{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:13:42Z","timestamp":1786605222111,"version":"build-2736575974"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioactive Materials"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bioactmat.2021.08.027","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T17:51:22Z","timestamp":1633801882000},"page":"32-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone"],"prefix":"10.1016","volume":"10","author":[{"given":"Wenhao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2568-0482","authenticated-orcid":false,"given":"Yuan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoman","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.C.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1270-1870","authenticated-orcid":false,"given":"Shuilin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin W.K.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bioactmat.2021.08.027_bib1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2106\/JBJS.G.01701","article-title":"Acetabular revision with impacted morselized cancellous bone graft and a cemented cup in patients with rheumatoid ArthritisA concise follow-up, at eight to nineteen years, of a previous report*","volume":"91","author":"Schreurs","year":"2009","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib2","first-page":"2253","article-title":"Treatment of aneurysmal bone cysts by introduction of demineralized bone and autogenous bone marrow","volume":"87","author":"Docquier","year":"2005","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib3","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1007\/s00198-004-1728-9","article-title":"Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone","volume":"16","author":"Augat","year":"2005","journal-title":"Osteoporosis Int"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib4","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.injury.2005.07.029","article-title":"Bone substitutes: an update","volume":"36","author":"Giannoudis","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/230949900901700218","article-title":"Bone transplantation and immune response","volume":"17","author":"Shegarfi","year":"2009","journal-title":"J. Orthop. Surg."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib6","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s10856-014-5240-2","article-title":"Bone substitutes in orthopaedic surgery: from basic science to clinical practice","volume":"25","author":"Campana","year":"2014","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nmat3937","article-title":"Materials as stem cell regulators","volume":"13","author":"Murphy","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.colsurfb.2018.01.022","article-title":"Tuning surface properties of bone biomaterials to manipulate osteoblastic cell adhesion and the signaling pathways for the enhancement of early osseointegration","volume":"164","author":"Chen","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib9","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1089\/ten.2006.0437","article-title":"Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds","volume":"13","author":"Sellaro","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib10","doi-asserted-by":"crossref","first-page":"8185","DOI":"10.1016\/j.biomaterials.2013.07.022","article-title":"The effect of sterilization methods on the osteoconductivity of allograft bone in a critical-sized bilateral tibial defect model in rabbits","volume":"34","author":"Russell","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bone.2017.01.020","article-title":"Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis","volume":"97","author":"Cohn Yakubovich","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bone.2014.01.006","article-title":"Bone embrittlement and collagen modifications due to high-dose gamma-irradiation sterilization","volume":"61","author":"Burton","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00003086-200006000-00026","article-title":"Complications of irradiated allografts in orthopaedic tumor surgery","volume":"375","author":"Lietman","year":"2000","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib14","article-title":"Fractal-like hierarchical organization of bone begins at the nanoscale","volume":"360","author":"Reznikov","year":"2018","journal-title":"Science (80)"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib15","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nmat2013","article-title":"The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder","volume":"6","author":"Dalby","year":"2007","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nmat2269","article-title":"Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells","volume":"7","author":"Benoit","year":"2008","journal-title":"Nat. Mater."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nbt1055","article-title":"Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering","volume":"23","author":"Lutolf","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib19","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1016\/j.biomaterials.2013.08.005","article-title":"The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing","volume":"34","author":"Hoffman","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib20","first-page":"1700550","article-title":"3D-Bioprinted osteoblast-laden nanocomposite hydrogel constructs with induced microenvironments promote cell viability, differentiation, and osteogenesis both in vitro and in vivo","author":"Zhai","year":"2017","journal-title":"Advanced Science"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bioactmat.2020.08.025","article-title":"Stepwise 3D-spatio-temporal magnesium cationic niche: nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification","volume":"6","author":"Shen","year":"2021","journal-title":"Bioactive materials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib22","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.biomaterials.2010.11.017","article-title":"Magnesium incorporation into hydroxyapatite","volume":"32","author":"Laurencin","year":"2011","journal-title":"Biomaterials"},{"issue":"S1","key":"10.1016\/j.bioactmat.2021.08.027_bib23","first-page":"S","article-title":"Magnesium ions enriched decellularized bone allografts for bone tissue engineering","volume":"21","author":"Wang","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib24","article-title":"Porous allograft bone scaffolds: doping with strontium","volume":"8","author":"Zhao","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib25","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1016\/j.biomaterials.2006.03.044","article-title":"The influence of processes for the purification of human bone allografts on the matrix surface and cytocompatibility","volume":"27","author":"Dumas","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0142-9612(99)00193-3","article-title":"Gamma irradiation of human bone allografts alters medullary lipids and releases toxic compounds for osteoblast-like cells","volume":"21","author":"Moreau","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.elecom.2007.12.003","article-title":"Monitoring local spatial distribution of Mg 2+, pH and ionic currents","volume":"10","author":"Lamaka","year":"2008","journal-title":"Electrochem. Commun."