{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:51:29Z","timestamp":1793379089547,"version":"4.5.0"},"reference-count":159,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.bioactmat.2020.12.010","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T05:45:30Z","timestamp":1608961530000},"page":"1973-1987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":400,"title":["The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment"],"prefix":"10.1016","volume":"6","author":[{"given":"Muyue","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-7503","authenticated-orcid":false,"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2020.12.010_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","article-title":"Tumor microenvironment and therapeutic response","volume":"387","author":"Wu","year":"2017","journal-title":"Canc. Lett."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-3-319-78127-3_6","article-title":"Stromal cells in the tumor microenvironment","volume":"1060","author":"Denton","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib3","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.7150\/ijbs.25720","article-title":"Effect of stromal cells in tumor microenvironment on metastasis initiation","volume":"14","author":"Guo","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib4","doi-asserted-by":"crossref","first-page":"a026781","DOI":"10.1101\/cshperspect.a026781","article-title":"Tumor microenvironment and differential responses to therapy","volume":"7","author":"Hirata","year":"2017","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib5","doi-asserted-by":"crossref","first-page":"11740","DOI":"10.1021\/acsnano.8b05893","article-title":"Nanoparticle-mediated remodeling of the tumor microenvironment to enhance immunotherapy","volume":"12","author":"Musetti","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib6","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/acs.biomac.8b00460","article-title":"Nanoparticle-based phototriggered cancer immunotherapy and its domino effect in the tumor microenvironment","volume":"19","author":"Rajendrakumar","year":"2018","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib7","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.1016\/j.semcancer.2015.02.007","article-title":"Cancer prevention and therapy through the modulation of the tumor microenvironment","volume":"35","author":"Casey","year":"2015","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib8","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1002\/jcb.26005","article-title":"Targeting immunotherapy to the tumor microenvironment","volume":"118","author":"Dougan","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib9","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1182\/blood-2011-10-383406","article-title":"A phase 1\/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia","volume":"119","author":"Uy","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/JTO.0000000000000193","article-title":"Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer","volume":"9","author":"Song","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1365-2141.2011.08864.x","article-title":"The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications","volume":"155","author":"Podar","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib12","doi-asserted-by":"crossref","first-page":"113287","DOI":"10.18632\/oncotarget.22938","article-title":"Microsatellite stability and mismatch repair proficiency in nasopharyngeal carcinoma may not predict programmed death-1 blockade resistance","volume":"8","author":"Liao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib13","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","article-title":"PD-1 blockade in tumors with mismatch-repair deficiency","volume":"372","author":"Le","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1200\/JCO.2017.35.4_suppl.TPS815","article-title":"KEYNOTE-177: randomized phase III study of pembrolizumab versus investigator-choice chemotherapy for mismatch repair-deficient or microsatellite instability-high metastatic colorectal carcinoma","volume":"35","author":"Overman","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib16","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/annonc\/mdu441","article-title":"Survival follow-up and ipilimumab retreatment of patients with advanced melanoma who received ipilimumab in prior phase II studies","volume":"25","author":"Lebb\u00e9","year":"2014","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib17","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1200\/JCO.2014.58.3708","article-title":"Overall survival and long-term safety of Nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer","volume":"33","author":"Gettinger","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.biomaterials.2017.10.024","article-title":"Overcoming obstacles in the tumor microenvironment: recent advancements in nanoparticle delivery for cancer theranostics","volume":"156","author":"Overchuk","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib19","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura","year":"1986","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib20","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1158\/0008-5472.CAN-12-4561","article-title":"Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology","volume":"73","author":"Prabhakar","year":"2013","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phrs.2017.05.004","article-title":"Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy","volume":"126","author":"Yang","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tips.2017.10.009","article-title":"Remodeling the tumor microenvironment with emerging nanotherapeutics","volume":"39","author":"Chen","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2018.03.044","article-title":"Nanoparticles designed to regulate tumor microenvironment for cancer therapy","volume":"201","author":"Li","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.phrs.2017.05.010","article-title":"Exploring the potential of nanotherapeutics in targeting tumor microenvironment for cancer therapy","volume":"126","author":"Muntimadugu","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2012.03.020","article-title":"Doxil\u00ae--the first FDA-approved nano-drug: lessons learned","volume":"160","author":"Barenholz","year":"2012","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib26","first-page":"99","article-title":"Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer","volume":"4","author":"Miele","year":"2009","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib27","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s12026-017-8931-1","article-title":"Dendritic