":"2004","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1210\/er.2002-0023","article-title":"Bone morphogenetic proteins, their antagonists, and the skeleton","volume":"24","author":"Canalis","year":"2003","journal-title":"Endocrine Reviews"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib9","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1172\/JCI114011","article-title":"Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-\u00df and retinoids","volume":"83","author":"Lafyatis","year":"1989","journal-title":"Journal of Clinical Investigation"},{"issue":"8","key":"10.1016\/j.berh.2006.06.009_bib10","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P","article-title":"Multipotent mesenchymal stem cells from adult human synovial membrane","volume":"44","author":"De Bari","year":"2001","journal-title":"Arthritis and Rheumatism"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/ar110","article-title":"Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis","volume":"2","author":"Edwards","year":"2000","journal-title":"Arthritis Research"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib12","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20041545","article-title":"Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes","volume":"200","author":"Valencia","year":"2004","journal-title":"Journal of Experimental Medicine"},{"issue":"supplement 3","key":"10.1016\/j.berh.2006.06.009_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/ar1431","article-title":"Synovial cadherin-11","volume":"6","author":"Lee","year":"2004","journal-title":"Arthritis Research and Therapy"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1359\/jbmr.2001.16.2.260","article-title":"The transition of cadherin expression in osteoblast differentiation from mesenchymal cells: consistent expression of cadherin-11 in osteoblast lineage","volume":"16","author":"Kawaguchi","year":"2001","journal-title":"Journal of Bone and Mineral Research"},{"issue":"1\u20132","key":"10.1016\/j.berh.2006.06.009_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0925-4773(98)00022-7","article-title":"Xenopus cadherin-11 (Xcadherin-11) expression requires the Wg\/Wnt signal","volume":"72","author":"Hadeball","year":"1998","journal-title":"Mechanisms of Development"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1006\/cbir.2000.0662","article-title":"Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow","volume":"25","author":"Ahmed","year":"2001","journal-title":"Cell Biology International"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib17","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1002\/art.11328","article-title":"Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor \u00df\/bone morphogenetic protein inhibitors during experimental osteoarthritis","volume":"48","author":"Scharstuhl","year":"2003","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.berh.2006.06.009_bib18","series-title":"Primer on the Rheumatic Diseases","first-page":"10","article-title":"The musculoskeletal system: A. Joints","author":"Simkin","year":"1997"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1172\/JCI200522263","article-title":"The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth","volume":"115","author":"Rhee","year":"2005","journal-title":"Journal of Clinical Investigation"},{"issue":"7","key":"10.1016\/j.berh.2006.06.009_bib20","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/1529-0131(200107)44:7<1608::AID-ART284>3.0.CO;2-T","article-title":"Molecular markers predictive of the capacity of expanded human\u00a0articular chondrocytes to form stable cartilage in vivo","volume":"44","author":"Dell'Accio","year":"2001","journal-title":"Arthritis and Rheumatism"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.139.2.541","article-title":"Expression of a truncated, kinase-defective TGF-\u00df type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis","volume":"139","author":"Serra","year":"1997","journal-title":"Journal of Cell Biology"},{"issue":"11","key":"10.1016\/j.berh.2006.06.009_bib22","doi-asserted-by":"crossref","first-page":"e355","DOI":"10.1371\/journal.pbio.0020355","article-title":"BMP receptor signaling is required for postnatal maintenance of articular cartilage","volume":"2","author":"Rountree","year":"2004","journal-title":"PLoS Biology"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib23","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1053\/berh.2001.0192","article-title":"Skeletal tissue engineering: opportunities and challenges","volume":"15","author":"Luyten","year":"2001","journal-title":"Best Practice & Research Clinical Rheumatology"},{"key":"10.1016\/j.berh.2006.06.009_bib24","series-title":"Progress in Inflammation Research","first-page":"243","article-title":"Bone morphogenetic proteins and the synovial joint","author":"Luyten","year":"2004"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/1529-0131(199802)41:2<263::AID-ART10>3.0.CO;2-5","article-title":"Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro","volume":"41","author":"Erlacher","year":"1998","journal-title":"Arthritis and Rheumatism"},{"issue":"8","key":"10.1016\/j.berh.2006.06.009_bib26","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.20441","article-title":"Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts","volume":"50","author":"Tardif","year":"2004","journal-title":"Arthritis and Rheumatism"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/002215540004800209","article-title":"Human articular chondrocytes express osteogenic protein-1","volume":"48","author":"Chubinskaya","year":"2000","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.berh.2006.06.009_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2106\/00004623-200300003-00011","article-title":"Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes","volume":"85A","author":"Fukui","year":"2003","journal-title":"Journal of Bone and Joint Surgery. American