{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:04:25Z","timestamp":1771031065824,"version":"3.50.1"},"reference-count":94,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"ZonMw","award":["116002005"],"award-info":[{"award-number":["116002005"]}]},{"name":"Reumafonds","award":["RF 901"],"award-info":[{"award-number":["RF 901"]}]}],"content-domain":{"domain":["bprclinrheum.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice & Research Clinical Rheumatology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.berh.2014.10.023","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T18:50:52Z","timestamp":1414695052000},"page":"589-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mesenchymal stromal cells for treatment of arthritis"],"prefix":"10.1016","volume":"28","author":[{"given":"J.F.","family":"Swart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"Wulffraat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.berh.2014.10.023_bib1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(98)05399-9","article-title":"Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis","volume":"353","author":"Wulffraat","year":"1999","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.berh.2014.10.023_bib2","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1038\/sj.bmt.1703946","article-title":"Long-term follow-up of autologous stem cell transplantation for refractory juvenile idiopathic arthritis","volume":"32","author":"Wulffraat","year":"2003","journal-title":"Bone Marrow Transpl"},{"key":"10.1016\/j.berh.2014.10.023_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/ard.62.3.236","article-title":"Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation","volume":"62","author":"Wulffraat","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2014.10.023_bib4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/08916930802200224","article-title":"Current perspectives of autologous stem cell transplantation for severe juvenile idiopathic arthritis","volume":"41","author":"Wulffraat","year":"2008","journal-title":"Autoimmunity"},{"key":"10.1016\/j.berh.2014.10.023_bib5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.berh.2010.01.008","article-title":"Stem cells in the treatment of inflammatory arthritis","volume":"24","author":"Tyndall","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.berh.2014.10.023_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.coph.2006.02.008","article-title":"Regenerative and immunomodulatory potential of mesenchymal stem cells","volume":"6","author":"Krampera","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.berh.2014.10.023_bib7","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/art.23485","article-title":"Synovial fluid mesenchymal stem cells in health and early osteoarthritis: detection and functional evaluation at the single-cell level","volume":"58","author":"Jones","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/art.20203","article-title":"Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis","volume":"50","author":"Jones","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib9","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/jor.20394","article-title":"Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow","volume":"25","author":"Endres","year":"2007","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.berh.2014.10.023_bib10","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/ard.2008.106435","article-title":"Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level","volume":"69","author":"Jones","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2014.10.023_bib11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/ard.2007.076174","article-title":"Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis","volume":"67","author":"Kastrinaki","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2014.10.023_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/rheumatology\/kel267","article-title":"Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in\u00a0vitro","volume":"46","author":"Bocelli-Tyndall","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.berh.2014.10.023_bib13","first-page":"1","article-title":"Mesenchymal stem cell therapy in proteoglycan induced arthritis","volume":"0","author":"Swart","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2014.10.023_bib14","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/art.22511","article-title":"Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis","volume":"56","author":"Augello","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00011-009-0090-y","article-title":"Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis","volume":"59","author":"Mao","year":"2010","journal-title":"Inflamm Res"},{"key":"10.1016\/j.berh.2014.10.023_bib16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/art.24405","article-title":"Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells","volume":"60","author":"Gonzalez","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib17","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/art.21012","article-title":"Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor alpha in collagen-induced arthritis","volume":"52","author":"Djouad","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib18","doi-asserted-by":"crossref","first-page":"e14247","DOI":"10.1371\/journal.pone.0014247","article-title":"IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis","volume":"5","author":"Bouffi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.berh.2014.10.023_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jbspin.2008.04.004","article-title":"Mesenchymal stem cells: a future for the treatment of arthritis?","volume":"75","author":"Swart","year":"2008","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.berh.2014.10.023_bib20","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","article-title":"Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells","volume":"363","author":"Le Blanc","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2014.10.023_bib21","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(08)60690-X","article-title":"Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study","volume":"371","author":"Le