cell-based immunotherapy: a basic review and recent advances","volume":"65","author":"Constantino","year":"2017","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.it.2016.09.006","article-title":"Dendritic cells and cancer immunity","volume":"37","author":"Gardner","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib29","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1158\/0008-5472.CAN-10-1439","article-title":"Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression","volume":"70","author":"Doedens","year":"2010","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature13490","article-title":"Functional polarization of tumour-associated macrophages by tumour-derived lactic acid","volume":"513","author":"Colegio","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jconrel.2012.05.010","article-title":"Targeting tumor antigens to dendritic cells using particulate carriers","volume":"161","author":"Joshi","year":"2012","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib32","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.vaccine.2009.10.153","article-title":"Targeting the tumor microenvironment with anti-neu\/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses","volume":"28","author":"Dominguez","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.biomaterials.2014.10.053","article-title":"CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses","volume":"40","author":"Rosalia","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jconrel.2014.07.040","article-title":"Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study","volume":"192","author":"Cruz","year":"2014","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib35","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00262-017-2079-7","article-title":"BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma","volume":"67","author":"Liu","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib36","doi-asserted-by":"crossref","first-page":"6918","DOI":"10.1021\/acsnano.5b01042","article-title":"Erythrocyte membrane-enveloped polymeric nanoparticles as nanovaccine for induction of antitumor immunity against melanoma","volume":"9","author":"Guo","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib37","doi-asserted-by":"crossref","first-page":"119464","DOI":"10.1016\/j.biomaterials.2019.119464","article-title":"Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma","volume":"223","author":"Luo","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib38","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nnano.2017.113","article-title":"Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy","volume":"12","author":"Min","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2017.09.029","article-title":"Liposomes-coated gold nanocages with antigens and adjuvants targeted delivery to dendritic cells for enhancing antitumor immune response","volume":"149","author":"Liang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","article-title":"Macrophages as regulators of tumour immunity and immunotherapy","volume":"19","author":"DeNardo","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib42","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrclinonc.2017.101","article-title":"The immune contexture in cancer prognosis and treatment","volume":"14","author":"Fridman","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.coi.2010.01.009","article-title":"Macrophages, innate immunity and cancer: balance, tolerance, and diversity","volume":"22","author":"Mantovani","year":"2010","journal-title":"Curr. Opin. Immunol."},{"issue":"2016","key":"10.1016\/j.bioactmat.2020.12.010_bib44","first-page":"6058147","article-title":"Tumor-associated macrophages and neutrophils in tumor microenvironment","author":"Kim","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib45","doi-asserted-by":"crossref","first-page":"14293","DOI":"10.1038\/ncomms14293","article-title":"Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging","volume":"8","author":"Cuccarese","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.it.2015.02.004","article-title":"Macrophages and cancer: from mechanisms to therapeutic implications","volume":"36","author":"Ostuni","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ccr.2013.02.013","article-title":"Macrophage regulation of tumor responses to anticancer therapies","volume":"23","author":"Palma","year":"2013","journal-title":"Canc. Cell"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.semcancer.2008.03.004","article-title":"Macrophage polarization in tumour progression","volume":"18","author":"Sica","year":"2008","journal-title":"Semin. Canc. Biol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib49","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib50","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1172\/JCI31422","article-title":"Altered macrophage differentiation and immune dysfunction in tumor development","volume":"117","author":"Sica","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib51","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2017.04.010","article-title":"Progress in tumor-associated macrophage (TAM)-targeted therapeutics","volume":"114","author":"Ngambenjawong","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib52","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/nnano.2016.168","article-title":"Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues","volume":"11","author":"Zanganeh","year":"2016","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib53","doi-asserted-by":"crossref","first-page":"12553","DOI":"10.1021\/acsnano.9b03288","article-title":"Amplified cancer immunotherapy of a surface-engineered antigenic microparticle vaccine by synergistically modulating tumor microenvironment","volume":"13","author":"Zhao","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib54","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1039\/C7SC04853J","article-title":"Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy","volume":"9","author":"Zhao","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib55","doi-asserted-by":"crossref","first-page":"42566","DOI":"10.1021\/acsami.7b13594","article-title":"A dual macrophage targeting nanovector for delivery of oligodeoxynucleotides to overcome cancer-associated immunosuppression","volume":"9","author":"He","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib56","doi-asserted-by":"crossref","first-page":"12096","DOI":"10.1021\/acsnano.8b05292","article-title":"Cell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth","volume":"12","author":"Deng","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib57","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1021\/acsnano.7b05465","article-title":"Molecular-targeted