{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:32:40Z","timestamp":1780698760074,"version":"3.54.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004739","name":"Chinese Academy of Sciences Youth Innovation Promotion Association","doi-asserted-by":"publisher","award":["2019230"],"award-info":[{"award-number":["2019230"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973216"],"award-info":[{"award-number":["51973216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873207"],"award-info":[{"award-number":["51873207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803006"],"award-info":[{"award-number":["51803006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51833010"],"award-info":[{"award-number":["51833010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52022095"],"award-info":[{"award-number":["52022095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011302","name":"State Key Laboratory of Advanced Technology for Materials Synthesis Processing","doi-asserted-by":"publisher","award":["2020-KF-5"],"award-info":[{"award-number":["2020-KF-5"]}],"id":[{"id":"10.13039\/501100011302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007724","name":"Wuhan University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20190303154SF"],"award-info":[{"award-number":["20190303154SF"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20200404182YY"],"award-info":[{"award-number":["20200404182YY"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20200201478JC"],"award-info":[{"award-number":["20200201478JC"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.bioactmat.2021.08.005","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T08:37:56Z","timestamp":1629448676000},"page":"446-460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Biofunctionalized composite scaffold to potentiate osteoconduction, angiogenesis, and favorable metabolic microenvironment for osteonecrosis therapy"],"prefix":"10.1016","volume":"9","author":[{"given":"Tongtong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-5663","authenticated-orcid":false,"given":"Mingran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-6298","authenticated-orcid":false,"given":"Xiaoyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xukai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-8863","authenticated-orcid":false,"given":"Jianxun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2021.08.005_bib1","doi-asserted-by":"crossref","first-page":"4176926","DOI":"10.1155\/2020\/4176926","article-title":"The proosteogenic and proangiogenic effects of small extracellular vesicles derived from bone marrow mesenchymal stem cells are attenuated in steroid-induced osteonecrosis of the femoral head","volume":"2020","author":"Li","year":"2020","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib2","first-page":"584","article-title":"Engineered three-dimensional scaffolds for enhanced bone regeneration in osteonecrosis","volume":"5","author":"Zhu","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib3","doi-asserted-by":"crossref","first-page":"115258","DOI":"10.1016\/j.bone.2020.115258","article-title":"Circular RNA CDR1 as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head","volume":"133","author":"Chen","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bioactmat.2021.08.005_bib4","article-title":"The expression of chondrogenesis-related and arthritis-related genes in human ONFH cartilage with different Ficat stages","volume":"7","author":"Chen","year":"2019","journal-title":"PeerJ"},{"issue":"4","key":"10.1016\/j.bioactmat.2021.08.005_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s100670200078","article-title":"Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment","volume":"21","author":"Koo","year":"2002","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.08.005_bib6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/14397595.2014.932038","article-title":"Epidemiology of nontraumatic osteonecrosis of the femoral head in Japan","volume":"25","author":"Ikeuchi","year":"2015","journal-title":"Mod. Rheumatol."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.biomaterials.2019.01.013","article-title":"Osteogenic magnesium incorporated into PLGA\/TCP porous scaffold by 3D printing for repairing challenging bone defect","volume":"197","author":"Lai","year":"2019","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.bioactmat.2021.08.005_bib8","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/jbmr.2542","article-title":"Blockage of Src by specific siRNA as a novel therapeutic strategy to prevent destructive repair in steroid-associated osteonecrosis in rabbits","volume":"30","author":"Zheng","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib9","doi-asserted-by":"crossref","first-page":"111101","DOI":"10.1016\/j.msec.2020.111101","article-title":"Antibacterial alginate\/nano-hydroxyapatite composites for bone tissue engineering: Assessment of their bioactivity, biocompatibility, and antibacterial activity","volume":"115","author":"Benedini","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib10","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.actbio.2020.05.032","article-title":"Mineral distribution spatially patterns bone marrow stromal cell behavior on monolithic bone scaffolds","volume":"112","author":"Zhou","year":"2020","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.08.005_bib11","first-page":"346","article-title":"Poly(lactic-co-glycolic