{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:31:50Z","timestamp":1793946710582,"version":"4.8.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016808","name":"Natural Science Foundation of Xiamen Municipality","doi-asserted-by":"publisher","award":["3502Z202471013"],"award-info":[{"award-number":["3502Z202471013"]}],"id":[{"id":"10.13039\/100016808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720250011"],"award-info":[{"award-number":["20720250011"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720240120"],"award-info":[{"award-number":["20720240120"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2024YFC3407000"],"award-info":[{"award-number":["2024YFC3407000"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32400058"],"award-info":[{"award-number":["32400058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270087"],"award-info":[{"award-number":["32270087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["BioDesign Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bidere.2026.100086","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:33:14Z","timestamp":1774971194000},"page":"100086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced growth of 1-butanol producing Escherichia coli via a metabolic buffer"],"prefix":"10.1016","volume":"8","author":[{"given":"Haidong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junru","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-190X","authenticated-orcid":false,"given":"Jifeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bidere.2026.100086_bib1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00253-009-2401-1","volume":"86","author":"Connor","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.bidere.2026.100086_bib2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nbt.1789","volume":"29","author":"Huo","year":"2011","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00253-016-7970-1","volume":"101","author":"Yuan","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10295-016-1855-2","volume":"44","author":"Yuan","year":"2017","journal-title":"J. Ind. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.bidere.2026.100086_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nbt.2509","volume":"31","author":"Avalos","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"34","key":"10.1016\/j.bidere.2026.100086_bib6","doi-asserted-by":"crossref","first-page":"11941","DOI":"10.1021\/jacs.7b05939","volume":"139","author":"Fu","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"42","key":"10.1016\/j.bidere.2026.100086_bib7","doi-asserted-by":"crossref","first-page":"24068","DOI":"10.1039\/C8RA02977F","volume":"8","author":"Kruger","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.bidere.2026.100086_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.enconman.2017.12.048","volume":"158","author":"Nanthagopal","year":"2018","journal-title":"Energy Convers. Manag."},{"key":"10.1016\/j.bidere.2026.100086_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2023.130667","volume":"361","author":"Waluyo","year":"2024","journal-title":"Fuel"},{"issue":"47","key":"10.1016\/j.bidere.2026.100086_bib10","doi-asserted-by":"crossref","first-page":"24734","DOI":"10.1039\/c3ra43011a","volume":"3","author":"Bankar","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.bidere.2026.100086_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fchem.2019.00326","volume":"7","author":"Rosi","year":"2019","journal-title":"Front. Chem."},{"issue":"16","key":"10.1016\/j.bidere.2026.100086_bib12","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1073\/pnas.1200074109","volume":"109","author":"Lan","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.bidere.2026.100086_bib13","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/biot.200700168","volume":"2","author":"D\u00fcrre","year":"2007","journal-title":"Biotechnol. J."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1196\/annals.1419.009","volume":"1125","author":"D\u00fcrre","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bidere.2026.100086_bib15","volume":"160","author":"Chen","year":"2024","journal-title":"J. Taiwan Inst. Chem. Eng."},{"issue":"3","key":"10.1016\/j.bidere.2026.100086_bib16","doi-asserted-by":"crossref","first-page":"fnw001","DOI":"10.1093\/femsle\/fnw001","volume":"363","author":"Moon","year":"2016","journal-title":"FEMS Microbiol. Lett."},{"issue":"2","key":"10.1016\/j.bidere.2026.100086_bib17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1042\/BST20211009","volume":"50","author":"Abdelaal","year":"2022","journal-title":"Biochem. Soc. Trans."},{"issue":"6","key":"10.1016\/j.bidere.2026.100086_bib18","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00253-007-1257-5","volume":"77","author":"Inui","year":"2008","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4-5","key":"10.1016\/j.bidere.2026.100086_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ymben.2009.05.003","volume":"11","author":"Nielsen","year":"2009","journal-title":"Metab. Eng."},{"issue":"2","key":"10.1016\/j.bidere.2026.100086_bib20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00253-010-2480-z","volume":"87","author":"Berezina","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"6","key":"10.1016\/j.bidere.2026.100086_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ymben.2008.08.001","volume":"10","author":"Shen","year":"2008","journal-title":"Metab. Eng."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13068-019-1565-x","volume":"12","author":"Ferreira","year":"2019","journal-title":"Biotechnol. Biofuels"},{"issue":"9","key":"10.1016\/j.bidere.2026.100086_bib23","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/AEM.03034-10","volume":"77","author":"Shen","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"issue":"7174","key":"10.1016\/j.bidere.2026.100086_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature06450","volume":"451","author":"Atsumi","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib25","volume":"6","author":"Shi","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12934-020-01337-w","volume":"19","author":"Nawab","year":"2020","journal-title":"Microb. Cell Fact."},{"issue":"12","key":"10.1016\/j.bidere.2026.100086_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11274-021-03173-5","volume":"37","author":"Li","year":"2021","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"9","key":"10.1016\/j.bidere.2026.100086_bib28","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1039\/C9EE01214A","volume":"12","author":"Liu","year":"2019","journal-title":"Energy Environ. Sci."