{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:00:02Z","timestamp":1790240402548,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["bprclinrheum.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Rheumatology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.berh.2014.10.022","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T09:44:37Z","timestamp":1414662277000},"page":"565-576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Stroma: Fertile soil for inflammation"],"prefix":"10.1016","volume":"28","author":[{"given":"Rikesh","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1096\/fj.06-7227rev","article-title":"Resolution of inflammation: state of the art, definitions and terms","volume":"21","author":"Serhan","year":"2007","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1189\/jlb.0911458","article-title":"Tissue stroma as a regulator of leukocyte recruitment in inflammation","volume":"91","author":"McGettrick","year":"2012","journal-title":"J\u00a0Leukoc Biol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jlb.62.3.301","article-title":"Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study","volume":"62","author":"Tailor","year":"1997","journal-title":"J\u00a0Leukoc Biol"},{"issue":"37","key":"10.1016\/j.berh.2014.10.022_bib4","first-page":"20","article-title":"Targeting stromal cells in chronic inflammation","volume":"7","author":"Filer","year":"2007","journal-title":"Discov Med"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib5","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1513\/pats.200708-146DR","article-title":"Biology of fibroblasts and myofibroblasts","volume":"5","author":"Phan","year":"2008","journal-title":"Proc Am Thorac Soc"},{"issue":"1\u20132","key":"10.1016\/j.berh.2014.10.022_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cellimm.2005.08.027","article-title":"Report on antibodies submitted to the stromal cell section of HLDA8","volume":"236","author":"Buckley","year":"2005","journal-title":"Cell Immunol"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"20","key":"10.1016\/j.berh.2014.10.022_bib8","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1073\/pnas.162488599","article-title":"Diversity, topographic differentiation, and positional memory in human fibroblasts","volume":"99","author":"Chang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib9","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3109\/14653249.2012.677822","article-title":"Mesenchymal stromal cells and fibroblasts: a case of mistaken identity?","volume":"14","author":"Hematti","year":"2012","journal-title":"Cytotherapy"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.stem.2013.09.006","article-title":"Mesenchymal stromal cells: sensors and switchers of inflammation","volume":"13","author":"Bernardo","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00174011","article-title":"Re-evaluation of fibroblasts and fibroblast-like cells","volume":"182","author":"Komuro","year":"1990","journal-title":"Anat Embryol Berl"},{"issue":"6","key":"10.1016\/j.berh.2014.10.022_bib12","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0272-6386(12)80352-0","article-title":"Characterization of human renal fibroblasts in health and disease: II. In\u00a0vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis","volume":"17","author":"Rodemann","year":"1991","journal-title":"Am J Kidney Dis"},{"issue":"16","key":"10.1016\/j.berh.2014.10.022_bib13","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1242\/dev.128.16.3117","article-title":"The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells","volume":"128","author":"Simian","year":"2001","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.berh.2014.10.022_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2249.2012.04634.x","article-title":"The role of stromal cells in the persistence of chronic inflammation","volume":"171","author":"Naylor","year":"2013","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.coph.2013.02.006","article-title":"The fibroblast as a therapeutic target in rheumatoid arthritis","volume":"13","author":"Filer","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.berh.2014.10.022_bib16","first-page":"416","article-title":"The role of non-hematopoietic stromal cells in the persistence of inflammation","volume":"3","author":"Barone","year":"2012","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","article-title":"Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation","volume":"22","author":"Buckley","year":"2001","journal-title":"Trends Immunol"},{"issue":"5570","key":"10.1016\/j.berh.2014.10.022_bib18","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1126\/science.1067431","article-title":"Stromal effects on mammary gland development and breast cancer","volume":"296","author":"Wiseman","year":"2002","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ijc.2910580314","article-title":"Fibroblast activation protein: purification, epitope mapping and induction by growth factors","volume":"58","author":"Rettig","year":"1994","journal-title":"Int J Cancer"},{"issue":"6005","key":"10.1016\/j.berh.2014.10.022_bib20","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1195300","article-title":"Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha","volume":"330","author":"Kraman","year":"2010","journal-title":"Science"},{"issue":"4726","key":"10.1016\/j.berh.2014.10.022_bib21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.2996144","article-title":"Wounding and its role in RSV-mediated tumor formation","volume":"230","author":"Dolberg","year":"1985","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib22","first-page":"1041","article-title":"Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast","volume":"5","author":"Brown","year":"1999","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0955-0674(02)00367-8","article-title":"Selectins: lectins that initiate cell adhesion under flow","volume":"14","author":"McEver","year":"2002","journal-title":"Curr Opin Cell Biol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.1990.70.2.427","article-title":"Cytokines and endothelial cell