{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:45:26Z","timestamp":1788050726369,"version":"build-2784847793"},"reference-count":47,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472077"],"award-info":[{"award-number":["81472077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672238"],"award-info":[{"award-number":["81672238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873990"],"award-info":[{"award-number":["81873990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873991"],"award-info":[{"award-number":["81873991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072425"],"award-info":[{"award-number":["82072425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072498"],"award-info":[{"award-number":["82072498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180001"],"award-info":[{"award-number":["BK20180001"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bioactmat.2021.02.039","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T05:05:55Z","timestamp":1616216755000},"page":"3343-3357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3\u03b2\/\u03b2-catenin signalling pathway"],"prefix":"10.1016","volume":"6","author":[{"given":"Kai","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-5563","authenticated-orcid":false,"given":"Jiaxiang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-7483","authenticated-orcid":false,"given":"Gaoran","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-8387","authenticated-orcid":false,"given":"Chen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-2803","authenticated-orcid":false,"given":"Dechun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bioactmat.2021.02.039_bib1","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.arth.2013.07.024","article-title":"Why are total knee arthroplasties failing today-has anything changed after 10 years?","volume":"29","author":"Sharkey","year":"2014","journal-title":"J. Arthroplasty"},{"key":"10.1016\/j.bioactmat.2021.02.039_bib2","series-title":"Hip, Knee & Shoulder Arthroplasty: 2019 Annual Report","first-page":"1","year":"2019"},{"issue":"9","key":"10.1016\/j.bioactmat.2021.02.039_bib3","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.arth.2017.03.066","article-title":"Current epidemiology of revision total knee arthroplasty in the United States","volume":"32","author":"Delanois","year":"2017","journal-title":"J. Arthroplasty"},{"issue":"34","key":"10.1016\/j.bioactmat.2021.02.039_bib4","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1016\/j.biomaterials.2007.06.035","article-title":"Wear particles, periprosthetic osteolysis and the immune system","volume":"28","author":"Goodman","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.02.039_bib5","first-page":"55","article-title":"Curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization in vitro and in vivo","volume":"8","author":"Li","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.02.039_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbrc.2016.03.065","article-title":"Autophagy mediated TiAl(6)V(4) particle-induced peri-implant osteolysis by promoting expression of TNF-alpha","volume":"473","author":"Liu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.02.039_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jor.1100140318","article-title":"Bone formation and bone resorption in failed total joint arthroplasties: histomorphometric analysis with histochemical and immunohistochemical technique","volume":"14","author":"Kadoya","year":"1996","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.02.039_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0736-0266(03)00156-6","article-title":"NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis","volume":"22","author":"Clohisy","year":"2004","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.02.039_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00264-014-2596-3","article-title":"Inhibitory effects of triptolide on titanium particle-induced osteolysis and receptor activator of nuclear factor-kappaB ligand-mediated osteoclast differentiation","volume":"39","author":"Kim","year":"2015","journal-title":"Int. Orthop."},{"issue":"32","key":"10.1016\/j.bioactmat.2021.02.039_bib10","doi-asserted-by":"crossref","first-page":"8937","DOI":"10.1016\/j.biomaterials.2014.06.055","article-title":"The prevention of titanium-particle-induced osteolysis by OA-14 through the suppression of the p38 signaling pathway and inhibition of osteoclastogenesis","volume":"35","author":"Tian","year":"2014","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.bioactmat.2021.02.039_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s40266-018-0525-7","article-title":"Denosumab: a review in postmenopausal osteoporosis","volume":"35","author":"Deeks","year":"2018","journal-title":"Drugs Aging"},{"issue":"8","key":"10.1016\/j.bioactmat.2021.02.039_bib12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"38","key":"10.1016\/j.bioactmat.2021.02.039_bib13","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib14","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1089\/ars.2011.4173","article-title":"Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation","volume":"16","author":"Leuner","year":"2012","journal-title":"Antioxidants Redox Signal."},{"issue":"21","key":"10.1016\/j.bioactmat.2021.02.039_bib15","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.4161\/cc.6.21.4866","article-title":"SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways","volume":"6","author":"Allison","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bioactmat.2021.02.039_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/srep22511","article-title":"Sirtuin 3 (SIRT3) maintains bone homeostasis by regulating AMPK-PGC-1beta axis in mice","volume":"6","author":"Huh","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.02.039_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jbmr.2974","article-title":"SOD2 and Sirt3 control osteoclastogenesis by regulating mitochondrial ROS","volume":"32","author":"Kim","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.02.039_bib18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7150\/ijbs.17053","article-title":"Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1a-SOD2-mediated regulation of mitochondrial function","volume":"13","author":"Ding","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib19","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.02.039_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"7381","key":"10.1016\/j.bioactmat.2021.02.039_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bioactmat.2021.02.039_bib22","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1172\/JCI93356","article-title":"Inflammatory osteolysis: a conspiracy against bone","volume":"127","author":"Mbalaviele","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.02.039_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jor.22190","article-title":"Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation","volume":"31","author":"Burton","year":"2013","journal-title":"J. Orthop. Res."