{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:19:32Z","timestamp":1790363972710,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673066"],"award-info":[{"award-number":["51673066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21875069"],"award-info":[{"award-number":["21875069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bioactmat.2021.08.010","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T01:38:44Z","timestamp":1628645924000},"page":"79-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-\u03baB\/NLRP3 pathways"],"prefix":"10.1016","volume":"10","author":[{"given":"Lihe","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-0694","authenticated-orcid":false,"given":"Shuizhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2021.08.010_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41579-020-0367-2","article-title":"Host-microbiota interactions in immune-mediated diseases","volume":"18","author":"Ruff","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41584-018-0137-y","article-title":"Preventing immune-complex-mediated disease","volume":"15","author":"Bernard","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib3","first-page":"22","article-title":"Immune-mediated disease genetics: the shared basis of pathogenesis, Trends","volume":"34","author":"Cotsapas","year":"2013","journal-title":"Immunol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/pgmj.2006.052688","article-title":"Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution","volume":"83","author":"Kuek","year":"2007","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13075-019-1980-1","article-title":"Risk of immune-mediated inflammatory diseases in newly diagnosed ankylosing spondylitis patients: a population-based matched cohort study","volume":"21","author":"Chen","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib6","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1007\/s12325-019-00964-z","article-title":"Risk of developing additional immune-mediated manifestations: a retrospective matched cohort study","volume":"36","author":"Aletaha","year":"2019","journal-title":"Adv. Ther."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1136\/annrheumdis-2017-211555","article-title":"Novel therapies for immune-mediated inflammatory diseases: what can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, crohn's disease and ulcerative colitis?","volume":"77","author":"Baker","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib8","doi-asserted-by":"crossref","first-page":"i43","DOI":"10.1093\/rheumatology\/key276","article-title":"JAK-inhibitors. new players in the field of immune-mediated diseases, beyond rheumatoid arthritis","volume":"58","author":"Fragoulis","year":"2019","journal-title":"Rheumatology"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib9","first-page":"4883","article-title":"The JAK inhibitor tofacitinib ameliorates immune-mediated liver injury in mice","volume":"20","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib10","first-page":"187","volume":"9","author":"Sahebjam","year":"2015","journal-title":"Autoimmune hepatitis, Front. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/apt.15370","article-title":"Increased risk of developing crohn's disease or ulcerative colitis in 17018 patients while under treatment with anti-TNF\u03b1 agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease","volume":"50","author":"Korzenik","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib12","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/imr.12557","article-title":"Innate and adaptive type 2 immunity in lung allergic inflammation","volume":"278","author":"Kubo","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib13","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.cgh.2019.03.040","article-title":"Incidence of immune-mediated inflammatory diseases among patients with inflammatory bowel diseases in Denmark","volume":"17","author":"Burisch","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1124\/pr.117.014878","article-title":"The purinergic system as a pharmacological target for the treatment of immune-mediated inflammatory diseases","volume":"71","author":"Antonioli","year":"2019","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib15","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/annrheumdis-2016-210715","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib16","first-page":"CD012437","article-title":"Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a cochrane systematic review and network meta-analysis (NMA)","volume":"11","author":"Singh","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib17","doi-asserted-by":"crossref","first-page":"ii2","DOI":"10.1136\/annrheumdis-2013-203348","article-title":"Updated consensus statement on biological agents for the treatment of rheumatic diseases","volume":"72","author":"Furst","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3899\/jrheum.140103","article-title":"Tuberculosis risk in patients treated with non-anti-tumor necrosis factor-\u03b1 (TNF-\u03b1) targeted biologics and recently licensed TNF-\u03b1 inhibitors: data from clinical trials and national registries","volume":"91","author":"Cantini","year":"2014","journal-title":"J. Rheumatol. Suppl."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2217\/imt-2018-0178","article-title":"Comparison of janus kinase inhibitors in the treatment of rheumatoid arthritis: a systemic literature review","volume":"11","author":"Jegatheeswaran","year":"2019","journal-title":"Immunotherapy"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/annrheumdis-2020-218690","article-title":"Janus kinase (JAK) inhibition with baricitinib in refractory juvenile dermatomyositis","volume":"80","author":"Kim","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nri3823","article-title":"The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases","volume":"15","author":"Klatzmann","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-020-2996-z","article-title":"Galactosaminogalactan activates the inflammasome to provide host protection","volume":"588","author":"Briard","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41564-018-0298-0","article-title":"Fungal ligands released by innate immune effectors promote inflammasome activation during aspergillus fumigatus infection","volume":"4","author":"Briard","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib24","first-page":"3343","article-title":"Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3\u03b2\/\u03b2-catenin signalling pathway","volume":"6","author":"Zheng","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib25","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2015.01.008","article-title":"NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases","volume":"4","author":"Abderrazak","year":"2015","journal-title":"Redox. Biol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41582-020-0366-y","article-title":"NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis","volume":"16","author":"Lempri\u00e8re","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2009.137","article-title":"The nuclear signaling of NF-\u03baB: current knowledge, new insights, and future perspectives","volume":"20","author":"Wan","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1158\/0008-5472.CAN-08-2442","article-title":"Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation","volume":"69","author":"Choi","year":"2009","journal-title":"Canc. Res."