{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:59:21Z","timestamp":1790553561962,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Rheumatology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.berh.2020.101505","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:43:00Z","timestamp":1585960980000},"page":"101505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Multiple hereditary exostoses and enchondromatosis"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-0466","authenticated-orcid":false,"given":"Anne Grethe","family":"Jurik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.berh.2020.101505_bib1","first-page":"557","article-title":"Enchondromatosis: insights on the different subtypes","volume":"3","author":"Pansuriya","year":"2010","journal-title":"Int J Clin Exp Pathol"},{"issue":"7","key":"10.1016\/j.berh.2020.101505_bib2","doi-asserted-by":"crossref","first-page":"986","DOI":"10.2106\/00004623-199407000-00005","article-title":"The natural history of hereditary multiple exostoses","volume":"76","author":"Schmale","year":"1994","journal-title":"J\u00a0Bone Jt Surg Am"},{"issue":"12","key":"10.1016\/j.berh.2020.101505_bib3","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/humu.21123","article-title":"Multiple osteochondromas: mutation update and description of the multiple osteochondromas mutation database (MOdb)","volume":"30","author":"Jennes","year":"2009","journal-title":"Hum Mutat"},{"issue":"7","key":"10.1016\/j.berh.2020.101505_bib4","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1302\/0301-620X.86B7.14815","article-title":"Severity of disease and risk of malignant change in hereditary multiple exostoses. A genotype-phenotype study","volume":"86","author":"Porter","year":"2004","journal-title":"J\u00a0Bone Jt Surg Br"},{"issue":"1","key":"10.1016\/j.berh.2020.101505_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ajmg.1320550113","article-title":"Natural history study of hereditary multiple exostoses","volume":"55","author":"Wicklund","year":"1995","journal-title":"Am J Med Genet"},{"issue":"24","key":"10.1016\/j.berh.2020.101505_bib6","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.2106\/JBJS.J.00949","article-title":"Genotype-phenotype correlation study in 529 patients with multiple hereditary exostoses: identification of \"protective\" and \"risk\" factors","volume":"93","author":"Pedrini","year":"2011","journal-title":"J\u00a0Bone Jt Surg Am"},{"issue":"1","key":"10.1016\/j.berh.2020.101505_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.knee.2012.10.029","article-title":"Can deformity of the knee and longitudinal growth of the leg be predicted in patients with hereditary multiple exostoses? A cross-sectional study","volume":"21","author":"Clement","year":"2014","journal-title":"Knee"},{"key":"10.1016\/j.berh.2020.101505_bib8","article-title":"Developmental pattern of the hip in patients with hereditary multiple exostoses","volume":"16","author":"Wang","year":"2015","journal-title":"BMC Muscoskel Disord"},{"issue":"1","key":"10.1016\/j.berh.2020.101505_bib9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/01241398-200201000-00025","article-title":"Natural history of multiple hereditary osteochondromatosis of the lower extremity and ankle","volume":"22","author":"Noonan","year":"2002","journal-title":"J\u00a0Pediatr Orthop"},{"issue":"6","key":"10.1016\/j.berh.2020.101505_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3171\/2014.10.SPINE14501","article-title":"Long-term outcomes in primary spinal osteochondroma: a multicenter study of 27 patients","volume":"22","author":"Sciubba","year":"2015","journal-title":"J\u00a0Neurosurg Spine"},{"issue":"8","key":"10.1016\/j.berh.2020.101505_bib11","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.2106\/JBJS.H.00762","article-title":"Involvement of the spine in patients with multiple hereditary exostoses","volume":"91","author":"Roach","year":"2009","journal-title":"J\u00a0Bone Jt Surg Am"},{"key":"10.1016\/j.berh.2020.101505_bib12","first-page":"114","article-title":"Chondrosarcoma transformation in hereditary multiple exostoses: a systematic review and clinical and cost-effectiveness of a proposed screening model","volume":"13","author":"Fei","year":"2018","journal-title":"J\u00a0Bone Oncol"},{"issue":"1","key":"10.1016\/j.berh.2020.101505_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00256-019-03268-z","article-title":"Whole-body MRI in assessing malignant transformation in multiple hereditary exostoses and enchondromatosis: audit results and literature review","volume":"49","author":"Jurik","year":"2020","journal-title":"Skeletal Radiol"},{"issue":"2","key":"10.1016\/j.berh.2020.101505_bib14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jse.2010.07.020","article-title":"Shoulder exostoses in hereditary multiple exostoses: probability of surgery and malignant change","volume":"20","author":"Clement","year":"2011","journal-title":"J\u00a0Shoulder Elbow Surg"},{"issue":"7","key":"10.1016\/j.berh.2020.101505_bib15","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s11999-015-4134-z","article-title":"What is the proportion of patients with multiple hereditary exostoses who undergo malignant degeneration?","volume":"473","author":"Czajka","year":"2015","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10.1016\/j.berh.2020.101505_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s002560050050","article-title":"Magnetic resonance