{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:28:28Z","timestamp":1790188108534,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772320"],"award-info":[{"award-number":["81772320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFB1101501"],"award-info":[{"award-number":["2016YFB1101501"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bioactmat.2021.05.007","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T06:58:35Z","timestamp":1620975515000},"page":"4542-4557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Practical strategy to construct anti-osteosarcoma bone substitutes by loading cisplatin into 3D-printed titanium alloy implants using a thermosensitive hydrogel"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4368-2913","authenticated-orcid":false,"given":"Zehao","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhua","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-5224","authenticated-orcid":false,"given":"Jiedong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-0043","authenticated-orcid":false,"given":"Daoyang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-0758","authenticated-orcid":false,"given":"Qingguang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-8023","authenticated-orcid":false,"given":"Teng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bioactmat.2021.05.007_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3322\/caac.21219","article-title":"Childhood and adolescent cancer statistics","volume":"64","author":"Ward","year":"2014","journal-title":"Ca-Cancer J. Clin."},{"issue":"27","key":"10.1016\/j.bioactmat.2021.05.007_bib2","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1200\/JCO.2014.59.4895","article-title":"Osteosarcoma: current treatment and a collaborative pathway to success","volume":"33","author":"Isakoff","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"Suppl 20","key":"10.1016\/j.bioactmat.2021.05.007_bib3","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1097\/BRS.0000000000001819","article-title":"Evidence-based review and survey of expert opinion of reconstruction of metastatic spine tumors","volume":"41","author":"Altaf","year":"2016","journal-title":"Spine"},{"issue":"3 Suppl","key":"10.1016\/j.bioactmat.2021.05.007_bib4","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.spinee.2015.01.005","article-title":"Reoperation rates in the surgical treatment of spinal metastases","volume":"15","author":"Quraishi","year":"2015","journal-title":"Spine J."},{"issue":"10","key":"10.1016\/j.bioactmat.2021.05.007_bib5","article-title":"Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study (vol 8, pg 773, 2007)","volume":"8","author":"Berrino","year":"2007","journal-title":"Lancet Oncol."},{"issue":"7","key":"10.1016\/j.bioactmat.2021.05.007_bib6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1470-2045(10)70062-0","article-title":"Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects","volume":"11","author":"Janeway","year":"2010","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0168-3659(03)00364-X","article-title":"In vivo anti-tumor effect through the controlled release of cisplatin from biodegradable gelatin hydrogel","volume":"92","author":"Konishi","year":"2003","journal-title":"J. Contr. Release"},{"issue":"6","key":"10.1016\/j.bioactmat.2021.05.007_bib8","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1227\/00006123-199512000-00013","volume":"37","author":"Walter","year":"1995","journal-title":"Intratumoral chemotherapy, Neurosurgery"},{"issue":"2","key":"10.1016\/j.bioactmat.2021.05.007_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0167-8140(98)00134-0","article-title":"Radiosensitization by intratumoral administration of cisplatin in a sustained-release drug delivery system","volume":"50","author":"Ning","year":"1999","journal-title":"Radiother. Oncol."},{"issue":"14","key":"10.1016\/j.bioactmat.2021.05.007_bib10","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1016\/j.biomaterials.2014.02.005","article-title":"Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes","volume":"35","author":"Mei","year":"2014","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.bioactmat.2021.05.007_bib11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/jbm.a.35592","article-title":"Interplay between self-assembled structure of bone morphogenetic protein-2 (BMP-2) and osteoblast functions in three-dimensional titanium alloy scaffolds: stimulation of osteogenic activity","volume":"104","author":"Nune","year":"2016","journal-title":"J. Biomed. Mater. Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib12","first-page":"169","article-title":"3D Systems' technology overview and new applications in manufacturing, engineering, science, and education, 3d Print Addit","volume":"1","author":"Snyder","year":"2014","journal-title":"Man (Lond.)"},{"key":"10.1016\/j.bioactmat.2021.05.007_bib13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.actbio.2019.08.008","article-title":"A comparative study on the nanoindentation behavior, wear resistance and in vitro biocompatibility of SLM manufactured CP-Ti and EBM manufactured Ti64 gyroid scaffolds","volume":"97","author":"Ataee","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.msec.2016.07.045","article-title":"Corrosion resistance characteristics of a Ti-6Al-4V alloy scaffold that is fabricated by electron beam melting and selective laser melting for implantation in vivo","volume":"70","author":"Zhao","year":"2017","journal-title":"Mat. Sci. Eng. C-Mater."