{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:28:09Z","timestamp":1770456489096,"version":"3.49.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CSAINV19may-0010"],"award-info":[{"award-number":["CSAINV19may-0010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSA-Inv\/0022\/2017"],"award-info":[{"award-number":["NMRC\/CSA-Inv\/0022\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Rheumatology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.berh.2021.101687","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T20:29:47Z","timestamp":1618345787000},"page":"101687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The microbiome and systemic sclerosis: A review of current evidence"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3859-6906","authenticated-orcid":false,"given":"Tze Chin","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Noviani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Ying","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Hsiu Ling","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.berh.2021.101687_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/BOR.0000000000000645","article-title":"Gastrointestinal involvement in systemic sclerosis: an update","volume":"31","author":"McMahan","year":"2019","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.berh.2021.101687_bib2","article-title":"Gastrointestinal involvement in systemic sclerosis: effects on morbidity and mortality and new therapeutic approaches","author":"Hoffmann-Vold","year":"2019","journal-title":"J\u00a0Scleroderma Relat Disord"},{"key":"10.1016\/j.berh.2021.101687_bib3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/annrheumdis-2013-203889","article-title":"Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): report from a single VEDOSS\/EUSTAR centre","volume":"74","author":"Lepri","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2021.101687_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/BOR.0000000000000429","article-title":"Intestinal microbiome in scleroderma: recent progress","volume":"29","author":"Volkmann","year":"2017","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.berh.2021.101687_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","article-title":"Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.berh.2021.101687_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/jbmr.2765","article-title":"The microbiome and musculoskeletal conditions of aging: a review of evidence for impact and potential therapeutics: microbiome and musculoskeletal conditions of aging","volume":"31","author":"Steves","year":"2016","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.berh.2021.101687_bib7","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.berh.2021.101687_bib8","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.berh.2021.101687_bib9","doi-asserted-by":"crossref","first-page":"10719","DOI":"10.1073\/pnas.1711233114","article-title":"Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice","volume":"114","author":"Berer","year":"2017","journal-title":"Proc Natl Acad Sci Unit States Am"},{"key":"10.1016\/j.berh.2021.101687_bib10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrrheum.2011.121","article-title":"The microbiome and rheumatoid arthritis","volume":"7","author":"Scher","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.berh.2021.101687_bib11","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.berh.2021.101687_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases","volume":"7","author":"Rinninella","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.berh.2021.101687_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064315","article-title":"Intestinal microbiota in healthy U.S. young children and adults-a high throughput microarray analysis","volume":"8","author":"Ringel-Kulka","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.berh.2021.101687_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.maturitas.2018.07.008","article-title":"Influence of gender and menopausal status on gut microbiota","volume":"116","author":"Santos-Marcos","year":"2018","journal-title":"Maturitas"},{"key":"10.1016\/j.berh.2021.101687_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154090","article-title":"Intestinal microbiota is influenced by gender and body mass index","volume":"11","author":"Haro","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.berh.2021.101687_bib16","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1136\/gutjnl-2015-309957","article-title":"High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome","volume":"65","author":"De Filippis","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.berh.2021.101687_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.12480","article-title":"Composition of gut microbiota and its association with body mass index and lifestyle factors in a cohort of 7\u201318 years old children from the American gut project","volume":"14","author":"Bai","year":"2019","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.berh.2021.101687_bib18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00203-018-1506-2","article-title":"Smoking and the intestinal microbiome","volume":"200","author":"Savin","year":"2018","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.berh.2021.101687_bib19","doi-asserted-by":"crossref","first-page":"G966","DOI":"10.1152\/ajpgi.00380.2011","article-title":"Colonic microbiome is altered in alcoholism","volume":"302","author":"Mutlu","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.berh.2021.101687_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.aad3369","article-title":"Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity","volume":"352","author":"Zhernakova","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.berh.2021.101687_bib21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gutjnl-2015-310861","article-title":"Proton pump inhibitors alter the composition of the gut microbiota","volume":"65","author":"Jackson","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.berh.2021.101687_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature15766","article-title":"Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota","volume":"528","author":"Forslund","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.berh.2021.101687_bib23","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201800560R","article-title":"Sex differences in NSAID-induced perturbation of human intestinal barrier function and microbiota","volume":"32","author":"Edogawa","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/j.berh.2021.101687_bib24","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/art.39572","article-title":"Systemic sclerosis is associated with a unique colonic microbial consortium","volume":"68","author":"Volkmann","year":"2016","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.berh.2021.101687_bib25","doi-asserted-by":"crossref","first-page":"14874","DOI":"10.1038\/s41598-017-14889-6","article-title":"Gut microbiota profile in systemic sclerosis patients with and without clinical evidence of gastrointestinal involvement","volume":"7","author":"Patrone","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.berh.2021.101687_bib26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2017-000134","article-title":"Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts","volume":"4","author":"Volkmann","year":"2017","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.berh.2021.101687_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/nyas.13736","article-title":"Microbial and metabolic multi-omic correlations in systemic sclerosis patients","volume":"1421","author":"Bellocchi","year":"2018","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.berh.2021.101687_bib28","first-page":"73","article-title":"Gut microbiota analysis in systemic sclerosis according to disease characteristics and nutritional status","volume":"38","author":"Natalello","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.berh.2021.101687_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/annrheumdis-2020-eular.4865","article-title":"Duration and systemic sclerosis subtype are associated with different gut microbiome