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib32","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1172\/JCI90699","article-title":"TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies","volume":"127","author":"McGeough","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib33","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/mnfr.201600106","article-title":"Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL\/6 mice","volume":"60","author":"Jhang","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib34","doi-asserted-by":"crossref","first-page":"108628","DOI":"10.1016\/j.foodres.2019.108628","article-title":"Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation","volume":"127","author":"Wang","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzz101","article-title":"Molecular mechanisms of epigallocatechin-3-gallate for prevention of chronic kidney disease and renal fibrosis: preclinical evidence","volume":"3","author":"Kanlaya","year":"2019","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib36","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/14728222.2018.1511706","article-title":"Lactate transporters as therapeutic targets in cancer and inflammatory diseases","volume":"22","author":"Pucino","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5657","article-title":"An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease","volume":"7","author":"Zhang","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib38","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.jaci.2017.08.049","article-title":"Protein corona-mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses","volume":"142","author":"Shen","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib39","doi-asserted-by":"crossref","first-page":"1606209","DOI":"10.1002\/adma.201606209","article-title":"Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization","volume":"29","author":"Dehaini","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2018.12.019","article-title":"Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic","volume":"294","author":"Wu","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib41","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.2217\/nnm-2017-0225","article-title":"Cell membrane coated nanoparticles: next-generation therapeutics","volume":"12","author":"Narain","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib42","doi-asserted-by":"crossref","first-page":"12096","DOI":"10.1021\/acsnano.8b05292","article-title":"Cell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth","volume":"12","author":"Deng","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41569-020-0433-5","article-title":"Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications","volume":"18","author":"Matyas","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib44","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","article-title":"Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease","volume":"26","author":"Bourgonje","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib45","first-page":"3461","article-title":"Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib46","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.3389\/fimmu.2019.02787","article-title":"Environmental exposures and asthma development: autophagy, mitophagy, and cellular senescence","volume":"10","author":"Sachdeva","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2018.05.086","article-title":"Oxidative stress in autoimmune rheumatic diseases","volume":"125","author":"Smallwood","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib48","first-page":"1","article-title":"ROS-responsive capsules engineered from EGCG-Zinc networks improve therapeutic angiogenesis in mouse limb ischemia","volume":"6","author":"Chen","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biomaterials.2017.08.008","article-title":"Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice","volume":"144","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib50","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1021\/acs.analchem.0c05364","article-title":"Monitoring the fluctuation of hydrogen peroxide in diabetes and its complications with a novel near-infrared fluorescent probe","volume":"93","author":"Wang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib51","doi-asserted-by":"crossref","first-page":"10111","DOI":"10.1002\/anie.201913149","article-title":"Nanoaggregate probe for breast cancer metastasis through multispectral optoacoustic tomography and aggregation-induced NIR-I\/II fluorescence imaging","volume":"59","author":"Ouyang","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib52","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1039\/C9SC06310B","article-title":"Bright red aggregation-induced emission nanoparticles for multifunctional applications in cancer therapy","volume":"11","author":"Zhang","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib53","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1039\/C9TB01012B","article-title":"NIR fluorescent probes with good water-solubility for detection of amyloid beta aggregates in alzheimer's disease","volume":"7","author":"Xu","year":"2019","journal-title":"J. Mater. Chem. B."