{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:15:33Z","timestamp":1772136933263,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice & Research Clinical Rheumatology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.berh.2008.09.005","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T12:14:46Z","timestamp":1227701686000},"page":"937-947","source":"Crossref","is-referenced-by-count":29,"title":["Musculoskeletal complications encountered in the lysosomal storage disorders"],"prefix":"10.1016","volume":"22","author":[{"given":"Gregory M.","family":"Pastores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.berh.2008.09.005_bib1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2141.2004.05293.x","article-title":"Lysosomal storage disorders","volume":"128","author":"Vellodi","year":"2005","journal-title":"British Journal of Haematology"},{"issue":"9","key":"10.1016\/j.berh.2008.09.005_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/00003072-200109000-00005","article-title":"Bone, bone marrow, and MIBI scintigraphic findings in Gaucher's disease \u2018bone crisis\u2019","volume":"26","author":"Blocklet","year":"2001","journal-title":"Clinical Nuclear Medicine"},{"issue":"3","key":"10.1016\/j.berh.2008.09.005_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00256-007-0425-0","article-title":"Recommendations for the assessment and monitoring of skeletal manifestations in children with Gaucher disease","volume":"37","author":"Maas","year":"2008","journal-title":"Skeletal Radiology"},{"issue":"4","key":"10.1016\/j.berh.2008.09.005_bib4","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2214\/ajr.179.4.1790961","article-title":"Quantification of skeletal involvement in adults with type I Gaucher's disease: fat fraction measured by Dixon quantitative chemical shift imaging as a valid parameter","volume":"179","author":"Maas","year":"2002","journal-title":"AJR. American Journal of Roentgenology"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1097\/00004728-200209000-00031","article-title":"Vertebra disc ratio as a parameter for bone marrow involvement and its application in Gaucher disease","volume":"26","author":"Vlieger","year":"2002","journal-title":"Journal of Computer Assisted Tomography"},{"issue":"12","key":"10.1016\/j.berh.2008.09.005_bib6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/GIM.0b013e31815cb197","article-title":"Osteopenia: a common aspect of Fabry disease. Predictors of bone mineral density","volume":"9","author":"Mersebach","year":"2007","journal-title":"Genetics in Medicine"},{"issue":"6","key":"10.1016\/j.berh.2008.09.005_bib7","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1442-200X.2007.02502.x","article-title":"Roles of specific cytokines in bone remodeling and hematopoiesis in Gaucher disease","volume":"49","author":"Yoshino","year":"2007","journal-title":"Pediatrics International"},{"issue":"5 Suppl","key":"10.1016\/j.berh.2008.09.005_bib8","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jpeds.2004.01.052","article-title":"The mucopolysaccharidoses: a heterogeneous group of disorders with variable pediatric presentations","volume":"144","author":"Muenzer","year":"2004","journal-title":"The Journal of Pediatrics"},{"issue":"3","key":"10.1016\/j.berh.2008.09.005_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/0883073807300528","article-title":"Carpal tunnel syndrome in children with mucopolysaccaridoses","volume":"22","author":"Yuen","year":"2007","journal-title":"Journal of Child Neurology"},{"issue":"2","key":"10.1016\/j.berh.2008.09.005_bib10","first-page":"196","article-title":"Attenuated type I mucopolysaccharidosis in the differential diagnosis of juvenile idiopathic arthritis: a series of 13 patients with Scheie syndrome","volume":"24","author":"Cimaz","year":"2006","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"1","key":"10.1016\/j.berh.2008.09.005_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/01241398-198901000-00015","article-title":"Atlantoaxial instability in mucopolysaccharidosis type VII","volume":"9","author":"Pizzutillo","year":"1989","journal-title":"Journal of Pediatric Orthopedics"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3171\/jns.1974.41.5.0618","article-title":"Spinal pachymeningitis secondary to mucopolysaccharidosis. Case report","volume":"41","author":"Paulson","year":"1974","journal-title":"Journal of Neurosurgery"},{"issue":"3","key":"10.1016\/j.berh.2008.09.005_bib13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0022-3468(93)90240-L","article-title":"Children with mucopolysaccharidosis: perioperative care, morbidity, mortality, and new findings","volume":"28","author":"Belani","year":"1993","journal-title":"Journal of Pediatric Surgery"},{"key":"10.1016\/j.berh.2008.09.005_bib14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/labinvest.3780345","article-title":"Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses","volume":"81","author":"Simonaro","year":"2001","journal-title":"Laboratory Investigation; A Journal of Technical Methods and Pathology"},{"key":"10.1016\/j.berh.2008.09.005_bib15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1203\/01.PDR.0000156510.96253.5A","article-title":"Joint and bone disease in mucopolysaccharidoses VI and VII: identification of new therapeutic targets and biomarkers using animal models","volume":"57","author":"Simonaro","year":"2005","journal-title":"Pediatric Research"},{"issue":"1","key":"10.1016\/j.berh.2008.09.005_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2353\/ajpath.2008.070564","article-title":"Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases","volume":"172","author":"Simonaro","year":"2008","journal-title":"The American Journal of Pathology"},{"issue":"4","key":"10.1016\/j.berh.2008.09.005_bib17","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1517\/14728214.10.4.891","article-title":"Current and emerging therapies for the lysosomal storage disorders","volume":"10","author":"Pastores","year":"2005","journal-title":"Expert Opinion on Emerging Drugs"},{"issue":"19","key":"10.1016\/j.berh.2008.09.005_bib18","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1111\/j.1742-4658.2007.06041.x","article-title":"Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors","volume":"274","author":"Fan","year":"2007","journal-title":"The FEBS Journal"},{"key":"10.1016\/j.berh.2008.09.005_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/j.1651-2227.2008.00811.x","article-title":"Outcome in six children with mucopolysaccharidosis type IH, Hurler syndrome, after haematopoietic stem cell transplantation (HSCT)","author":"Malm","year":"2008","journal-title":"Acta Paediatrica"},{"issue":"2","key":"10.1016\/j.berh.2008.09.005_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ymgme.2006.08.007","article-title":"A follow-up study of MPS I patients treated with laronidase enzyme replacement therapy for 6 years","volume":"90","author":"Sifuentes","year":"2007","journal-title":"Molecular Genetics and Metabolism"},{"issue":"1","key":"10.1016\/j.berh.2008.09.005_bib21","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1542\/peds.2006-2156","article-title":"Enzyme replacement therapy in patients who have mucopolysaccharidosis I and are younger than 5 years: results of a multinational study of recombinant human alpha-L-iduronidase (laronidase)","volume":"120","author":"Wraith","year":"2007","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.berh.2008.09.005_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ymgme.2006.12.012","article-title":"Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid","volume":"91","author":"Dickson","year":"2007","journal-title":"Molecular Genetics and Metabolism"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jpeds.2007.10.015","article-title":"Enzyme replacement therapy for mucopolysaccharidoses: opinions of patients and families","volume":"152","author":"Coman","year":"2008","journal-title":"The Journal of Pediatrics"},{"issue":"2","key":"10.1016\/j.berh.2008.09.005_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3324\/haematol.11193","article-title":"Therapy of adult Gaucher disease","volume":"92","author":"Schmitz","year":"2007","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.berh.2008.09.005_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1399-0004.2007.00769.x","article-title":"The effect of enzyme replacement therapy on bone crisis and bone pain in patients with type 1 Gaucher disease","volume":"71","author":"Charrow","year":"2007","journal-title":"Clinical Genetics"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1399-0004.2008.00978.x","article-title":"Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study","volume":"73","author":"Sims","year":"2008","journal-title":"Clinical Genetics"},{"issue":"6","key":"10.1016\/j.berh.2008.09.005_bib27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1399-0004.2007.00811.x","article-title":"Imiglucerase (Cerezyme) improves quality of life in patients with skeletal manifestations of Gaucher disease","volume":"71","author":"Weinreb","year":"2007","journal-title":"Clinical Genetics"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jpeds.2004.01.046","article-title":"Enzyme replacement therapy for mucopolysaccharidosis I: a randomized, double-blinded, placebo-controlled, multinational study of recombinant human alpha-L-iduronidase (laronidase)","volume":"144","author":"Wraith","year":"2004","journal-title":"The Journal of Pediatrics"},{"issue":"2","key":"10.1016\/j.berh.2008.09.005_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ymgme.2006.09.003","article-title":"The long-term international safety experience of imiglucerase therapy for Gaucher disease","volume":"90","author":"Starzyk","year":"2007","journal-title":"Molecular Genetics and Metabolism"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib30","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1182\/blood-2003-11-3854","article-title":"Gaucher disease: alendronate disodium improves bone mineral density in adults receiving enzyme therapy","volume":"104","author":"Wenstrup","year":"2004","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.berh.2008.09.005_bib31","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.clinthera.2007.08.006","article-title":"Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies","volume":"29","author":"Pastores","year":"2007","journal-title":"Clinical Therapeutics"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00247-007-0428-y","article-title":"Fractures in children with Pompe disease: a potential long-term complication","volume":"37","author":"Case","year":"2007","journal-title":"Pediatric Radiology"},{"issue":"24","key":"10.1016\/j.berh.2008.09.005_bib33","first-page":"iii","article-title":"The clinical effectiveness and cost-effectiveness of enzyme replacement therapy for Gaucher's disease: a systematic review","volume":"10","author":"Connock","year":"2006","journal-title":"Health Technology Assessment (Winchester, England)"},{"issue":"20","key":"10.1016\/j.berh.2008.09.005_bib34","first-page":"iii","article-title":"A systematic review of the clinical effectiveness and cost-effectiveness of enzyme replacement therapies for Fabry's disease and mucopolysaccharidosis type 1","volume":"10","author":"Connock","year":"2006","journal-title":"Health Technology Assessment (Winchester, England)"},{"issue":"3","key":"10.1016\/j.berh.2008.09.005_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2165\/00019053-200725030-00003","article-title":"Enzyme replacement therapy in orphan and ultra-orphan diseases: the limitations of standard economic metrics as exemplified by Fabry-Anderson disease","volume":"25","author":"Moore","year":"2007","journal-title":"Pharmacoeconomics"},{"issue":"1","key":"10.1016\/j.berh.2008.09.005_bib36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1054\/arth.2001.19162","article-title":"Outcome of total hip arthroplasty in patients with Gaucher disease","volume":"16","author":"Lebel","year":"2001","journal-title":"The Journal of Arthroplasty"},{"issue":"5","key":"10.1016\/j.berh.2008.09.005_bib37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1054\/arth.2002.33272","article-title":"Cemented revision total hip arthroplasty with impaction bone grafting in Gaucher's disease","volume":"17","author":"George","year":"2002","journal-title":"The Journal of Arthroplasty"},{"issue":"457","key":"10.1016\/j.berh.2008.09.005_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1651-2227.2008.00652.x","article-title":"Newborn screening for lysosomal storage disorders","volume":"97","author":"Matern","year":"2008","journal-title":"Acta Paediatrica (Oslo, Norway: 1992). Supplement"}],"container-title":["Best Practice & Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694208001009?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694208001009?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T04:59:06Z","timestamp":1545627546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694208001009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S1521694208001009"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2008.09.005","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}