acid)-based composite bone-substitute materials","volume":"6","author":"Zhao","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib12","doi-asserted-by":"crossref","first-page":"119617","DOI":"10.1016\/j.biomaterials.2019.119617","article-title":"Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation","volume":"230","author":"Cui","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.005_bib13","doi-asserted-by":"crossref","first-page":"119985","DOI":"10.1016\/j.biomaterials.2020.119985","article-title":"Exosome-mimetics as an engineered gene-activated matrix induces in-situ vascularized osteogenesis","volume":"247","author":"Zha","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2021.08.005_bib14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/adma.201403943","article-title":"Evaluating 3D-printed biomaterials as scaffolds for vascularized bone tissue engineering","volume":"27","author":"Wang","year":"2015","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.bioactmat.2021.08.005_bib15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.cellbi.2005.03.011","article-title":"Osteocalcin is angiogenic in vivo","volume":"29","author":"Cantatore","year":"2005","journal-title":"Cell Biol. Int."},{"issue":"2","key":"10.1016\/j.bioactmat.2021.08.005_bib16","first-page":"58","article-title":"Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview)","volume":"3","author":"Xie","year":"2015","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biomaterials.2018.09.030","article-title":"The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis","volume":"187","author":"Maruyama","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.005_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.10.025","article-title":"Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits","volume":"153","author":"Lai","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.005_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.progpolymsci.2019.01.002","article-title":"Electrospun polymer biomaterials","volume":"90","author":"Ding","year":"2019","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actbio.2018.11.039","article-title":"Three-dimensional (3D) printed scaffold and material selection for bone repair","volume":"84","author":"Zhang","year":"2019","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.bioactmat.2021.08.005_bib21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/0885328207077632","article-title":"Preparation and properties of poly(lactide-co-glycolide) (PLGA)\/nano-hydroxyapatite (nHA) scaffolds by thermally induced phase separation and rabbit MSCs culture on scaffolds","volume":"22","author":"Huang","year":"2008","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib22","first-page":"185","article-title":"Mussel-inspired polydopamine induced the osteoinductivity to ice-templating PLGA\u2013gelatin matrix for bone tissue engineering application","volume":"3","author":"Rezaei","year":"2020","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib23","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5082\/3\/3\/034103","article-title":"Design and fabrication of a novel porous implant with preset channels based on ceramic stereolithography for vascular implantation","volume":"3","author":"Bian","year":"2011","journal-title":"Biofabrication"},{"issue":"1","key":"10.1016\/j.bioactmat.2021.08.005_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/01.RES.0000050588.35034.3C","article-title":"Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction","volume":"92","author":"Iuchi","year":"2003","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/os.12680","article-title":"Role of junction-mediating and regulatory protein in the pathogenesis of glucocorticoid-induced endothelial cell lesions","volume":"12","author":"Zuo","year":"2020","journal-title":"Orthop. Surg."},{"issue":"4","key":"10.1016\/j.bioactmat.2021.08.005_bib26","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.7150\/thno.40103","article-title":"A bioceramic scaffold composed of strontium-doped three-dimensional hydroxyapatite whiskers for enhanced bone regeneration in osteoporotic defects","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib27","first-page":"680","article-title":"Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application","volume":"5","author":"Gao","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib28","doi-asserted-by":"crossref","first-page":"100752","DOI":"10.1016\/j.jbior.2020.100752","article-title":"The roles of osteocalcin in lipid metabolism in adipose tissue and liver","volume":"78","author":"Otani","year":"2020","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.actbio.2020.05.023","article-title":"An \"all-in-one\" scaffold targeting macrophages to direct endogenous bone repair in situ","volume":"111","author":"Niu","year":"2020","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.bioactmat.2021.08.005_bib30","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1021\/acsbiomaterials.6b00202","article-title":"High-pressure compression-molded porous resorbable polymer\/hydroxyapatite composite scaffold for cranial bone regeneration","volume":"2","author":"Zhang","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.actbio.2020.04.047","article-title":"3D-printed scaffolds with carbon nanotubes for bone tissue