Volume"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib29","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1172\/JCI200419899","article-title":"Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts","volume":"113","author":"Seto","year":"2004","journal-title":"Journal of Clinical Investigation"},{"issue":"Pt 5","key":"10.1016\/j.berh.2006.06.009_bib30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1469-7580.2001.19950503.x","article-title":"The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites","volume":"199","author":"Benjamin","year":"2001","journal-title":"Journal of Anatomy"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib31","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI23738","article-title":"Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis","volume":"115","author":"Lories","year":"2005","journal-title":"Journal of Clinical Investigation"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib32","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/art.1780370601","article-title":"Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis","volume":"37","author":"Zvaifler","year":"1994","journal-title":"Arthritis and Rheumatism"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib33","first-page":"1607","article-title":"Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice","volume":"149","author":"Muller-Ladner","year":"1996","journal-title":"American Journal of Pathology"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/ar113","article-title":"Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis","volume":"2","author":"Pap","year":"2000","journal-title":"Arthritis Research"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/1529-0131(200103)44:3<676::AID-ANR117>3.0.CO;2-6","article-title":"Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion","volume":"44","author":"Pap","year":"2001","journal-title":"Arthritis and Rheumatism"},{"issue":"20","key":"10.1016\/j.berh.2006.06.009_bib36","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1073\/pnas.94.20.10895","article-title":"Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium","volume":"94","author":"Firestein","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0002-9440(10)64356-8","article-title":"Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis","volume":"160","author":"Yamanishi","year":"2002","journal-title":"American Journal of Pathology"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib38","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/art.1780330602","article-title":"How important are T cells in chronic rheumatoid synovitis?","volume":"33","author":"Firestein","year":"1990","journal-title":"Arthritis and Rheumatism"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/art.502","article-title":"How important are T cells in chronic rheumatoid synovitis?: II. T cell- independent mechanisms from beginning to end","volume":"46","author":"Firestein","year":"2002","journal-title":"Arthritis and Rheumatism"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard.61.1.3","article-title":"Mesenchymal precursor cells","volume":"61","author":"Corr","year":"2002","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"supplement 2","key":"10.1016\/j.berh.2006.06.009_bib41","doi-asserted-by":"crossref","first-page":"ii92","DOI":"10.1136\/ard.2004.028332","article-title":"Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease","volume":"63","author":"Buckley","year":"2004","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.it.2004.11.014","article-title":"A stromal address code defined by fibroblasts","volume":"26","author":"Parsonage","year":"2005","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.berh.2006.06.009_bib43","series-title":"Rheumatoid Arthritis: Frontiers in Pathophysiology and Treatment","article-title":"Mesenchymal stem cells in arthritis","author":"Luyten","year":"2006"},{"issue":"supplement 2","key":"10.1016\/j.berh.2006.06.009_bib44","first-page":"ii11","article-title":"Pathogenesis of bone and cartilage destruction in rheumatoid arthritis","volume":"42","author":"Goldring","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.berh.2006.06.009_bib45","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.0105-2896.2005.00338.x","article-title":"Rheumatic diseases: the effects of inflammation on bone","volume":"208","author":"Walsh","year":"2005","journal-title":"Immunological Reviews"},{"key":"10.1016\/j.berh.2006.06.009_bib46","first-page":"54","article-title":"Integrating biologic therapy into the comprehensive care of patients with rheumatoid arthritis","volume":"72","author":"Lipsky","year":"2005","journal-title":"Journal of Rheumatology. Supplement"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib47","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/art.10816","article-title":"Interleukin-17 in rheumatoid arthritis \u2013 if T cells were to contribute to inflammation and destruction through synergy","volume":"48","author":"Miossec","year":"2003","journal-title":"Arthritis and Rheumatism"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/ar1478","article-title":"The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models","volume":"7","author":"Lubberts","year":"2004","journal-title":"Arthritis Research and Therapy"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P","article-title":"Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor","volume":"43","author":"Gravallese","year":"2000","journal-title":"Arthritis and Rheumatism"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/rheumatology\/40.6.623","article-title":"Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint","volume":"40","author":"Haynes","year":"2001","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib51","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/rheumatology\/keg047","article-title":"Osteoprotegerin expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathies and osteoarthritis and normal controls","volume":"42","author":"Haynes","year":"2003","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib52","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/ard.61.12.1047","article-title":"Receptor activator