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib24","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1172\/JCI83260","article-title":"Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects","volume":"125","author":"Traba","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.bioactmat.2021.02.039_bib25","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.biomaterials.2009.11.069","article-title":"Protection against titanium particle induced osteolysis by cannabinoid receptor 2 selective antagonist","volume":"31","author":"Geng","year":"2010","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.bioactmat.2021.02.039_bib26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.arcmed.2010.10.002","article-title":"Effect of fluid shear stress on cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells","volume":"41","author":"Huang","year":"2010","journal-title":"Arch. Med. Res."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8122091","article-title":"Periprosthetic osteolysis: mechanisms, prevention and treatment","volume":"8","author":"Goodman","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bioactmat.2021.02.039_bib28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.blo.0000238813.95035.1b","article-title":"The cellular and molecular biology of periprosthetic osteolysis","volume":"454","author":"Purdue","year":"2007","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"36","key":"10.1016\/j.bioactmat.2021.02.039_bib29","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1016\/j.biomaterials.2006.08.023","article-title":"Effects of orthopaedic wear particles on osteoprogenitor cells","volume":"27","author":"Goodman","year":"2006","journal-title":"Biomaterials"},{"issue":"13","key":"10.1016\/j.bioactmat.2021.02.039_bib30","doi-asserted-by":"crossref","first-page":"R569","DOI":"10.1016\/j.cub.2015.05.012","article-title":"Sirtuins and the metabolic hurdles in cancer","volume":"25","author":"German","year":"2015","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.02.039_bib31","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2016.10.016","article-title":"Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization","volume":"167","author":"Yang","year":"2016","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bioactmat.2021.02.039_bib32","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/15548627.2015.1052208","article-title":"SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin","volume":"11","author":"Pi","year":"2015","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/j.bioactmat.2021.02.039_bib33","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.tem.2015.06.001","article-title":"SIRT3 regulates progression and development of diseases of aging","volume":"26","author":"McDonnell","year":"2015","journal-title":"Trends Endocrinol. Metabol."},{"issue":"10","key":"10.1016\/j.bioactmat.2021.02.039_bib34","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nrc3985","article-title":"The multifaceted functions of sirtuins in cancer","volume":"15","author":"Chalkiadaki","year":"2015","journal-title":"Nat. Rev. Canc."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.02.039_bib35","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120722","article-title":"SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury","volume":"4","author":"Kurundkar","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bioactmat.2021.02.039_bib36","article-title":"Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.bioactmat.2021.02.039_bib37","first-page":"2758","article-title":"Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioactmat.2021.02.039_bib38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fnins.2018.00414","article-title":"Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats","volume":"12","author":"Zheng","year":"2018","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.02.039_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jbm.a.35581","article-title":"Lipoteichoic acid modulates inflammatory response in macrophages after phagocytosis of titanium particles through Toll-like receptor 2 cascade and inflammasomes","volume":"104","author":"Naganuma","year":"2016","journal-title":"J. Biomed. Mater. Res."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.02.039_bib40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1359\/jbmr.071002","article-title":"Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death","volume":"23","author":"McCall","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.02.039_bib41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.bbrc.2017.02.007","article-title":"NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation","volume":"484","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib42","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1359\/jbmr.070802","article-title":"Bone regeneration is regulated by wnt signaling","volume":"22","author":"Kim","year":"2007","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23123086","article-title":"l-quebrachitol promotes the proliferation, differentiation, and mineralization of MC3T3-E1 cells: involvement of the BMP-2\/Runx2\/MAPK\/Wnt\/beta-catenin signaling pathway","volume":"23","author":"Yodthong","year":"2018","journal-title":"Molecules"},{"issue":"52","key":"10.1016\/j.bioactmat.2021.02.039_bib44","doi-asserted-by":"crossref","first-page":"20764","DOI":"10.1073\/pnas.0805133106","article-title":"Regulation of bone formation by osteoclasts involves Wnt\/BMP signaling and the chemokine sphingosine-1-phosphate","volume":"105","author":"Pederson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bioactmat.2021.02.039_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.275","article-title":"Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3beta\/beta-catenin signal pathway","volume":"8","author":"Gu","year":"2017","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.bioactmat.2021.02.039_bib46","first-page":"1255","article-title":"Synergistic anti-inflammatory and osteogenic n-HA\/resveratrol\/chitosan composite microspheres for osteoporotic bone regeneration","volume":"6","author":"Li","year":"2021","journal-title":"Bioact. Mater."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.02.039_bib47","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1016\/j.jid.2019.05.017","article-title":"SIRT3 regulates macrophage-mediated inflammation in diabetic wound repair","volume":"139","author":"Boniakowski","year":"2019","journal-title":"J. Invest. Dermatol."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21001018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21001018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:54:57Z","timestamp":1762530897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21001018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2452199X21001018"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.02.039","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3\u03b2\/\u03b2-catenin signalling pathway","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.02.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}