{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:07:41Z","timestamp":1772492861575,"version":"3.50.1"},"reference-count":101,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Best Practice &amp; Research Clinical Rheumatology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.berh.2024.101935","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:33:12Z","timestamp":1709289192000},"page":"101935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Problems with opioids - beyond misuse"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6366-8575","authenticated-orcid":false,"given":"Dorna","family":"Kheirabadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeba","family":"Minhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rezvan","family":"Ghaderpanah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Clauw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.berh.2024.101935_bib1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.15585\/mmwr.mm6626a4","article-title":"Vital signs: changes in opioid prescribing in the United States, 2006\u20132015","volume":"66","author":"Guy","year":"2017","journal-title":"MMWR (Morb Mortal Wkly Rep)"},{"issue":"8","key":"10.1016\/j.berh.2024.101935_bib2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jpain.2015.05.002","article-title":"Estimates of pain prevalence and severity in adults: United States, 2012","volume":"16","author":"Nahin","year":"2015","journal-title":"J Pain"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/2049463720974053","article-title":"Hopes and fears before opioid tapering: a quantitative and qualitative study of patients with chronic pain and long-term opioids","volume":"15","author":"Quinlan","year":"2021","journal-title":"Br J Pain"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/08897077.2017.1381663","article-title":"The conundrum of opioid tapering in long-term opioid therapy for chronic pain: a commentary","volume":"39","author":"Manhapra","year":"2018","journal-title":"Subst Abuse"},{"issue":"23","key":"10.1016\/j.berh.2024.101935_bib5","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1001\/jama.2018.18472","article-title":"Opioids for chronic noncancer pain: a systematic review and meta-analysis","volume":"320","author":"Busse","year":"2018","journal-title":"JAMA"},{"issue":"9904","key":"10.1016\/j.berh.2024.101935_bib6","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/S0140-6736(13)61530-5","article-title":"Global burden of disease attributable to illicit drug use and dependence: findings from the Global Burden of Disease Study 2010","volume":"382","author":"Degenhardt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.berh.2024.101935_bib7","volume":"vol. 3","author":"Card","year":"2017"},{"issue":"15","key":"10.1016\/j.berh.2024.101935_bib8","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2016.1464","article-title":"CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016","volume":"315","author":"Dowell","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.berh.2024.101935_bib9","series-title":"Opioid treatments for chronic pain","author":"Chou","year":"2020"},{"issue":"1\u20132","key":"10.1016\/j.berh.2024.101935_bib10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pain.2006.06.009","article-title":"Critical issues on opioids in chronic non-cancer pain:: an epidemiological study","volume":"125","author":"Eriksen","year":"2006","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.berh.2024.101935_bib11","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s11864-022-00985-x","article-title":"Complex persistent opioid dependence\u2014an opioid-induced chronic pain syndrome","volume":"23","author":"Manhapra","year":"2022","journal-title":"Curr Treat Options Oncol"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1037\/a0013628","article-title":"Opioids and the treatment of chronic pain: controversies, current status, and future directions","volume":"16","author":"Rosenblum","year":"2008","journal-title":"Exp Clin Psychopharmacol"},{"key":"10.1016\/j.berh.2024.101935_bib93","series-title":"Opioids and acute kidney injury","first-page":"11","author":"Mallappallil","year":"2021"},{"issue":"10","key":"10.1016\/j.berh.2024.101935_bib13","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1093\/gerona\/glaa038","article-title":"Opioid use and the risk of falls, fall injuries and fractures among older adults: a systematic review and meta-analysis","volume":"75","author":"Yoshikawa","year":"2020","journal-title":"J Gerontol: Series A"},{"issue":"3","key":"10.1016\/j.berh.2024.101935_bib14","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1213\/ANE.0000000000003307","article-title":"Opioid use disorders and the risk of postoperative pulmonary complications","volume":"127","author":"Sayal","year":"2018","journal-title":"Anesth Analg"},{"issue":"9","key":"10.1016\/j.berh.2024.101935_bib15","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1111\/crj.12948","article-title":"Chronic opioid use and clinical outcomes