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib54","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1021\/acs.analchem.0c04537","article-title":"Construction of NIR and ratiometric fluorescent probe for monitoring carbon monoxide under oxidative stress in zebrafish","volume":"93","author":"Jiang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib55","first-page":"4209","article-title":"MoS2-based nanocomposites for cancer diagnosis and therapy","volume":"6","author":"Wang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib56","first-page":"794","article-title":"Cyanine conjugates in cancer theranostics","volume":"6","author":"Li","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.biomaterials.2014.10.014","article-title":"Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT)","volume":"37","author":"Beziere","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib58","first-page":"312","article-title":"Reversing cold tumors to hot: an immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy","volume":"6","author":"Fan","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib59","doi-asserted-by":"crossref","first-page":"120736","DOI":"10.1016\/j.biomaterials.2021.120736","article-title":"NAD(P)H-triggered probe for dual-modal imaging during energy metabolism and novel strategy of enhanced photothermal therapy in tumor","volume":"271","author":"Tian","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib60","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1038\/s41467-018-06499-1","article-title":"Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography","volume":"9","author":"Wu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib61","doi-asserted-by":"crossref","first-page":"7924","DOI":"10.1039\/D1CS00358E","article-title":"Emerging contrast agents for multispectral optoacoustic imaging and their biomedical applications","volume":"50","author":"Wu","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib62","doi-asserted-by":"crossref","first-page":"10216","DOI":"10.1039\/D0NR00963F","article-title":"Real-time monitoring and accurate diagnosis of drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite","volume":"12","author":"Zhuang","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib63","doi-asserted-by":"crossref","first-page":"11102","DOI":"10.1039\/D0CC04635C","article-title":"An activatable probe for detecting alcoholic liver injury via multispectral optoacoustic tomography and fluorescence imaging","volume":"56","author":"Chen","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib64","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1039\/C7SC03454G","article-title":"A mitochondrial-targeted prodrug for NIR imaging guided and synergetic NIR photodynamic-chemo cancer therapy","volume":"8","author":"Liu","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib65","doi-asserted-by":"crossref","first-page":"41003","DOI":"10.1021\/acsami.8b07527","article-title":"A targeted and pH-responsive bortezomib nanomedicine in the treatment of metastatic bone tumors","volume":"10","author":"Wang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib66","doi-asserted-by":"crossref","first-page":"11488","DOI":"10.1073\/pnas.1714267114","article-title":"Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management","volume":"114","author":"Thamphiwatana","year":"2017","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib67","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41467-020-16439-7","article-title":"Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib68","doi-asserted-by":"crossref","first-page":"1804023","DOI":"10.1002\/adma.201804023","article-title":"Pretreated macrophage-membrane-coated gold nanocages for precise drug delivery for treatment of bacterial infections","volume":"30","author":"Wang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib69","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/hep.29140","article-title":"Toll-like receptor 5 signaling restrains T-cell\/natural killer T-cell activation and protects against concanavalin A-induced hepatic injury","volume":"65","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib70","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0168-8278(02)00059-4","article-title":"Antithrombin III prevents concanavalin A-induced liver injury through inhibition of macrophage inflammatory protein-2 release and production of prostacyclin in mice","volume":"36","author":"Nakamura","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib71","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2019.11.033","article-title":"Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-\u03baB signaling","volume":"147","author":"Zhang","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib72","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3389\/fimmu.2018.01881","article-title":"Quantitative proteomic analysis reveals that arctigenin alleviates concanavalin A-induced hepatitis through suppressing immune system and regulating autophagy","volume":"9","author":"Feng","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib73","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1039\/C9CC01747J","article-title":"Photocontrolled endogenous reactive oxygen species (ROS) generation","volume":"55","author":"Sharma","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib74","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-079X.1997.tb00342.x","article-title":"Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity","volume":"23","author":"Cuzzocrea","year":"1997","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib75","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.freeradbiomed.2012.09.001","article-title":"Nitroxides attenuate carrageenan-induced inflammation in rat paws by reducing neutrophil infiltration and the resulting myeloperoxidase-mediated damage","volume":"53","author":"Queiroz","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bioactmat.2021.08.010_bib76","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/00000542-200607000-00022","article-title":"Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (part 1): hyperalgesia, edema, and systemic cytokines","volume":"105","author":"Beloeil","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib77","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3390\/antiox9070600","article-title":"N-acetylcysteine nanocarriers protect against oxidative stress in a cellular model of Parkinson's disease","volume":"9","author":"Mursaleen","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.bioactmat.2021.08.010_bib78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20130282","article-title":"ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors","volume":"454","author":"Halasi","year":"2013","journal-title":"Biochem. J."}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21003868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21003868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:02:17Z","timestamp":1778889737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21003868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":78,"alternative-id":["S2452199X21003868"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.08.010","relation":{},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-\u03baB\/NLRP3 pathways","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.08.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}