immunotherapeutic strategy for melanoma via dual-targeting nanoparticles delivering small interfering RNA to tumor-associated macrophages","volume":"11","author":"Qian","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib58","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3389\/fimmu.2017.01454","article-title":"Bruton's tyrosine kinase: an emerging key player in innate immunity","volume":"8","author":"Weber","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.actbio.2019.05.030","article-title":"Targeted delivery of ibrutinib to tumor-associated macrophages by sialic acid-stearic acid conjugate modified nanocomplexes for cancer immunotherapy","volume":"92","author":"Qiu","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib60","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/acs.bioconjchem.8b00068","article-title":"Enhanced cellular ablation by attenuating hypoxia status and reprogramming tumor-associated macrophages via NIR light-responsive upconversion nanocrystals","volume":"29","author":"Ai","year":"2018","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib61","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.it.2019.02.003","article-title":"Targeting tumor-associated macrophages in cancer","volume":"40","author":"Pathria","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib62","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib63","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/acsnano.5b06779","article-title":"Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and attenuating tumor hypoxia","volume":"10","author":"Song","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib64","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib65","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fcell.2018.00131","article-title":"Macrophages and fibroblasts, key players in cancer chemoresistance","volume":"6","author":"Ireland","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib66","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib67","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.yexcr.2010.04.032","article-title":"Activation of fibroblasts in cancer stroma","volume":"316","author":"R\u00e4s\u00e4nen","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib68","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.addr.2015.07.007","article-title":"Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment","volume":"99","author":"Ishii","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib69","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.3748\/wjg.v22.i30.6841","article-title":"Cancer-associated fibroblasts in hepatocellular carcinoma","volume":"22","author":"Kubo","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib70","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13058-016-0740-2","article-title":"Tumor-associated stromal cells as key contributors to the tumor microenvironment","volume":"18","author":"Bussard","year":"2016","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib71","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1002\/anie.201403036","article-title":"Engineered nanoparticles for drug delivery in cancer therapy","volume":"53","author":"Sun","year":"2014","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib72","first-page":"623","article-title":"Tumor-associated fibroblasts (part II): functional impact on tumor tissue","volume":"17","author":"Kunz-Schughart","year":"2002","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib73","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1016\/j.biomaterials.2010.12.056","article-title":"Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions","volume":"32","author":"Alili","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib74","doi-asserted-by":"crossref","first-page":"530957","DOI":"10.1155\/2015\/530957","article-title":"Effect of Fe3O4 nanoparticles on skin tumor cells and dermal fibroblasts","volume":"2015","author":"Alili","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.09.031","article-title":"Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo","volume":"290","author":"Mardhian","year":"2018","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib76","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/anie.201506262","article-title":"Transformable peptide nanocarriers for expeditious drug release and effective cancer therapy via cancer-associated fibroblast activation","volume":"55","author":"Ji","year":"2016","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib77","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.nano.2015.10.001","article-title":"A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts","volume":"12","author":"Chen","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib78","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3390\/ijms20061263","article-title":"Nano-strategies to target breast cancer-associated fibroblasts: rearranging the tumor microenvironment to achieve antitumor efficacy","volume":"20","author":"Truffi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib79","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1021\/acs.nanolett.6b04150","article-title":"Protein nanocage mediated fibroblast-activation protein targeted photoimmunotherapy to enhance cytotoxic T cell infiltration and tumor control","volume":"17","author":"Zhen","year":"2017","journal-title":"Nano Lett."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib80","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/acs.molpharmaceut.8b00419","article-title":"Photosensitizer-encapsulated ferritins mediate photodynamic therapy against cancer-associated fibroblasts and improve tumor accumulation of nanoparticles","volume":"15","author":"Li","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib81","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib82","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ijc.30067","article-title":"Tumour angiogenesis-origin of blood vessels","volume":"139","author":"Krishna Priya","year":"2016","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib83","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nm0603-685","article-title":"Molecular regulation of vessel maturation","volume":"9","author":"Jain","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib84","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc.2017.51","article-title":"Microenvironmental regulation of tumour angiogenesis","volume":"17","author":"De Palma","year":"2017","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib85","first-page":"5879","article-title":"Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia","volume":"60","author":"Maity","year":"2000","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib86","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-\u03b21: tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12307-012-0102-2","article-title":"Pericytes on the tumor vasculature: jekyll or hyde?","volume":"6","author":"Barlow","year":"2013","journal-title":"Canc. Microenviron."