imaging of cartilaginous tumors: is it useful or necessary?","volume":"25","author":"De Beuckeleer","year":"1996","journal-title":"Skeletal Radiol"},{"issue":"1","key":"10.1016\/j.berh.2020.101505_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002560050466","article-title":"Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. II. Juxtacortical cartilage tumors","volume":"28","author":"Brien","year":"1999","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.berh.2020.101505_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.blo.0000069888.31220.2b","article-title":"Secondary chondrosarcoma in osteochondroma: report of 107 patients","volume":"411","author":"Ahmed","year":"2003","journal-title":"Clin Orthop Relat Res"},{"issue":"9","key":"10.1016\/j.berh.2020.101505_bib19","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/1097-0142(19820501)49:9<1890::AID-CNCR2820490923>3.0.CO;2-U","article-title":"Chondrosarcoma arising in osteochondroma","volume":"49","author":"Garrison","year":"1982","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.berh.2020.101505_bib20","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1302\/0301-620X.101B9.BJJ-2019-0190.R1","article-title":"Secondary chondrosarcoma arising from osteochondroma: outcomes and prognostic factors","volume":"101-B","author":"Tsuda","year":"2019","journal-title":"Bone Joint Lett J"},{"issue":"6","key":"10.1016\/j.berh.2020.101505_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11832-013-0526-3","article-title":"Metachondromatosis: more than just multiple osteochondromas","volume":"7","author":"Fisher","year":"2013","journal-title":"J\u00a0Child Orthop"},{"issue":"3","key":"10.1016\/j.berh.2020.101505_bib22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ajmg.a.36326","article-title":"Complex chromosomal rearrangements causing Langer-Giedion syndrome atypical phenotype: genotype-phenotype correlation and literature review","volume":"164A","author":"Cappuccio","year":"2014","journal-title":"Am J Med Genet"},{"issue":"6","key":"10.1016\/j.berh.2020.101505_bib23","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.3928\/01477447-20150603-58","article-title":"Ollier disease: pathogenesis, diagnosis, and management","volume":"38","author":"Kumar","year":"2015","journal-title":"Orthopedics"},{"issue":"12","key":"10.1016\/j.berh.2020.101505_bib24","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/ng.994","article-title":"Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2","volume":"43","author":"Amary","year":"2011","journal-title":"Nat Genet"},{"issue":"10047","key":"10.1016\/j.berh.2020.101505_bib25","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0140-6736(16)00088-X","article-title":"Multiple enchondromas and skin angiomas: Maffucci syndrome","volume":"388","author":"Maione","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.berh.2020.101505_bib26","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/1097-0142(19870401)59:7<1376::AID-CNCR2820590725>3.0.CO;2-F","article-title":"Bone sarcomas associated with Ollier's disease","volume":"59","author":"Liu","year":"1987","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.berh.2020.101505_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00776-007-1152-z","article-title":"Secondary chondrosarcoma in cartilage bone tumors: report of 32 patients","volume":"12","author":"Altay","year":"2007","journal-title":"J\u00a0Orthop Sci"},{"issue":"12","key":"10.1016\/j.berh.2020.101505_bib28","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1634\/theoncologist.2011-0200","article-title":"Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients","volume":"16","author":"Verdegaal","year":"2011","journal-title":"Oncol"},{"issue":"4","key":"10.1016\/j.berh.2020.101505_bib29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/107110070602700403","article-title":"Differentiating clinical and radiographic features of enchondroma and secondary chondrosarcoma in the foot","volume":"27","author":"Gajewski","year":"2006","journal-title":"Foot Ankle Int"},{"issue":"5","key":"10.1016\/j.berh.2020.101505_bib30","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1148\/radiographics.18.5.9747616","article-title":"Enchondroma versus chondrosarcoma in the appendicular skeleton: differentiating features","volume":"18","author":"Murphey","year":"1998","journal-title":"Radiographics"},{"issue":"6","key":"10.1016\/j.berh.2020.101505_bib31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s002560050246","article-title":"Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. I. The intramedullary cartilage tumors","volume":"26","author":"Brien","year":"1997","journal-title":"Skeletal Radiol"}],"container-title":["Best Practice &amp; Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169422030022X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152169422030022X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:19:36Z","timestamp":1761499176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152169422030022X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S152169422030022X"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2020.101505","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple hereditary exostoses and enchondromatosis","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Rheumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.berh.2020.101505","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101505"}}