engineering: Fast and homogeneous one-step functionalization","volume":"111","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biomaterials.2018.10.033","article-title":"Vascularized 3D printed scaffolds for promoting bone regeneration","volume":"190","author":"Yan","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.005_bib33","doi-asserted-by":"crossref","first-page":"119552","DOI":"10.1016\/j.biomaterials.2019.119552","article-title":"Periosteal matrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis","volume":"227","author":"Qiu","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.bioactmat.2021.08.005_bib34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/jcp.28998","article-title":"Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway","volume":"235","author":"Zhao","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.bioactmat.2021.08.005_bib35","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1159\/000496039","article-title":"Shikimic acid inhibits osteoclastogenesis in vivo and in vitro by blocking RANK\/TRAF6 association and suppressing NF-\u03baB and MAPK signaling pathways","volume":"51","author":"Chen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/jcp.21898","article-title":"Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-\u03baB and NFAT activity","volume":"221","author":"Ang","year":"2009","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11306-019-1491-8","article-title":"Global urinary metabolic profiling of the osteonecrosis of the femoral head based on UPLC\u2013QTOF\/MS","volume":"15","author":"Yang","year":"2019","journal-title":"Metabolomics"},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1254\/jphs.10310FP","article-title":"A negative correlation between expression profiles of runt-related transcription factor-2 and cystine\/glutamate antiporter xCT subunit in ovariectomized mouse bone","volume":"115","author":"Uno","year":"2011","journal-title":"J. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.bioactmat.2021.08.005_bib39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/metabo10060223","article-title":"Metabolomic profiling in the characterization of degenerative bone and joint diseases","volume":"10","author":"Swank","year":"2020","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/j.bioactmat.2021.08.005_bib40","doi-asserted-by":"crossref","first-page":"H2061","DOI":"10.1152\/ajpheart.00525.2011","article-title":"Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction","volume":"301","author":"Shimazu","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bioactmat.2021.08.005_bib41","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bone.2019.06.021","article-title":"Genome-wide DNA methylation profiling of hip articular cartilage identifies differentially methylated loci associated with osteonecrosis of the femoral head","volume":"127","author":"Wu","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.bioactmat.2021.08.005_bib42","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1039\/C9FO01944H","article-title":"Metabolomics strategy reveals the osteogenic mechanism of yak (Bos grunniens) bone collagen peptides on ovariectomy-induced osteoporosis in rats","volume":"11","author":"Ye","year":"2020","journal-title":"Food Funct"},{"issue":"3","key":"10.1016\/j.bioactmat.2021.08.005_bib43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.bioactmat.2021.08.005_bib44","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.18632\/oncotarget.24150","article-title":"A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head","volume":"9","author":"Ren","year":"2018","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.bioactmat.2021.08.005_bib45","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1039\/C9FO02882J","article-title":"Untargeted metabolomics revealed therapeutic mechanisms of icariin on low bone mineral density in older caged laying hens","volume":"11","author":"Huang","year":"2020","journal-title":"Food Funct"},{"key":"10.1016\/j.bioactmat.2021.08.005_bib46","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jpba.2019.01.019","article-title":"Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid-induced osteoporosis","volume":"166","author":"Xia","year":"2019","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"12","key":"10.1016\/j.bioactmat.2021.08.005_bib47","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1182\/blood-2007-11-126680","article-title":"An essential role for SRC-activated STAT-3 in 14,15-EET\u2013induced VEGF expression and angiogenesis","volume":"111","author":"Cheranov","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bioactmat.2021.08.005_bib48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41467-018-08097-7","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21003686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21003686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:02:25Z","timestamp":1778889745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21003686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":48,"alternative-id":["S2452199X21003686"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.08.005","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biofunctionalized composite scaffold to potentiate osteoconduction, angiogenesis, and favorable metabolic microenvironment for osteonecrosis therapy","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}