{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:35:49Z","timestamp":1792373749987,"version":"4.4.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007735","name":"Deutsche Gesellschaft f\u00fcr Neurologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010572","name":"Deutsche Kniegesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE 4328\/9\u20131"],"award-info":[{"award-number":["BE 4328\/9\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Rheumatology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.berh.2021.101722","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T16:43:05Z","timestamp":1635698585000},"page":"101722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The role of calcium crystals and their effect on osteoarthritis pathogenesis"],"prefix":"10.1016","volume":"35","author":[{"given":"Sina","family":"St\u00fccker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Garbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10264","key":"10.1016\/j.berh.2021.101722_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a lancet commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.rehab.2016.01.006","article-title":"Risk factors and burden of osteoarthritis","volume":"59","author":"Palazzo","year":"2016","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.berh.2021.101722_bib3","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20575.1","article-title":"Recent advances in understanding the phenotypes of osteoarthritis","volume":"8","author":"Mobasheri","year":"2019","journal-title":"F1000Research"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/ar3299","article-title":"Osteoarthritis subpopulations and implications for clinical trial design","volume":"13","author":"Bierma-Zeinstra","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.berh.2021.101722_bib5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/ard.45.7.603","article-title":"Patterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dihydrate crystal deposition in the knee","volume":"45","author":"Halverson","year":"1986","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11926-996-0042-2","article-title":"Calcium-containing crystals and osteoarthritis: implications for the clinician","volume":"7","author":"Wu","year":"2005","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dev.130807","article-title":"Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes","volume":"144","author":"Hu","year":"2017","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib8","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbagen.2017.11.005","article-title":"Matrix vesicles from chondrocytes and osteoblasts: their biogenesis, properties, functions and biomimetic models","volume":"1862","author":"Bottini","year":"2018","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"45","key":"10.1016\/j.berh.2021.101722_bib9","doi-asserted-by":"crossref","first-page":"35577","DOI":"10.1074\/jbc.M005648200","article-title":"The roles of annexins and types II and X collagen in matrix vesicle-mediated mineralization of growth plate cartilage","volume":"275","author":"Kirsch","year":"2000","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.joca.2008.05.020","article-title":"Inorganic pyrophosphate as a regulator of hydroxyapatite or calcium pyrophosphate dihydrate mineral deposition by matrix vesicles","volume":"17","author":"Thouverey","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"14","key":"10.1016\/j.berh.2021.101722_bib11","doi-asserted-by":"crossref","first-page":"9445","DOI":"10.1073\/pnas.142063399","article-title":"Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization","volume":"99","author":"Hessle","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib12","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.2001.281.1.C1","article-title":"Inorganic pyrophosphate generation and disposition in pathophysiology","volume":"281","author":"Terkeltaub","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1039\/C7MD00015D","article-title":"Nucleotide pyrophosphatase\/phosphodiesterase 1 (NPP1) and its inhibitors","volume":"8","author":"Lee","year":"2017","journal-title":"Med Chem Commun"},{"issue":"7","key":"10.1016\/j.berh.2021.101722_bib14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1136\/annrheumdis-2011-200892","article-title":"Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice","volume":"71","author":"Bertrand","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"5477","key":"10.1016\/j.berh.2021.101722_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.289.5477.265","article-title":"Role of the mouse ank gene in control of tissue calcification and arthritis","volume":"289","author":"Ho","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/03008207.2010.491928","article-title":"Parallel regulation of extracellular ATP and inorganic pyrophosphate: roles of growth factors, transduction modulators, and ANK","volume":"52","author":"Costello","year":"2011","journal-title":"Connect Tissue Res"},{"issue":"4","key":"10.1016\/j.berh.2021.101722_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.joca.2003.12.004","article-title":"Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess","volume":"12","author":"Johnson","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3899\/jrheum.111476","article-title":"Upregulation of ANK protein expression in joint tissue in calcium pyrophosphate dihydrate crystal deposition disease","volume":"41","author":"Uzuki","year":"2014","journal-title":"J Rheumatol"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005634","article-title":"Control of vertebrate skeletal mineralization by polyphosphates","volume":"4","author":"Omelon","year":"2009","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.berh.2021.101722_bib20","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1359\/jbmr.070714","article-title":"Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification","volume":"22","author":"Narisawa","year":"2007","journal-title":"J Bone Miner Res : Off J Am Soc Bone Miner Res"},{"issue":"10","key":"10.1016\/j.berh.2021.101722_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8101544","article-title":"Rotator cuff tenocytes differentiate into hypertrophic chondrocyte-like cells to produce calcium deposits in an alkaline phosphatase-dependent manner","volume":"8","author":"Darrieutort-Laffite","year":"2019","journal-title":"J Clin Med"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib22","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJMoa0912923","article-title":"NT5E mutations and arterial calcifications","volume":"364","author":"St Hilaire","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.berh.2021.101722_bib23","article-title":"Clinical and subclinical findings in heterozygous ABCC6 carriers: results from a Belgian cohort and clinical practice guidelines","author":"Nollet","year":"2021","journal-title":"J Med Genet"},{"issue":"7954","key":"10.1016\/j.berh.2021.101722_bib24","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0140-6736(76)91400-8","article-title":"Apatite deposition disease. A new