},{"issue":"7","key":"10.1016\/j.bioactmat.2021.05.007_bib15","article-title":"A comparison of biocompatibility of a titanium alloy fabricated by electron beam melting and selective laser melting","volume":"11","author":"Wang","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.bioactmat.2021.05.007_bib16","first-page":"94","article-title":"Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models","volume":"19","author":"Li","year":"2019","journal-title":"J. Orthop. Transl."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s13534-018-0080-5","article-title":"Design and 3D-printing of titanium bone implants: brief review of approach and clinical cases","volume":"8","author":"Popov","year":"2018","journal-title":"Biomed. Eng. Lett."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.05.007_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ocl.2018.08.009","article-title":"Additive manufacturing in total joint arthroplasty","volume":"50","author":"Narra","year":"2019","journal-title":"Orthop. Clin. N. Am."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109908","article-title":"Comparison of 3D-printed porous tantalum and titanium scaffolds on osteointegration and osteogenesis","volume":"104","author":"Wang","year":"2019","journal-title":"Mat. Sci. Eng. C-Mater."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib20","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.msec.2019.01.024","article-title":"The effect of surface topography and porosity on the tensile fatigue of 3D printed Ti-6Al-4V fabricated by selective laser melting","volume":"98","author":"Kelly","year":"2019","journal-title":"Mat. Sci. Eng. C-Mater."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.oraloncology.2018.01.005","article-title":"Three-dimensional printing of patient-specific surgical plates in head and neck reconstruction: a prospective pilot study","volume":"78","author":"Yang","year":"2018","journal-title":"Oral Oncol."},{"issue":"10","key":"10.1016\/j.bioactmat.2021.05.007_bib22","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1016\/j.actbio.2014.06.010","article-title":"Influence of cell shape on mechanical properties of Ti-6Al-4V meshes fabricated by electron beam melting method","volume":"10","author":"Li","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmbbm.2018.04.010","article-title":"Osteogenesis of 3D printed porous Ti6Al4V implants with different pore sizes","volume":"84","author":"Ran","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"7","key":"10.1016\/j.bioactmat.2021.05.007_bib24","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.spinee.2018.02.018","article-title":"Bony ingrowth potential of 3D-printed porous titanium alloy: a direct comparison of interbody cage materials in an in vivo ovine lumbar fusion model","volume":"18","author":"McGilvray","year":"2018","journal-title":"Spine J."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jmbbm.2018.08.049","article-title":"The effect of 3D-printed Ti6Al4V scaffolds with various macropore structures on osteointegration and osteogenesis: a biomechanical evaluation","volume":"88","author":"Wang","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1166\/jbn.2018.2551","article-title":"Enhancing the osteogenic differentiation and rapid osseointegration of 3D printed Ti6Al4V implants via nano-topographic modification","volume":"14","author":"Wang","year":"2018","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-981-13-1396-7_27","article-title":"3D Printing in spine surgery","volume":"1093","author":"Cai","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.05.007_bib28","doi-asserted-by":"crossref","first-page":"E50","DOI":"10.1097\/BRS.0000000000001179","article-title":"Reconstruction of the upper cervical spine using a personalized 3D-printed vertebral body in an adolescent with ewing sarcoma","volume":"41","author":"Xu","year":"2016","journal-title":"Spine"},{"issue":"12","key":"10.1016\/j.bioactmat.2021.05.007_bib29","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s00586-013-2976-1","article-title":"Evaluation of a new type of titanium mesh cage versus the traditional titanium mesh cage for single-level, anterior cervical corpectomy and fusion","volume":"22","author":"Yu","year":"2013","journal-title":"Eur. Spine J."},{"issue":"5","key":"10.1016\/j.bioactmat.2021.05.007_bib30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/BSD.0b013e3182425eab","article-title":"The effect of angular mismatch between vertebral endplate and vertebral body replacement endplate on implant subsidence","volume":"26","author":"Mohammad-Shahi","year":"2013","journal-title":"J. Spinal Disord. Tech."},{"issue":"5","key":"10.1016\/j.bioactmat.2021.05.007_bib31","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ab9078","article-title":"Functionalization of 3D-printed titanium alloy orthopedic implants: a literature review","volume":"15","author":"Jing","year":"2020","journal-title":"Biomed. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib32","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/8\/4\/045012","article-title":"Incorporating simvastatin\/poloxamer 407 hydrogel into 3D-printed porous Ti6Al4V scaffolds for the promotion of angiogenesis, osseointegration and bone ingrowth","volume":"8","author":"Liu","year":"2016","journal-title":"Biofabrication"},{"issue":"5","key":"10.1016\/j.bioactmat.2021.05.007_bib33","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1039\/C9BM01655D","article-title":"Improved osseointegration with rhBMP-2 intraoperatively loaded in a specifically designed 3D-printed porous Ti6Al4V vertebral implant","volume":"8","author":"Zhang","year":"2020","journal-title":"Biomater. Sci-Uk"},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib34","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/10\/3\/035013","article-title":"Enhanced angiogenesis and osteogenesis in critical bone defects by the controlled release of BMP-2 and VEGF: implantation of electron beam melting-fabricated porous Ti6Al4V scaffolds incorporating growth factor-doped fibrin glue","volume":"10","author":"Lv","year":"2015","journal-title":"Biomed. Mater."