in lung transplant recipients: a single\u2010center cohort study","volume":"12","author":"Drees","year":"2018","journal-title":"The Clinical Respiratory Journal"},{"issue":"11","key":"10.1016\/j.berh.2024.101935_bib16","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.spinee.2018.03.015","article-title":"Chronic preoperative opioid use is a risk factor for increased complications, resource use, and costs after cervical fusion","volume":"18","author":"Jain","year":"2018","journal-title":"Spine J"},{"issue":"19","key":"10.1016\/j.berh.2024.101935_bib17","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/BRS.0000000000002609","article-title":"Preoperative chronic opioid therapy: a risk factor for complications, readmission, continued opioid use and increased costs after one-and two-level posterior lumbar fusion","volume":"43","author":"Jain","year":"2018","journal-title":"Spine"},{"issue":"14","key":"10.1016\/j.berh.2024.101935_bib18","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1111\/bph.13750","article-title":"Opioids and the immune system\u2013friend or foe","volume":"175","author":"Plein","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.berh.2024.101935_bib19","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1007\/s11606-020-06155-9","article-title":"The association between prescribed opioid receipt and community-acquired pneumonia in adults: a systematic review and meta-analysis","volume":"35","author":"Steffens","year":"2020","journal-title":"J Gen Intern Med"},{"issue":"22","key":"10.1016\/j.berh.2024.101935_bib20","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1001\/jama.2016.7789","article-title":"Prescription of long-acting opioids and mortality in patients with chronic noncancer pain","volume":"315","author":"Ray","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.berh.2024.101935_bib21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/DDDT.S342409","article-title":"Less well-known consequences of the long-term use of opioid analgesics: a comprehensive literature review","volume":"16","author":"Kotli\u0144ska-Lemieszek","year":"2022","journal-title":"Drug Des Dev Ther"},{"issue":"11","key":"10.1016\/j.berh.2024.101935_bib22","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3390\/ph14111091","article-title":"Opioid analgesia and opioid-induced adverse effects: a review","volume":"14","author":"Paul","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"9","key":"10.1016\/j.berh.2024.101935_bib23","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/ejp.1797","article-title":"Long\u2010term opioid treatment and endocrine measures in chronic non\u2010cancer pain patients: a systematic review and meta\u2010analysis","volume":"25","author":"Diasso","year":"2021","journal-title":"Eur J Pain"},{"key":"10.1016\/j.berh.2024.101935_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.coemr.2019.04.007","article-title":"Opioid-induced androgen deficiency (OPIAD): prevalence, consequence, and efficacy of testosterone replacement","volume":"6","author":"Ho","year":"2019","journal-title":"Current Opinion in Endocrine and Metabolic Research"},{"issue":"12","key":"10.1016\/j.berh.2024.101935_bib25","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s40618-018-0964-3","article-title":"Testosterone deficiency in non-cancer opioid-treated patients","volume":"41","author":"Coluzzi","year":"2018","journal-title":"Journal of endocrinological investigation"},{"key":"10.1016\/j.berh.2024.101935_bib26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11914-020-00585-4","article-title":"The effect of opiates on bone formation and bone healing","volume":"18","author":"Coluzzi","year":"2020","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib27","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/1440-1681.13246","article-title":"Opioid\u2010induced hypogonadism: pathophysiology, clinical and therapeutics review","volume":"47","author":"Antony","year":"2020","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"10","key":"10.1016\/j.berh.2024.101935_bib28","article-title":"Long-term opioids linked to hypogonadism and the role of testosterone supplementation therapy","volume":"12","author":"Marudhai","year":"2020","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/papr.12731","article-title":"An internet\u2010based survey to assess Clinicians' knowledge and attitudes towards opioid\u2010induced hypogonadism","volume":"19","author":"Hochberg","year":"2019","journal-title":"Pain Pract"},{"issue":"3","key":"10.1016\/j.berh.2024.101935_bib30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s11930-018-0160-7","article-title":"Opioid-related sexual dysfunction in men","volume":"10","author":"Nguyen","year":"2018","journal-title":"Curr Sex Health Rep"},{"key":"10.1016\/j.berh.2024.101935_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drugalcdep.2015.01.038","article-title":"Testosterone suppression in opioid users: a systematic review and meta-analysis","volume":"149","author":"Bawor","year":"2015","journal-title":"Drug