arthropathy","volume":"1","author":"Dieppe","year":"1976","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib25","doi-asserted-by":"crossref","DOI":"10.1097\/BOR.0000000000000245","article-title":"Basic calcium phosphate crystals and osteoarthritis pathogenesis: novel pathways and potential targets","volume":"28","author":"Stack","year":"2016","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13075-017-1225-0","article-title":"Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells","volume":"19","author":"Corr","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"1145","key":"10.1016\/j.berh.2021.101722_bib27","article-title":"Disease-associated particulates and joint inflammation; mechanistic insights and potential","volume":"9","author":"Mahon","year":"2018","journal-title":"Ther Targets"},{"key":"10.1016\/j.berh.2021.101722_bib28","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/j.joca.2018.02.134","article-title":"BCP crystals drive chondrocyte hypertrophic differentiation via binding WNT ligands and activation of canonical WNT signaling","volume":"26","author":"Bertrand","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.berh.2021.101722_bib29","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/annrheumdis-2019-216648","article-title":"BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a","volume":"79","author":"Bertrand","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"10.1016\/j.berh.2021.101722_bib30","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1002\/art.24774","article-title":"Calcification of articular cartilage in human osteoarthritis","volume":"60","author":"Fuerst","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.berh.2021.101722_bib31","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/gerona\/60.9.1118","article-title":"Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli","volume":"60","author":"Forsyth","year":"2005","journal-title":"J Gerontol A, Biol Sci Med Sci"},{"issue":"7","key":"10.1016\/j.berh.2021.101722_bib32","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3390\/ijms21072358","article-title":"The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression","volume":"21","author":"Rim","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"5\u20136","key":"10.1016\/j.berh.2021.101722_bib33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/ten.tea.2011.0279","article-title":"A hydrogel-mineral composite scaffold for osteochondral interface tissue engineering","volume":"18","author":"Khanarian","year":"2012","journal-title":"Tissue Eng"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib34","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/ar3117","article-title":"Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders","volume":"12","author":"Dreier","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.berh.2021.101722_bib35","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.bbrc.2005.06.041","article-title":"The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner","volume":"333","author":"Yano","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.berh.2021.101722_bib36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.lfs.2019.05.011","article-title":"MicroRNA-320c inhibits development of osteoarthritis through downregulation of canonical Wnt signaling pathway","volume":"228","author":"Hu","year":"2019","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib37","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.96308","article-title":"Inhibition of Wnt\/\u03b2-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis","volume":"3","author":"Lietman","year":"2018","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.berh.2021.101722_bib38","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.joca.2018.02.908","article-title":"Targeting \u03b2-catenin dependent Wnt signaling via peptidomimetic inhibitors in murine chondrocytes and OA cartilage","volume":"26","author":"Held","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.201011051","article-title":"WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways","volume":"193","author":"Nalesso","year":"2011","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00223-018-0494-1","article-title":"Basic calcium phosphate crystals induce osteoarthritis-associated changes in phenotype markers in primary human chondrocytes by a calcium\/calmodulin kinase 2-dependent mechanism","volume":"104","author":"Rong","year":"2019","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"10.1016\/j.berh.2021.101722_bib41","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1136\/annrheumdis-2015-207487","article-title":"Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis","volume":"75","author":"Nasi","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.berh.2021.101722_bib42","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/ard.2010.139105","article-title":"European League against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis","volume":"70","author":"Zhang","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib43","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/art.20162","article-title":"Distribution of radiographic osteoarthritis between the right and left hands, hips, and knees","volume":"50","author":"Neame","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02563991","article-title":"An ultrastructural study of the articular cartilage in calcium pyrophosphate dihydrate (CPPD) crystal deposition disease (chondrocalcinosis articularis)","volume":"19","author":"Bjelle","year":"1975","journal-title":"Calcif Tissue Res"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib45","article-title":"Calcium pyrophosphate crystal size and characteristics","volume":"3","author":"Zell","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/acr.22652","article-title":"Does chondrocalcinosis associate with a distinct radiographic phenotype of osteoarthritis in knees and hips? A case\u2013control study","volume":"68","author":"Abhishek","year":"2016","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.berh.2021.101722_bib47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4103\/2277-9175.211835","article-title":"Prevalence of chondrocalcinosis in patients above 50 Years and the relationship with osteoarthritis","volume":"6","author":"Karimzadeh","year":"2017","journal-title":"Adv Biomed Res"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib48","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.joca.2014.10.009","article-title":"CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study","volume":"23","author":"Misra","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib49","first-page":"692","article-title":"Linkage of early-onset osteoarthritis and chondrocalcinosis to human chromosome 8q","volume":"56","author":"Baldwin","year":"1995","journal-title":"Am J Hum Genet"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib50","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/geno.1999.5997","article-title":"Physical map and characterization of transcripts in the candidate interval for familial chondrocalcinosis at chromosome 