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s40843-017-9208-x","article-title":"Polydopamine-assisted functionalization of heparin and vancomycin onto microarc-oxidized 3D printed porous Ti6Al4V for improved hemocompatibility, osteogenic and anti-infection potencies","volume":"61","author":"Zhang","year":"2018","journal-title":"Sci. Chn. Mater."},{"issue":"9","key":"10.1016\/j.bioactmat.2021.05.007_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1470-2045(02)00846-X","article-title":"Part I: chemotherapy for epithelial ovarian cancer - treatment at first diagnosis","volume":"3","author":"Harries","year":"2002","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib37","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/jso.10123","article-title":"Surgical quality in trials of adjuvant cancer therapy","volume":"80","author":"Hundahl","year":"2002","journal-title":"J. Surg. Oncol."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1040-8428(99)00017-7","article-title":"Intraperitoneal chemotherapy","volume":"31","author":"Markman","year":"1999","journal-title":"Crit. Rev. Oncol.-Hematol."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1051-0443(07)61423-7","article-title":"Neoadjuvant chemotherapy by transcatheter arterial infusion method for uterine cervical cancer","volume":"11","author":"Nagata","year":"2000","journal-title":"J. Vasc. Intervent. Radiol."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2008.01.005","article-title":"In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery","volume":"127","author":"He","year":"2008","journal-title":"J. Contr. Release"},{"issue":"8","key":"10.1016\/j.bioactmat.2021.05.007_bib41","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1039\/b713009k","article-title":"Injectable hydrogels as unique biomedical materials","volume":"37","author":"Yu","year":"2008","journal-title":"Chem. Soc. Rev."},{"issue":"1\u20133","key":"10.1016\/j.bioactmat.2021.05.007_bib42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0168-3659(01)00276-0","article-title":"Biodegradable block copolymers for delivery of proteins and water-insoluble drugs","volume":"72","author":"Zentner","year":"2001","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib43","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1023\/A:1011074915438","article-title":"Controlled release of insulin from injectable biodegradable triblock copolymer","volume":"18","author":"Kim","year":"2001","journal-title":"Pharm. Res. (N. Y.)"},{"issue":"30","key":"10.1016\/j.bioactmat.2021.05.007_bib44","doi-asserted-by":"crossref","first-page":"8723","DOI":"10.1016\/j.biomaterials.2014.06.045","article-title":"PLK1shRNA and doxorubicin co-loaded thermosensitive PLGA-PEG-PLGA hydrogels for osteosarcoma treatment","volume":"35","author":"Ma","year":"2014","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib45","doi-asserted-by":"crossref","DOI":"10.1208\/s12248-019-0326-x","article-title":"Biodegradable thermosensitive PLGA-PEG-PLGA polymer for non-irritating and sustained ophthalmic drug delivery","volume":"21","author":"Chan","year":"2019","journal-title":"AAPS J."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.05.007_bib46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejpb.2013.03.036","article-title":"Characterization of dynamics in complex lyophilized formulations: II. Analysis of density variations in terms of glass dynamics and comparisons with global mobility, fast dynamics, and Positron Annihilation Lifetime Spectroscopy (PALS)","volume":"85","author":"Chieng","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"9\u201310","key":"10.1016\/j.bioactmat.2021.05.007_bib47","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1515\/pac-2014-1117","article-title":"Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report)","volume":"87","author":"Thommes","year":"2015","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.bioactmat.2021.05.007_bib48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.msec.2017.12.033","article-title":"Introducing an attractive method for total biomimetic creation of a synthetic biodegradable bioactive bone scaffold based on statistical experimental design","volume":"86","author":"Shahbazi","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"issue":"2","key":"10.1016\/j.bioactmat.2021.05.007_bib49","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aa698e","article-title":"Structural monitoring and modeling of the mechanical deformation of three-dimensional printed poly(epsilon-caprolactone) scaffolds","volume":"9","author":"Ribeiro","year":"2017","journal-title":"Biofabrication"},{"issue":"36","key":"10.1016\/j.bioactmat.2021.05.007_bib50","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.1016\/j.biomaterials.2013.08.024","article-title":"Effects of compatibility of deproteinized antler cancellous bone with various bioactive factors on their osteogenic potential","volume":"34","author":"Zhang","year":"2013","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.bioactmat.2021.05.007_bib51","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1021\/acsami.9b22474","article-title":"Controlled