biology","volume":"70","author":"Pober","year":"1990","journal-title":"Physiol Rev"},{"key":"10.1016\/j.berh.2014.10.022_bib25","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1146\/annurev.ph.57.030195.004143","article-title":"Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration","volume":"57","author":"Springer","year":"1995","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib26","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1084\/jem.181.3.1179","article-title":"P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow","volume":"181","author":"Luscinskas","year":"1995","journal-title":"J\u00a0Exp Med"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/(SICI)1521-4141(199803)28:03<961::AID-IMMU961>3.0.CO;2-4","article-title":"The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig","volume":"28","author":"Piali","year":"1998","journal-title":"Eur J Immunol"},{"issue":"11","key":"10.1016\/j.berh.2014.10.022_bib28","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.4049\/jimmunol.164.11.5961","article-title":"Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils","volume":"164","author":"Luu","year":"2000","journal-title":"J\u00a0Immunol"},{"issue":"8","key":"10.1016\/j.berh.2014.10.022_bib29","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/sj.bjp.0706281","article-title":"Differing mechanisms of leukocyte recruitment and sensitivity to conditioning by shear stress for endothelial cells treated with tumour necrosis factor-alpha or interleukin-1beta","volume":"145","author":"Sheikh","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1189\/jlb.0704421","article-title":"Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in\u00a0vivo","volume":"77","author":"Dangerfield","year":"2005","journal-title":"J\u00a0Leukoc Biol"},{"issue":"1","key":"10.1016\/j.berh.2014.10.022_bib31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1189\/jlb.0508301","article-title":"Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration","volume":"85","author":"McGettrick","year":"2009","journal-title":"J\u00a0Leukoc Biol"},{"issue":"1","key":"10.1016\/j.berh.2014.10.022_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/eji.200838232","article-title":"Fibroblasts from different sites may promote or inhibit recruitment of flowing lymphocytes by endothelial cells","volume":"39","author":"McGettrick","year":"2009","journal-title":"Eur J Immunol"},{"issue":"7","key":"10.1016\/j.berh.2014.10.022_bib33","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1002\/art.21930","article-title":"Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils","volume":"54","author":"Filer","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"Suppl. 3","key":"10.1016\/j.berh.2014.10.022_bib34","first-page":"S111","article-title":"Role of fibroblast activation in inducing interstitial fibrosis","volume":"13","author":"Zeisberg","year":"2000","journal-title":"J\u00a0Nephrol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib35","first-page":"317","article-title":"Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation","volume":"151","author":"Smith","year":"1997","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib36","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4049\/jimmunol.1700196","article-title":"CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts","volume":"160","author":"Zhang","year":"1998","journal-title":"J\u00a0Immunol"},{"issue":"6","key":"10.1016\/j.berh.2014.10.022_bib37","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1046\/j.1523-1755.1998.00176.x","article-title":"Novel roles for chemokines and fibroblasts in interstitial fibrosis","volume":"54","author":"Hogaboam","year":"1998","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/ar113","article-title":"Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis","volume":"2","author":"Pap","year":"2000","journal-title":"Arthritis Res"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib39","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.4049\/jimmunol.163.4.2193","article-title":"Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models","volume":"163","author":"Hogaboam","year":"1999","journal-title":"J\u00a0Immunol"},{"issue":"12","key":"10.1016\/j.berh.2014.10.022_bib40","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1002\/art.25018","article-title":"DNA hypomethylation in rheumatoid arthritis synovial fibroblasts","volume":"60","author":"Karouzakis","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.berh.2014.10.022_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.autrev.2011.04.001","article-title":"Inflammatory memories: is epigenetics the missing link to persistent stromal cell activation in rheumatoid arthritis?","volume":"10","author":"Ospelt","year":"2011","journal-title":"Autoimmun Rev"},{"issue":"7","key":"10.1016\/j.berh.2014.10.022_bib42","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/art.23545","article-title":"Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium","volume":"58","author":"Smith","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.berh.2014.10.022_bib43","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1002\/art.21394","article-title":"A\u00a0novel mechanism of neutrophil recruitment in a coculture model of the rheumatoid synovium","volume":"52","author":"Lally","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2567.2010.03307.x","article-title":"Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium","volume":"131","author":"McGettrick","year":"2010","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.berh.2014.10.022_bib45","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/art.11219","article-title":"Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue","volume":"48","author":"Bradfield","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"6746","key":"10.1016\/j.berh.2014.10.022_bib46","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/23495","article-title":"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells","volume":"400","author":"Campbell","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib47","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.4049\/jimmunol.174.3.1693","article-title":"A\u00a0chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritis","volume":"174","author":"Burman","year":"2005","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/clin.1994.1144","article-title":"Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis","volume":"72","author":"Fries","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib49","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0952-7915(00)00097-2","article-title":"Inflammation, a