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib88","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri.2017.145","article-title":"Improving immune-vascular crosstalk for cancer immunotherapy","volume":"18","author":"Huang","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib89","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrc1456","article-title":"High interstitial fluid pressure-an obstacle in cancer therapy","volume":"4","author":"Heldin","year":"2004","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib90","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fonc.2013.00211","article-title":"Vascular permeability and drug delivery in cancers","volume":"3","author":"Azzi","year":"2013","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib91","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3389\/fonc.2019.01227","article-title":"Nanoparticle delivery and tumor vascular normalization: the chicken or the egg?","volume":"9","author":"Mattheolabakis","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib92","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.nano.2011.01.011","article-title":"Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge","volume":"7","author":"Arvizo","year":"2011","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib93","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijpharm.2017.07.085","article-title":"Sequential delivery of erlotinib and doxorubicin for enhanced triple negative Breast cancer treatment using polymeric nanoparticle","volume":"530","author":"Zhou","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib94","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biomaterials.2017.09.021","article-title":"Tumor vasculature normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy","volume":"148","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib95","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1039\/C8BM01350K","article-title":"Attempts to strengthen and simplify the tumor vascular normalization strategy using tumor vessel normalization promoting nanomedicines","volume":"7","author":"Du","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib96","doi-asserted-by":"crossref","first-page":"1802070","DOI":"10.1002\/advs.201802070","article-title":"Therapeutic remodeling of the tumor microenvironment enhances nanoparticle delivery","volume":"6","author":"Chen","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib97","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.18632\/oncotarget.14260","article-title":"Combining vasculature disrupting agent and Toll-like receptor 7\/8 agonist for cancer therapy","volume":"8","author":"Seth","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib98","first-page":"173692","article-title":"Vascular disrupting agents in cancer therapy","author":"Smolarczyk","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib99","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0014-4827(80)90051-8","article-title":"Endothelial cell phagokinesis in response to specific metal ions","volume":"130","author":"McAuslan","year":"1980","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib100","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biomaterials.2019.01.007","article-title":"Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer","volume":"195","author":"Zhou","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib101","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrc3581","article-title":"History of myeloid-derived suppressor cells","volume":"13","author":"Talmadge","year":"2013","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib102","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1189\/jlb.5VMR1116-493R","article-title":"Myeloid-derived suppressor cells and T regulatory cells in tumors: unraveling the dark side of the force","volume":"102","author":"Hatziioannou","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib103","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/cmi.2017.35","article-title":"B cell regulation in cancer and anti-tumor immunity","volume":"14","author":"Sarvaria","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib104","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124507","article-title":"Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy","volume":"3","author":"Fransen","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib105","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s00262-019-02330-y","article-title":"Unlocking the therapeutic potential of primary tumor-draining lymph nodes","volume":"68","author":"Rotman","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib106","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.4049\/jimmunol.173.5.3148","article-title":"Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors","volume":"173","author":"Fifis","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib107","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1021\/nn502975r","article-title":"Nanogel-based immunologically stealth vaccine targets macrophages in the medulla of lymph node and induces potent antitumor immunity","volume":"8","author":"Muraoka","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib108","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2017.04.024","article-title":"Effects of gold nanoparticle-based vaccine size on lymph node delivery and cytotoxic T-lymphocyte responses","volume":"256","author":"Kang","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib109","doi-asserted-by":"crossref","first-page":"6131","DOI":"10.2147\/IJN.S140772","article-title":"Gold nanoparticles enlighten the future of cancer theranostics","volume":"12","author":"Guo","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib110","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1158\/2326-6066.CIR-14-0019-T","article-title":"Enhancing efficacy of anticancer vaccines by targeted delivery to tumor-draining lymph nodes","volume":"2","author":"Jeanbart","year":"2014","journal-title":"Canc. Immunol. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib111","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biomaterials.2018.02.034","article-title":"Polymeric nanoparticles encapsulating novel TLR7\/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy","volume":"164","author":"Kim","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib112","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41563-018-0147-9","article-title":"Biomaterial-assisted targeted modulation of immune cells in cancer treatment","volume":"17","author":"Wang","year":"2018","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib113","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/08830180305221","article-title":"Tumor-associated antigens: from discovery to immunity","volume":"22","author":"Lewis","year":"2003","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib114","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2018.02.033","article-title":"Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality","volume":"164","author":"Kang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib115","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41467-020-14906-9","article-title":"Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib116","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nri.2017.103","article-title":"Regulation of immunity and inflammation by hypoxia in immunological niches","volume":"17","author":"Taylor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib117","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature10169","article-title":"Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells","volume":"475","author":"Facciabene","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib118","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1158\/0008-5472.CAN-10-1439","article-title":"Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression","volume":"70","author":"Doedens","year":"2010","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib119","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1084\/jem.20100587","article-title":"HIF-1\u03b1 regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment","volume":"207","author":"Corzo","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib120","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1158\/0008-5472.CAN-13-0992","article-title":"A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells","volume":"74","author":"Barsoum","year":"2014","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib121","doi-asserted-by":"crossref","first-page":"51210","DOI":"10.18632\/oncotarget.17214","article-title":"PD-1 and PD-L1 expression in 132 recurrent nasopharyngeal carcinoma: the correlation with anemia and outcomes","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib122","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ijc.30077","article-title":"PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma","volume":"139","author":"Ruf","year":"2016","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib123","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1073\/pnas.1700600114","article-title":"Metabolic origins of spatial organization in the tumor microenvironment","volume":"114","author":"Carmona-Fontaine","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib124","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jconrel.2017.03.013","article-title":"Exploiting the cancer niche: tumor-associated macrophages and hypoxia as promising synergistic targets for nano-based therapy","volume":"253","author":"Silva","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib125","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1002\/adma.201601902","article-title":"Intelligent albumin-MnO2 nanoparticles as pH-\/H2O2-responsive dissociable nanocarriers to modulate tumor hypoxia for effective combination therapy [published correction appears in Adv Mater. 2018 Feb;30(8):]","volume":"28","author":"Chen","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib126","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41467-017-01050-0","article-title":"Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib127","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1021\/acsnano.8b07045","article-title":"Hypoxia-triggered transforming immunomodulator for cancer immunotherapy via photodynamically enhanced antigen presentation of dendritic cell","volume":"13","author":"Im","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib128","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mrrev.2010.01.002","article-title":"Enhancement of radiation effect by heavy elements","volume":"704","author":"Kobayashi","year":"2010","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib129","doi-asserted-by":"crossref","first-page":"685308","DOI":"10.1155\/2013\/685308","article-title":"Microenvironment and radiation therapy","volume":"2013","author":"Yoshimura","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/adma.201701429","article-title":"Erythrocyte-membrane-enveloped perfluorocarbon as nanoscale artificial red blood cells to relieve tumor hypoxia and enhance cancer radiotherapy","volume":"29","author":"Gao","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib131","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1002\/adma.201504617","article-title":"Perfluorocarbon-loaded hollow Bi2Se3 nanoparticles for timely supply of oxygen under near-infrared light to enhance the radiotherapy of cancer","volume":"28","author":"Song","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib132","first-page":"1","article-title":"Perfluorocarbon-based oxygen carriers: from physics to physiology","volume":"3","author":"J\u00e4gers","year":"2020","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib133","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biomaterials.2016.10.020","article-title":"TaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapy","volume":"112","author":"Song","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib134","doi-asserted-by":"crossref","first-page":"16971","DOI":"10.1021\/jacs.8b11593","article-title":"Nanoscale metal-organic layers for radiotherapy-radiodynamic therapy","volume":"140","author":"Lan","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib135","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1038\/s41467-018-06655-7","article-title":"Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy","volume":"9","author":"Ni","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib136","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1038\/s41467-018-04703-w","article-title":"Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy","volume":"9","author":"Ni","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib137","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41551-018-0203-4","article-title":"Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy","volume":"2","author":"Lu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib138","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.trecan.2016.10.016","article-title":"Hypoxia-inducible factors: master regulators of cancer progression","volume":"2","author":"Schito","year":"2016","journal-title":"Trends Canc."