NF-kappaB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis","volume":"61","author":"Crotti","year":"2002","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib53","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"Gravallese","year":"1998","journal-title":"American Journal of Pathology"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib54","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0002-9440(10)63016-7","article-title":"TRANCE\/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis","volume":"159","author":"Pettit","year":"2001","journal-title":"American Journal of Pathology"},{"issue":"6759","key":"10.1016\/j.berh.2006.06.009_bib55","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/46303","article-title":"Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand","volume":"402","author":"Kong","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib56","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/art.10097","article-title":"Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin","volume":"46","author":"Redlich","year":"2002","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib57","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0002-9440(10)64417-3","article-title":"Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis","volume":"161","author":"Romas","year":"2002","journal-title":"American Journal of Pathology"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib58","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.175.4.2579","article-title":"Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis","volume":"175","author":"Jimenez-Boj","year":"2005","journal-title":"Journal of Immunology"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib59","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1359\/JBMR.040205","article-title":"Arthritis induces lymphocytic bone marrow inflammation and endosteal bone formation","volume":"19","author":"Gortz","year":"2004","journal-title":"Journal of Bone and Mineral Research"},{"issue":"10","key":"10.1016\/j.berh.2006.06.009_bib60","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1002\/art.21354","article-title":"Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis","volume":"52","author":"Wu","year":"2005","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/berh.1999.0047","article-title":"Pathogenesis of joint damage in rheumatoid arthritis: evidence of a dominant role for interleukin-I","volume":"13","author":"van Den Berg","year":"1999","journal-title":"Best Practice & Research Clinical Rheumatology"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib62","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4","article-title":"Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappa B \u2013 Differential regulation of collagenase 1 and collagenase 3","volume":"43","author":"Mengshol","year":"2000","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.berh.2006.06.009_bib63","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Frontiers in Bioscience"},{"issue":"6079","key":"10.1016\/j.berh.2006.06.009_bib64","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/322547a0","article-title":"Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage","volume":"322","author":"Saklatvala","year":"1986","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib65","first-page":"306","article-title":"Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo","volume":"75","author":"Henderson","year":"1989","journal-title":"Clinical and Experimental Immunology"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib66","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/art.1780331208","article-title":"Modulation of the effects of interleukin-1 on glycosaminoglycan synthesis by the urine-derived interleukin-1 inhibitor, but not by interleukin-6","volume":"33","author":"Seckinger","year":"1990","journal-title":"Arthritis and Rheumatism"},{"issue":"7","key":"10.1016\/j.berh.2006.06.009_bib67","first-page":"1274","article-title":"Quantitation of metalloproteinase gene expression in rheumatoid and psoriatic arthritis synovial tissue distal and proximal to the cartilage-pannus junction","volume":"31","author":"Kane","year":"2004","journal-title":"Journal of Rheumatology"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib68","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nature Immunology"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib69","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/ni1274","article-title":"Limiting inflammatory responses during activation of innate immunity","volume":"6","author":"Han","year":"2005","journal-title":"Nature Immunology"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib70","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/00002281-200405000-00008","article-title":"T-cell regulation in rheumatoid arthritis","volume":"16","author":"Goronzy","year":"2004","journal-title":"Current Opinion in Rheumatology"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib71","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbrc.2005.05.133","article-title":"Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues","volume":"333","author":"Shukunami","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"10","key":"10.1016\/j.berh.2006.06.009_bib72","first-page":"2207","article-title":"Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis","volume":"30","author":"Hayami","year":"2003","journal-title":"Journal of Rheumatology"},{"issue":"9","key":"10.1016\/j.berh.2006.06.009_bib73","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/1529-0131(200009)43:9<2011::AID-ANR12>3.0.CO;2-Y","article-title":"Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis","volume":"43","author":"Fran\u00e7ois","year":"2000","journal-title":"Arthritis and Rheumatism"},{"issue":"5477","key":"10.1016\/j.berh.2006.06.009_bib74","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.289.5477.265","article-title":"Role of the mouse ank gene in control of tissue calcification and arthritis","volume":"289","author":"Ho","year":"2000","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib75","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.ATV.0000154774.71187.f0","article-title":"Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1\u2212\/\u2212 mice","volume":"25","author":"Johnson","year":"2005","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib76","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1086\/343053","article-title":"Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH","volume":"71","author":"Williams","year":"2002","journal-title":"American Journal of Human Genetics"},{"issue":"8","key":"10.1016\/j.berh.2006.06.009_bib77","first-page":"1507","article-title":"Fibroblast function in psoriatic-arthritis. 