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib28","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1021\/la104876w","article-title":"Interfacial pH: a critical factor for osteoporotic bone regeneration","volume":"27","author":"Shen","year":"2011","journal-title":"Langmuir"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1046\/j.1365-2141.2003.04217.x","article-title":"Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase","volume":"120","author":"Mihara","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3109\/10428190903406798","article-title":"Vincristine but not imatinib could suppress mesenchymal niche's support to lymphoid leukemic cells","volume":"51","author":"Fung","year":"2010","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib31","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1016\/j.biomaterials.2013.08.071","article-title":"Cytocompatibility, osseointegration, and bioactivity of three-dimensional porous and nanostructured network on polyetheretherketone","volume":"34","author":"Zhao","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.05.011","article-title":"Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA\/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration","volume":"174","author":"Lin","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.11.018","article-title":"Osseointegration and current interpretations of the bone-implant interface","volume":"84","author":"Shah","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jbm.10270","article-title":"Mechanisms of magnesium\u2010stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants","volume":"62","author":"Zreiqat","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/adhm.201200197","article-title":"Engineering the regenerative microenvironment with biomaterials","volume":"2","author":"Rice","year":"2013","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biomaterials.2015.10.054","article-title":"Magnesium from bioresorbable implants: distribution and impact on the nano- and mineral structure of bone","volume":"76","author":"Grunewald","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib37","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nm.4162","article-title":"Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib38","doi-asserted-by":"crossref","first-page":"1900209","DOI":"10.1002\/advs.201900209","article-title":"A magnesium-enriched 3D culture system that mimics the bone development microenvironment for vascularized bone regeneration","volume":"6","author":"Lin","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib39","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.bioactmat.2021.01.018","article-title":"Regulation of extracellular bioactive cations in bone tissue microenvironment induces favorable osteoimmune conditions to accelerate in situ bone regeneration","volume":"6","author":"Lin","year":"2021","journal-title":"Bioactive materials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.apmt.2019.07.012","article-title":"3D-printed nanocomposite scaffolds with tunable magnesium ionic microenvironment induce in situ bone tissue regeneration","volume":"16","author":"Shen","year":"2019","journal-title":"Applied Materials Today"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib41","series-title":"Reviews: Clinical Implications of Disordered Magnesium Homeostasis in Chronic Renal Failure and Dialysis","first-page":"37","author":"Navarro\u2010Gonz\u00e1lez","year":"2009"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bioactmat.2020.08.025","article-title":"Stepwise 3D-spatio-temporal magnesium cationic niche: nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification","volume":"6","author":"Shen","year":"2021","journal-title":"Bioactive materials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib43","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1016\/j.biomaterials.2014.04.044","article-title":"The effect of metallic magnesium degradation products on osteoclast-induced osteolysis and attenuation of NF-kappaB and NFATc1 signaling","volume":"35","author":"Zhai","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib44","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.injury.2011.03.031","article-title":"The biology of fracture healing","volume":"42","author":"Marsell","year":"2011","journal-title":"Injury"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib45","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib46","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.joca.2010.06.005","article-title":"Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins","volume":"18","author":"Shimaya","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib47","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1089\/scd.2011.0615","article-title":"Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation","volume":"21","author":"Frith","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib48","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.117.5.1109","article-title":"Regulation of alpha 2 beta 1-mediated fibroblast migration on type I collagen by shifts in the concentrations of extracellular Mg2+ and Ca2+","volume":"117","author":"Grzesiak","year":"1992","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib49","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0022-2836(91)90369-H","article-title":"Ionic interactions with parvalbumins: crystal structure determination of pike 4.10 parvalbumin in four different ionic environments","volume":"220","author":"Declercq","year":"1991","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib50","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1002\/term.1861","article-title":"Magnesium ions facilitate integrin alpha 2- and alpha 3-mediated proliferation and enhance alkaline phosphatase expression and activity in hBMSCs","volume":"10","author":"Leem","year":"2016","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/(SICI)1097-4644(20000501)77:2<265::AID-JCB9>3.0.CO;2-6","article-title":"Regulation of \u03b1V\u03b23 and \u03b1V\u03b25 integrins by dexamethasone in normal human osteoblastic cells","volume":"77","author":"Cheng","year":"2000","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib52","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biomaterials.2008.10.047","article-title":"Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability","volume":"30","author":"Martino","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.bioactmat.2021.08.027_bib53","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/jcmm.12061","article-title":"Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation","volume":"17","author":"Wang","year":"2013","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib54","doi-asserted-by":"crossref","first-page":"18587","DOI":"10.1073\/pnas.0812334106","article-title":"Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis","volume":"106","author":"Hamidouche","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib55","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scr.2013.09.009","article-title":"Novel markers of osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach","volume":"12","author":"Gran\u00e9li","year":"2014","journal-title":"Stem Cell Res."},{"issue":"Suppl 1","key":"10.1016\/j.bioactmat.2021.08.027_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/03008207.2014.923877","article-title":"Role of magnesium ions on osteogenic response in bone marrow stromal cells","volume":"55","author":"Yoshizawa","year":"2014","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib57","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1016\/j.actbio.2014.02.002","article-title":"Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation","volume":"10","author":"Yoshizawa","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib58","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00003086-200006000-00026","article-title":"Complications of irradiated allografts in orthopaedic tumor surgery","volume":"375","author":"Lietman","year":"2000","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib59","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.medengphy.2011.11.021","article-title":"The effect of gamma irradiation on the anisotropy of bovine cortical bone","volume":"34","author":"Russell","year":"2012","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.bioactmat.2021.08.027_bib60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jor.20478","article-title":"Effects of gamma irradiation on osteoinduction associated with demineralized bone matrix","volume":"26","author":"Han","year":"2008","journal-title":"J. Orthop. Res."}],"updated-by":[{"DOI":"10.1016\/j.bioactmat.2022.04.009","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000}}],"container-title":["Bioactive Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21004035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452199X21004035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T13:19:09Z","timestamp":1641907149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452199X21004035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":60,"alternative-id":["S2452199X21004035"],"URL":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.08.027","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.bioactmat.2022.04.009","asserted-by":"object"}]},"ISSN":["2452-199X"],"issn-type":[{"value":"2452-199X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone","name":"articletitle","label":"Article Title"},{"value":"Bioactive Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bioactmat.2021.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by KeAi Communications Co., Ltd.","name":"copyright","label":"Copyright"}]}}