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib139","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cardiores.2005.09.019","article-title":"Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells","volume":"69","author":"Wu","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib140","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000104457","article-title":"Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics","volume":"53","author":"Airley","year":"2007","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib141","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.intimp.2018.02.021","article-title":"Gold-manganese oxide nanocomposite suppresses hypoxia and augments pro-inflammatory cytokines in tumor associated macrophages","volume":"57","author":"Nath","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib142","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jconrel.2015.08.050","article-title":"Stimuli-responsive nanoparticles for targeting the tumor microenvironment","volume":"219","author":"Du","year":"2015","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib143","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.biotechadv.2013.08.002","article-title":"Tumor extracellular acidity-activated nanoparticles as drug delivery systems for enhanced cancer therapy","volume":"32","author":"Du","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib144","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jconrel.2007.12.017","article-title":"A review of stimuli-responsive nanocarriers for drug and gene delivery","volume":"126","author":"Ganta","year":"2008","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib145","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.ccr.2013.03.007","article-title":"Coordination bonding based pH-responsive drug delivery systems","volume":"257","author":"Zheng","year":"2013","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib146","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.addr.2013.09.008","article-title":"Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers","volume":"66","author":"Li","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib147","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1021\/acs.accounts.0c00475","article-title":"Nano-immune-engineering approaches to advance cancer immunotherapy: lessons from ultra-pH-sensitive nanoparticles","volume":"53","author":"Li","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib148","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1002\/anie.200907210","article-title":"A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery","volume":"49","author":"Du","year":"2010","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib149","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1002\/adma.201202296","article-title":"Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor","volume":"24","author":"Yuan","year":"2012","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib150","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/adhm.201300549","article-title":"Smart pH-responsive nanocarriers based on nano-graphene oxide for combined chemo-and photothermal therapy overcoming drug resistance","volume":"3","author":"Feng","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib151","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1002\/adfm.201202992","article-title":"Imaging-guided pH-sensitive photodynamic therapy using charge reversible upconversion nanoparticles under near-infrared light","volume":"23","author":"Wang","year":"2013","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib152","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.1522080113","article-title":"Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib153","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1002\/adfm.201501248","article-title":"Multistage nanovehicle delivery system based on stepwise size reduction and charge reversal for programmed nuclear targeting of systemically administered anticancer drugs","volume":"25","author":"Li","year":"2015","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib154","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biomaterials.2016.09.025","article-title":"CaCO3 nanoparticles as an ultra-sensitive tumor-pH-responsive nanoplatform enabling real-time drug release monitoring and cancer combination therapy","volume":"110","author":"Dong","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2004.11.015","article-title":"Drug-incorporating calcium carbonate nanoparticles for a new delivery system","volume":"103","author":"Ueno","year":"2005","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib156","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/anie.201408510","article-title":"A preloaded amorphous calcium carbonate\/doxorubicin@ silica nanoreactor for pH-responsive delivery of an anticancer drug","volume":"54","author":"Zhao","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib157","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1021\/acsnano.5b06175","article-title":"Ultrasound-induced reactive oxygen species mediated therapy and imaging using a fenton reaction activable polymersome","volume":"10","author":"Li","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2020.12.010_bib158","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/anie.201510031","article-title":"Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized fenton reaction","volume":"55","author":"Zhang","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioactmat.2020.12.010_bib159","doi-asserted-by":"crossref","first-page":"17157","DOI":"10.1039\/C9NR05371A","article-title":"The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective","volume":"11","author":"Li","year":"2019","journal-title":"Nanoscale"}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X20303352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X20303352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:54:34Z","timestamp":1762530874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X20303352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":159,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S2452199X20303352"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2020.12.010","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2020.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}