Blanc","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2014.10.023_bib22","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s10067-014-2754-4","article-title":"Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy","volume":"33","author":"Gu","year":"2014","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.berh.2014.10.023_bib23","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/ard.2009.123463","article-title":"Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study","volume":"69","author":"Liang","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2014.10.023_bib24","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/ar4520","article-title":"Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study","volume":"16","author":"Wang","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.berh.2014.10.023_bib25","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.3727\/096368911X582769c","article-title":"Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience","volume":"22","author":"Wang","year":"2013","journal-title":"Cell Transpl"},{"key":"10.1016\/j.berh.2014.10.023_bib26","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1182\/blood-2006-06-030551","article-title":"Nonhematopoietic\/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment","volume":"109","author":"Anjos-Afonso","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.blre.2005.11.002","article-title":"The role of mesenchymal stem cells in haemopoiesis","volume":"20","author":"Dazzi","year":"2006","journal-title":"Blood Rev"},{"key":"10.1016\/j.berh.2014.10.023_bib28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/art.22111","article-title":"Stem cells and rheumatology: update on adult stem cell therapy in autoimmune diseases","volume":"55","author":"Tyndall","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0301-472X(01)00769-X","article-title":"Mesenchymal stem cells suppress lymphocyte proliferation in\u00a0vitro and prolong skin graft survival in\u00a0vivo","volume":"30","author":"Bartholomew","year":"2002","journal-title":"Exp Hematol"},{"key":"10.1016\/j.berh.2014.10.023_bib30","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood-2002-07-2104","article-title":"Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide","volume":"101","author":"Krampera","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib31","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1089\/ten.2006.12.2263","article-title":"Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves","volume":"12","author":"Batten","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1016\/j.berh.2014.10.023_bib32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1440-1711.2006.01458.x","article-title":"Mesenchymal stem cells in immunoregulation","volume":"84","author":"Chen","year":"2006","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.berh.2014.10.023_bib33","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"24","author":"Krampera","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.berh.2014.10.023_bib34","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.4049\/jimmunol.179.5.2824","article-title":"The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells","volume":"179","author":"Jones","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.berh.2014.10.023_bib35","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1002\/eji.200636416","article-title":"Immunoregulatory function of mesenchymal stem cells","volume":"36","author":"Uccelli","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.berh.2014.10.023_bib38","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0301-472X(03)00106-1","article-title":"Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion","volume":"31","author":"Baksh","year":"2003","journal-title":"Exp Hematol"},{"key":"10.1016\/j.berh.2014.10.023_bib41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/excr.2001.5278","article-title":"Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components","volume":"268","author":"Barry","year":"2001","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.berh.2014.10.023_bib42","first-page":"225","article-title":"T\u00a0cell proliferative response to type II collagen in the inflammatory process and joint damage in patients with rheumatoid arthritis","volume":"32","author":"Kim","year":"2005","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.berh.2014.10.023_bib43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/rheumatology\/kem284","article-title":"Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritis","volume":"47","author":"Zheng","year":"2008","journal-title":"Rheumatology"},{"issue":"Suppl. 37","key":"10.1016\/j.berh.2014.10.023_bib44","first-page":"S3","article-title":"Mesenchymal stem cells isolated from synovial fluid of patients with juvenile idiopathic arthritis exert immunomodulatory functions abstracts of the XII annual scientific meeting of PReS 2005, Versailles, France","volume":"23","author":"Kordowich","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.berh.2014.10.023_bib45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00005-008-0030-5","article-title":"Relationship between impaired apoptosis of lymphocytes and distribution of dendritic cells in peripheral blood and synovial fluid of children with juvenile idiopathic arthritis","volume":"56","author":"Smolewska","year":"2008","journal-title":"Arch Immunol Ther Exp (Warsz )"},{"key":"10.1016\/j.berh.2014.10.023_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007183","article-title":"Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells","volume":"4","author":"Vercoulen","year":"2009","journal-title":"Plos One"},{"key":"10.1016\/j.berh.2014.10.023_bib47","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.transproceed.2006.12.019","article-title":"Stem cell transplantation: the lung barrier","volume":"39","author":"Schrepfer","year":"2007","journal-title":"Transpl Proc"},{"key":"10.1016\/j.berh.2014.10.023_bib48","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1743-6109.2006.00153.x","article-title":"Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat","volume":"14","author":"McFarlin","year":"2006","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.berh.2014.10.023_bib49","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1002\/stem.187","article-title":"Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in\u00a0vivo bioluminescent imaging","volume":"27","author":"Kidd","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.berh.2014.10.023_bib50","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1182\/blood-2002-06-1830","article-title":"Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates","volume":"101","author":"Devine","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib51","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/jgm.452","article-title":"Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome","volume":"5","author":"Chapel","year":"2003","journal-title":"J\u00a0Gene Med"},{"key":"10.1016\/j.berh.2014.10.023_bib52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000047856","article-title":"The dynamic in\u00a0vivo distribution of bone