{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:22:38Z","timestamp":1781292158491,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019035","name":"Science and Technology Program of Hubei Province","doi-asserted-by":"publisher","award":["2021BAD001"],"award-info":[{"award-number":["2021BAD001"]}],"id":[{"id":"10.13039\/501100019035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019937","name":"State Key Laboratory of Biocatalysis and Enzyme Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905000"],"award-info":[{"award-number":["2019YFA0905000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioDesign Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bidere.2025.100025","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T01:22:28Z","timestamp":1746062548000},"page":"100025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficient synthesis of clascoterone via lipase-catalyzed solvent-free alcoholysis"],"prefix":"10.1016","volume":"7","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bidere.2025.100025_bib1","first-page":"412","article-title":"Cortexolone 17\u03b1-propionate (clascoterone) is a novel androgen receptor antagonist that Inhibits production of lipids and inflammatory cytokines from sebocytes in vitro","volume":"18","author":"Rosette","year":"2019","journal-title":"J. Drugs Dermatol."},{"issue":"2","key":"10.1016\/j.bidere.2025.100025_bib2","first-page":"197","article-title":"Cortexolone 17\u03b1-propionate (clascoterone) is an androgen receptor antagonist in dermal Papilla cells in vitro","volume":"18","author":"Rosette","year":"2019","journal-title":"J. Drugs Dermatol."},{"issue":"6","key":"10.1016\/j.bidere.2025.100025_bib3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1001\/jamadermatol.2020.0465","article-title":"Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: two phase 3 randomized clinical trials","volume":"156","author":"Hebert","year":"2020","journal-title":"JAMA Dermatol."},{"issue":"5","key":"10.1016\/j.bidere.2025.100025_bib4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s13555-024-01175-3","article-title":"Comparison of the efficacy of clascoterone, trifarotene, and tazarotene for the treatment of acne: a systematic literature review and meta-analysis","volume":"14","author":"Shergill","year":"2024","journal-title":"Dermatol. Ther."},{"issue":"16","key":"10.1016\/j.bidere.2025.100025_bib5","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s40265-020-01417-6","article-title":"Clascoterone: first approval","volume":"80","author":"Dhillon","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.bidere.2025.100025_bib6","series-title":"Enzymatic Process for Obtaining 17 Alpha-Monoesters of Cortexolone And\/or its 9,11-dehydroderivatives","author":"Mauro","year":"2020"},{"issue":"13","key":"10.1016\/j.bidere.2025.100025_bib7","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0040-4039(00)71749-7","article-title":"Corticosteroid 17\u03b1-monoesters from 17\u03b1,21-cyclic orthoesters","volume":"2","author":"Gardi","year":"1961","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.bidere.2025.100025_bib8","series-title":"17-monoesters of 17alpha, 21-dihydroxy Steroids and Process for the Preparation Thereof","author":"Ercoli","year":"1964"},{"key":"10.1016\/j.bidere.2025.100025_bib9","author":"Mauro","year":"2008"},{"issue":"4","key":"10.1016\/j.bidere.2025.100025_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124882","article-title":"A novel calb-type lipase discovered by fungal genomes mining","volume":"10","author":"Vaquero","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bidere.2025.100025_bib11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0141-3910(02)00357-9","article-title":"Solvent effects on the lipase catalyzed biodegradation of poly (\u03b5-caprolactone) in solution","volume":"79","author":"Sivalingam","year":"2003","journal-title":"Polym. Degrad. Stabil."},{"issue":"21","key":"10.1016\/j.bidere.2025.100025_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202200435","article-title":"Lipase-catalysed enzymatic kinetic resolution of aromatic Morita-Baylis-Hillman derivatives by hydrolysis and transesterification","volume":"23","author":"Mathebula","year":"2022","journal-title":"Chembiochem"},{"issue":"15","key":"10.1016\/j.bidere.2025.100025_bib13","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/cbic.200800318","article-title":"Direct epoxidation in Candida antarctica lipase B studied by experiment and theory","volume":"9","author":"Svedendahl","year":"2008","journal-title":"Chembiochem"},{"key":"10.1016\/j.bidere.2025.100025_bib14","series-title":"Enzymatic Polymerization towards Green Polymer Chemistry","first-page":"105","article-title":"Synthesis of polyesters I: hydrolase as catalyst for polycondensation (condensation polymerization)","author":"Kobayashi","year":"2019"},{"key":"10.1016\/j.bidere.2025.100025_bib15","series-title":"Process for the Production of 21-(acetyloxy)-17-(propionyloxy)-Pregn-4-Ene-3, 20-dione","author":"Lenna","year":"2024"},{"issue":"1","key":"10.1016\/j.bidere.2025.100025_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/jf990836p","article-title":"Synthesis of structured triacylglycerols by lipase-catalyzed acidolysis in a packed bed bioreactor","volume":"48","author":"Xu","year":"2000","journal-title":"J. Agric. Food Chem."},{"issue":"15","key":"10.1016\/j.bidere.2025.100025_bib17","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1021\/ja111346c","article-title":"Continuous flow enzyme-catalyzed polymerization in a microreactor","volume":"133","author":"Kundu","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bidere.2025.100025_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ces.2018.03.026","article-title":"A review on microreactors: reactor fabrication, design, and cutting-edge applications","volume":"189","author":"Suryawanshi","year":"2018","journal-title":"Chem. Eng. Sci."},{"issue":"4","key":"10.1016\/j.bidere.2025.100025_bib19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acsbiomedchemau.1c00071","article-title":"A comprehensive review on steroidal bioconjugates as promising leads in drug discovery","volume":"2","author":"Bansal","year":"2022","journal-title":"ACS Bio. Med. Chem. Au"},{"key":"10.1016\/j.bidere.2025.100025_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.128127","article-title":"Structural studies of trenbolone, trenbolone acetate, hexahydrobenzylcarbonate and enanthate esters","volume":"1212","author":"Borodi","year":"2020","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bidere.2025.100025_bib21","series-title":"Steroid Chemistry at a Glance","first-page":"102","article-title":"Pregnanes, Part 2: corticosteroids","author":"Daniel","year":"2010"},{"key":"10.1016\/j.bidere.2025.100025_bib22","series-title":"Steroid Chemistry at a Glance","first-page":"122","article-title":"Miscellaneous steroids","author":"Daniel","year":"2010"}],"container-title":["BioDesign Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2693125725000263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2693125725000263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T23:26:50Z","timestamp":1762644410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2693125725000263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2693125725000263"],"URL":"https:\/\/doi.org\/10.1016\/j.bidere.2025.100025","relation":{},"ISSN":["2693-1257"],"issn-type":[{"value":"2693-1257","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficient synthesis of clascoterone via lipase-catalyzed solvent-free alcoholysis","name":"articletitle","label":"Article Title"},{"value":"BioDesign Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bidere.2025.100025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Nanjing Agricultural University.","name":"copyright","label":"Copyright"}],"article-number":"100025"}}