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib29","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1038\/s41467-025-59753-8","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.bidere.2026.100086_bib30","volume":"3","author":"El-Shemy","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bidere.2026.100086_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.34133\/bdr.0048","volume":"6","author":"Wu","year":"2024","journal-title":"BioDesign Res."},{"issue":"7","key":"10.1016\/j.bidere.2026.100086_bib32","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/asia.201901680","volume":"15","author":"Liu","year":"2020","journal-title":"Chem. Asian J."},{"issue":"38","key":"10.1016\/j.bidere.2026.100086_bib33","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1021\/acs.jafc.1c03960","volume":"69","author":"Fu","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"16","key":"10.1016\/j.bidere.2026.100086_bib34","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1007\/s00253-017-8386-2","volume":"101","author":"Lin","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"10","key":"10.1016\/j.bidere.2026.100086_bib35","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1128\/AEM.66.10.4440-4448.2000","volume":"66","author":"Taroncher-Oldenburg","year":"2000","journal-title":"Appl. Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nbt0197-63","volume":"15","author":"Sim","year":"1997","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.bidere.2026.100086_bib37","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nbt1244","volume":"24","author":"Pohlmann","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"9","key":"10.1016\/j.bidere.2026.100086_bib38","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1039\/c3ee41405a","volume":"6","author":"Lan","year":"2013","journal-title":"Energy Environ. Sci."},{"issue":"8","key":"10.1016\/j.bidere.2026.100086_bib39","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.febslet.2007.03.013","volume":"581","author":"Tucci","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bidere.2026.100086_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.biortech.2017.09.024","volume":"245","author":"Wang","year":"2017","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib41","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bidere.2026.100086_bib42","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00253-007-1063-0","volume":"76","author":"Liu","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"9","key":"10.1016\/j.bidere.2026.100086_bib43","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1007\/s00253-019-09707-0","volume":"103","author":"Guevara-Mart\u00ednez","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bidere.2026.100086_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.128911","volume":"376","author":"Islam","year":"2023","journal-title":"Bioresour. Technol."},{"issue":"7360","key":"10.1016\/j.bidere.2026.100086_bib45","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature10333","volume":"476","author":"Dellomonaco","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bidere.2026.100086_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.129814","volume":"389","author":"Islam","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.bidere.2026.100086_bib47","author":"Chen","year":"2026","journal-title":"Adv. Sci."},{"issue":"18","key":"10.1016\/j.bidere.2026.100086_bib48","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1007\/s00253-018-9153-8","volume":"102","author":"Mart\u00ednez-Tob\u00f3n","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.bidere.2026.100086_bib49","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nbt.3485","volume":"34","author":"Choi","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.bidere.2026.100086_bib50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cels.2016.07.012","volume":"3","author":"Lo","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.bidere.2026.100086_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jbiotec.2020.06.008","volume":"320","author":"Vasylkivska","year":"2020","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bidere.2026.100086_bib52","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.copbio.2015.02.010","volume":"33","author":"Cray","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"issue":"3","key":"10.1016\/j.bidere.2026.100086_bib53","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.biotechadv.2017.12.004","volume":"36","author":"Patakova","year":"2018","journal-title":"Biotechnol. Adv."},{"issue":"4","key":"10.1016\/j.bidere.2026.100086_bib54","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11274-016-2022-7","volume":"32","author":"Li","year":"2016","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib55","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/msb.2010.98","volume":"6","author":"Atsumi","year":"2010","journal-title":"Mol. Syst. Biol."},{"issue":"19","key":"10.1016\/j.bidere.2026.100086_bib56","doi-asserted-by":"crossref","first-page":"8399","DOI":"10.1007\/s00253-014-6004-0","volume":"98","author":"Yuan","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"11","key":"10.1016\/j.bidere.2026.100086_bib57","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11274-018-2542-4","volume":"34","author":"Horinouchi","year":"2018","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.bidere.2026.100086_bib58","volume":"12","author":"Tian","year":"2019","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.bidere.2026.100086_bib59","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fbioe.2018.00122","volume":"6","author":"Otoupal","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bidere.2026.100086_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.seppur.2016.12.008","volume":"177","author":"Patra\u015fcu","year":"2017","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.bidere.2026.100086_bib61","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.biortech.2016.07.060","volume":"218","author":"Lee","year":"2016","journal-title":"Bioresour. Technol."}],"container-title":["BioDesign Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2693125726000166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2693125726000166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:05:49Z","timestamp":1793945149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2693125726000166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2693125726000166"],"URL":"https:\/\/doi.org\/10.1016\/j.bidere.2026.100086","relation":{},"ISSN":["2693-1257"],"issn-type":[{"value":"2693-1257","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced growth of 1-butanol producing Escherichia coli via a metabolic buffer","name":"articletitle","label":"Article Title"},{"value":"BioDesign Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bidere.2026.100086","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Nanjing Agricultural University.","name":"copyright","label":"Copyright"}],"article-number":"100086"}}