marrow-derived mesenchymal stem cells after infusion","volume":"169","author":"Gao","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.berh.2014.10.023_bib53","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","article-title":"Concise review: mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair\u2013current views","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.berh.2014.10.023_bib54","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.coi.2010.10.012","article-title":"Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?","volume":"22","author":"Uccelli","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.berh.2014.10.023_bib55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3899\/jrheum.100614","article-title":"Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes","volume":"38","author":"Hermida-Gomez","year":"2011","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.berh.2014.10.023_bib56","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.knee.2009.12.003","article-title":"The potential of stem cells in the treatment of knee cartilage defects","volume":"17","author":"Khan","year":"2010","journal-title":"Knee"},{"key":"10.1016\/j.berh.2014.10.023_bib57","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1089\/hum.2010.138","article-title":"Mesenchymal stem cells and osteoarthritis: remedy or accomplice?","volume":"21","author":"Coleman","year":"2010","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.berh.2014.10.023_bib58","doi-asserted-by":"crossref","first-page":"e14698","DOI":"10.1371\/journal.pone.0014698","article-title":"Interferon-gamma regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO)","volume":"6","author":"Croitoru-Lamoury","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.berh.2014.10.023_bib59","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1073\/pnas.0608249103","article-title":"Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD\/scid mice","volume":"103","author":"Lee","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.berh.2014.10.023_bib60","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0301-472X(00)00635-4","article-title":"Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion","volume":"29","author":"Devine","year":"2001","journal-title":"Exp Hematol"},{"key":"10.1016\/j.berh.2014.10.023_bib61","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1634\/stemcells.2008-0616","article-title":"Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect","volume":"27","author":"Horie","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.berh.2014.10.023_bib62","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","article-title":"Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice","volume":"106","author":"Eliopoulos","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib63","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood-2005-11-011650","article-title":"Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting","volume":"108","author":"Nauta","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib64","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/mt.2009.157","article-title":"Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis","volume":"17","author":"Rafei","year":"2009","journal-title":"Mol Ther"},{"key":"10.1016\/j.berh.2014.10.023_bib65","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood-2005-07-2775","article-title":"Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation","volume":"107","author":"Spaggiari","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1749-6632.2012.06667.x","article-title":"Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders","volume":"1266","author":"Bernardo","year":"2012","journal-title":"Ann N. Y Acad Sci"},{"key":"10.1016\/j.berh.2014.10.023_bib68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/187152809788462635","article-title":"Treatment of inflammatory diseases with mesenchymal stem cells","volume":"8","author":"Newman","year":"2009","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.berh.2014.10.023_bib69","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1056\/NEJM197505152922003","article-title":"Immediate hypersensitivity to hog trypsin resulting from industrial exposure","volume":"292","author":"Colten","year":"1975","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.berh.2014.10.023_bib70","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0301-0546(01)79069-6","article-title":"Anaphylactic shock caused by impurities in orgotein preparations","volume":"29","author":"de Benito","year":"2001","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.berh.2014.10.023_bib71","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1398-9995.1991.tb00576.x","article-title":"Bovine serum albumin immunization: a new risk of allergy during protocols for in\u00a0vitro fertilization","volume":"46","author":"Moneret-Vautrin","year":"1991","journal-title":"Allergy"},{"key":"10.1016\/j.berh.2014.10.023_bib72","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3324\/haematol.11446","article-title":"No alloantibodies against mesenchymal stromal cells, but presence of anti-fetal calf serum antibodies, after transplantation in allogeneic hematopoietic stem cell recipients","volume":"92","author":"Sundin","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.berh.2014.10.023_bib73","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ymthe.2004.02.012","article-title":"Internalized antigens must be removed to prepare hypoimmunogenic mesenchymal stem cells for cell and gene therapy","volume":"9","author":"Spees","year":"2004","journal-title":"Mol Ther"},{"key":"10.1016\/j.berh.2014.10.023_bib74","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1182\/blood-2006-12-063412","article-title":"Potential risks of bone marrow cell transplantation into infarcted hearts","volume":"110","author":"Breitbach","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib75","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1681\/ASN.2007010044","article-title":"Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes","volume":"18","author":"Kunter","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.berh.2014.10.023_bib76","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1182\/blood-2009-05-219907","article-title":"Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation","volume":"115","author":"Tarte","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.berh.2014.10.023_bib77","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1158\/0008-5472.CAN-10-1305","article-title":"Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track \u2013 