prototype for organogenesis of the lymphopoietic\/hematopoietic system","volume":"12","author":"Nishikawa","year":"2000","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib50","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80199-5","article-title":"BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis","volume":"12","author":"Luther","year":"2000","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.berh.2014.10.022_bib51","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.4049\/jimmunol.164.8.3955","article-title":"Cutting edge: ectopic expression of the chemokine TCA4\/SLC is sufficient to trigger lymphoid neogenesis","volume":"164","author":"Fan","year":"2000","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib52","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.0903710","article-title":"CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice","volume":"185","author":"Henry","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"9","key":"10.1016\/j.berh.2014.10.022_bib53","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.4049\/jimmunol.0803974","article-title":"Inflammation recapitulates the ontogeny of lymphoid stromal cells","volume":"182","author":"Peduto","year":"2009","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib54","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/eji.200425830","article-title":"Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis","volume":"35","author":"Manzo","year":"2005","journal-title":"Eur J Immunol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib55","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1189\/jlb.69.3.331","article-title":"Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines","volume":"69","author":"Hjelmstrom","year":"2001","journal-title":"J\u00a0Leukoc Biol"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib56","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1136\/ard.2010.139287","article-title":"Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time?","volume":"70","author":"van de Sande","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.berh.2014.10.022_bib57","doi-asserted-by":"crossref","first-page":"e7475","DOI":"10.1371\/journal.pone.0007475","article-title":"Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts","volume":"4","author":"Pilling","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib58","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<1041::AID-IMMU1041>3.0.CO;2-#","article-title":"Interferon-beta mediates stromal cell rescue of T cells from apoptosis","volume":"29","author":"Pilling","year":"1999","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib59","first-page":"688","article-title":"Global gene expression profiles in fibroblasts from synovial, skin and lymphoid tissue reveals distinct cytokine and chemokine expression patterns","volume":"90","author":"Parsonage","year":"2003","journal-title":"Thromb Haemost"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib60","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0002-9440(10)65474-0","article-title":"Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin","volume":"155","author":"Pablos","year":"1999","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.berh.2014.10.022_bib61","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0960-9822(00)00380-8","article-title":"Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation","volume":"10","author":"Agace","year":"2000","journal-title":"Curr Biol"},{"issue":"5203","key":"10.1016\/j.berh.2014.10.022_bib62","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib63","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.4049\/jimmunol.161.4.1619","article-title":"The role of apoptosis in the resolution of T cell-mediated cutaneous inflammation","volume":"161","author":"Orteu","year":"1998","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib64","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI119178","article-title":"Inhibition of T cell apoptosis in the rheumatoid synovium","volume":"99","author":"Salmon","year":"1997","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1046\/j.1365-2249.2000.01333.x","article-title":"The inhibition of cutaneous T cell apoptosis may prevent resolution of inflammation in atopic eczema","volume":"122","author":"Orteu","year":"2000","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib66","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/eji.1830260204","article-title":"Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression","volume":"26","author":"Akbar","year":"1996","journal-title":"Eur J Immunol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib67","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1084\/jem.178.2.427","article-title":"The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory","volume":"178","author":"Akbar","year":"1993","journal-title":"J\u00a0Exp Med"},{"issue":"1","key":"10.1016\/j.berh.2014.10.022_bib68","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/187152808784165199","article-title":"Molecular targets of rheumatoid arthritis","volume":"7","author":"Okamoto","year":"2008","journal-title":"Inflamm Allergy Drug Targets"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib69","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1172\/JCI11092","article-title":"Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism","volume":"107","author":"Burger","year":"2001","journal-title":"J\u00a0Clin Invest"},{"issue":"10","key":"10.1016\/j.berh.2014.10.022_bib70","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1136\/ard.2011.150219","article-title":"A\u00a0BAFF\/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells","volume":"70","author":"Bombardieri","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib71","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/art.1780360313","article-title":"The