5p15.1","volume":"62","author":"Rojas","year":"1999","journal-title":"Genomics"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib51","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrrheum.2010.182","article-title":"Pathophysiology of articular chondrocalcinosis--role of ANKH","volume":"7","author":"Abhishek","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib52","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/ar4453","article-title":"The association between ANKH promoter polymorphism and chondrocalcinosis is independent of age and osteoarthritis: results of a case-control study","volume":"16","author":"Abhishek","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.berh.2021.101722_bib53","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.joca.2005.04.006","article-title":"Genetics of chondrocalcinosis","volume":"13","author":"Zaka","year":"2005","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib54","first-page":"321","article-title":"Ferrous [Fe++] but not ferric [Fe] ions inhibit de novo formation of calcium pyrophosphate dihydrate crystals: possible relationships to chondrocalcinosis and hemochromatosis","volume":"15","author":"Cheng","year":"1988","journal-title":"J Rheumatol"},{"issue":"5\u20136","key":"10.1016\/j.berh.2021.101722_bib55","first-page":"713","article-title":"Chondrocalcinosis related to familial hypomagnesemia with hypercalciuria and nephrocalcinosis","volume":"28","author":"Cimbek","year":"2015","journal-title":"J Pediatr Endocrinol Metab : JPEM (J Pediatr Endocrinol Metab)"},{"issue":"12","key":"10.1016\/j.berh.2021.101722_bib56","first-page":"2434","article-title":"Hypomagnesemia and chondrocalcinosis in short bowel syndrome","volume":"32","author":"Richette","year":"2005","journal-title":"J Rheumatol"},{"issue":"12","key":"10.1016\/j.berh.2021.101722_bib57","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1007\/s10067-016-3450-3","article-title":"Musculoskeletal manifestations of primary hyperparathyroidism","volume":"35","author":"Pappu","year":"2016","journal-title":"Clin Rheumatol"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib58","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00296-008-0710-9","article-title":"How can calcium pyrophosphate crystals induce inflammation in hypophosphatasia or chronic inflammatory joint diseases?","volume":"29","author":"Beck","year":"2009","journal-title":"Rheumatol Int"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/jfb10020018","article-title":"Adsorption of proteins on m-CPPD and urate crystals inhibits crystal-induced cell responses: study on albumin-crystal interaction","volume":"10","author":"Renaudin","year":"2019","journal-title":"J Funct Biomater"},{"issue":"637","key":"10.1016\/j.berh.2021.101722_bib60","article-title":"Chondrocytes from osteoarthritic and chondrocalcinosis cartilage represent different phenotypes","volume":"9","author":"Meyer","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10.1016\/j.berh.2021.101722_bib61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib62","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/rheumatology\/keh127","article-title":"Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro","volume":"43","author":"Zhou","year":"2004","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib63","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1128\/MCB.19.3.2109","article-title":"Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts","volume":"19","author":"Stein","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib64","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbrc.2020.04.097","article-title":"Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1\/P53\/P21 pathway in surgery-induced osteoarthritis","volume":"528","author":"Xu","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib65","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41598-018-36500-2","article-title":"Identification of chondrocyte genes and signaling pathways in response to acute joint inflammation","volume":"9","author":"Lv","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib66","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/ar4494","article-title":"p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis","volume":"16","author":"Philipot","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.berh.2021.101722_bib67","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0002-9440(10)61682-3","article-title":"Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa","volume":"159","author":"Johnson","year":"2001","journal-title":"Am J Pathol"},{"issue":"15","key":"10.1016\/j.berh.2021.101722_bib68","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1016\/j.yexcr.2012.04.012","article-title":"GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) \u03b21-induced senescence","volume":"318","author":"Byun","year":"2012","journal-title":"Exp Cell Res"},{"issue":"11","key":"10.1016\/j.berh.2021.101722_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143865","article-title":"Lithium chloride dependent glycogen synthase kinase 3 inactivation links oxidative DNA damage, hypertrophy and senescence in human articular chondrocytes and reproduces chondrocyte phenotype of obese osteoarthritis patients","volume":"10","author":"Guidotti","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.berh.2021.101722_bib70","first-page":"470005","article-title":"Chondrocyte-specific RUNX2 overexpression causes chondrodysplasia during development, but is not sufficient to induce OA-like articular cartilage degeneration in adult mice without","author":"Catheline","year":"2018","journal-title":"Injury"},{"issue":"23","key":"10.1016\/j.berh.2021.101722_bib71","doi-asserted-by":"crossref","first-page":"11263","DOI":"10.1158\/0008-5472.CAN-07-3016","article-title":"Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts","volume":"67","author":"Kilbey","year":"2007","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.berh.2021.101722_bib72","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.joca.2019.10.010","article-title":"Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization","volume":"28","author":"Mahon","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.berh.2021.101722_bib73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11926-018-0721-9","article-title":"Calcium-containing crystals and osteoarthritis: an unhealthy alliance","volume":"20","author":"Conway","year":"2018","journal-title":"Curr Rheumatol Rep"}],"container-title":["Best Practice &amp; Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694221000644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694221000644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:22:37Z","timestamp":1761499357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694221000644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1521694221000644"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2021.101722","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of calcium crystals and their effect on osteoarthritis pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Rheumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.berh.2021.101722","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101722"}}