letter","volume":"70","author":"Torsvik","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.berh.2014.10.023_bib78","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1126\/science.329.5995.1004","article-title":"Cell biology. To scientists' dismay, mixed-up cell lines strike again","volume":"329","author":"Vogel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.berh.2014.10.023_bib79","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3109\/14653249.2010.507330","article-title":"Defining the risks of mesenchymal stromal cell therapy","volume":"12","author":"Prockop","year":"2010","journal-title":"Cytotherapy"},{"key":"10.1016\/j.berh.2014.10.023_bib80","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.nucmedbio.2011.03.008","article-title":"In\u00a0vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis","volume":"38","author":"Gholamrezanezhad","year":"2011","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.berh.2014.10.023_bib81","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/stem.1118","article-title":"Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation","volume":"30","author":"von Bahr","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.berh.2014.10.023_bib82","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1073\/pnas.132252399","article-title":"Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone","volume":"99","author":"Horwitz","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.berh.2014.10.023_bib84","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/art.22698","article-title":"Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis","volume":"56","author":"Cipriani","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2014.10.023_bib85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/0961203306075793","article-title":"Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus","volume":"16","author":"Sun","year":"2007","journal-title":"Lupus"},{"key":"10.1016\/j.berh.2014.10.023_bib86","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1001\/jama.2012.25321","article-title":"Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial","volume":"308","author":"Hare","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.berh.2014.10.023_bib87","doi-asserted-by":"crossref","first-page":"455","DOI":"10.5966\/sctm.2012-0184","article-title":"Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts","volume":"2","author":"Melief","year":"2013","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.berh.2014.10.023_bib88","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1089\/scd.2013.0016","article-title":"Mesenchymal stromal cell characteristics vary depending on their origin","volume":"22","author":"Wegmeyer","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.berh.2014.10.023_bib89","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.jacc.2009.06.055","article-title":"A\u00a0randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction","volume":"54","author":"Hare","year":"2009","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.berh.2014.10.023_bib90","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbmt.2013.11.033","article-title":"Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients","volume":"20","author":"Introna","year":"2014","journal-title":"Biol Blood Marrow Transpl"},{"key":"10.1016\/j.berh.2014.10.023_bib91","doi-asserted-by":"crossref","first-page":"e47559","DOI":"10.1371\/journal.pone.0047559","article-title":"Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and Meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.berh.2014.10.023_bib92","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/term.299","article-title":"Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months","volume":"5","author":"Wakitani","year":"2011","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.berh.2014.10.023_bib93","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/157488810790442796","article-title":"Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique","volume":"5","author":"Centeno","year":"2010","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.berh.2014.10.023_bib94","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2174\/157488811797904371","article-title":"Safety and complications reporting update on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique","volume":"6","author":"Centeno","year":"2011","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.berh.2014.10.023_bib95","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1016\/j.arthro.2013.09.074","article-title":"Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up","volume":"29","author":"Wong","year":"2013","journal-title":"Arthroscopy"},{"key":"10.1016\/j.berh.2014.10.023_bib96","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2106\/JBJS.M.00058","article-title":"Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study","volume":"96","author":"Vangsness","year":"2014","journal-title":"J\u00a0Bone Jt Surg Am"},{"key":"10.1016\/j.berh.2014.10.023_bib97","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1089\/scd.2013.0023","article-title":"Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy","volume":"22","author":"Wang","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.berh.2014.10.023_bib98","series-title":"Abstract at the Annual Scientific Meeting ACR","article-title":"Phase Ib\/IIa study on intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis patients","author":"Alvaro-Gracia","year":"2013"},{"key":"10.1016\/j.berh.2014.10.023_bib99","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10067-011-1816-0","article-title":"Allogeneic mesenchymal stem cells transplantation in patients with refractory RA","volume":"31","author":"Liang","year":"2012","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.berh.2014.10.023_bib100","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/1479-5876-9-181","article-title":"Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells","volume":"9","author":"Ra","year":"2011","journal-title":"J\u00a0Transl Med"}],"container-title":["Best Practice & Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694214001053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694214001053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T11:39:39Z","timestamp":1589283579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694214001053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1521694214001053"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2014.10.023","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stromal cells for treatment of arthritis","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Rheumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.berh.2014.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}