measurement of collagenase, tissue inhibitor of metalloproteinases (TIMP), and collagenase-TIMP complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis","volume":"36","author":"Clark","year":"1993","journal-title":"Arthritis Rheum"},{"issue":"6484","key":"10.1016\/j.berh.2014.10.022_bib72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A\u00a0matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib73","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/jcp.10445","article-title":"CXCL12 chemokine up-regulates bone resorption and MMP-9 release by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid arthritis patients","volume":"199","author":"Grassi","year":"2004","journal-title":"J\u00a0Cell Physiol"},{"issue":"6","key":"10.1016\/j.berh.2014.10.022_bib74","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1186\/ar2080","article-title":"Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes","volume":"8","author":"Bauer","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.berh.2014.10.022_bib75","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/clinchem\/38.9.1694","article-title":"Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis","volume":"38","author":"Huet","year":"1992","journal-title":"Clin Chem"},{"issue":"6","key":"10.1016\/j.berh.2014.10.022_bib76","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0934-8832(11)80142-3","article-title":"Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL\/I mice and patients with rheumatoid arthritis","volume":"10","author":"Trabandt","year":"1990","journal-title":"Matrix"},{"issue":"7","key":"10.1016\/j.berh.2014.10.022_bib77","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/rheumatology\/36.7.735","article-title":"Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells","volume":"36","author":"Lemaire","year":"1997","journal-title":"Br J Rheumatol"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib78","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/bies.950190408","article-title":"Cyclins, cyclin-dependent kinases and differentiation","volume":"19","author":"Gao","year":"1997","journal-title":"Bioessays"},{"issue":"12","key":"10.1016\/j.berh.2014.10.022_bib79","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.4049\/jimmunol.165.12.7246","article-title":"Adenoviral transfer of cyclin-dependent kinase inhibitor genes suppresses collagen-induced arthritis in mice","volume":"165","author":"Nasu","year":"2000","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib80","doi-asserted-by":"crossref","first-page":"838","DOI":"10.4049\/jimmunol.170.2.838","article-title":"IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts","volume":"170","author":"Perlman","year":"2003","journal-title":"J\u00a0Immunol"},{"issue":"9","key":"10.1016\/j.berh.2014.10.022_bib81","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.4049\/jimmunol.171.9.4913","article-title":"Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis","volume":"171","author":"Nonomura","year":"2003","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib82","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/art.10117","article-title":"How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis","volume":"46","author":"Visser","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.berh.2014.10.022_bib83","doi-asserted-by":"crossref","first-page":"R784","DOI":"10.1186\/ar1733","article-title":"Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin","volume":"7","author":"Raza","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.berh.2014.10.022_bib84","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1084\/jem.167.2.332","article-title":"The essential role of B cell stimulatory factor 2 (BSF-2\/IL-6) for the terminal differentiation of B cells","volume":"167","author":"Muraguchi","year":"1988","journal-title":"J\u00a0Exp Med"},{"issue":"1","key":"10.1016\/j.berh.2014.10.022_bib85","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3899\/jrheum.100717","article-title":"Tocilizumab for rheumatoid arthritis: a cochrane systematic review","volume":"38","author":"Singh","year":"2011","journal-title":"J\u00a0Rheumatol"},{"issue":"3","key":"10.1016\/j.berh.2014.10.022_bib86","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/ard.2011.150284","article-title":"The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon","volume":"71","author":"Rosengren","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.berh.2014.10.022_bib87","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/art.24453","article-title":"Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes","volume":"60","author":"Kiener","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.berh.2014.10.022_bib88","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1002\/art.27701","article-title":"CD248 and its cytoplasmic domain: a therapeutic target for arthritis","volume":"62","author":"Maia","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.berh.2014.10.022_bib89","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.4049\/jimmunol.167.8.4686","article-title":"AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice","volume":"167","author":"Matthys","year":"2001","journal-title":"J\u00a0Immunol"}],"container-title":["Best Practice &amp; Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694214001041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694214001041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T18:14:22Z","timestamp":1689617662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694214001041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":89,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1521694214001041"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2014.10.022","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stroma: Fertile soil for inflammation","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Rheumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.berh.2014.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}