Alcohol Depend"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.sxmr.2018.04.003","article-title":"Management strategies in opioid abuse and sexual dysfunction: a review of opioid-induced androgen deficiency","volume":"6","author":"Hsieh","year":"2018","journal-title":"Sexual medicine reviews"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/and.13026","article-title":"Tramadol (opioid) abuse is associated with a dose\u2010and time\u2010dependent poor sperm quality and hyperprolactinaemia in young men","volume":"50","author":"Farag","year":"2018","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib34","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/pm\/pny040","article-title":"Hormone replacement therapy and opioid tapering for opioid-induced hypogonadism among patients with chronic noncancer pain: a systematic review","volume":"20","author":"AminiLari","year":"2019","journal-title":"Pain Med"},{"issue":"1","key":"10.1016\/j.berh.2024.101935_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11102-021-01202-y","article-title":"Opioids and pituitary function: expert opinion","volume":"25","author":"Gadelha","year":"2022","journal-title":"Pituitary"},{"key":"10.1016\/j.berh.2024.101935_bib36","series-title":"Opioid-induced adrenal insufficiency","first-page":"937","author":"Donegan","year":"2018"},{"issue":"1","key":"10.1016\/j.berh.2024.101935_bib37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S2213-8587(19)30254-2","article-title":"Opioid-induced endocrinopathies","volume":"8","author":"Fountas","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib38","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1210\/clinem\/dgz022","article-title":"Opioids and their endocrine effects: a systematic review and meta-analysis","volume":"105","author":"de Vries","year":"2020","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"7","key":"10.1016\/j.berh.2024.101935_bib39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11892-022-01473-0","article-title":"The clash of two epidemics: the relationship between opioids and glucose metabolism","volume":"22","author":"Koekkoek","year":"2022","journal-title":"Curr Diabetes Rep"},{"key":"10.1016\/j.berh.2024.101935_bib40","first-page":"1","article-title":"Metabolic profiles associated with opioid use and opioid use disorder: a narrative review of the literature","author":"Byanyima","year":"2023","journal-title":"Current Addiction Reports"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib41","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/fcp.12655","article-title":"Tramadol\u2010induced hypoglycemia: a pharmacovigilance study","volume":"35","author":"De Canecaude","year":"2021","journal-title":"Fund Clin Pharmacol"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib42","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/pds.4278","article-title":"National trends in long\u2010term use of prescription opioids","volume":"27","author":"Mojtabai","year":"2018","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220216","article-title":"An updated analysis of opioids increasing the risk of fractures","volume":"15","author":"Yue","year":"2020","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.berh.2024.101935_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.14740\/jh689","article-title":"Impact of opioid use in hematological malignancies: clinical, immunological and concomitant aspects","volume":"9","author":"Tregubenko","year":"2020","journal-title":"Journal of Hematology"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/AIA.0000000000000268","article-title":"The role of opioids in cancer progression","volume":"58","author":"Ramirez","year":"2020","journal-title":"Int Anesthesiol Clin. Spring"},{"key":"10.1016\/j.berh.2024.101935_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104938","article-title":"Opioid receptors beyond pain control: the role in cancer pathology and the debated importance of their pharmacological modulation","volume":"159","author":"Carli","year":"2020","journal-title":"Pharmacol Res"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib47","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1016\/j.bja.2018.09.030","article-title":"The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target","volume":"122","author":"Chen","year":"2019","journal-title":"British journal of anaesthesia"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neo.2020.12.011","article-title":"Opioids drive breast cancer metastasis through the \u03b4-opioid receptor and oncogenic STAT3","volume":"23","author":"Tripolt","year":"2021","journal-title":"Neoplasia"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib49","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bja.2020.07.051","article-title":"Increased mu-opioid receptor expression is associated with reduced disease-free and overall survival in laryngeal squamous cell carcinoma","volume":"125","author":"Zhang","year":"2020","journal-title":"British journal of