2. Increased expression of \u00df-platelet-derived growth-factor receptors and increased production of growth-factor and cytokines","volume":"21","author":"Espinoza","year":"1994","journal-title":"Journal of Rheumatology"},{"issue":"8","key":"10.1016\/j.berh.2006.06.009_bib78","first-page":"1502","article-title":"Fibroblast function in psoriatic arthritis. I. Alteration of cell kinetics and growth factor responses","volume":"21","author":"Espinoza","year":"1994","journal-title":"Journal of Rheumatology"},{"issue":"7","key":"10.1016\/j.berh.2006.06.009_bib79","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/1529-0131(199907)42:7<1481::AID-ANR23>3.0.CO;2-E","article-title":"Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis","volume":"42","author":"Reece","year":"1999","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib80","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","article-title":"Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation","volume":"22","author":"Buckley","year":"2001","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.berh.2006.06.009_bib81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/ard.2004.033928","article-title":"Psoriatic arthritis and imaging","volume":"64","author":"Ory","year":"2005","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"7","key":"10.1016\/j.berh.2006.06.009_bib82","first-page":"1430","article-title":"Ankylosing spondylitis, psoriatic arthritis, and reactive arthritis show increased bone resorption, but differ with regard to bone formation","volume":"29","author":"Grisar","year":"2002","journal-title":"Journal of Rheumatology"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib83","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1148\/radiographics.15.5.7501856","article-title":"Sapho syndrome","volume":"15","author":"Cotten","year":"1995","journal-title":"Radiographics"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib84","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1136\/ard.57.3.135","article-title":"Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis?","volume":"57","author":"Helliwell","year":"1998","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib85","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/jcp.10275","article-title":"Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats","volume":"196","author":"Maric","year":"2003","journal-title":"Journal of Cellular Physiology"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib86","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/42.6.8189035","article-title":"Expression of messenger-RNA for Il1-\u00df, Il6 and Tgf-\u00df-1 in developing human bone and cartilage","volume":"42","author":"Dodds","year":"1994","journal-title":"Journal of Histochemistry and Cytochemistry"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib87","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/art.1780380407","article-title":"Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis","volume":"38","author":"Braun","year":"1995","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib88","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S8756-3282(03)00204-7","article-title":"Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments","volume":"33","author":"Tanno","year":"2003","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.berh.2006.06.009_bib89","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s004390050993","article-title":"Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"104","author":"Nakamura","year":"1999","journal-title":"Human Genetics"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib90","first-page":"S10","article-title":"OMERACT: an international initiative to improve outcome measurement in rheumatology","volume":"23","author":"Boers","year":"2005","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1016\/j.berh.2006.06.009_bib91","first-page":"84","article-title":"The effectiveness of systematic monitoring of RA disease activity in daily practice (TRAC): a multicentre cluster-RCT","volume":"63","author":"Fransen","year":"2004","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"10","key":"10.1016\/j.berh.2006.06.009_bib92","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1136\/ard.2005.041871","article-title":"To be in remission or not: is that the question?","volume":"64","author":"van Riel","year":"2005","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"8","key":"10.1016\/j.berh.2006.06.009_bib93","first-page":"1848","article-title":"Synovitis occurs in some clinically normal and asymptomatic joints in patients with early arthritis","volume":"27","author":"Pando","year":"2000","journal-title":"Journal of Rheumatology"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib94","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/art.20982","article-title":"Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement - a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study","volume":"52","author":"Smolen","year":"2005","journal-title":"Arthritis and Rheumatism"},{"issue":"7","key":"10.1016\/j.berh.2006.06.009_bib95","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/ard.62.7.671","article-title":"Erosion healing in rheumatoid arthritis after anakinra treatment","volume":"62","author":"Rau","year":"2003","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib96","first-page":"1102","article-title":"Repair