profiles","volume":"79","author":"Braun-Moscovici","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2021.101687_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.2005.073817","article-title":"Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach","volume":"55","author":"Manichanh","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.berh.2021.101687_bib31","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1136\/annrheumdis-2018-214856","article-title":"Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal","volume":"78","author":"Azzouz","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2021.101687_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-016-0299-7","article-title":"An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis","volume":"8","author":"Chen","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.berh.2021.101687_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/postgradmedj-2015-133285","article-title":"Gut microbiota, obesity and diabetes","volume":"92","author":"Patterson","year":"2016","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.berh.2021.101687_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080702","article-title":"A\u00a0modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease","volume":"8","author":"Tong","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.berh.2021.101687_bib35","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1038\/s41598-017-10034-5","article-title":"Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients","volume":"7","author":"Santoru","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.berh.2021.101687_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000441768","article-title":"Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn's disease","volume":"93","author":"Takahashi","year":"2016","journal-title":"Digestion"},{"key":"10.1016\/j.berh.2021.101687_bib37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13075-016-1182-z","article-title":"Intestinal dysbiosis is common in systemic sclerosis and associated with gastrointestinal and extraintestinal features of disease","volume":"18","author":"Andr\u00e9asson","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.berh.2021.101687_bib38","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function: review: role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.berh.2021.101687_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.chom.2018.11.009","article-title":"A\u00a0diet-sensitive commensal lactobacillus strain mediates TLR7-dependent systemic autoimmunity","volume":"25","author":"Zegarra-Ruiz","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.berh.2021.101687_bib40","article-title":"Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus","volume":"84","author":"Luo","year":"2017","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.berh.2021.101687_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1053\/j.gastro.2019.03.045","article-title":"Interactions between commensal bacteria and enteric neurons, via FPR1 induction of ROS, increase gastrointestinal motility in mice","volume":"157","author":"Chandrasekharan","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.berh.2021.101687_bib42","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn's disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.berh.2021.101687_bib43","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1440-1746.2002.02834.x","article-title":"Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody","volume":"17","author":"Ohkusa","year":"2002","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.berh.2021.101687_bib44","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3389\/fmicb.2020.01550","article-title":"Gut microbiome and metabolome were altered and strongly associated with platelet count in adult patients with primary immune thrombocytopenia","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.berh.2021.101687_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.berh.2021.101687_bib46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.berh.2021.101687_bib47","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1111\/j.1582-4934.2009.00686.x","article-title":"Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening","volume":"13","author":"Kunze","year":"2009","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.berh.2021.101687_bib48","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/MIB.0000000000000332","article-title":"Using corticosteroids to reshape the gut microbiome: implications for inflammatory bowel diseases","volume":"21","author":"Huang","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.berh.2021.101687_bib49","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The immune response to Prevotella bacteria in chronic inflammatory disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.berh.2021.101687_bib50","doi-asserted-by":"crossref","first-page":"10713","DOI":"10.1073\/pnas.1711235114","article-title":"Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models","volume":"114","author":"Cekanaviciute","year":"2017","journal-title":"Proc Natl Acad Sci Unit States Am"},{"key":"10.1016\/j.berh.2021.101687_bib51","first-page":"1089","article-title":"Gut microbiota and risk of persistent nonalcoholic fatty liver diseases","volume":"8","author":"Kim","year":"2019","journal-title":"J\u00a0Clin Med"},{"issue":"Suppl1","key":"10.1016\/j.berh.2021.101687_bib52","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/annrheumdis-2020-eular.5481","article-title":"Altered immune recognition of specific gut bacteria by immunoglobulins in early systemic sclerosis","volume":"79","author":"Hoffmann-Vold","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.berh.2021.101687_bib53","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1086\/523341","article-title":"Probiotics: definition, sources, selection, and uses","volume":"46","author":"Sanders","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.berh.2021.101687_bib54","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/rheumatology\/kez160","article-title":"Effect of probiotics on gastrointestinal symptoms and immune parameters in systemic sclerosis: a randomized placebo-controlled trial","volume":"58","author":"Marighela","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.berh.2021.101687_bib55","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.semarthrit.2019.05.006","article-title":"A\u00a0double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease","volume":"49","author":"Low","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.berh.2021.101687_bib56","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/1744666X.2019.1656528","article-title":"Just another crappy commentary: the future of fecal microbiota transplantation","volume":"15","author":"Rosenbaum","year":"2019","journal-title":"Expet Rev Clin Immunol"},{"key":"10.1016\/j.berh.2021.101687_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232739","article-title":"Fecal microbiota transplantation in systemic sclerosis: a double-blind, placebo-controlled randomized pilot trial","volume":"15","author":"Fretheim","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.berh.2021.101687_bib58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","article-title":"Pathophysiology of systemic sclerosis: current understanding and new insights","volume":"15","author":"Cutolo","year":"2019","journal-title":"Expet Rev Clin Immunol"},{"key":"10.1016\/j.berh.2021.101687_bib59","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1038\/ncomms9424","article-title":"Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis","volume":"6","author":"Zanvit","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.berh.2021.101687_bib60","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1126\/science.1219328","article-title":"Microbial exposure during early life has persistent effects on natural killer T cell function","volume":"336","author":"Olszak","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.berh.2021.101687_bib61","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.jid.2017.06.019","article-title":"Early-life antibiotic exposure causes intestinal dysbiosis and exacerbates skin and lung pathology in experimental systemic sclerosis","volume":"137","author":"Mehta","year":"2017","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["Best Practice &amp; Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694221000292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694221000292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:20:48Z","timestamp":1761499248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694221000292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1521694221000292"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2021.101687","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The microbiome and systemic sclerosis: A review of current evidence","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Rheumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.berh.2021.101687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101687"}}