anaesthesia"},{"key":"10.1016\/j.berh.2024.101935_bib50","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s11481-020-09960-5","article-title":"Opioid-mediated HIV-1 immunopathogenesis","volume":"15","author":"Buch","year":"2020","journal-title":"J Neuroimmune Pharmacol"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/10738584211030493","article-title":"The interplay between chronic pain, opioids, and the immune system","volume":"28","author":"Malafoglia","year":"2022","journal-title":"Neuroscientist"},{"key":"10.1016\/j.berh.2024.101935_bib52","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fimmu.2020.00094","article-title":"Bidirectional regulation of opioid and chemokine function","volume":"11","author":"Rogers","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.berh.2024.101935_bib53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12974-022-02453-7","article-title":"Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1","volume":"19","author":"Peng","year":"2022","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.berh.2024.101935_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajem.2022.03.048","article-title":"Opioid usage and COVID-19 prognosis: a systematic review and meta-analysis","author":"Ao","year":"2022","journal-title":"Am J Emerg Med"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib55","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/ADM.0000000000000928","article-title":"Trends in hospitalizations for serious infections among people with opioid use disorder in Ontario, Canada","volume":"16","author":"Gomes","year":"2022","journal-title":"J Addiction Med"},{"key":"10.1016\/j.berh.2024.101935_bib56","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3389\/fimmu.2020.01455","article-title":"Toll-like receptor 4 (TLR4)\/opioid receptor pathway crosstalk and impact on opioid analgesia, immune function, and gastrointestinal motility","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.berh.2024.101935_bib57","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.3389\/fimmu.2019.02904","article-title":"The role of opioid receptors in immune system function","volume":"10","author":"Eisenstein","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.berh.2024.101935_bib58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/DHPS.S151073","article-title":"Concomitant use of opioid medications with triptans or serotonergic antidepressants in US office-based physician visits","author":"Molina","year":"2018","journal-title":"Drug Healthc Patient Saf"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00204-022-03402-2","article-title":"Opioid toxicity: histamine, hypersensitivity, and MRGPRX2","volume":"97","author":"Baldo","year":"2023","journal-title":"Arch Toxicol"},{"issue":"8","key":"10.1016\/j.berh.2024.101935_bib60","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00204-021-03068-2","article-title":"Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity","volume":"95","author":"Baldo","year":"2021","journal-title":"Arch Toxicol"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib61","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jpain.2022.09.013","article-title":"The delta-opioid receptor bidirectionally modulates itch","volume":"24","author":"Smith","year":"2023","journal-title":"J Pain"},{"key":"10.1016\/j.berh.2024.101935_bib62","first-page":"392","article-title":"Assessment and management of opioid side effects","author":"Sweeney","year":"2006","journal-title":"Textbook of palliative medicine"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib63","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awaa430","article-title":"Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition","volume":"144","author":"Wang","year":"2021","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib64","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1016\/j.bja.2018.09.019","article-title":"Evidence of opioid-induced hyperalgesia in clinical populations after chronic opioid exposure: a systematic review and meta-analysis","volume":"122","author":"Higgins","year":"2019","journal-title":"Br J Anaesth"},{"issue":"suppl_1","key":"10.1016\/j.berh.2024.101935_bib65","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1111\/pme.12914","article-title":"Opioid induced hyperalgesia","volume":"16","author":"Yi","year":"2015","journal-title":"Pain Med"},{"issue":"9","key":"10.1016\/j.berh.2024.101935_bib66","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3390\/cancers14092253","article-title":"Chronic cancer pain: opioids within tumor microenvironment affect neuroinflammation, tumor and pain evolution","volume":"14","author":"Santoni","year":"2022","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib67","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bja.2019.07.026","article-title":"Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential","volume":"123","author":"Guo","year":"2019","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.berh.2024.101935_bib68","series-title":"Delta