of erosions in rheumatoid arthritis does occur. Results from 2 studies by the OMERACT subcommittee on healing of erosions","volume":"30","author":"Sharp","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.berh.2006.06.009_bib97","doi-asserted-by":"crossref","first-page":"ii10","DOI":"10.1136\/ard.62.suppl_2.ii10","article-title":"Imaging: do erosions heal?","volume":"62","author":"van der Heijde","year":"2005","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"1","key":"10.1016\/j.berh.2006.06.009_bib98","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1172\/JCI2237","article-title":"Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat","volume":"102","author":"Vukicevic","year":"1998","journal-title":"Journal of Clinical Investigation"},{"issue":"7","key":"10.1016\/j.berh.2006.06.009_bib99","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-\u00df 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nature Medicine"},{"issue":"23","key":"10.1016\/j.berh.2006.06.009_bib100","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1161\/01.CIR.0000097001.79750.78","article-title":"Mobilized endothelial progenitor cells by granulocyte-macrophage colony-stimulating factor accelerate reendothelialization and reduce vascular inflammation after intravascular radiation","volume":"108","author":"Cho","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib101","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/01.ATV.0000124891.57581.9f","article-title":"Endothelial progenitor cells: more than an inflammatory response?","volume":"24","author":"Rabelink","year":"2004","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"issue":"9","key":"10.1016\/j.berh.2006.06.009_bib102","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1002\/1529-0131(200009)43:9<2046::AID-ANR16>3.0.CO;2-8","article-title":"Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint","volume":"43","author":"Marinova-Mutafchieva","year":"2000","journal-title":"Arthritis and Rheumatism"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib103","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/art.10126","article-title":"Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis","volume":"46","author":"Marinova-Mutafchieva","year":"2002","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"10.1016\/j.berh.2006.06.009_bib104","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.biocel.2003.11.001","article-title":"Mesenchymal stem cells: clinical applications and biological characterization","volume":"36","author":"Barry","year":"2004","journal-title":"International Journal of Biochemistry and Cell Biology"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib105","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.copbio.2004.08.003","article-title":"Tissue engineering through autologous mesenchymal stem cells","volume":"15","author":"Jorgensen","year":"2004","journal-title":"Current Opinion in Biotechnology"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib106","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1582-4934.2004.tb00320.x","article-title":"Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy","volume":"8","author":"Baksh","year":"2004","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"5","key":"10.1016\/j.berh.2006.06.009_bib107","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/01.bor.0000130284.64686.63","article-title":"Mesenchymal stem cells in osteoarthritis","volume":"16","author":"Luyten","year":"2004","journal-title":"Current Opinion in Rheumatology"},{"issue":"14","key":"10.1016\/j.berh.2006.06.009_bib108","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1056\/NEJM199410063311401","article-title":"Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation","volume":"331","author":"Brittberg","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.berh.2006.06.009_bib109","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/00003086-200005000-00020","article-title":"Two- to 9-year outcome after autologous chondrocyte transplantation of the knee","volume":"374","author":"Peterson","year":"2000","journal-title":"Clinical Orthopaedics and Related Research"},{"key":"10.1016\/j.berh.2006.06.009_bib110","doi-asserted-by":"crossref","first-page":"S337","DOI":"10.1097\/00003086-200110001-00031","article-title":"Autologous chondrocytes used for articular cartilage repair \u2013 an update","volume":"391","author":"Brittberg","year":"2001","journal-title":"Clinical Orthopaedics and Related Research"},{"issue":"2","key":"10.1016\/j.berh.2006.06.009_bib111","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1302\/0301-620X.85B2.13543","article-title":"A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee","volume":"85B","author":"Bentley","year":"2003","journal-title":"Journal of Bone and Joint Surgery. British Volume"},{"issue":"3","key":"10.1016\/j.berh.2006.06.009_bib112","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2106\/00004623-200403000-00001","article-title":"Autologous chondrocyte implantation compared with microfracture in the knee \u2013 a randomized trial","volume":"86A","author":"Knutsen","year":"2004","journal-title":"Journal of Bone and Joint Surgery. American Volume"},{"issue":"12","key":"10.1016\/j.berh.2006.06.009_bib113","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1002\/art.11365","article-title":"Stem cell therapy in a caprine model of osteoarthritis","volume":"48","author":"Murphy","year":"2003","journal-title":"Arthritis and Rheumatism"}],"container-title":["Best Practice &amp; Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694206000805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694206000805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T22:49:52Z","timestamp":1736549392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694206000805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":113,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S1521694206000805"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2006.06.009","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}