delivery of curcumin and vitamin K2 from hydroxyapatite-coated titanium implant for enhanced in vitro chemoprevention, osteogenesis, and in vivo osseointegration","volume":"12","author":"Sarkar","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"30","key":"10.1016\/j.bioactmat.2021.05.007_bib52","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1016\/j.biomaterials.2011.06.072","article-title":"Biodegradable polymer - cisplatin(IV) conjugate as a pro-drug of cisplatin(II)","volume":"32","author":"Xiao","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2021.05.007_bib53","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s13287-020-01917-y","article-title":"Human amniotic epithelial cells ameliorate kidney damage in ischemia-reperfusion mouse model of acute kidney injury","volume":"11","author":"Ren","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.bioactmat.2021.05.007_bib54","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF00391826","article-title":"Estimation of liver tumor volume using different formulas - an experimental study in rats","volume":"105","author":"Carlsson","year":"1983","journal-title":"J. Canc. Res. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib55","first-page":"293","article-title":"[Effect of electroacupuncture stimulation of \"Feishu\" (BL 13) on lung index, serum and lung IL-10 and TNF-alpha levels in mice with viral pneumonia]","volume":"39","author":"Luo","year":"2014","journal-title":"Zhen ci yan jiu = Acupuncture Research"},{"issue":"10","key":"10.1016\/j.bioactmat.2021.05.007_bib56","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1021\/acsami.5b00331","article-title":"Improving osteointegration and osteogenesis of three-dimensional porous Ti6Al4V scaffolds by polydopamine-assisted biomimetic hydroxyapatite coating","volume":"7","author":"Li","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"28","key":"10.1016\/j.bioactmat.2021.05.007_bib57","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1021\/acsami.6b05893","article-title":"Tailored surface treatment of 3D printed porous Ti6Al4V by microarc oxidation for enhanced osseointegration via optimized bone in-growth patterns and interlocked bone\/implant interface","volume":"8","author":"Xiu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"10","key":"10.1016\/j.bioactmat.2021.05.007_bib58","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1074\/jbc.M707568200","article-title":"ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis","volume":"283","author":"Pabla","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.05.007_bib59","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.canlet.2012.01.007","article-title":"DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis","volume":"332","author":"Roos","year":"2013","journal-title":"Canc. Lett."},{"issue":"5","key":"10.1016\/j.bioactmat.2021.05.007_bib60","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4161\/cbt.23761","article-title":"Chemotherapy induced DNA damage response: convergence of drugs and pathways","volume":"14","author":"Woods","year":"2013","journal-title":"Canc. Biol. Ther."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.05.007_bib61","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular processing of platinum anticancer drugs","volume":"4","author":"Wang","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"52","key":"10.1016\/j.bioactmat.2021.05.007_bib62","doi-asserted-by":"crossref","first-page":"52084","DOI":"10.1074\/jbc.M310120200","article-title":"Multiple states of stalled T7 RNA polymerase at DNA lesions generated by platinum anticancer agents","volume":"278","author":"Jung","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.05.007_bib63","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00204-015-1633-3","article-title":"DNA damage response in cisplatin-induced nephrotoxicity","volume":"89","author":"Zhu","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"49","key":"10.1016\/j.bioactmat.2021.05.007_bib64","doi-asserted-by":"crossref","first-page":"85150","DOI":"10.18632\/oncotarget.19554","article-title":"The synergistic antitumor effect of cinobufagin and cisplatin in human osteosarcoma cell line in vitro and in vivo","volume":"8","author":"Dai","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib65","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/jbm.a.31468","article-title":"Bone growth in rapid prototyped porous titanium implants","volume":"85","author":"Lopez-Heredia","year":"2008","journal-title":"J. Biomed. Mater. Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.05.007_bib66","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/jor.22527","article-title":"Cisplatin inhibits bone healing during distraction osteogenesis","volume":"32","author":"Stine","year":"2014","journal-title":"J. Orthop. Res."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21002267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21002267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T15:54:01Z","timestamp":1762530841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21002267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":66,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S2452199X21002267"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.05.007","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Practical strategy to construct anti-osteosarcoma bone substitutes by loading cisplatin into 3D-printed titanium alloy implants using a thermosensitive hydrogel","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}