opioid receptors and cardioprotection","first-page":"301","author":"See Hoe","year":"2018"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib69","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jacc.2020.11.002","article-title":"Cardiovascular complications of opioid use: JACC state-of-the-art review","volume":"77","author":"Krantz","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib70","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.NURSE.0000554247.12754.28","article-title":"Long-term effects of opioids on the cardiovascular system: examine the evidence","volume":"49","author":"Corbett","year":"2019","journal-title":"Nursing"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib71","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/dar.13449","article-title":"High cardiovascular risk in older patients with opioid use disorder: differences with the general population","volume":"41","author":"Vallecillo","year":"2022","journal-title":"Drug Alcohol Rev"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib72","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000492616","article-title":"Opioids and cardiac arrhythmia: a literature review","volume":"27","author":"Behzadi","year":"2018","journal-title":"Med Princ Pract"},{"key":"10.1016\/j.berh.2024.101935_bib73","first-page":"1","article-title":"Use of tramadol and the risk of bleeding complications in patients on oral anticoagulants: a systematic review and meta-analysis","author":"L\u00e9vy","year":"2022","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.berh.2024.101935_bib74","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.sleep.2019.06.012","article-title":"Opioids and sleep\u2013a review of literature","volume":"67","author":"Tripathi","year":"2020","journal-title":"Sleep Med"},{"issue":"11","key":"10.1016\/j.berh.2024.101935_bib75","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.5664\/jcsm.8062","article-title":"Chronic opioid therapy and sleep: an American Academy of Sleep Medicine position statement","volume":"15","author":"Rosen","year":"2019","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib76","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/MCP.0000000000000733","article-title":"Opioids and sleep","volume":"26","author":"Cutrufello","year":"2020","journal-title":"Curr Opin Pulm Med"},{"issue":"9","key":"10.1016\/j.berh.2024.101935_bib77","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1097\/j.pain.0000000000001600","article-title":"Opioid use, pain intensity, age and sleep architecture in patients with fibromyalgia and insomnia","volume":"160","author":"Curtis","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.berh.2024.101935_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2022.101672","article-title":"The short-term effects of opioid and non-opioid pharmacotherapies on sleep in people with chronic low back pain: a systematic review and meta-analysis of randomized controlled trials","author":"Puterflam","year":"2022","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.berh.2024.101935_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101441","article-title":"The relationship between opioid use and obstructive sleep apnea: a systematic review and meta-analysis","volume":"58","author":"Ahmad","year":"2021","journal-title":"Sleep Med Rev"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib80","doi-asserted-by":"crossref","first-page":"H739","DOI":"10.1152\/ajpheart.00285.2015","article-title":"Sleep, death, and the heart","volume":"309","author":"Mansukhani","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"10.1016\/j.berh.2024.101935_bib81","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1164\/rccm.202108-2014CI","article-title":"Opioid use disorder, sleep deficiency, and ventilatory control: bidirectional mechanisms and therapeutic targets","volume":"206","author":"Eckert","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib82","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.berh.2024.101935_bib83","series-title":"Narcotic bowel syndrome","author":"Kong","year":"2018"},{"key":"10.1016\/j.berh.2024.101935_bib84","series-title":"Handbook of gastrointestinal motility and disorders of gut-brain interactions","first-page":"375","article-title":"Opioid-induced bowel disorder and narcotic bowel syndrome","author":"Allen-Brady","year":"2023"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib85","doi-asserted-by":"crossref","first-page":"doy003","DOI":"10.1093\/dote\/doy003","article-title":"A concise review of opioid-induced esophageal dysfunction: is this a new clinical entity?","volume":"31","author":"Ortiz","year":"2018","journal-title":"Dis Esophagus"},{"issue":"5","key":"10.1016\/j.berh.2024.101935_bib86","article-title":"Reduction in pain: is it worth the gain? The effect of opioids on the GI tract","volume":"30","author":"Nee","year":"2018","journal-title":"Neuro Gastroenterol Motil"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib87","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/cid\/ciy936","article-title":"Gastrointestinal microbiota disruption and risk of colonization with carbapenem-resistant Pseudomonas aeruginosa in intensive care unit patients","volume":"69","author":"Pettigrew","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib88","article-title":"Opioid-induced constipation in advanced cancer patients","volume":"13","author":"Almouaalamy","year":"2021","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jhm.2102","article-title":"Opioid utilization and opioid\u2010related adverse events in nonsurgical patients in US hospitals","volume":"9","author":"Herzig","year":"2014","journal-title":"J Hosp Med"},{"issue":"12","key":"10.1016\/j.berh.2024.101935_bib90","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000853","article-title":"Role of opioid signaling in kidney damage during the development of salt-induced hypertension","volume":"3","author":"Golosova","year":"2020","journal-title":"Life Sci Alliance"},{"issue":"6","key":"10.1016\/j.berh.2024.101935_bib91","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/MNH.0000000000000646","article-title":"Pain management in patients with chronic kidney disease and end-stage kidney disease","volume":"29","author":"Roy","year":"2020","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib92","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41581-021-00484-6","article-title":"Opioids for chronic pain management in patients with dialysis-dependent kidney failure","volume":"18","author":"Tobin","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"10.1016\/j.berh.2024.101935_bib94","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/pm\/pnac113","article-title":"Pain, opioid analgesics, and cognition: a conceptual framework in older adults","volume":"24","author":"Warner","year":"2023","journal-title":"Pain Med"},{"issue":"3","key":"10.1016\/j.berh.2024.101935_bib95","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/AJP.0000000000000536","article-title":"The relationship between chronic pain and neurocognitive function: a systematic review","volume":"34","author":"Higgins","year":"2018","journal-title":"Clin J Pain"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib96","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0885-3924(03)00310-5","article-title":"Neuropsychological effects of long-term opioid use in chronic pain patients","volume":"26","author":"Jamison","year":"2003","journal-title":"J Pain Symptom Manag"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib97","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jpainsymman.2019.10.022","article-title":"The effects of opioids on cognition in older adults with cancer and chronic noncancer pain: a systematic review","volume":"59","author":"Pask","year":"2020","journal-title":"J Pain Symptom Manag"},{"issue":"3","key":"10.1016\/j.berh.2024.101935_bib98","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/papr.12741","article-title":"Systematic review and meta\u2010analysis on neuropsychological effects of long\u2010term use of opioids in patients with chronic noncancer pain","volume":"19","author":"Allegri","year":"2019","journal-title":"Pain Pract"},{"issue":"1","key":"10.1016\/j.berh.2024.101935_bib99","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/00952990.2018.1517262","article-title":"Neuropsychological functioning in opioid use disorder: a research synthesis and meta-analysis","volume":"45","author":"Wollman","year":"2019","journal-title":"Am J Drug Alcohol Abuse"},{"issue":"11","key":"10.1016\/j.berh.2024.101935_bib100","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1097\/j.pain.0000000000001305","article-title":"Depression in chronic pain: might opioids be responsible?","volume":"159","author":"Mazereeuw","year":"2018","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.berh.2024.101935_bib101","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.artd.2018.07.002","article-title":"The interaction of depression and prior opioid use on pain and opioid requirements after total joint arthroplasty","volume":"4","author":"Rubenstein","year":"2018","journal-title":"Arthroplasty Today"}],"container-title":["Best Practice &amp; Research Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694224000068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521694224000068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T14:28:36Z","timestamp":1724423316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521694224000068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1521694224000068"],"URL":"https:\/\/doi.org\/10.1016\/j.berh.2024.101935","relation":{},"ISSN":["1521-6942"],"issn-type":[{"value":"1521-6942","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Problems with opioids - beyond misuse","name":"articletitle","label":"Article Title"},{"value":"Best Practice & Research Clinical Rheumatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.berh.2024.101935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101935"}}